Clinical Guide. A Guide to Nutri s Gut Transformation Programme. Managing a healthy digestive system. Your guide to transforming gut function

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1 For professional use only Clinical Guide A Guide to Nutri s Gut Transformation Programme Digestive Health Managing a healthy digestive system The Gut Transformation Programme is an intensive gut clearance protocol which aims to free patients of unpleasant, nagging gut-related issues which they may have been suffering with for years. Bloating, gas, irritable bowel, gastric discomfort, fatigue and poor concentration are all symptoms of poor GI function and the Gut Transformation Programme aims to restore healthy gut function with a range of targeted formulations, together with a specific food plan. Safety Research Efficacy Your guide to transforming gut function In this clinical guide, you ll find important information on the following: The Gut Transformation Programme The principles of the 5R approach Product descriptions & recommendations Protocols Nutri s commitment to clinical excellence Nutri is dedicated to providing science-based, premium quality nutritional supplements and metabolic foods that represent the forefront of natural health science. This commitment is reflected in our range of products from companies using cutting-edge genetic, cellular, and clinical testing procedures and NPA, NSF, and TGA GMP-certified facilities for the production of high quality formulations.

2 Gastrointestinal function and chronic disease Every day, healthcare practitioners are challenged by cases involving gastrointestinal complaints. In addition, gastrointestinal dysfunction is associated with a myriad of diseases, symptoms and disorders, meaning that conditions in which symptoms are systemic, rather than localised to the gut, can often be traced back to an underlying GI dysfunction. Compromised GI function may, for example, result in macromolecules that would normally be excluded from the body instead passing through the intestinal barrier and entering circulation - a condition called intestinal permeability, or leaky gut - which can lead to systemic inflammatory and immune-related symptoms, such as asthma, eczema and rheumatoid arthritis, amongst others. With so many complex interactions it can be difficult to know where to begin, but the 5R approach aims to provide a focus for evaluation of gastrointestinal function, with targeted nutritional, digestive enzyme and probiotic formulas, which, in addition to a gut friendly food plan, can support the normalisation of healthy gut function. The 5R approach The 5R approach within the Gut Transformation Programme aims to: 1. Remove the underlying cause of the imbalance, whether that means removing offending substances from the diet, or unwanted compounds from the body. Certain herbs and nutrients such as garlic or berberine can be used to support the first step in the transformation programme and support a balanced intestinal environment. 2. Replace digestive enzymes or stomach acid, components that facilitate the breakdown of food. Any insufficiency in these compounds will inhibit digestion and the utilisation of nutrients, and broad spectrum enzymatic supplementation, and hydrochloric acid support if necessary, will support healthy GI function. Remove Berberine & Grapefruit Seed Broad Spectrum Herbal Formula with Standardised Extracts of Berberine & Grapefruit Seed Berberine & Grapefruit Seed Formula is a broad spectrum formula with standardised herbal extracts which is designed to support a healthy intestinal environment. Grapefruit seed extract may support a healthy microbial balance in the gut Provides garlic which contains Allicin, a sulphur compound, which may also support microbial balance Gentian root contains bitter compounds which support normal digestive function Ideal for those wishing to support a balanced intestinal environment Ideal support during the remove phase of the 5R programme Berberine HCl 100 mg, Grapefruit seed extract (Citrus grandis) 4:1 100 mg, Gentian Root Extract (Gentiana lutea) 4:1 concentrate 75 mg, Goldenseal root extract (Hydrastis canadensis) (5% alkaloids) 50 mg, Sweet Annie Aerial Parts (Artemesia annua) 10/1 part extract 50 mg, Quassia Bark Extract (Picrasma excelsa) 4:1 concentrate 50 mg, Black Walnut, Green Hull extract (Juglans nigra) 4:1 concentrate 50 mg, Garlic Bulb extract (Allium sativum) 1.2% Allicin 35 mg (Yielding 420mg allicin) Take 2 capsules daily, or as directed. 120 capsules 5550-A 3. Reinoculate the gut with beneficial bacteria. Specific probiotic strains such as L. acidophilus NCFM will help to support a healthy balance of microflora in the GI tract, ensuring optimal digestion and immune function. 4. Repair the GI barrier through dietary and lifestyle modifications, as well as targeted nutritional support. Nutrients such as l-glutamine and quercetin support the integrity of the gut lining. 5. Retain healthy gut function by eating healthily, taking regular exercise, managing stress, ensuring good quality sleep and applying foundation nutritional support, such as multivitamins and minerals, probiotics and l-glutamine. The Gut Transformation Programme provides nutritional support for each of the areas mentioned above. If additional support is required, one of our add-on formulas may also be included in the programme. Our 6-week Gut Transformation Protocol and add-on formulas can be found on the back page of this clinical guide.

3 Replace Similase Vegetarian Enzyme Formula Similase is a highly concentrated digestive enzyme formula that is stable and active from the acid environment of the stomach to the alkaline environment of the small intestine. Well tolerated by sensitive individuals and provides balanced support for digestion of fats, carbohydrates and proteins. Features protease, which supports the breakdown of proteins into absorbable peptides and amino acids Contains lipase, which breaks down triglycerides into absorbable free fatty acids and glycerol Provides amylase, for the breakdown of starch, and maltase, lactase and sucrase, for the breakdown of maltose, lactose and sucrose Ideal for those requiring support for the digestion of proteins, carbohydrates and fats Excellent support during the replace phase of the 5R programme Proprietary Enzyme Blend providing: 328 mg (Protease HUT), Amylase USP, Cellulase 175 CU, Lipase 1050 LU, Phytase 0.85 PU, Lactase 800 LacU, Sucrase 150 INVU, Maltase DP) Take 1-2 capsules at the start of each meal, or as recommended 90 capsules 5600 Reinoculate Ultra Probioplex ND Caps Non-dairy Lactobacillus acidophilus NCFM and Bifidobacterium lactis Formula Ultra Probioplex ND Capsules are a patented probiotic supplement featuring highly viable, pure strains of Lactobacillus acidophilus (NCFM strain) and Bifidobacterium lactis. Everyday support for optimal microflora in the small and large intestine Contains the NCFM strain of Lactobacillus acidophilus, one of the most extensively tested and effective acidophilus species available Also contains Bifidobacterium, one of the most abundant and perhaps most important types of bacteria in humans Provides a guaranteed 15 billion live organisms per capsule an amount found to be clinically beneficial Supports digestion of lactose (milk) Can be used during pregnancy and whilst breastfeeding Reinoculation support as part of the 5R programme Every day supplementation Microflora balance concerns Intestinal lining protection Suitable for all ages, even babies Lactobacillus acidophilus NCFM strain 7.5 billion live organisms, Bifidobacterium lactis Bi-07 culture 7.5 billion live organisms; Vitamin D (cholecalciferol) 2.5µg 1 capsule twice daily, or as directed 60 capsules 44076

4 Repair Glutagenics High Strength L-Glutamine Powder with Quercetin and Zinc Glutagenics features glutamine, quercetin and zinc that together comprehensively support the integrity and optimal function of the gastrointestinal lining. It provides Sustamine (l-alanyl-l-glutamine) which has also been shown to protect the integrity of the gastrointestinal tract, contributing to better nutrient absorption. Supplies high levels of the amino acid glutamine, which provides both a source of fuel and precursors for growth to the rapidly dividing cells of the intestinal lining. Provides Sustamine which is a dipeptide that combines L-Glutamine and L-Alanine. Research shows that this combination of L-Glutamine and L-Alanine has superior absorption, stability and solubility when compared to L-Glutamine alone. Quercetin has been shown to have a gastroprotective effect. Zinc helps to support immune health and also helps regenerate the gut lining. Powdered form for ease of use and flexible dosing. Tasty orange flavour. Ideal for the repair phase of the 5R programme Provides soothing support for the gut Support for the integrity of the gastrointestinal lining One teaspoon supplies: L-glutamine 2000mg, Zinc (citrate) 5mg, Quercetin 100mg, L-alanyl- L-glutamine (Sustamine ) 100mg Mix 1 teaspoon with water twice daily, or as directed 167g powder (60 servings) Retain UltraInflamX Metabolic Food with Ginger, Rosemary & Turmeric One of our best-selling products and perhaps the most versatile of our metabolic foods, UltraInflamX has been formulated to support healthy inflammatory pathways and normal eicosanoid activity throughout the body, and is particularly useful for supporting a healthy GI tract, bowel and joints. Features a unique blend of vitamins, minerals, amino acids, rutin, curcuminoids, and quercetin to nutritionally support healthy inflammatory pathways Also provides L-glutamine to support the protective mucous membranes of the GI tract Supports phase II detoxification, gastrointestinal mucosa integrity and protects against damaging free radical generation Provides a low allergy rice protein concentrate that is augmented with essential amino acids for increased biological value Provides an excellent source of antioxidants with a high ORAC value of 17,108 Comprehensive support for balanced inflammatory processes Ideal for the retain phase of the 5R programme Blend, shake or briskly stir 3 level scoops (52g) into 8 ounces of water or juice. Serving size: 3 scoops (52g) 728g powder (14 servings) mango 3531 Caution: Not recommended during pregnancy or whilst breastfeeding. This product contains vitamin A. Do not exceed 750µg of vitamin A (as retinal) per day if pregnant of likely to become pregnant except on the advice of a doctor or antenatal clinic. Not recommended for children under 12 years of age unless directed by a healthcare professional. If taking any kind of medication or have a medical condition, consult a healthcare practitioner before using this product.

5 Imbalanced gut ph Nutriflux Liquorice & Marshmallow Complex with Glycine and Herbal Blend Nutriflux is a combination of deglycyrrhizinised liquorice as GutGard, together with marshmallow, chamomile, fennel, ginger and lemon balm, and the amino acid l-glycine. Botanicals such as ginger, liquorice and lemon balm may all help to support a healthy digestion. Features liquorice, which helps to maintain balance and comfort in the digestive system Contains GutGard, a unique DGL liquorice extract which is standardised to 3.5% glabridin, a key pharmacological marker Provides glycine, which may support a healthy ph balance in the gut Features marshmallow, which has soothing effects in the gut Provides a herbal blend, including chamomile, which may have a soothing effect on the mucous membranes in the GI tract Ideal for those wanting to maintain a healthy ph balance in the gut Those who require soothing support for the gut Deglycyrrhizinised liquorice extract (Glycyrrhiza glabra) (GutGard ), 75 mg Marshmallow root powdered extract (Althaea officinalis) 60 mg, L-glycine 250 mg, Chamomile powder (Matricaria chamomilla) 25 mg, Fennel extract (Foeniculum vulgare)25 mg, Ginger (Zingiber officinale) 25 mg, Lemon balm leaf (Melissa officinalis) 25 mg Take one tablet, twice daily, with meals, or as directed by your healthcare practitioner. 60 capsules capsules 1503-A What are Metabolic Foods? Metabolic foods are a special range of powdered formulas designed to support unique metabolic needs that are difficult to meet by normal diet alone. Metabolic foods are different to other dietary supplements as they provide comprehensive nutritional support including high quality protein, glycaemically balanced carbohydrates, vitamins, minerals, phytochemicals and other nutrients blended into a mixture that closely resembles nutrient dense food. Metabolic foods are easily mixed with water to make a tasty and convenient shake that can be used either as a meal replacement, snack replacement or meal accompaniment, thereby enhancing a healthy diet and lifestyle programme by delivering a greater volume of high quality macro and micronutrients than is achievable in a capsule or tablet formulation. Easy to use, great tasting, low allergy and patient friendly The nutrient-dense powders used in the metabolic foods allow for easy mixing with water, juice, milk, or milk alternatives for a great tasting shake. Simply pop the powder in a shaker cup and take it with you when you re on the go. Just add water, shake vigorously and you re off! Metabolic foods can also be blended with fruit to make delicious smoothies that can serve as a healthy snack or meal while providing comprehensive nutritional support. The metabolic foods are formulated without gluten, wheat, yeast, tree nuts, egg, artificial colours, flavours, or sweeteners. There are also dairy, lactose and soy-free options for patients with sensitivities or intolerances. The Gut Transformation Programme pack includes: 1 x Berberine & Grapefruit Seed 120 Capsules 1 x Similase 90 Capsules 1 x Ultra Probioplex ND Capsules 60 Capsules 1 x Glutagenics 260g Powder 1 x UltraInflamX (Mango) 728g Powder 1 x Information pack including food plan, recipes, menu planner & supplement protocol Gut Transformation Programme pack code: GTPROD

6 Imbalanced gut ph Metagest High Strength Betaine HCl with Pepsin Metagest features the acidifying factor betaine HCl combined with the proteolytic enzyme pepsin, to support digestion. Features hydrochloric acid, which facilitates the digestive action of enzymes Provides support for those who may have a less than optimal level of hydrochloric acid in the gut One tablet supplies: Betaine HCl 650 mg, Pepsin 45 mg 1-2 tablets with each meal, or as directed. 90 tablets tablets Bowel function Caricol Organic Pureed Papaya Caricol is an entirely natural organic product made from the pulp of tree-ripened papaya, to support a healthy digestive system. Provides papaya, a fruit naturally rich in papain, a potent proteolytic enzyme. Proteolytic enzymes support the breakdown of proteins. Papaya supports optimal bowel function. It has also been shown to have soothing effects on the stomach and digestive tract. Ideal for those wishing to support a slow colon transit time. One stickpack supplies: Papaya fruit 20.5g, organic fruit juice concentrate from mango and plum, natural flavours. 1 stickpack serving after a meal, up to three times daily or as directed. Take with a glass of water on the side, or dissolved into water as a fruit beverage. 20 stickpacks 3650 Bowel function GiSol Saccharomyces Boulardii Saccharomyces boulardii is a non-pathogenic yeast which has been shown to support a healthy balance of flora in the gut. Saccharomyces Boulardii has been down to support numerous digestive concerns featuring rapid transit time Has been proven to survive the digestive process Those who wish to support a fast colon transit time Ideal for clients who are on antibiotic therapy Saccharomyces Boulardii 1.5 billion organisms* (*at date of expiry) 2 capsules daily, or as directed. 30 capsules capsules 3294-A

7 Microbial imbalance Nutrispore High Potency Caprylic Acid with Supportive Herbal Compounds Nutrispore is a highly potent formula containing caprylic acid, herbal compounds and supporting nutrients to help support a healthy microbial balance in the gut. Features caprylic acid, a fatty acid that has a long history of use with purging unwanted compounds from the gut Provides aloe vera, which has soothing effects on the gut Ideal support for healthy microbial balance in the gut When yeast imbalance is suspected One tablet supplies: Caprylic acid (magnesium caprylate) 240 mg, Garlic 20 mg, Cinnamon (bark) 20 mg, Thyme (leaf) 12 mg, Basil (leaf) 12 mg, Undecylenic acid 10 mg, Turmeric extract 10 mg, Black walnut hulls powder 10 mg, Beet (root) 10mg, Aloe vera (leaf) 10 mg, Grapefruit (seed) extract 10 mg, Clove (flower bud) 10 mg, Oregano (leaf) 5 mg, Zinc (picolinate) 5 mg 1 tablet three times daily, or as directed. 60 tablets tablets 3203-A Inflammatory Support CurcuDyn Max Strength Bioavailable Curcumin with Ginger, Vitamin C and Vitamin D CurcuDyn contains a highly bioavailable form of curcumin, shown in research to be 185 times more bioavailable than native curcumin, as well as ginger extract. Both curcumin and ginger support a healthy inflammatory response within the body, as well as healthy joints. CurcuDyn also contains vitamin D, which supports the normal function of the muscles, bones and the immune system, and it features vitamin C, which contributes to collagen formation for the function of cartilage. Provides a highly bioavailable form of curcumin shown in research to be 185 times more bioavailable than normal powdered curcumin, meaning the body absorbs and retains much higher levels of curcumin, and gets to work quickly. Curcumin and ginger are both known for their ability to support joint health. Ginger helps to maintain mobility of joints and may help to alleviate morning joint stiffness. Curcumin and ginger are both known for their ability to help manage inflammation. Features vitamin D, which supports the normal function of the muscles, bones and immune system. Contains vitamin C, which contributes to collagen formation for normal function of cartilage - the connective tissue that covers the surfaces of our joints. Take 2-4 capsules daily, or as recommended by your healthcare practitioner. 60 Capsules Caution: If pregnant, breastfeeding, taking medication or have a medical condition, consult a healthcare practitioner before using this product. If taking anticoagulants, have an obstructed bile duct or have gallstones, consult a medical practitoner before using this product.

8 The Gut Transformation Programme 6-Week Protocol Weeks 1-2 Formula Breakfast Mid-morning Lunch Mid-afternoon Dinner Bedtime Berberine & Grapefruit Seed Formula 1 capsule 1 capsule 1 capsule Similase 1 capsule 1 capsule 1 capsule Weeks 3-4 Formula Breakfast Mid-morning Lunch Mid-afternoon Dinner Bedtime Berberine & Grapefruit Seed Formula 1 capsule 1 capsule 1 capsule Similase 1 capsule 1 capsule 1 capsule Ultra Probioplex ND Capsules 1 capsule 1 capsule Glutagenics 1 serve 1 serve Weeks 5-6 Formula Breakfast Mid-morning Lunch Mid-afternoon Dinner Bedtime Ultra Probioplex ND Capsules 1 capsule 1 capsule Glutagenics 1 serve 1 serve UltraInflamX 1 serve Add-ons for Gut Transformation Programme Imbalanced Gut ph Bowel function Suspected yeast imbalance or inflammation High stomach acid Low stomach acid Rapid transit time Slow transit time Yeast imbalance Inflammatory support required Nutriflux 2 capsules daily Metagest 1 tablet with each meal GiSol 2 capsules daily Caricol 1 stickpack up to 3 times daily Nutrispore 1 tablet 3 times daily CurcuDyn 2-4 capsules daily Nutri Advanced Ltd, Botany Business Park, Whaley Bridge, High Peak, SK23 7DQ Freephone