The polymerised fraction from bilberry with proven efficacy.

Transcription

1 The polymerised fraction from bilberry with proven efficacy.

2 A CLINICALLY PROVEN ACTION AS VASCULAR PROTECTOR Catocyanic Complex belongs to the flavonoid family. Its vasoprotective properties have been demonstrated by pharmacology studies in various experimental models. The mechanism proposed to explain this activity is based on the participation of collagen in the vessel wall in the control of vascular permeability. Catocyanic Complex interacts with collagen, increases its reticulation and hence decreases vascular permeability. Catocyanic Complex proved to play a beneficial role in venous and capillary disorders and their complications such as: Lymphedema* Varicose and spider veins* Heavy legs and leg edema of venous origin* Bruises, petechiae, vasculitis * Couperose* * These statements have not been evaluated by the Food and Drug Administration. Catocyanic Complex is not intended to diagnose, treat, cure or prevent any disease.

3 WHAT IS CATOCYANIC COMPLEX Catocyanic Complex is an active polymerised fraction extracted from bilberry composed of aglycon cyanidins, delphinidine, malvidine and peonidine. R R1 HO O + R2 R1 = OH R2 = H, OH or OMe (Me = Methyl: -CH3) OH OH n EXTRACTION PROCESS Thanks to a natural friendly fermentation process (no added SO2) the nutritive and active properties of the compound are preserved. Accurate chemicals, physical and microbiological tests are performed in house according to pharmacopeias and cgmp. Our unique extraction process allows the genins to polymerise together, cutting out the molecule of sugar. For this reason, the final compound is paticularly suitable for diabetic needs.

4 CATOCYANIC COMPLEX MECHANISMS OF ACTION ACTION ON COLLAGEN Catocyanic Complex inhibits the degradation of collagen. It protects the vascular wall from the action of collagenase (1,2,3,4). FIBERS OF COLLAGEN ACTION ON ELASTASE Catocyanic Complex inhibits the enzymatic activity of elastase (5). Elastase is a proteolytic enzyme which plays a role in the deterioration of connective tissues and elastic fibers and is involved in certain vascular disease conditions. ACTION ON CAPILLARY PERMEABILITY Catocyanic Complex limits the thickening of the vessel basal membrane, decreases capillary permeability and strengthens the capillary wall (6,7,8) ELASTASE ACTIVITY Destruction of collagen 0,1 0,2 0,4 0,8 b a INHIBITORS (mg) Decrease of resistance This figure shows a: vitis vinifera, b: ccomplex, c: pinus marittimus and their inhibitning power on the elastase 0,2 0,4 0,8 1,6 c Resistance is enforced ACTION ON CAPILLARY RESISTANCE Catocyanic Complex improves capillary resistance in subjects suffering from bruises and/or petechiae in venous and lymphatic disorders (9,10,11,12) Abnormal permeability CATOCYANIC COMPLEX Permeability becomes normal

5 CATOCYANIC COMPLEX BENEFITS Thanks to its special mode of action, and its ability in repairing changes in the venous wall, Catocyanic Complex is commonly used to: Improve capillary and venular flow. Maintain the integrity of the connective tissue surrounding the vessels by protecting collagen and elastic fibers. Increase lymphatic flow. Support general circulation. Reduce edema and bruises by normalizing capillary permeability and facilitating the reabsorption of fluids. 1) Boniface R et al Pharmacological properties of Myrtillus anthocyanosides : correlation with results of treatment of diabetic microangiopathy. Flavonoïds and bioflavonoids, ed. Farkas 1985 p ) Lagrue G., Robert A.M. et al Pathology of the microcirculation in diabetes and altérations of the biosynthesis of intercellular matrix macromolécules. Front. Matrix Biol 1979, Vol. 7, pp ) Robert, Miskulin, Godeau, et al Action of anthocyanosides on the Permeability of the blood-brain barrier Front Matrix Biol 1979 vol 7 4) Boniface R, Robert AM Effect of antocyanes on human connective tissue metabolism Klin Monatsbl Augenheilkd Dec 96, 209 (6) ) Jonadet, Meunier, Bastide Anthocyanoside extraits de Vitis Vinifera, de Vaccinium myrtillus et de Pinus Maritimus"J. Pharm Belg ) Cohen, Boulakia et al In Vivo Sequential study of skeletal muscle capillary permability in diabetic rats: effect of anthocyanosides Metabolism July 2000 vol 49 7) Detre, Jellinek, Miskulin, Robert Studies on vascular permeability in hypertension : action of anthocyanosides Clin physiol biochem ) Miskulin, Detre, Jellinek Variation in vascular permeability in the initial phase of experimental hyperetension in the rat Paroi Arterielle ) Hiltgen, Guermonprez Modification de la résistance capillaire chez 40 diabétiques traités par les anthocyanoside de myrtille Extrait de la medecine praticienne, sept 1972 P481 10) Salanova Action des anthocyanoside de myrtille sur la resistance capillaire des obeses et des diabetiques Medica sept ) Amouretti Interet therapeutique des anthocyanosides de Vaccinium Myrtillus dans un service de medecine interne Extrait de therapeutique ) SevinR., Guendet J.F. Effet d'une association d'anthocyanosides sur la résistance capillaire des diabétiques. Ophtalmologia 152, 1966 p Catocyanic Complex is already being used in a prescription drug for venous disorders (Difrarel 100) and in a cream formulation for heavy leg (Antoven) ALL THE STUDIES ARE PERFORMED WITH CATOCYANIC COMPLEX

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