Metabolic supplement for 50+ skins
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- Jodie May
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1 Metabolic supplement for 50+ skins Temporary version
2 Unisteron Y-50 Natural metabolic precursors to stimulate the vital functions of mature skins. Unisteron Y-50 stimulates important biological precursors to counteract the aging process by: Hormonal changes upon age, environmental aggressions Enhancing skin s lipidic content Improving skin hydration Reducting wrinkles depth Soya beans Root of the Wild Yam Unisteron Y-50 is composed of active molecules extracted from two different plant sources: phytosterols from soya beans and saponins the main glucosidic constituents of the Wild Yam root. Modification of hormonal balance delayed cell division reduction in collagen synthesis reduction in the formation of the hydrolipidic film Consequences on skin aging: - loss of skin barrier function - loss of elasticity - wrinkles formation
3 Unisteron Y-50 Natural metabolic precursors to stimulate the vital functions of mature skins. Unisteron Y-50 stimulates important biological precursors to counteract the aging process by: Enhancing skin s lipidic content Improving skin hydration Reducting wrinkles depth Soya beans Hormonal changes upon age, environmental aggressions Unisteron Y-50 = Bioactive phytosterol precursors Support the hydrolipidic film of the skin to maintain skin barrier integrity for a good hydration to reinforce skin elasticity Root of the Wild Yam Unisteron Y-50 is composed of active molecules extracted from two different plant sources: phytosterols from soya beans and saponins the main glucosidic constituents of the Wild Yam root. For a well balanced skin
4 Improvement of skin s lipid content (clinical efficacy) Protocol: A placebo and a cream containing 5% Unisteron Y-50 were tested in a clinical trial on 20 women volunteers (ages between 55-66) to evaluate skin s lipid content. The creams were applied twice a day on the inside of the forearm, for 8 weeks. Result: Unisteron Y-50 significantly increases skin lipid content after 28 days: +137% compared to placebo. After 56 day, the product maintains a continuous upward trend. Lipid content (µg/cm 2 ) Skin surface lipid content Sebumeter SM % Start 7 days 28 days 56 days p<0.05 compared to placebo, Wilcoxon matched pairs signed rank test Untreated Placebo Unisteron Y-50 5% +254%
5 Improvement of skin hydration (clinical efficacy) Protocol: A placebo and a cream containing 5% Unisteron Y-50 were tested in a clinical trial on 20 women volunteers (ages between 55-66) to evaluate skin hydration. The creams were applied twice a day on the inside of the forearm, for 4 weeks. Result: Unisteron Y-50 significantly increases skin hydration by 125%, compared to placebo, after only 7 days. Skin hydration (% vs T0) Skin hydration measurement Corneometer CM % +109% 7 days 28 days p<0.05 compared to placebo, Wilcoxon matched pairs signed rank test Untreated Placebo Unisteron Y-50 5%
6 Improvement of skin elasticity (clinical efficacy) Protocol: A placebo and a cream containing 5% Unisteron Y-50 were tested in a clinical trial on 20 women volunteers (ages between 55-66) to evaluate skin firmness. The creams were applied twice a day on the inside of the forearms, for 4 weeks. Result: Unisteron Y-50 significantly increases skin elasticity by 50%, compared to placebo, after 28 days. Skin elasticity (% vs T0) Skin firmness measurement Cutometer SEM % 7 days 28 days p<0.05 compared to placebo, Wilcoxon matched pairs signed rank test Untreated Placebo Unisteron Y-50 5%
7 Improvement of skin smoothness (clinical efficacy) Protocol: A placebo and a cream containing 5% Unisteron Y-50 were tested in a clinical trial on 20 women volunteers (ages between 55-66) to evaluate skin smoothness. The creams were applied twice a day on the inside of the forearms, for 4 weeks. Result: Unisteron Y-50 significantly increases skin smoothness by 57%, compared to placebo, after 28 days. Skin smoothness (% vs T0) Skin smoothness measurement Skinviometer SV % 7 days 28 days p<0.05 compared to placebo, Wilcoxon matched pairs signed rank test Untreated Placebo Unisteron Y-50 5%
8 Reduction of wrinkle depth (clinical efficacy) Protocol: A placebo and a cream containing 5% Unisteron Y-50 were tested in a clinical trial on 20 women volunteers (ages between 55-66) to evaluate skin wrinkles depth. The creams were applied twice a day on the inside of the forearms, for 4 weeks. Silicone impressions of the skin were done to measure skin relief. Result: Unisteron Y-50 offers a significant lasting effect in terms of reduction of wrinkle depth: +37% compared to placebo, after 28 days. Reduction of Wrinkle depth (% vs T0) Reduction of the wrinkle depth Profilometry with ORF 01 scanner +37% 7 days 28 days p<0.05 compared to placebo, Wilcoxon matched pairs signed rank test Placebo Unisteron Y-50 5%
9 TECHNICAL INFORMATION INCI: Origin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Oleyl Alcohol, Dioscorea Villosa (Wild Yam) Root Extract, Glycine Soja (Soybean) Sterols Native Soya, Dioscorea Villosa and Organic synthesis Preservative free Clear, slightly yellow liquid Oils, alcohols, glycols soluble 5% Can be added at the end of the formulation process under stirring or homogenizing or can be heated for a short time with the water phase of a formulation Formulate at ph between 5.0 to 8.0 and temperature below 50 C CN, JP, KR, HK, AU, ASEAN, USA, CA, South-Am., Mid-East, EU Lipid production activation, moisturizing, anti-aging Registration pending SAFETY ASSESSMENT Ocular irritation: Skin irritation: Mutagenicity: Sensibilization: Cytotoxicity on fibroblast - practically non irritant at 100% Closed epicutan patch test - non irritant at 50% Ames assay - OECD non mutagenic HRIPT assay - non sensitizing at 10%
10 Thank you Induchem AG Industriestrasse 8A CH-8604 Volketswil Induchem USA, Inc. 535 Fifth Avenue, Floor 23 New-York, NY10017 Induchem France SAS 171 Bis Avenue Charles de Gaulle FR Neuilly Sur Seine
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