Research also suggests that the lactoferrin protein activates specific strands of DNA that turn on the genes that launch the immune response.

Transcription

1 Description John Hopkins published a paper that document Lactoferrin efficacy in enhancing immunity against cancer. They recommend it for life specially for normal population with positive family history for cancer. Lactoferonal is an immunity boosting product. It contains: Bovine Colostrum Calcium & Iron Lactoferrin Omega3 Probiotics Dietary Supplement. All Natural - Colour-Free - Preservative-Free. Ingredients Skimmed Milk - Fruits mixture (Orange - Apple - Banana - Pineapple) - Cooked Oat - Calcium caseinate - Cooked Soy Protein - Bovine Colostrum - Whey protein - Soy Lecithin - Maltodextrin - Mineral and Vitamin Mixture - Cod Fish Oil (source of Omega 3) - Yoghurt Starter (Lactobacillus Paracaese) - Bifidobacterium longum). Lactoferrin Lactoferrin, a protein found in bovine colostrum, binds iron in the blood, keeping it away from cancerous cells, bacteria, viruses and other pathogens that require iron to grow. Thus it inhibits: angiogenesis and decreases tumor growth. Research also suggests that the lactoferrin protein activates specific strands of DNA that turn on the genes that launch the immune response. It has also been shown to have anti-viral activity. Lactoferrin can also kill H. pylori bacterium, the bacteria that causes ulcers. Lactoferrin exists naturally in the milk of most mammals, and is found throughout the human body and occurs in all secretions that bathe mucous membranes, such as saliva, tears, bronchial and nasal secretions, hepatic bile, and pancreatic fluids. It is an essential factor in the immune response. Lactoferrin is concentrated in oral cavities where it will come in direct contact with pathogens (i.e. viruses, bacteria, etc.) and kills or greatly suppresses these pathogens through a variety of

2 different mechanisms In fact, there are specific receptors for lactoferrin found on many key immune cells, such as lymphocytes, monocytes and macrophages, and is known to be directly involved in the upregulation of natural killer (NK) cell activity. Lactoferrin appears to play a key role as a host defense (protector) at the mucosal surface in the gut. Based on research observations, it is thought that lactoferrins are not absorbed via traditional routes in the gut, but instead may act directly on intestinal epithelial cells and the gut-associated lymphoid tissue (GALT) cells, probably through a receptor-mediated mechanism. Lactoferrin has been shown to improve inflammatory diseases in animals. Its release during inflammation suggests it is involved with phagocytosis. Suppression of intestinal overgrowth and bacterial translocation of enterobacteria as well as a protective effect against infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans has been reported in mice. In a rat model of colon cancer, lactoferrin taken orally suppressed the formation of precancerous lesions in the large intestine and the incidence of carcinoma was reduced significantly. Again, in tumor bearing mice, oral administration of lactoferrin was shown to increase the number of NK cells, CD4+ T cells and CD8+T cells in the peripheral blood and small intestine. The authors suggested that lactoferrin may modulate intestinal mucosal immunity. Among various animal models, a preventive effect on cancer (in urinary bladder, esophageus, and lung) has been demonstrated. Multiple studies using both rats and mice exposed to a toxic chemical (azoxymethane) known to cause tumors throughout the gastrointestinal tract, administered concomitantly with lactoferrin, showed a large reduction in intestinal polyp development. Just as important, there were no toxic effects to intestinal epithelial tissues. Another study found the addition of lactoferrin to cancer prone mice subjected to cancer causing chemicals reduced the number of tumors and suppressed angiogenesis (the production of new blood vessels), which tumors need to survive. This study also found lactoferrin significantly inhibited liver and lung metastasis of cancer cells in these animals. In addition to what appears to be direct cancer inhibiting properties of lactoferrin. Additional studies have found it increased natural killer (NK) cell toxicity to several cancer cell lines at low concentrations. This shows lactoferrin plays a systemic role in improving immune cell

3 effectiveness to cancer cells, as well as a direct effect through mechanisms that are not fully clear at this time. Intriguing human research supports functional uses for lactoferrin. In the guts of human babies, increases in bifidobacteria rich flora were reported in those fed lactoferrin-enriched infant formula. In adults with skin fungal infections, symptoms improved with oral consumption of lactoferrin. Yet another study found lactoferrin to be very effective at suppressing the growth of human pancreatic cancer cells. So much so the researchers concluded that lactoferrin: might become one of the new drugs of choice for the adjuvant therapy against pancreatic cancer. Several studies suggest lactoferrin reduces oxidative stress. Diseases such as cancer, heart diseases and AIDS are all closely related to oxidative stress either as a causative factor or as a factor in progression of the disease. One study that examined the role of whey proteins, multifermented whey proteins and lactoferrin in oxidative stress made the bold statement: We can conclude that whey protein, lactoferrin and multifermented whey are good candidates as dietary inhibitors of oxidative stress and should be considered as potential medicinal foods in various pathologies as HIV infection and cancer. In a study published in November 2004, higher concentrations of lactoferrin in the tumor cells of breast cancer patients were associated with longer survival. Among various animal models, a preventive effect on cancer (in urinary bladder, esophageus,. Lactoferrin is a potential breakthrough as a natural non-toxic treatment in a range of human ailments. The iron-depleted form of lactoferrin called apolactoferrin is recommended by the Life Extension Foundation to be the superior form of the supplement. Dr. Flavin-Koenig recommends a dosage of 1 gram dissolved slowly in the mouth at bedtime. Further Reading NATURAL CANCER TREATMENTS: Immune System Control: Colostrum & Lactoferrin by Beth M.Ley Lactoferrin: Interactions and Biological Functions by T. William Hutchens, et al Advances in Lactoferrin Research by G. Spik Lactoferrin: Structure, Function and Applications Lactoferrin: Natural - Multifunctional - Antimicrobial by A. S. Naidu References: Expression and prognostic value of lactoferrin mrna isoforms in human breast cancer

4 s= naturetreatments Colostrum Colostrum is the first breast secretion that a mammal provides for its newborn during the first hours. It contains numerous immune system and growth factors as well as essential nutrients, trypsin, and protease inhibitors that protect it from destruction in the GI tract. It is estimated that colostrum triggers at least fifty processes in the newborn. Bovine (cow) colostrum is biologically transferable to all mammals, including man and is apparently much higher in immune factors than human mothers colostrum. Laboratory analyses of immune and growth factors from bovine colostrum are identical to those found in human colostrum except for the fact that the levels of these factors are significantly higher in the bovine version. Dr. John Maras says: For example, human colostrum contains 2% of IgG while cow colostrum contains 86% of IgG, the most important of the immuno-globulins found in the body. Bovine colostrum contains a blocking hormone to prevent the calf from becoming sensitized to its own mothers immune factors. Studies indicate that all species, including man, benefit from the immune boosting properties of bovine colostrum with no reports of allergic or anaphylactic reactions to date. It is in a very limited supply because colostrum is only available for a day or two after calving. The needs of the newborn calf must be met first and only high quality colostrum is taken from cows that have been certified free of antibiotics, pesticides, and synthetic hormones. Colostrum must be processed at low temperatures so that the immune and growth factors remain biologically viable. The past 20 years has also witnessed the publication of over 2003 research papers supportive of both colostrum and its numerous components. In Colostrum, Lifes First Food, Dr. Daniel G. Clarks basic message, as printed on the back cover of his book, is that "bovine colostrum rebuilds the immune system, destroys viruses, bacteria, and fungi, accelerates healing of all body tissue, helps lose weight, burn fat, increase bone and lean muscle mass and slows down and even reverses aging. According to Clark and the well-known naturopathic physician, Dr. Bernard Jensen, colostrum has a therapeutic role to play in AIDS, cancer, heart disease, diabetes, autoimmune diseases, allergies, herpes, bacterial, viral and parasitic infections, gingivitis, colds, the flu and much more. Colostrum has antioxidant properties, is anti-inflammatory, and is a source of many vitamins, minerals, enzymes, and amino acids. Ayurvedic physicians have used bovine colostrum therapeutically in India for thousands of years. The most important components of colostrum can be broken down into two major categories: immune system factors and growth factors. Immune system factors:

5 Immunoglobulins (A, D, E, G, and M) the most abundant of the immune factors found in colostrum; IgG neutralizes toxins and microbes in the lymph and circulatory system; IgM destroys bacteria while IgE and IgD are highly antiviral. Lactoferrin - an antiviral, anti-bacterial, anti-inflammatory, iron-binding protein with therapeutic effects in cancer, HIV, Cytomegalovirus, herpes, Chronic fatigue syndrome, Candida albicans, and other infections. Lactoferrin helps deprive bacteria of the iron they require to reproduce and releases iron into the red blood cells, enhancing oxygenation of tissues. Lactoferrin modulates cytokine release and its receptors have been found on most immune cells including lymphocytes, monocytes, macrophages, and platelets. See Lactoferrin. Proline-Rich Polypeptide (PRP) - a hormone that regulates the thymus gland, stimulating an under active immune system or down regulating an overactive immune system as seen in autoimmune disease (MS, rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, allergies, etc.). Growth Factors Epithelial growth factor (EgF) Insulin-like growth factor-i and II (IGF-1 and IGF-II) Fibroblast growth factor (FgF) Platelet-derived growth factor (PDGF) Transforming growth factors A & B (TgA and B) Growth hormone (GH) These all help stimulate cell and tissue growth by stimulating DNA formation. Genetically engineered versions of IGF-1 and GH are now marketed as anti-aging and AIDS drugs. They are found naturally and in high concentrations in colostrum. Several studies show that these growth factors are capable of increasing T-cell production, accelerate healing, balance blood glucose, reduce insulin need, increase muscle and bone growth and repair while metabolizing fat for fuel. Clinical Applications for symptomatic adults: clinicians usually prescribe 1000 to 2000 mgs. twice daily of the dried, encapsulated form of colostrum, best taken on an empty stomach with 8-12 ounces of water. Preventive doses have not been established but several authors recommend continuous dosing at levels decided upon primarily by the consumer/patient. For those who show no clinical response to colostrum, the dosage can safely be doubled or even tripled as needed until the desired results are obtained. Children can also take colostrum but require proportionately less. Herxheimer reactions (mainly flu-like symptoms) can occur in up to 40% of the cases but are usually mild and disappear with continued supplementation at the same dosage level. Through hundreds of years of use and over 1000 clinical studies, colostrum has been demonstrated to be completely safe without drug interactions or side effects at any level of ingestion. The benefits of cytokines in the treatment of cancer were first popularized by the 1985 Steven Rosenberg book, Quiet Strides in the War on Cancer. Since that time, the same cytokines found in

6 colostrum (Interleukins 1, 6, 10, Interferon G and Lymphokines) have been the single most researched protocols in scientific research for the cure for cancer. Colostrum Lactalbumin has been found to be able to cause the selective death apoptosis of cancer cells, leaving the surrounding non-cancerous tissues unaffected. Further Reading and References: Quiet Strides in the War on Cancer by Steven Rosenberg Colostrum: Nature's Gift to the Immune System (Health Learning Handbook) by Beth M. Ley Immune System Control: Colostrum & Lactoferrin by Beth M. Ley Colostrum: Nature's Healing Miracle (Volume 1) by Donald R. Henderson Colostrum: Life's First Food the White Gold (Dr. Jensen's Health Handbooks Series) by Bernard Jensen Colostrum: Amazing Immune System Enhancer by C. M. Hawken The Colostrum Option: All the Natural Anti-Aging Growth Hormones & Immune Enhancers Provided by Mother Nature! by Zoltan P. Rona, et al The Colostrum Miracle: The Anti-Aging Super Food That Can Boost Immunity and Prevent Premature Aging by Anthony, Ph., D. Kleinsmith Omega 3 Fatty Acids Omega-3 fatty acids protect against the spread of solid-tumor cancers that are related to hormone production, particularly breast cancer. Consumption of omega-3 fatty acids can slow the growth of cancer xenografts, increase the efficacy of chemotherapy and reduce the side effects of the chemotherapy or of the cancer. Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include: 1. Suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor 2. Decreasing the expression of AP-1 and ras, implicated in tumor promotion 3. Inducing differentiation of cancer cells 4. Suppressing nuclear factor-kappab activation and bcl-2 expression, thus allowing apoptosis of cancer cells 5. Reducing cancer-induced cachexia. It seems reasonable to assume that after appropriate cancer therapy, consumption of omega-3 fatty acids might slow or stop the growth of metastatic cancer cells, increase longevity of cancer patients and improve their quality of life. It is also very beneficial to cancer patients undergoing major operations. Omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in

7 patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues. Nutritional supplements containing one form of omega 3 fat, eicosapentaenoic acid (EPA), significantly reduced weight loss among inoperable cancer patients. No previous nutritional formulation revealed such an outcome, with supplemented patients maintaining all aspects of their body composition in the three weeks following surgery. It also prevents loss of muscle mass by reducing the amount of inflammatory markers in the blood - this means the metabolism is not as stressed as it usually is post surgery. Probiotics They are live microbial supplement that beneficially affect the host by improving its intestinal microbial balance. They are found in food such as yogurt, cheese and honey. The word (probiotic) comes from the Greek word pro, meaning promoting and biotic, meaning "life". The potential for probiotics as an adjunct to cancer treatments is intriguing as a low risk, low cost measure for increasing the effectiveness of established therapies. Preparation Add 1 sachet (10 gm) into 1/2 cup of water, milk or juice then stir well. 1-2 sachets recommended daily dose or according to physician's advice. Nutrition Facts Each sachet (10 gm) Amount per serving: Calories 55 - Calories from fat 7 Each sachet (10 gm) contains (Daily value%) Lactoferrin 100 mg Probiotics 50 mg - [5.10(7)cfu] Omega 3 Fatty acids 50 mg Total Fat 0.75 g Sodium 22.5 mg (1%) Carbohydrates 7.5 g (1%) Proteins 6 g (2.5%) Vitamin A 15% Vitamin B1 15% Vitamin B2 18.5% Vitamin B6 15% Vitamin B % Vitamin C 20% Vitamin D3 22.5% Vitamin E 30% Pantothenate 15% Folic Acid 10%

8 Calcium 25% Iron 22.5% Phosphorus 15% Zinc 22.5% Iodine 15% Selenium 20% Percent Daily Values are based on a 2000 calories/day These values could vary due to the natural raw materials used. Free from flavors - synthetic colors - preservatives Presentation It is available in powder form, each box contain 15 sachets (packs). Each sachet contains 15 grams of the mix with 100 mg Lactoferrin dose needed daily. It is a unique & effective natural product with strawberry delicious taste. Company Packed by: LEMACO United company on behalf of: I-PHARM Egypt 3 Mohamed Mossa St., Azarita, Attarin, Alexandria, Egypt. Tel.: Mobile: