Simon McAdoo APC Regal Processors Limited

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Christopher Johnson
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1 Simon McAdoo APC Regal Processors Limited

The Lauridsen Group Companies APC GLOBAL PRESENCE Feed ingredients

Meat byproducts for the food, pet food, feed and pharmaceutical

Clinically safe biotherapeutics that address unmet needs.

Vercheres, Quebec including Ankeny, Iowa stocks, broths, flavors,

LATIN AMERICA Buenos Aires, Argentina Araçatuba, Brazil Chapecó,

$High-purity plasma fractions Doncaster, England for the diagnostic,$ biopharmaceutical Villarrobledo, and Spain veterinary vaccine

2 The Lauridsen Group Companies APC GLOBAL PRESENCE Feed ingredients and user-ready consumer products that support animal health. Meat byproducts for the food, pet food, feed and pharmaceutical industries. Processed poultry byproducts. Clinically safe biotherapeutics that address unmet needs. NORTH AMERICA Functional Calgary, Alberta protein solutions Vercheres, Quebec including Ankeny, Iowa stocks, broths, flavors, [Global Headquarters] fats, health and Boone, Iowa nutrition and fish products. Denison, Iowa Dubuque, Iowa Selma, North Carolina Sublette, Kansas LATIN AMERICA Buenos Aires, Argentina Araçatuba, Brazil Chapecó, Brazil San Luis, Brazil EUROPE Craigavon, Northern Ireland High-purity plasma fractions Doncaster, England for the diagnostic, Poznan, Poland life science research, Granollers, Spain biopharmaceutical Villarrobledo, and Spain veterinary vaccine industries. [European Headquarters] ASIA PACIFIC Deproteinized Dezhou, China whey for Hebei, China global Lin bakery, Yi, China beverage, confectionery, Tokyo, Japan dairy and [Sales Office] prepared foods markets.

manufacturing plasma used as performance

$in protein fractionation Has a product$ and complete end-user products

3 APC Europe American Protein Corporation European Production Facilities APC Was founded in the USA in 1981 Craigavon, Northern Ireland Doncaster, England Is the world s largest producer of spray-dried plasma proteins Evolved from manufacturing plasma used as performance enhancers in swine diets to specializing in protein fractionation Has a product line of nearly 20 different ingredients and complete end-user products Granollers, Spain European Headquarters Poznan, Poland Villarrobledo, Spain

process over 90% of the available bovine and porcine blood on the island of Ireland,

4 REGAL PROCESSORS LIMITED located in County Armagh In existence for >40yr s, part of the APC group for the past 23yrs. Regal Processors Ltd. process over 90% of the available bovine and porcine blood on the island of Ireland, sourced from EC approved slaughterhouses, for the manufacture of spray dried animal blood products functional proteins. Regal Processors

5 What we do: APC Spray Dried Proteins Whole Blood Highly Digestible Blood Cells Functional Plasma Protein AP301 AP820

6 Manufacturing Process Summary Finished products include spray dried bovine plasma, porcine plasma, bovine haemoglobin (red cells), porcine haemoglobin (red cells) and whole blood. Category 3 blood from bovine and porcine approved for the manufacturing of blood products according to R1069/2009 anticoagulant storage Chiller Storage tanks Dedicated tankers Q/A steps Storage tanks Standards include: HACCP ISO 9001 ISO Staging Spray-drier Centrifuge Plasma GMP - feed materials Bagging Concentration Further processing RBC

7 USE OF BLOOD PRODUCTS AS FEED ADDITIVE FOR ANIMAL CONSUMPTION AND INDUSTRIAL USE APC is the world s largest producer of spray dried blood & plasma proteins for feed and industrial applications approximately 75% worldwide. Applications in the following: Animal Health & Nutrition Swine Ruminant Poultry Companion Aquaculture Industrial Applications Plywood Fertilizer Cement Plaster/Stucco

8 LEGISLATION The EC Regulations regarding the manufacture of spray dried blood products are enforced nationally by DAERA NI Department of Agriculture, Environment and Rural Affairs for Northern Ireland.

LEGISLATION REGULATION (EC) No 1069/2009 animal by-products and derived products not intended for human consumption Category 3 materials Article 10 (a) ( ) parts of animals slaughtered ( ) and which

9 LEGISLATION REGULATION (EC) No 1069/2009 animal by-products and derived products not intended for human consumption Category 3 materials Article 10 (a) ( ) parts of animals slaughtered ( ) and which are fit for human consumption ( ) but are not intended for human consumption for commercial reasons; Blood post-mortem inspected and fit for human: food grade (b) (i) ( ) parts of animals which are rejected as unfit for human consumption ( ) but which did not show any signs of disease communicable to humans or animals ( ) originating ( ) from animals that have been slaughtered in a slaughterhouse and were considered fit for slaughter for human consumption following an ante-mortem inspection Blood antemortem inspected (EC) No 999/2001 as regards prohibitions concerning animal feeding of processed animal proteins derived from non-ruminant animals (latest amendment 56/2013) II. Derogations from the prohibitions provided for in Article 7(1) and (2)( ) A. The prohibitions provided for in Article 7(1) and (2) shall not apply to: (a) the feeding to farmed animals of ( ): (iv) hydrolysed proteins derived from parts of non-ruminants and from ruminant hides and skins; (b) the feeding to non-ruminant farmed animals of( ): (iii) blood products derived from non-ruminants; (iv) processed animal proteins, other than fishmeal, derived from non-ruminants ( ) (includes blood meal) Implemented by EC Reg. 142/2011

Raw material Only porcine blood referred to in Article 10(a) and Article 10(b)(i) of

10 LEGISLATION REGULATION (EC) No 142/2011 animal by-products and derived products not intended for human consumption Porcine Blood Products 1. Raw material Only porcine blood referred to in Article 10(a) and Article 10(b)(i) of Regulation (EC) No 1069/2009 may be used for the production of blood products. 2. Species of destination SWINE POULTRY AQUA PETFOOD FUR

11 LEGISLATION REGULATION (EC) No 142/2011 animal by-products and derived products not intended for human consumption Bovine/ Mixed Species Blood Products 1. Raw material Only bovine blood referred to in Article 10(a) and Article 10(b)(i) of Regulation (EC) No 1069/2009 may be used for the production of blood products. 2. Species of destination PETFOOD FUR 3. Exceptions in non-eu countries

12 ADDITIONAL SAFETY STEPS EAPA (European Animal Protein Association) Code of Practice: Porcine blood products destined for swine feeds manufacturing 1. Minimum 80ºC outlet temperature 2. Minimum 180ºC inlet temperature 3. Hold plasma and red cells going to swine for at least 2 minimum 20ºC 4. Water activity below 0.6 and moisture content less than 8 % 5. Keeping appropriate records S18

Key Business Strategies Research & Product

relating to the efficacy and use of blood and

13 Key Business Strategies Research & Product Development Leadership APC s staff of researchers and product developers has published more than 400 scientific papers relating to the efficacy and use of blood and plasma proteins. COW SWINE FUR PETFOOD POULTRY AGRICULTURE AQUA INDUSTRIAL

14 WE ARE BACKED BY SOUND SCIENCE More than 400 peer-reviewed studies over 30 years across species demonstrate effectiveness

15 APC R&D Team 15 People in R&D and Technical Service. 2 R&D Groups : USA group and European group Work closely with Universities and External Research groups on both sides of the ocean. Spanish R&D and Pilot Plant Facilities LAB (Lauridsen Advance Building)

16 R&D Project Focus Projects Oriented to Maintain /Expanding Actual Business Projects Oriented to Develop a New Product/New Process Basic Research Biosafety

17 R&D Project Focus Publications related with the Biosafety of Blood Products S12

R&D Projects Expanding Actual Business /

Food Dry Pet Food Calves New Applications

Dairy Cows Aqua Poultry Field trials SDAP

18 R&D Projects Expanding Actual Business / Incremental Innovations Swine Wet Pet Food Dry Pet Food Calves New Applications / New Products /Breakthrough Innovations Dairy Cows Aqua Poultry Field trials SDAP in antibiotic free diets. Biosafety Projects Virus and bacteria safety trials APC R&D Projects Basic Research /Breakthrough Innovations Mode of Action Hydrolyzed Products Plasma Fractionation Industrial Projects

Other Activities in The R&D Department During The Year 2017 5 Published/Accepted articles in Peer-Review J WAS 1 Abstract (Aqua) Crenshaw et al. JSHP 25(1):10-18.

Use of Peptein in Dairy Cows IPPE 2018 1 Abstract submitted (Poultry) Crenshaw et al. Plasma vs alternative proteins AMENA 2017: 2 Abstract (Swine & Poultry) Morrison et al. J Dairy Sci.

Use of Pepton in cherry tomato 17 White Papers / Articles in specialized magazines Blázquez et al. UV and SD effect on E. coli Digestibility of Turkey blood Blázquez et al.

19 Other Activities in The R&D Department During The Year Published/Accepted articles in Peer-Review J WAS 1 Abstract (Aqua) Crenshaw et al. JSHP 25(1): SDP in pigs positive for PRRS Aquaculture Europe 1 Abstract (Aqua) Blázquez et al. PLoS ONE 12(4):e UV effect on Salmonella Leman Conference 1 Abstract (Biosafety) Bach et al.. AFST 231 : Use of Peptein in Dairy Cows IPPE Abstract submitted (Poultry) Crenshaw et al. Plasma vs alternative proteins AMENA 2017: 2 Abstract (Swine & Poultry) Morrison et al. J Dairy Sci. 100(6):1-13 Gut Health 2017: 1 Abstract submitted (Swine) ABRAVES Abstract (swine) 6 Articles submitted in Peer-Rev. J. MW ASAS Abstract (Plasma with Formaldehyde) Polo & Matas. Use of Pepton in cherry tomato 17 White Papers / Articles in specialized magazines Blázquez et al. UV and SD effect on E. coli Digestibility of Turkey blood Blázquez et al. SD effect on Salmonella strains Plasma in poultry. New Leeson paper Campbell et al. Feeding UV-SDPP to naïve pigs 4 Tech Notes about use of plasma in Aqua Lee et al., Plasma effect on Dairy Cows 4 Tech Notes about the use of plasma in swine Pérez-Bosque et al. Aging papers 2 Discoveries related with the use of plasma in swine. Pepton in Olive trees SDP in wet cat food improves digestibility 21 Abstract/papers in specialized Congress Use of SDP in farm with problems with PCV2 and PRRS ESPHM Abstracts and Posters (Biosafety) AASV Abstract and Oral presentation (Swine) AASV Absrtract submitted and accepted (Biosafety) ADSA Abstracts and Posters (Dairy Cows) ESS Abstract (Horses) ISIN Abstract (MOA) Microbiota Congress 1 Abstract (MOA)

20 THE FUTURE THREATS/OPPORTUNITIES OPPORTUNITITES: ATB REPLACEMENT BAN ON ZINC OXIDE (ZnO) TREATS: BREXIT??? ANIMAL DISEASE AND SUBSEQUENT LEGISLATION think about the impact of BSE in the past! What about ASF in CEE (Poland, Russia, Belarus, Romania etc) RETAILER BAN ON THE USE OF ANIMAL PROTEINS.

21 Meat Association and Retailers ban on the use of Animal Proteins

22 THANK YOU FOR YOUR ATTENTION. For further information on our company, our products, or the science backing up as the leader in blood products research, you can: Visit us at functionalproteins.com/europe Contact us at: Call us at:

Who we are. The name Essentia tells the story of refinement and purification, turning something basic into its most valuable form its essence.

Who we are. The name Essentia tells the story of refinement and purification, turning something basic into its most valuable form its essence. Who we are The name Essentia tells the story of refinement and purification, turning something basic into its most valuable form its essence. Through advanced extraction processes we create protein solutions