FACULTY. Director, Heart Failure program Washington DC VA Medical Center

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2 FACULTY William Abraham, MD, FACC, FHFSA, Physiology, and Cell Biology Chair of Excellence in Cardiovascular Medicine Director, Division of Cardiovascular Medicine Associate Dean for Clinical Research Director, Clinical Trials Management Office Deputy Director, Davis Heart and Lung Research Institute The Ohio State University Tariq Ahmad, MD, FACC Advanced Heart Failure and Transplant Assistant Yale New Haven Health System Ana Barac, MD, PhD Director, Cardio-Oncology program Medical Director, Cardiac Rehabilitation program MedStar Heart and Vascular Institute Assistant, Georgetown University Linda Bogar MD, FACC Surgical Director of the Heart and Lung Transplant Programs Eugene Braunwald, MD, MACC, FAHA, FESC Distinguished Hersey Harvard Medical School Founding Chairman of the TIMI Study Group Brigham and Women's Hospital Michael Bristow, MD, PhD, FACC, FHFSA (Cardiology) Director of Pharmacogenomics University of Colorado Division of Cardiology President and CEO, ARCA biopharma Javed Butler, MD, MPH, MBA, FACC, FHFSA Professor of Physiology and Biophysics Director, Division of Cardiovascular Medicine Co-Director, Heart Institute Stony Brook University Robert Califf, MD, MACC Vice-Chancellor for Health Data Science Senior Management Team, Verily Life Sciences Former FDA Commissioner Peter Carson, MD, FACC Clinical Georgetown University Director, Heart Failure program Washington DC VA Medical Center Lauren Cooper, MD, MHS, FACC Director of Heart Failure Disease Management Clinic Associate Director of Heart Failure Research Inova Heart & Vascular Institute James Daubert, MD, FACC Chief, Cardiac Electrophysiology Shashank Desai, MD, FACC Medical Director Advanced Heart Failure and Transplant Program G. Michael Felker, MD, FACC, FHFSA Chief of the Heart Failure Section Mona Fiuzat, PharmD, FACC, FHFSA, FHA Former Sr. Scientific Advisor to FDA Commissioner Associate Mardi Gomberg-Maitland, MD, MSc, FACC, VCU Co-Director of Pulmonary Vascular Disease James Januzzi, MD, FACC Hutter Family Senior Cardiometabolic Faculty Baim Institute for Clinical Research Harvard Medical School Mariell Jessup, MD, FACC Chief Scientific Officer Fondation Leducq and Leducq Corporation Marvin A. Konstam, MD, FACC, FHFSA Chief Physician Executive The CardioVascular Center Tufts University School of Medicine Harlan Krumholz, MD, SM, FACC Harold H. Hines, Jr. Professor in the Institute for Social and Policy Studies Director, Center for Outcomes Research and Evaluation Yale University

3 Carl Chip J Lavie MD, FACC, FACP, FCCP Medical Director, Cardiac Rehabilitation and Preventive Cardiology and Director, Exercise Laboratories, Ochsner Medical Center JoAnn Lindenfeld, MD, FACC, FAHA, FHFSA Director, Heart Failure and Transplant Program Vanderbilt University Doug Mann, MD, FACC, FHFSA Lewin Chair and Chief, Cardiovascular Division, Cell Biology and Physiology Washington University School of Medicine Christopher W. May, MD, FACP, FACC, FHFSA Heart Failure/Transplant Program Medical Director CTUN Alan B Miller MD, FACC, FHFSA University of Florida/Jacksonville Christopher O Connor, MD, FACC, FESC, FHFSA CEO and Executive Director Inova Heart & Vascular Institute, Mitchell Psotka, MD Advanced Heart Failure, Transplant, and Pulmonary Hypertension Associate Director Heart Failure Site Based Research and Heart Failure Outreach Programs Joseph G. Rogers, MD, FACC, FHFSA, Division of Cardiology Interim Chair, Department of Medicine Palak Shah, MD, MS, FACC, FHFSA Director, Cardiovascular Genomics Center Director, Heart Failure Research Assistant, GW University Scott Solomon, MD, FACC, FHFSA The Edward D. Frohlich Distinguished Chair Harvard Medical School Director, Noninvasive Cardiology Brigham and Women s Hospital Alan Speir, MD, FACC Director, Cardiothoracic Surgery Professor, Department of Surgery Division of Cardiothoracic Surgery Virginia Commonwealth University John Teerlink, MD, FACC, FHFSA Director, Heart Failure Program and Clinical Echocardiography Lab, San Francisco VA Medical Center, UCSF Orly Vardeny, PharmD, MS, FHFSA Associate Professor of Pharmacy and Medicine University of Minnesota Hector O. Ventura, MD, FACC, FACP Section Head Cardiomyopathy and Heart Transplantation Ochsner Medical Center Mary N. Walsh, MD, FACC, FHFSA Medical Director, Heart Failure and Transplantation Director, Nuclear Cardiology St. Vincent Heart Center David Whellan, MD, FACC, FHFSA James C. Wilson Associate Provost for Clinical Research Associate Dean for Clinical Research Executive Director, Jefferson Clinical Research Institute Thomas Jefferson University, MACC, FAHA, FHFSA Vice Dean for Diversity and Inclusion Chief of Cardiology, Department of Medicine Northwestern Feinberg School of Medicine Ramesh Singh MD, FACS, FACC Surgical Director of Mechanical Circulatory Support

4 PROGRAM 7:45 8:30 AM Registration, Coffee, Exhibits 8:00 8:30 AM Breakout Session 8:30 8:35 AM Opening Remarks Christopher M. O Connor, MD Shashank Desai, MD PHARMACOLOGY: NOVEL APPROACHES TO DRUG THERAPY FOR HEART FAILURE Session Moderator: Michael Bristow, MD, PhD Panel Moderator: Mona Fiuzat, PharmD SESSION 1: DRUG THERAPY 8:35 8:45 AM: Current Management Strategies in HFpEF: The New Worldwide Epidemic Scott Solomon, MD 8:45 8:55 AM: Should Race and Gender Affect Drug Therapy Decisions? 8:55 9:05 AM: Novel Therapies: New Generation Therapies Orly Vardeny, PharmD 9:05 9:15 AM: Beyond Diuretics Anything Else for Symptom Relief? G. Michael Felker, MD 9:15 9:25 AM: Antiplatelets and Anticoagulation in HF Good for All? John Teerlink, MD 9:25 9:35 AM: Novel Therapies for Diabetes and HF: SGLT2 inhibitors and GLP1 Agonists Javed Butler, MD 9:35 9:45 AM: Treating Pulmonary Hypertension and RV Failure Mardi Gomberg, MD 9:45 9:55 AM: What s Hot in the ACC/AHA/HFSA Guidelines? Mariell Jessup, MD 9:55 10:15 AM: Clinical Cases and Panel Discussion (Moderator: Mona Fiuzat, PharmD) Orly Vardeny, PharmD Clinical Case #1 Mariell Jessup, MD Clinical Case #2 Scott Solomon, MD G. Michael Felker, MD John Teerlink, MD Javed Butler, MD Mardi Gomberg, MD Patient Representative (TBD) 10:15-10:55 AM: Exhibit and Networking Break, Posters 10:20 10:55 AM: Breakout Session

5 DEVICES: CUTTING EDGE DEVICE THERAPY FOR HEART FAILURE Session Moderator: Alan Miller, MD Panel Moderator: Peter Carson, MD 10:55 11:05 AM: Sensor Strategies for Heart Failure Apple, Oranges and Bananas David Whellan, MD SESSION 2: DEVICES 11:05 11:15 AM: Ablation, ICD s and CRT for Heart Failure James Daubert, MD 11:15 11:25 AM: Sleep Apnea To Treat or Not to Treat? Christopher O Connor, MD 11:25 11:35 AM: Novel Device Therapies for HF William Abraham, MD 11:35 11:45 AM: Treating Mitral Regurgitation in HF JoAnn Lindenfeld, MD 11:45 11:55 AM: The Intersection of A. Fib and HF Michael Bristow, MD, PhD 11:55 12:05 PM: Patient Decisions about Device Therapy Mary Walsh, MD 12:05 pm-12:25 PM: Clinical Cases and Panel Discussion (Moderator: Peter Carson, MD) Mary Walsh, MD Clinical Case #1 Alan Miller, MD Clinical Case #2 David Whellan, MD Michael Bristow, MD, PhD JoAnn Lindenfeld, MD Christopher O Connor, MD William Abraham, MD James Daubert, MD 12:25 1:05 PM: Lunch, Exhibits and Networking 12:30 12:45 PM: Poster Session Moderators / Judges: Lauren Cooper, MD; Mitch Psotka, MD; Palak Shah, MD, Chris defilippi, MD 12:35 1:05 PM: Breakout Session 1:05 2:05 PM KEYNOTE SESSION 1:05 1:25 PM: THE FUTURE OF THERAPEUTIC DEVELOPMENT IN HEART FAILURE Eugene Braunwald, MD 1:25 1:45 PM: THE FUTURE OF HEALTHCARE AND CV MEDICINE IN AMERICA Robert Califf, MD 1:45 2:05 PM: PANEL Moderator: Christopher M. O Connor Panelists: Eugene Braunwald, MD; Robert Califf, MD; Alan Speir, MD

6 Debates and Health Policy Session Moderator: Marvin Konstam, MD Panel Moderator: G. Michael Felker, MD SESSION 3: DEBATES DEBATE 1: CARDIO-ONCOLOGY: DOES LVEF MATTER? 2:05 2:15 PM: LVEF Changes Should be Managed Ana Barac, MD 2:15 2:25 PM: No Clear Evidence Marvin Konstam, MD DEBATE 2: SHOULD WE USE BIOMARKERS TO GUIDE THERAPY? 2:25 2:35 PM: Use Biomarkers to Guide Therapy James Januzzi, MD 2:35 2:45 PM: Guideline Directed, not Biomarker Guided DEBATE 3: Blood Pressure Targets: Is there a J-Curve? (The REMATCH) 2:45 2:55 PM: The Lower the Better Carl Chip Lavie, MD 2:55 3:05 PM: There s a Limit: Too Much of a Good Thing Hector Ventura, MD 3:05 3:20 PM: Panel Discussion (Moderator: G. Michael Felker, MD) Carl Chip Lavie, MD Hector Ventura, MD Ana Barac, MD Marvin Konstam, MD James Januzzi, MD 3:20 3:35 PM: Exhibits and Networking Coffee Break

7 SESSION 4: ADVANCED HF CUTTING EDGE CONCEPTS IN ADVANCED HEART FAILURE Session Moderator: JoAnn Lindenfeld, MD Panel Moderator: Shashank Desai, MD 3:35 3:45 PM: The New Allocation System: Who is Appropriate for Heart Transplant or Mechanical Support? Shashank Desai, MD 3:45 3:55 PM: Novel Mechanical Support Devices in 2018 Ramesh Singh, MD 3:55 4:05 PM: Palliative Care in End Stage Heart Failure: Symptom Management Joseph Rogers, MD 4:05 4:15 PM: Medical Management of LVAD patients for the Non-LVAD Specialist Tariq Ahmad, MD 4:15 4:25 PM: LVAD Explantation Can it Be Done? Doug Mann, MD 4:25 4:35 PM: Cutting Edge Concepts in Surgical Options Linda Bogar, MD 4:35 4:55 PM Clinical Cases and Panel Discussion (Moderator: Shashank Desai, MD) Palak Shah, MD Clinical Case #1 IHVI Nurse, TBD Clinical Case #2 Christopher May, MD Linda Bogar, MD Ramesh Singh, MD Joseph Rogers, MD Doug Mann, MD Tariq Ahmad, MD 4:55 5:00 PM: Poster Awards, Closing Remarks Christopher M. O Connor

FACULTY. James Daubert, MD, FACC Chief, Cardiac Electrophysiology Professor of Medicine Duke University

FACULTY. James Daubert, MD, FACC Chief, Cardiac Electrophysiology Professor of Medicine Duke University FACULTY William Abraham, MD, FACC, FHFSA, Physiology, and Cell Biology Director and Chair, Division of Cardiovascular Medicine Associate Dean for Clinical Research Director, Clinical Trials Management