DOWNLOAD OR READ : SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE IN MALIGNANCY PDF EBOOK EPUB MOBI

Size: px
Start display at page:

Download "DOWNLOAD OR READ : SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE IN MALIGNANCY PDF EBOOK EPUB MOBI"

Transcription

1 DOWNLOAD OR READ : SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE IN MALIGNANCY PDF EBOOK EPUB MOBI Page 1

2 Page 2

3 syndrome of inappropriate secretion of antidiuretic hormone in malignancy syndrome of inappropriate secretion pdf syndrome of inappropriate secretion of antidiuretic hormone in malignancy The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is defined by the hyponatremia and hypo-osmolality resulting from inappropriate, continued secretion or action of the antidiuretic hormone arginine vasopressin (AVP) despite normal or increased plasma volume, which results in impaired water excretion.the key to understanding the... syndrome of inappropriate secretion of antidiuretic hormone in malignancy Definitions and Pathophysiologic Mechanisms of SIADH. SIADH is a disease categorized as hypo-osmolar hyponatremia; small amount of volume expansion is caused by excess of renal water reabsorption through inappropriate antidiuretic hormone (ADH) secretion ( 11 ). Before the diagnosis of SIADH, other diseases such as dysfunctions of heart,... syndrome of inappropriate secretion of antidiuretic hormone in malignancy SIADH of malignancy is the inappropriate, uncontrolled se- cretion of ADH, which causes increased water reabsorption by the renal tubules that leads to decreased excretion of wa- ter (Jones, 1999). The volume of total body water increases and is distributed into the extracellular and intracellular fluid. Syndrome of Inappropriate Antidiuretic Hormone syndrome of inappropriate secretion of antidiuretic hormone in malignancy CASE REPORT S Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lisinopril Zakir Hussain A Shaikh, Harris C Taylor, Praful V Maroo, and Luis A Llerena OBJECTIVE: To describe a case of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with lisinopril therapy. syndrome of inappropriate secretion of antidiuretic hormone in malignancy Discussion. Symptoms generally present at plasma sodium concentrations less than 130 mmol/l and include anorexia, nausea and vomiting, headache, diarrhoea, weakness, lethargy, confusion, convulsions and coma. Severity is usually determined by the speed of onset and extent of the fluid and electrolyte disturbances. Drug-induced syndrome of inappropriate antidiuretic hormone secretion occurs when excessive levels of antidiuretic hormones (hormones that help the kidneys, and body, conserve the correct amount of water) are produced. The syndrome causes the body to retain water and certain levels of electrolytes in the blood to fall (such as sodium). SIADH is rare in children. syndrome of inappropriate secretion of antidiuretic hormone in malignancy Inappropriate secretion of TSH syndrome. Both forms are characterized by high levels of free thyroxine (FT4) and free triiodothyronine (FT3) in the presence of measurable TSH concentrations, a biochemical picture which is in contrast to primary hyperthyroidism where TSH levels are always undetectable. (PDF) Inappropriate secretion of TSH syndrome syndrome of inappropriate secretion of antidiuretic hormone in malignancy The syndrome of inappropriate antidiuretic Page 3

4 hormone secretion (SIADH) is a condition that causes your body to make too much antidiuretic hormone (ADH). ADH is a chemical that helps keep the right balance of fluids in your body. Increased ADH may cause too much water to remain inside your body. Chemicals in your blood, such as salt, may decrease. syndrome of inappropriate secretion of antidiuretic hormone in malignancy Hereditary syndrome of inappropriate antidiuretic hormone secretion. Two genetic syndromes, one affecting the gene for renal V2 receptor and the other affecting osmolality sensing in hypothalamus, have been identified. The former is called nephrogenic syndrome and the latter is termed as hypothalamic syndrome. Syndrome of inappropriate antidiuretic hormone secretion hormone secretion. Appropriate ADH secretion is regulated by osmoreceptors on the hypothalamic cells that synthesize and store ADH: plasma hypertonicity activates these receptors, ADH is released into the blood stream, the kidney increases solute-free water return to the circulation,... Syndrome of inappropriate antidiuretic hormone secretion hormone secretion (SIADH) is characterized by excessive release of antidiuretic hormone from the posterior pituitary gland or another source. The increase in fluid retention often results in dilutional hyponatremia in which the plasma sodium levels are lowered. SIADH may present with euvolemic hyponatremia with continued urinary sodium excretion. Page 4

5 Page 5

Antidiuretic Hormone

Antidiuretic Hormone 1 Antidiuretic Hormone 2 Physiology of the Posterior Pituitary The posterior pituitary gland secretes two hormones which are: oxytocin, increase uterine contractions during parturition Contraction of mammary

More information

Overview. Fluid & Electrolyte Disorders. Water distribution. Introduction 5/10/2014

Overview. Fluid & Electrolyte Disorders. Water distribution. Introduction 5/10/2014 Overview Fluid & Electrolyte Disorders Dr Nicola Barlow Clinical Biochemistry Department, City Hospital Introduction Fluid and electrolyte homeostasis Electrolyte disturbances Analytical parameters Methods

More information

Hyponatraemia- Principles, Investigation and Management. Sirazum Choudhury Biochemistry

Hyponatraemia- Principles, Investigation and Management. Sirazum Choudhury Biochemistry Hyponatraemia- Principles, Investigation and Management Sirazum Choudhury Biochemistry Contents Background Investigation Classification Normal Osmolality General management and SIADH Cases Background Relatively

More information

Guidelines for management of. Hyponatremia

Guidelines for management of. Hyponatremia Guidelines for management of Hyponatremia Children s Kidney Centre University Hospital of Wales Cardiff CF14 4XW DISCLAIMER: These guidelines were produced in good faith by the authors reviewing available

More information

BODY FLUID. Outline. Functions of body fluid Water distribution in the body Maintenance of body fluid. Regulation of fluid homeostasis

BODY FLUID. Outline. Functions of body fluid Water distribution in the body Maintenance of body fluid. Regulation of fluid homeostasis BODY FLUID Nutritional Biochemistry Yue-Hwa Chen Dec 13, 2007 Chen 1 Outline Functions of body fluid Water distribution in the body Maintenance of body fluid Intake vs output Regulation of body fluid Fluid

More information

The Urinary System 15PART B. PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College

The Urinary System 15PART B. PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College The Urinary System 15PART B Ureters Slender tubes attaching the kidney to the bladder Continuous with

More information

For more information about how to cite these materials visit

For more information about how to cite these materials visit Author(s): Roger Grekin, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/

More information

Renal Physiology Part II. Bio 219 Napa Valley College Dr. Adam Ross

Renal Physiology Part II. Bio 219 Napa Valley College Dr. Adam Ross Renal Physiology Part II Bio 219 Napa Valley College Dr. Adam Ross Fluid and Electrolyte balance As we know from our previous studies: Water and ions need to be balanced in order to maintain proper homeostatic

More information

Hyponatraemia: confident diagnosis, effective treatment and avoiding disasters. Dr James Ahlquist Endocrinologist Southend Hospital

Hyponatraemia: confident diagnosis, effective treatment and avoiding disasters. Dr James Ahlquist Endocrinologist Southend Hospital Hyponatraemia: confident diagnosis, effective treatment and avoiding disasters Dr James Ahlquist Endocrinologist Southend Hospital Hyponatraemia: a common electrolyte disorder Electrolyte disorder Prevalence

More information

Hyponatremia. Mis-named talk? Basic Pathophysiology

Hyponatremia. Mis-named talk? Basic Pathophysiology Hyponatremia Great Lakes Hospital Medicine Symposium by Brian Wolfe, MD Assistant Professor of Internal Medicine University of Colorado Denver Mis-named talk? Why do we care about Hyponatremia? concentration

More information

Body fluids. Lecture 13:

Body fluids. Lecture 13: Lecture 13: Body fluids Body fluids are distributed in compartments: A. Intracellular compartment: inside the cells of the body (two thirds) B. Extracellular compartment: (one third) it is divided into

More information

Hypothalamus & Pituitary Gland

Hypothalamus & Pituitary Gland Hypothalamus & Pituitary Gland Hypothalamus and Pituitary Gland The hypothalamus and pituitary gland form a unit that exerts control over the function of several endocrine glands (thyroid, adrenals, and

More information

Wales Critical Care & Trauma Network (North) Management of Hyponatraemia in Intensive Care Guidelines

Wales Critical Care & Trauma Network (North) Management of Hyponatraemia in Intensive Care Guidelines Wales Critical Care & Trauma Network (North) Management of Hyponatraemia in Intensive Care Guidelines Author: Richard Pugh June 2015 Guideline for management of hyponatraemia in intensive care Background

More information

Renal physiology D.HAMMOUDI.MD

Renal physiology D.HAMMOUDI.MD Renal physiology D.HAMMOUDI.MD Functions Regulating blood ionic composition Regulating blood ph Regulating blood volume Regulating blood pressure Produce calcitrol and erythropoietin Regulating blood glucose

More information

Done By: Lulu Al-Obaid - Abdulrahman Al-Rashed Reviewed By: Mohammed Jameel Khulood Al-Raddadi

Done By: Lulu Al-Obaid - Abdulrahman Al-Rashed Reviewed By: Mohammed Jameel Khulood Al-Raddadi Done By: Lulu Al-Obaid - Abdulrahman Al-Rashed Reviewed By: Mohammed Jameel Khulood Al-Raddadi At the end of this lecture student should be able to describe: The loop of Henle is referred to as countercurrent

More information

SODIUM BALANCE Overview

SODIUM BALANCE Overview SODIUM BALANCE Overview UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS III Seminar VJ Temple 1 How are solute and solvent related to solution?

More information

Hormonal Control of Osmoregulatory Functions *

Hormonal Control of Osmoregulatory Functions * OpenStax-CNX module: m44828 1 Hormonal Control of Osmoregulatory Functions * OpenStax This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of

More information

Iposodiemia: diagnosi e trattamento

Iposodiemia: diagnosi e trattamento Iposodiemia: diagnosi e trattamento Enrico Fiaccadori Unita di Fisiopatologia dell Insufficienza Renale Acuta e Cronica Dipartimento di Medicina Clinica e Sperimentale Universita degli Studi di Parma Hyponatremia

More information

SAMSCA (tolvaptan) oral tablet

SAMSCA (tolvaptan) oral tablet SAMSCA (tolvaptan) oral tablet Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Pharmacy Coverage

More information

Public Assessment Report. Scientific discussion. Natriumklorid Abcur (sodium chloride) SE/H/1443/01/MR

Public Assessment Report. Scientific discussion. Natriumklorid Abcur (sodium chloride) SE/H/1443/01/MR Public Assessment Report Scientific discussion Natriumklorid Abcur (sodium chloride) SE/H/1443/01/MR This module reflects the scientific discussion for the approval of Natriumklorid Abcur. The procedure

More information

Composition of Body Fluids

Composition of Body Fluids Water and electrolytes disturbances Fluid and Electrolyte Disturbances Hao, Chuan-Ming MD Huashan Hospital Sodium balance Hypovolemia Water balance Hyponatremia Hypernatremia Potassium balance Hypokelemia

More information

Instrumental determination of electrolytes in urine. Amal Alamri

Instrumental determination of electrolytes in urine. Amal Alamri Instrumental determination of electrolytes in urine Amal Alamri What is the Electrolytes? Electrolytes are positively and negatively chargedions, Found in Within body's cells extracellular fluids, including

More information

Endocrine Glands: Hormone-secreting organs are called endocrine glands

Endocrine Glands: Hormone-secreting organs are called endocrine glands University of Jordan Department of Physiology and Biochemistry Nursing students, Academic year 2017/2018. ******************************************************************* Ref: Principles of Anatomy

More information

H 2 O, Electrolytes and Acid-Base Balance

H 2 O, Electrolytes and Acid-Base Balance H 2 O, Electrolytes and Acid-Base Balance Body Fluids Intracellular Fluid Compartment All fluid inside the cells 40% of body weight Extracellular Fluid Compartment All fluid outside of cells 20% of body

More information

WATER, SODIUM AND POTASSIUM

WATER, SODIUM AND POTASSIUM WATER, SODIUM AND POTASSIUM Attila Miseta Tamás Kőszegi Department of Laboratory Medicine, 2016 1 Average daily water intake and output of a normal adult 2 Approximate contributions to plasma osmolality

More information

Endocrine part two. Presented by Dr. Mohammad Saadeh The requirements for the Clinical Chemistry Philadelphia University Faculty of pharmacy

Endocrine part two. Presented by Dr. Mohammad Saadeh The requirements for the Clinical Chemistry Philadelphia University Faculty of pharmacy Endocrine part two Presented by Dr. Mohammad Saadeh The requirements for the Clinical Chemistry Philadelphia University Faculty of pharmacy Cushing's disease: increased secretion of adrenocorticotropic

More information

CCRN/PCCN Review Course May 30, 2013

CCRN/PCCN Review Course May 30, 2013 A & P Review CCRN/PCCN Review Course May 30, 2013 Endocrine Anterior pituitary Growth hormone: long bone growth Thyroid stimulating hormone: growth, thyroid secretion Adrenocorticotropic hormone: growth,

More information

Pathology of pituitary gland. By: Shifaa Qa qa

Pathology of pituitary gland. By: Shifaa Qa qa Pathology of pituitary gland By: Shifaa Qa qa Sella turcica Adenohypophysis (80%): - epithelial cells - acidophil, basophil, chromophobe - Somatotrophs, Mammosomatotrophs, Corticotrophs, Thyrotrophs, Gonadotrophs

More information

EXCRETION QUESTIONS. Use the following information to answer the next two questions.

EXCRETION QUESTIONS. Use the following information to answer the next two questions. EXCRETION QUESTIONS Use the following information to answer the next two questions. 1. Filtration occurs at the area labeled A. V B. X C. Y D. Z 2. The antidiuretic hormone (vasopressin) acts on the area

More information

Questions? Homework due in lab 6. PreLab #6 HW 15 & 16 (follow directions, 6 points!)

Questions? Homework due in lab 6. PreLab #6 HW 15 & 16 (follow directions, 6 points!) Questions? Homework due in lab 6 PreLab #6 HW 15 & 16 (follow directions, 6 points!) Part 3 Variations in Urine Formation Composition varies Fluid volume Solute concentration Variations in Urine Formation

More information

BIOL 2402 Fluid/Electrolyte Regulation

BIOL 2402 Fluid/Electrolyte Regulation Dr. Chris Doumen Collin County Community College BIOL 2402 Fluid/Electrolyte Regulation 1 Body Water Content On average, we are 50-60 % water For a 70 kg male = 40 liters water This water is divided into

More information

Water (Dysnatremia) & Sodium (Dysvolemia) Disorders Ahmad Raed Tarakji, MD, MSPH, PGCertMedEd, FRCPC, FACP, FASN, FNKF, FISQua

Water (Dysnatremia) & Sodium (Dysvolemia) Disorders Ahmad Raed Tarakji, MD, MSPH, PGCertMedEd, FRCPC, FACP, FASN, FNKF, FISQua Water (Dysnatremia) & Sodium (Dysvolemia) Disorders Ahmad Raed Tarakji, MD, MSPH, PGCertMedEd, FRCPC, FACP, FASN, FNKF, FISQua Assistant Professor Nephrology Unit, Department of Medicine College of Medicine,

More information

The Endocrine System/Hormones

The Endocrine System/Hormones The Endocrine System/Hormones Controls many body functions exerts control by releasing special chemical substances into the blood called hormones Hormones affect other endocrine glands or body systems

More information

Disorders of water and sodium homeostasis. Prof A. Pomeranz 2017

Disorders of water and sodium homeostasis. Prof A. Pomeranz 2017 Disorders of water and sodium homeostasis Prof A. Pomeranz 2017 Pediatric (Nephrology) Tool Box Disorders of water and sodium homeostasis Pediatric Nephrology Tool Box Hyponatremiaand and Hypernatremia

More information

Kidneys and Homeostasis

Kidneys and Homeostasis 16 The Urinary System The Urinary System OUTLINE: Eliminating Waste Components of the Urinary System Kidneys and Homeostasis Urination Urinary Tract Infections Eliminating Waste Excretion Elimination of

More information

Endocrine secretion cells secrete substances into the extracellular fluid

Endocrine secretion cells secrete substances into the extracellular fluid Animal Hormones Concept 30.1 Hormones Are Chemical Messengers Endocrine secretion cells secrete substances into the extracellular fluid Exocrine secretion cells secrete substances into a duct or a body

More information

The Endocrine System. The Endocrine System

The Endocrine System. The Endocrine System The Endocrine System Like nervous system, endocrine system provides communication and control. Messages are relayed from one cell to another via chemical messengers (hormones). Unlike nervous system which

More information

Eggplant: The Story of Sodium in Neurocritical Care

Eggplant: The Story of Sodium in Neurocritical Care Eggplant: The Story of Sodium in Neurocritical Care Larry Burris, DO Medical Director NCC - Sanford Health Medical Director Renal Transplant - Sanford Health Assistant Professor of Medicine SSOM NaCl Facts

More information

Osmotic Regulation and the Urinary System. Chapter 50

Osmotic Regulation and the Urinary System. Chapter 50 Osmotic Regulation and the Urinary System Chapter 50 Challenge Questions Indicate the areas of the nephron that the following hormones target, and describe when and how the hormones elicit their actions.

More information

CATEGORY Endocrine System Review. Provide labels for the following diagram CHAPTER 13 BLM

CATEGORY Endocrine System Review. Provide labels for the following diagram CHAPTER 13 BLM CHAPTER 13 BLM 13.1.1 CATEGORY Endocrine System Review Provide labels for the following diagram. 1. 6. 2. 7. 3. 8. 4. 9. 5. 10. CHAPTER 13 BLM 13.1.2 OVERHEAD Glands and Their Secretions Endocrine gland

More information

Diuretic Agents Part-2. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia

Diuretic Agents Part-2. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Diuretic Agents Part-2 Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Potassium-sparing diuretics The Ion transport pathways across the luminal and basolateral

More information

Excretory System. Biology 2201

Excretory System. Biology 2201 Excretory System Biology 2201 Excretory System How does the excretory system maintain homeostasis? It regulates: Body heat Water-salt concentrations Acid-base concentrations Metabolite concentrations ORGANS

More information

Excretory System. Excretory System

Excretory System. Excretory System Excretory System Biology 2201 Excretory System How does the excretory system maintain homeostasis? It regulates: Body heat Water-salt concentrations Acid-base concentrations Metabolite concentrations 1

More information

Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + )

Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + ) Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + ) concentration in body fluids Precise regulation of ph at

More information

Chapter Nine. Temperature Regulation, Thirst, and Hunger

Chapter Nine. Temperature Regulation, Thirst, and Hunger Chapter Nine Temperature Regulation, Thirst, and Hunger Regulating Systems Homeostasis: Physiological equilibrium Epic FAIL with weight? Obesity rates 1980-2000 Motivation: Activating and directing behavior

More information

Renal System and Excretion

Renal System and Excretion Renal System and Excretion Biology 105 Lecture 19 Chapter 16 Outline Renal System I. Functions II. Organs of the renal system III. Kidneys 1. Structure 2. Function IV. Nephron 1. Structure 2. Function

More information

Nephron Structure inside Kidney:

Nephron Structure inside Kidney: In-Depth on Kidney Nephron Structure inside Kidney: - Each nephron has two capillary regions in close proximity to the nephron tubule, the first capillary bed for fluid exchange is called the glomerulus,

More information

Regulation of Body Fluids: Na + and Water Linda Costanzo, Ph.D.

Regulation of Body Fluids: Na + and Water Linda Costanzo, Ph.D. Regulation of Body Fluids: Na + and Water Linda Costanzo, Ph.D. OBJECTIVES: After studying this lecture, the student should understand: 1. Why body sodium content determines ECF volume and the relationships

More information

Use the following diagram to answer the next question. 1. In the diagram above, pressure filtration occurs in a. W b. X c. Y d. Z

Use the following diagram to answer the next question. 1. In the diagram above, pressure filtration occurs in a. W b. X c. Y d. Z Part A: Multiple Choice Questions Value: 32 Marks Suggested time: 40 minutes Instructions: For each question select the best answer and record your choice on the Scantron card provided. Using an HB pencil,

More information

The Endocrine System. Hormone =

The Endocrine System. Hormone = The Endocrine System Hormone = Types: peptide or protein = at least 3 amino acids steroid = derived from cholesterol amine = derived from single amino acids (tryptophan, tyrosine) Peptide Hormones Synthesis/transport/half-life

More information

5/18/2017. Specific Electrolytes. Sodium. Sodium. Sodium. Sodium. Sodium

5/18/2017. Specific Electrolytes. Sodium. Sodium. Sodium. Sodium. Sodium Specific Electrolytes Hyponatremia Hypervolemic Replacing water (not electrolytes) after perspiration Freshwater near-drowning Syndrome of Inappropriate ADH Secretion (SIADH) Hypovolemic GI disease (decreased

More information

Case Report Tolvaptan in the Treatment of Acute Hyponatremia Associated with Acute Kidney Injury

Case Report Tolvaptan in the Treatment of Acute Hyponatremia Associated with Acute Kidney Injury Case Reports in Nephrology Volume 2013, Article ID 801575, 4 pages http://dx.doi.org/10.1155/2013/801575 Case Report Tolvaptan in the Treatment of Acute Hyponatremia Associated with Acute Kidney Injury

More information

DIURETICS-4 Dr. Shariq Syed

DIURETICS-4 Dr. Shariq Syed DIURETICS-4 Dr. Shariq Syed AIKTC - Knowledge Resources & Relay Center 1 Pop Quiz!! Loop diuretics act on which transporter PKCC NKCC2 AIKTCC I Don t know AIKTC - Knowledge Resources & Relay Center 2 Pop

More information

Acid-Base Balance Dr. Gary Mumaugh

Acid-Base Balance Dr. Gary Mumaugh Acid-Base Balance Dr. Gary Mumaugh Introduction Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + ) concentration

More information

Renal Physiology. April, J. Mohan, PhD. Lecturer, Physiology Unit, Faculty of Medical Sciences, U.W.I., St Augustine.

Renal Physiology. April, J. Mohan, PhD. Lecturer, Physiology Unit, Faculty of Medical Sciences, U.W.I., St Augustine. Renal Physiology April, 2011 J. Mohan, PhD. Lecturer, Physiology Unit, Faculty of Medical Sciences, U.W.I., St Augustine. Office : Room 105, Physiology Unit. References: Koeppen B.E. & Stanton B.A. (2010).

More information

Homeostatic Regulation

Homeostatic Regulation Homeostatic Regulation A hormone is :a Water-soluble hormones: Composed of amino acids and bind a receptor protein on the of the target cell. This starts a signal cascade inside the cell and the signal

More information

SIMULTANEOUSLY PRESENTATION OF TWO PARANEOPLASTIC SYNDROMES IN A PATIENT WITH LUNG CARCINOMA

SIMULTANEOUSLY PRESENTATION OF TWO PARANEOPLASTIC SYNDROMES IN A PATIENT WITH LUNG CARCINOMA Bulletin of the Transilvania University of Braşov Series VI: Medical Sciences Vol. 6 (55) No. 1-2013 SIMULTANEOUSLY PRESENTATION OF TWO PARANEOPLASTIC SYNDROMES IN A PATIENT WITH LUNG CARCINOMA A. STOICESCU

More information

Monday, 17 April 2017 BODY FLUID HOMEOSTASIS

Monday, 17 April 2017 BODY FLUID HOMEOSTASIS Monday, 17 April 2017 BODY FLUID HOMEOSTASIS Phenomenon: shipwrecked sailor on raft in ocean ("water, water everywhere but not a drop to drink") Why are the sailors thirsty? (What stimulated thirst?) Why

More information

Chapter 27: WATER, ELECTROLYTES, AND ACID-BASE BALANCE

Chapter 27: WATER, ELECTROLYTES, AND ACID-BASE BALANCE Chapter 27: WATER, ELECTROLYTES, AND ACID-BASE BALANCE I. RELATED TOPICS Integumentary system Cerebrospinal fluid Aqueous humor Digestive juices Feces Capillary dynamics Lymph circulation Edema Osmosis

More information

The Urinary System. BIOLOGY OF HUMANS Concepts, Applications, and Issues. Judith Goodenough Betty McGuire

The Urinary System. BIOLOGY OF HUMANS Concepts, Applications, and Issues. Judith Goodenough Betty McGuire BIOLOGY OF HUMANS Concepts, Applications, and Issues Fifth Edition Judith Goodenough Betty McGuire 16 The Urinary System Lecture Presentation Anne Gasc Hawaii Pacific University and University of Hawaii

More information

Pediatric Sodium Disorders

Pediatric Sodium Disorders Pediatric Sodium Disorders Guideline developed by Ron Sanders, Jr., MD, MS, in collaboration with the ANGELS team. Last reviewed by Ron Sanders, Jr., MD, MS on May 20, 2016. Definitions, Physiology, Assessment,

More information

Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience

Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience ORIGINAL ARTICLE Korean J Intern Med 2018;33:561-567 Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience Gun Ha Park 1,2, Chang Min

More information

Renal Quiz - June 22, 21001

Renal Quiz - June 22, 21001 Renal Quiz - June 22, 21001 1. The molecular weight of calcium is 40 and chloride is 36. How many milligrams of CaCl 2 is required to give 2 meq of calcium? a) 40 b) 72 c) 112 d) 224 2. The extracellular

More information

Chapter 13 worksheet

Chapter 13 worksheet Name: Chapter 13 worksheet The Endocrine System Please label the: hypothalamus pineal gland pituitary gland thyroid gland parathyroid gland thymus heart stomach liver adrenal glands kidneys pancreas small

More information

Temperature, Regulation, Thirst, and Hunger

Temperature, Regulation, Thirst, and Hunger PSYB64 Lecture 6 Temperature, Regulation, Thirst, and Hunger 1. Homeostasis 2. Temperature 3. Thirst 4. Hunger 5. Obesity & Hunger Disorders HOMEOSTASIS Homeostasis: Physiological equilibrium Motivation:

More information

The Urinary System PART B

The Urinary System PART B 15 The Urinary System PART B PowerPoint Lecture Slide Presentation by Jerry L. Cook, Sam Houston University ESSENTIALS OF HUMAN ANATOMY & PHYSIOLOGY EIGHTH EDITION ELAINE N. MARIEB Urinary Bladder Smooth,

More information

Hyponatraemia. Detlef Bockenhauer

Hyponatraemia. Detlef Bockenhauer Hyponatraemia Detlef Bockenhauer Key message Plasma sodium can be low due to either excess water or deficiency of salt In clinical practice, dysnatraemias almost always reflect an abnormality of water

More information

Fal Fal P h y s i o l o g y 6 1 1, S a n F r a n c i s c o S t a t e U n i v e r s i t y

Fal Fal P h y s i o l o g y 6 1 1, S a n F r a n c i s c o S t a t e U n i v e r s i t y Fall 12 OSMOTIC REGULATION OF THE RENAL SYSTEM: Effects of fasting and ingestion of water, coke, or Gatorade on urine flow rate and specific gravity Dorette Franks The purpose of the physiology experiment

More information

NATURAL HISTORY AND SURVIVAL OF PATIENTS WITH ASCITES. PATIENTS WHO DO NOT DEVELOP COMPLICATIONS HAVE MARKEDLY BETTER SURVIVAL THAN THOSE WHO DEVELOP

NATURAL HISTORY AND SURVIVAL OF PATIENTS WITH ASCITES. PATIENTS WHO DO NOT DEVELOP COMPLICATIONS HAVE MARKEDLY BETTER SURVIVAL THAN THOSE WHO DEVELOP PROGNOSIS Mortality rates as high as 18-30% are reported for hyponatremic patients. High mortality rates reflect the severity of underlying conditions and are not influenced by treatment of hyponatremia

More information

BALANCE 13 DISORDERS OF WATER DISORDERS CHARACTERISED BY POLYDIPSIA AND POLYURIA. (vasopressin deficiency) 1 [primary] [secondary 6C] insipidus

BALANCE 13 DISORDERS OF WATER DISORDERS CHARACTERISED BY POLYDIPSIA AND POLYURIA. (vasopressin deficiency) 1 [primary] [secondary 6C] insipidus Wit JM, Ranke MB, Kelnar CJH (eds): ESPE classification of paediatric endocrine diagnosis. 13. Disorders of water balance. Horm Res 2007;68(suppl 2):96 97 ESPE Code Diagnosis OMIM ICD10 13 DISORDERS OF

More information

Chapter 26 Fluid, Electrolyte, and Acid- Base Balance

Chapter 26 Fluid, Electrolyte, and Acid- Base Balance Chapter 26 Fluid, Electrolyte, and Acid- Base Balance 1 Body Water Content Infants: 73% or more water (low body fat, low bone mass) Adult males: ~60% water Adult females: ~50% water (higher fat content,

More information

Basic approach to: Hyponatremia Adley Wong, MHS PA-C

Basic approach to: Hyponatremia Adley Wong, MHS PA-C 2016 Topics in Acute and Ambulatory Care CAPA Conference 2018 for Advanced Practice Providers Basic approach to: Hyponatremia Adley Wong, MHS PA-C Goals Physiology of hyponatremia Why we care about hyponatremia

More information

Abnormalities in serum sodium. David Metz Paediatric Nephrology

Abnormalities in serum sodium. David Metz Paediatric Nephrology Abnormalities in serum sodium David Metz Paediatric Nephrology Basics Total body sodium regulated by aldosterone and ANP Mediated by intravascular volume (not sodium) RAAS and intrarenal determines Na

More information

Fluid and electrolyte balance, imbalance

Fluid and electrolyte balance, imbalance Fluid and electrolyte balance, imbalance Body fluid The fluids are distributed throughout the body in various compartments. Body fluid is composed primarily of water Water is the solvent in which all solutes

More information

Pituitary Disorders. Eiman Ali Basheir Mob: /1/2019

Pituitary Disorders. Eiman Ali Basheir Mob: /1/2019 Pituitary Disorders Eiman Ali Basheir Mob: 0915020385 31/1/2019 Objectives By the end of this lecture the students will be able to: Understand basic Pituitary axis physiology State the common causes of

More information

Urinary. Smooth, collapsible, muscular sac stores urine. Figure Slide 15.21a

Urinary. Smooth, collapsible, muscular sac stores urine. Figure Slide 15.21a Urinary Smooth, collapsible, muscular sac stores urine Figure 15.6 Slide 15.21a Urinary Bladder Wall Walls are and folded in an empty bladder Bladder can significantly without increasing internal pressure

More information

1.&Glomerular/Pressure&Filtration&

1.&Glomerular/Pressure&Filtration& Urine&Formation& Overall&Process&! Urine gets rid of wastes (NH 3, urea, uric acid, creatinine) and other substances (vitamins, penicillin, histamines) found in excess in the blood!! blood is filtered

More information

Assessment of the Patient with Endocrine Dysfunction. Objective. Endocrine. Endocrine Facts. Physical Assessment 10/3/2013

Assessment of the Patient with Endocrine Dysfunction. Objective. Endocrine. Endocrine Facts. Physical Assessment 10/3/2013 Objective Endocrine Jennifer MacDermott, MS, RN, ACNS BC, NP C, CCRN Clinical Nurse Specialist Surgical Intensive Care Unit Identify abnormal assessment finding sin a patient with endocrine dysfunction.

More information

Excretory System 1. a)label the parts indicated above and give one function for structures Y and Z

Excretory System 1. a)label the parts indicated above and give one function for structures Y and Z Excretory System 1 1. Excretory System a)label the parts indicated above and give one function for structures Y and Z W- X- Y- Z- b) Which of the following is not a function of the organ shown? A. to produce

More information

I. Metabolic Wastes Metabolic Waste:

I. Metabolic Wastes Metabolic Waste: I. Metabolic Wastes Metabolic Waste: a) Carbon Dioxide: by-product of cellular respiration. b) Water: by-product of cellular respiration & dehydration synthesis reactions. c) Inorganic Salts: by-product

More information

The Posterior Pituitary Gland and Related Issues (Vasopressin and Oxytocin) R.J. Witorsch, Ph.D.

The Posterior Pituitary Gland and Related Issues (Vasopressin and Oxytocin) R.J. Witorsch, Ph.D. The Posterior Pituitary Gland and Related Issues (Vasopressin and Oxytocin) R.J. Witorsch, Ph.D. OBJECTIVES: At the end of this lecture, the student should be able to: 1. Construct the relationships between

More information

營養學. 營養學 Nutrition ~ Water (H 2 O) ~

營養學. 營養學 Nutrition ~ Water (H 2 O) ~ 營養學 營養學 Nutrition ~ Water (H 2 O) ~ 謝明哲 M.J.Shieh 臺北醫學大學公共衛生暨營養學院 保健營養學系 研究所 clark@tmu.edu.tw 1 Outline Function Homeostasis Requirement Deficiency syndrome Water Toxicity 2 Water (H 2 O) ~ An essential

More information

Disclaimer. Chapter 3 Disorder of Water, Electrolyte and Acid-base Professor A. S. Alhomida. Disorder of Water and Electrolyte

Disclaimer. Chapter 3 Disorder of Water, Electrolyte and Acid-base Professor A. S. Alhomida. Disorder of Water and Electrolyte Disclaimer King Saud University College of Science Department of Biochemistry The texts, tables, figures and images contained in this course presentation (BCH 376) are not my own, they can be found on:

More information

Sunday, July 17, 2011 URINARY SYSTEM

Sunday, July 17, 2011 URINARY SYSTEM URINARY SYSTEM URINARY SYSTEM Let s take a look at the anatomy first! KIDNEYS: are complex reprocessing centers where blood is filtered through and waste products are removed. Wastes and extra water become

More information

Renal System Dr. Naim Kittana Department of Biomedical Sciences Faculty of Medicine & Health Sciences An-Najah National University

Renal System Dr. Naim Kittana Department of Biomedical Sciences Faculty of Medicine & Health Sciences An-Najah National University Renal System Dr. Naim Kittana Department of Biomedical Sciences Faculty of Medicine & Health Sciences An-Najah National University Declaration The content and the figures of this seminar were directly

More information

Proceeding of the ACVP Annual Meeting

Proceeding of the ACVP Annual Meeting http://www.ivis.org Proceeding of the ACVP Annual Meeting Oct.17-21, 2015 Minneapolis, MN, USA Next Meeting: Dec. 3-7, 2016 - New Orleans, LA, USA Reprinted in the IVIS website with the permission of the

More information

Structures of the Excretory System include: ü Skin ü Lung ü Liver ü Kidneys ü Ureter ü Urinary Bladder ü Urethra

Structures of the Excretory System include: ü Skin ü Lung ü Liver ü Kidneys ü Ureter ü Urinary Bladder ü Urethra Excretory System Structures of the Excretory System include: ü Skin ü Lung ü Liver ü Kidneys ü Ureter ü Urinary Bladder ü Urethra Function of the Excretory System The function of the excretory system is

More information

Physiology of the body fluids, Homeostasis

Physiology of the body fluids, Homeostasis Physiology of the body fluids, Homeostasis Tamas Banyasz The Body as an open system 1. Open system: The body exchanges material and energy with its environment 2. Homeostasis: The process through which

More information

Extracellular fluid (ECF) compartment volume control

Extracellular fluid (ECF) compartment volume control Water Balance Made Easier Joon K. Choi, DO. Extracellular fluid (ECF) compartment volume control Humans regulate ECF volume mainly by regulating body sodium content. Several major systems work together

More information

HYPONATRAEMIA: NUH GUIDELINE FOR INITIAL ASSESSMENT AND MANAGEMENT.

HYPONATRAEMIA: NUH GUIDELINE FOR INITIAL ASSESSMENT AND MANAGEMENT. HYPONATRAEMIA: NUH GUIDELINE FOR INITIAL ASSESSMENT AND MANAGEMENT. HYPONATRAEMIA: SODIUM < 130 MMOL/L SIGNIFICANT. Symptoms/signs usually only occur when sodium < 125 mmol/l. Acute hyponatraemia is less

More information

HORMONES OF THE POSTERIOR PITUITARY

HORMONES OF THE POSTERIOR PITUITARY HORMONES OF THE POSTERIOR PITUITARY HORMONES OF THE POSTERIOR PITUITARY In contrast to the hormones of the anterior lobe of the pituitary, those of the posterior lobe, vasopressin and oxytocin, are not

More information

Treating the syndrome of inappropriate ADH secretion with isotonic saline

Treating the syndrome of inappropriate ADH secretion with isotonic saline Q J Med 1998; 91:749 753 Treating the syndrome of inappropriate ADH secretion with isotonic saline W. MUSCH and G. DECAUX1 From the Department of Internal Medicine, Bracops Hospital, Brussels, and 1Department

More information

Faculty version with model answers

Faculty version with model answers Faculty version with model answers Urinary Dilution & Concentration Bruce M. Koeppen, M.D., Ph.D. University of Connecticut Health Center 1. Increased urine output (polyuria) can result in a number of

More information

URINE CONCENTRATION AND REGULATION OF ECF OSMOLARITY

URINE CONCENTRATION AND REGULATION OF ECF OSMOLARITY URINE CONCENTRATION AND REGULATION OF ECF OSMOLARITY Dilute and concentrated urine 1-Dilute urine : Nephron function continuous reabsorption. Solutes while failing to reabsorbe water in distal tubule and

More information

Endocrine System. Chemical Control

Endocrine System. Chemical Control Endocrine System Chemical Control Endocrine System - the system that secretes hormones in the body - hormones can last for minutes or for hours - a major gland, once called the master gland, is the pituitary

More information

Water, Electrolytes, and Acid-Base Balance

Water, Electrolytes, and Acid-Base Balance Chapter 27 Water, Electrolytes, and Acid-Base Balance 1 Body Fluids Intracellular fluid compartment All fluids inside cells of body About 40% of total body weight Extracellular fluid compartment All fluids

More information

NOTES: CH 44 Regulating the Internal Environment (Homeostasis & The Urinary System)

NOTES: CH 44 Regulating the Internal Environment (Homeostasis & The Urinary System) NOTES: CH 44 Regulating the Internal Environment (Homeostasis & The Urinary System) HOMEOSTASIS **Recall HOMEOSTASIS is the steady-state physiological condition of the body. It includes: 1) Thermoregulation:

More information

9.2 Hormonal Regulation of Growth

9.2 Hormonal Regulation of Growth 9.2 Hormonal Regulation of Growth Hormonal Regulation of Growth Pituitary gland regulates growth and development Thyroid gland regulates metabolic rate (exception: some hormones for growth and development)

More information

Urinary System and Excretion. Bio105 Lecture 20 Chapter 16

Urinary System and Excretion. Bio105 Lecture 20 Chapter 16 Urinary System and Excretion Bio105 Lecture 20 Chapter 16 1 Outline Urinary System I. Function II. Organs of the urinary system A. Kidneys 1. Function 2. Structure III. Disorders of the urinary system

More information

Neuroendocrine challenges following hemispherectomy

Neuroendocrine challenges following hemispherectomy Neuroendocrine challenges following hemispherectomy Philip S. Zeitler MD. PhD Professor and Head Section of Endocrinology Children s Hospital Colorado University of Colorado Anschutz Medical Campus I am

More information