University: Alexandria Faculty : Medicine Program Specifications (Academic year: 2015\2016 )

Transcription

1 الهيئة القومية لضمان جودة التعليم واالعتماد University: Alexandria Faculty : Medicine Program Specifications (Academic year: 2015\2016 )

2 الهيئة القومية لضمان جودة التعليم واالعتماد A. Basic Information: 1. Program title: : Master Degree in Hematology 2. Department offering the program; Internal medicine ( Clinical Hematology Unit) 3. Program Coordinator: Prof. Dr. Nahla A. Hamed. 4. External evaluator(s): Prof Dr Sameh Shamaa 5. Type of the program: Single 6. Date of most recent program specifications approval: October B. Professional Information: 1- Program Aims: This program is designed to provide candidates with the basic knowledge and skills that allow them to: 1.1. Diagnose and manage successfully common diseases of blood and bone marrow Identify hematological manifestations of medical diseases and solid tumors Deal with emergency situation in hematology Perform the main procedures required in hematology Acquire the skills needed in carrying out research. 2- Acdemic reference standards (ARS)& ILOs: Academic reference standards of Master Degree in Hematology designed and approved by Department of Internal Medicine (Hematology Unit) Faculty of Medicine. Alexandria University. Based on: Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt (2009). Published by National Authority for Quality Assurance and Accreditation of Education (NAQAAE) National [ Adapted from; Specialty Training Curriculum for Hematology by Joint Royal Colleges of Physicians Training Board ( Domain A. Knowledge and understanding Academic Reference Standards (ARS) Graduate of this program must: Demonstrate the basic knowledge of established and evolving data about types, diagnosis, management of anaemia, coagulation abnormalities. ILOs a1 Describe the indications and technique of performing bone marrow aspirate and trephine biopsy. a2 Identify the underlying causes of anemia. a3 Describe steps and regulation of hematopoiesis. a4 Discuss presentation, complications, diagnosis and management of different types of

3 الهيئة القومية لضمان جودة التعليم واالعتماد Understand the classification, course and management of haematological malignancies Demonstrate basic knowledge concerning dealing with special situation such as pregnancy, solid tumors amd systemic diseaseas anemia a5 Outline the molecular basis of abnormal hemoglobins and thalassemia syndromes and explain the laboratory methods used in their screening and diagnosis. a6 Describe pathology, diagnosis and management of inherited and acquired bone marrow failure. a7 Describe presentation, diagnosis, classification and management of acute and chronic leukemias in adults. a8 Describe the classification, natural history, molecular biology, presentation, staging and therapeutic modalities of hematological malignancies. a9 Outline the most recent histological classification of lymphomas approved by the WHO. a10 Describe normal hemostasis and fibrinolysis. a11 Outline the natural history, presentation and complications of congenital coagulation and platelet disorders, the diagnostic methods used in their assessment and their management a12 Describe the pharmaceuticals and blood products available for the management of excessive bleeding, their indications and side-effects. a13 Describe the etiology, natural history and classification of pancytopenia a14 Explain the use of blood product support, the principles of clinical blood transfusion and define the complications of long term transfusion. a15 Describe the

4 الهيئة القومية لضمان جودة التعليم واالعتماد B. Intellectual skills Demonstrate basic data in therapy especially chemotherapy and bone marrow transplantation Interpret and correlate clinical data to make diagnostic and therapeutic decisions based on best evidence Interact with patients in a respected and sympathetic manner. Cooperate appropriately with pathophysiology and classification of myeloproliferative disorders, the required diagnostic methods and the therapeutic options. a16 Outline the impact of systemic disease on the blood and bone marrow. a17 Identify the role of the hematologist in management of haemostatic problems in pregnancy a18 Identify hematological manifestations of solid tumors a19 Outline indications and complications of bone marrow transplantation a20 Define the principles of chemotherapy regimens: mode of action, side effects and interactions of agents used in the management of hematological malignancies. b1 Perform collection of entry and follow up data. b2 Conduct history and examination competently. b3 Interpret laboratory testing results and advise on the initial management of common hematological disorders. b4 Apply knowledge of lymphoma classification to the patient management. b5 Correlate the examination, differential diagnosis and investigations to establish the diagnosis and appropriate treatment planning. b6 Explain planned treatment clearly to the patient b7 Contribute to work of multidisciplinary team for managing complication through

5 الهيئة القومية لضمان جودة التعليم واالعتماد members of medical staff. an appropriate writing of letter of referral b8 Apply evidence based medicine from updated reference. C. Professional skills provide patient care in a compassionate, appropriate, and effective manner for the treatment of health problems and the promotion of health Apply specific maneuvers required by haematologist Perform laboratory tests and interpret reports. c1 Analyze and interpret blood films and bone marrow smears c2 Interpret presenting features and conduct history and examination competently c3 Select and evaluate appropriate laboratory investigations to establish diagnosis. c4 Interpret and apply laboratory results to patient management. c5 Formulate an appropriate management plan and offer full explanation to patients. c6 Prescribe combination chemotherapy regimens appropriately. c7 Practice appropriate use of antibiotic regimens for treatment and prophylaxis in the immunosuppressed patient. c8 Manage complications of blood transfusion appropriately c9 Interpret and evaluate monitoring of anticoagulation and advises appropriately c10 Assess suitability for stem cell transplantation c11 -Diagnose & provide initial management of hematological emergencies. c12 Practice appropriate use of Central lines. c13 Perform lumbar puncture competently and obtains CSF sample for analysis c14 Administer intrathecal chemotherapy under guide c15 Perform and interpret blood film, marrow aspirate and trephine biopsy under

6 الهيئة القومية لضمان جودة التعليم واالعتماد D. General and transferrable skills E. Attitudes and ethical behavior Graduate should: Perfect communication skills with patients. Co-operate with colleagues and seniors. Integrate information from different sources. Appreciate ethical, religious and law regulations during his practice. supervision. d1- Offer full explanation of the side effects of chemotherapy to patients. d2-communicate effectively with blood donors d3- Manage effectively the use of transplantation and its limitations to patient and family. d4-communicate effectively with colleagues in other specialties for proper diagnosis and treatment of the patients. d5-perform leadership responsibilities in his work d6- Refer the patient to seniors whenever indicated. d7- Write appropriate reports. d8-recognize the value of continuous self lifelong learning d9-upgrade his scientific information utilizing all available printed and electronic sources. e1 Treat patients with respect. e2 Demonstrate ethical communication of informed consent after full discussion with the patient and relative. e3 Consult to obtain appropriate action. e4 - Communicate effectively with terminal patients and their relatives. e5 Recognize the importance of supportive care for successive patient outcome. e6 Consult with other relevant specialist appropriately. e7 Recognize the importance of good communication in hematology practice. e8 Contribute in multidisciplinary team working. e9 Demonstrate ability to conduct

7 الهيئة القومية لضمان جودة التعليم واالعتماد Program courses ILOs Matrix sympathetically bad news including terminal progress. ILOs Course title A 1 A 2 A 3 A 4 A 5 A 6 A 7 A 8 Medical Biochemistry x Medical Physiology x x x x x Pharmacology x x x x Microbiology and X x Immunology General Pathology x x Clinical Pathology x x X x x Internal Medicine for hematology l Internal Medicine for hematology ll Hemopoiesis Iron metabolism. And anemia, x x x x x x Acute leukemias X x Chronic leukemias x Stem cell disorders x Lymphomas I x, myeloma I x Hemostasis x Blood transfusion x X Hematological manifestations of medical diseases integrated hematology I A 9 A 1 0 A 1 1 A 1 2 A 1 3 A 1 4 A 1 5 A 1 6 x x A 1 7 A 1 8 x x x A 1 9 A 2 0

8 الهيئة القومية لضمان جودة التعليم واالعتماد ILOs Course title Medical Biochemistry Medical Physiology B 1 B 2 Pharmacology x x Microbiology and Immunology General Pathology x x x B 3 x B 4 B 5 B 6 B 7 B 8 Clinical Pathology x x x x Internal Medicine for hematology l x x x Internal Medicine for hematology ll x x x Hemopoiesis Iron metabolism. And anemia, x x x x x Acute leukemias x x x x x x x x x x x x x x x Chronic leukemias x x x x x x x x Stem cell disorders x x x x x x Lymphomas, x x x x x x Myeloma x x x x x x Hemostasis x x x x x x x Blood transfusion Hematological manifestations of medical diseases integrated hematology I C 1 C 2 C 3 C 4 C 5 C 6 C 7 C 8 x C 9 C 1 0 C 1 1 C13 C 1 2 C 1 3 C 1 4 C 1 5 ILOs Course title Medical Biochemistry Medical Physiology Pharmacology Microbiology Immunology and d1 d2 d3 d4 d5 d6 d7 d8 d9 e1 e2 e3 e4 e5 e6 e7 e8 e9 General Pathology x x Clinical Pathology Internal Medicine for hematology l Internal Medicine for hematology ll Hemopoiesis Iron metabolism. And anemia, x Acute leukemias x x x x x x Chronic leukemias x Stem cell disorders x x Lymphomas, x x myeloma x x Hemostasis x x Blood transfusion x Hematological manifestations of medical diseases integrated hematology I x x x x

9 الهيئة القومية لضمان جودة التعليم واالعتماد 3- Curriculum Structure: -Program duration: This program is fulfilled in not less than 2 years with a maximum of 5 years (4 semesters & thesis). -Program structure: 1. Total hours: 40 Credit hours. 2. basics of Research: 3 credit Hours 3. Obligatory subjects: 29 Credit Hours. 4. Thesis :8 Credit Hours Elective Subjects: one Credit Hour Each. -Program Content: A. Obligatory Courses: Code Course Credit Hours Contact hours Lectures Practical Others Basic of research Medical Biochemistry for 1 14 Haematology MedicalPhysiology for Haematology Clinical Pharmacology for 1 14 Haematology MedicalMicrobiology for 1 14 Haematology Pathology for Haematology Internal Medicine for Haematology I Internal Medicine for Haematology II Clinical and chemical Pathology for Haematology I Haemopoiesis I Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis, Megaloblastic Anaemia, Haemolytic Anaemias, Aplastic Anaemia Acute Leukaemias I Chronic Leukaemias I Stem Cell Disorders I Lymphomas I Myeloma I Haemostasis I Blood Transfusion I Hematological Manifestations of 2 28 Medical Diseases Integrated hematology I 3 42 Prerequisite

10 الهيئة القومية لضمان جودة التعليم واالعتماد B. Elective Courses: Course Code Course Title No of Hours/Week Contact hours Biostatistics and 1 Computer General Psychiatry Imaging for 1 haematology Molecular Biology 1 - Others According to the Field of the Thesis 1 Lectures Practical Others 4- Program Admission Requirements: According to the regulations of the credit hour bylaws of the Faculty of Medicine Alexandria University (annex). 5- Regulations for Progression and Program Completion: According to the regulations of the credit hour bylaws of the Faculty of Medicine Alexandria University (annex). 6- Methods of student assessment: Methods 1. Written Exam a1-a20,c6,c7 2. Practical Exam b1-8, c1-15, e1-9 Intended Learning outcomes to be assessed 3. Assignments d1-9 4.Thesis b1,2-c2,3-d4,5,8,9-e2,3,7,8 7- Methods of program evaluation: Evaluator Tool Sample 1. Students enrolled in the program Questionnaires. 2. Alumni Stakeholders (Employers) Focus group 4. External Evaluator (s) yes 5. Others: Program Director: Prof. Dr. Hassan Nafea Program Coordinator: Prof Dr. Nahla A Hamed

11 الهيئة القومية لضمان جودة التعليم واالعتماد COURSE DESCRIPTION 1 Code Credit hours (2) Course Prerequisites Medical Biochemistry - This course is given in 1 credit hour lectures including: introduction to carbohydrate structure, digestion and absorption of carbohydrates, glycolysis, fates of pyruvate, hexose monophosphate shunt, glycogen metabolism, uronic acid pathway, metabolism of galactose and fructose, regulation of carbohydrate metabolism, introduction for lipid structures, digestion and absorption of lipids, oxidation of fatty acids, ketone body metabolism, cholesterol metabolism, fatty acid synthesis, metabolism of acyl glycerols, phospholipids and glycolipid synthesis, regulation of lipid metabolism, introduction for protein structure, digestion and absorption of proteins, removal of amino acid ammonia and catabolism of amino acids. 2 Code Credit hours (2) Course Prerequisites Physiology In this course the student is studying essential information on the functions of different body organs and their abnormalities. 3 Code Credit hours (2) Course Prerequisites Pharmacology for Haematology General Pharmacology; Drug sources and formulations, routes of drug administration, pharmacodynamic concepts, ligands, agonists, antagonist, reverse agonists, dose-responses, affinity, efficacy, potency,.. etc. Kinetic of drug/channel/receptor/enzyme interaction, molecular concepts, on channels: G proteins coupled receptors: PKs: receptor TK, Ras-MAP Kinase/JAK-STAT pathways, on non-receptor TK, serine, threonine kinases, on cytosolic & nuclear receptors, on cell cycle machinery, on apoptotic machinery, Pharmacokinetic concepts, absorption, 1st pass metabolism, protein binding, distribution kinetics (AUC, zero order, 1st order kinetics), metablosim and biotransformation, elimination, cmax, t1/2, steady state, peak/trough ration, factors modifying drug response, tolerance, idiosyncrasy, dependence, adverse drug reactions, drug interactions. Drug Toxicology; Drug safely, drug hazards, narrow therapeutic index, drug monitoring, mechanisms of drug toxicity, toxic drug categories, drugs and organ toxicity, rational treatment of drug toxicity, antidotes. Autonomic Pharmacology; Adrenoceptor agonists, adrenoceptor antagonist, adrenolytis, cholinomimetics, cholinolytics, NANC. Paracrine Autocrine and Immunopharmacology of; Monoamines, Purines, NO, Peptides, Eicosanoides, Cytokine, Chemokines, adhesion molecules, immunoglobulin and other immunotherapeutic trends. 4 Code Credit hours (2) Course Prerequisites General Microbiology

12 الهيئة القومية لضمان جودة التعليم واالعتماد This course includes 15 theoretical Credit hours (1) (2 credit hours). The Credit hours (1) cover the following topics: Bacterial growth; focal metabolites and their interconversions; cell structure and endospores; protein synthesis; synthesis of cell wall peptidoglycan and lipopolysaccharides; enzyme synthesis and regulation; oncogenes and tumor suppressor genes; gene therapy and apoptosis. 5 Code Credit hours (2) Course Prerequisites General Pathology for Other Departments Cell injury, acute and chronic inflammation, tissue repair, hemodynamic disorders, disorders of the immune system, neoplasia, genetic diseases, environmental diseases, general pathology of infectious diseases, granulomatous diseases. 6 Code Credit hours (6) Course Prerequisites Internal Medicine for - haematology Chest diseases -renal diseases - heptobiliary diseases - endocrinology diseases - CNS diseases - Diabetes and metabolic diseases - Muscloskeletal diseases - CVS diseases - GIT diseases. 7 Code Credit hours (2) Course Prerequisites Laboratory Clinical - Pathology Include all clinical pathological test involved in hematology. 8 Code Credit hours (12) Course Prerequisites Hematology Principles - Haempoiesis -The red cell -Basic aspects of anaemia - Iron metabolism and hypochromic anaemias - Aplastic anaemia and bone marrow failure -Haemolytic anaemias - Polycythaemias - Quantitative disorders of leucocytes - Acute lymphoblastic leukaemia - Acute myeloid leukaemia -Chronic lymphocytic leukaemia - Chronic granulocytic leukaemia -Myeloproliferative Diseases - Multiple Myeloma - Malignant lymphomas -Haemostasis and abnormal bleeding. Clinical examinations.

13 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Program in which the Course is Given Master Degree in Hematology Course Name: Hematological Manifestations of Medical Diseases Number of Credit Hours 1 Theoretical 1 Clinical/Practical Course Aims to provide candidates with the basic data and skills that allow them to diagnose Hematological Manifestations of Medical Diseases Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a16 Outline the impact of systemic disease on the blood and bone marrow. a17 Identify the role of the hematologist in management of haemostatic problems in pregnancy Course ILOs a1 Identify basic facts in the Hematological Manifestations accompanying liver, renal, endocrine and connective tissue diseases a2 Describe treatment aspects of anaemia of chronic disease a3 Identify the effect of pregnancy on peripheral blood and bone marrow a4 Describe mode of treatment of haematological abnormalities accompanying pregnancy B. Intellectual skills a18 Identify haematological manifestations of solid tumors a5 -Identify haemostatic changes accompanying solid tumor a6 Describe causes and manifestations of anaemia associating with solid tumors

14 C.Professional and Practical Skills D. General Skills Course Content(Units/Topics) Hematological Manifestations of Connective tissue disorders Hematological Manifestations of liver disease Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Hematological Manifestations of renal disease Hematological Manifestations of endocrine disease Hematological Manifestations of pregnancy Hematological Manifestations of cancer Please check () the appropriate method.

15 Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 100 % Practical/Clinical Exam % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Nahla AM Hamed Signature: Program Coordinator Name: Nahla AM Hamed Signature: Program Director (Head of Department) Name: Tarek Thabet Signature:

16 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: Laboratory Clinical Pathology Program in which the Course is Given: Master Degree in Hematology Number of Credit Hours 2 Theoretical 1 Clinical/Practical 1 Course Aims By the end of this course the students should be able to relevantly order hematological investigations, understand sampling conditions and precautions, to be able to interpret properly the results of different investigations and correlate these results with the clinical condition of the patients to reach a proper diagnosis. Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a1 a1 Describe the indications and technique of performing bone marrow aspirate and trephine biopsy. Course ILOs a1 identify different indications and methods of performing bone marrow aspirate. a2 identify different indications and methods of performing trephine biopsy. a4 Discuss presentation, complications, diagnosis and management of different types of anemia a3 Discuss investigations necessary for diagnosing haemolytic anaemia a4 Discuss required investigations required for differentiating different types of anemia a7 Describe presentation, diagnosis, classification and management of acute and chronic leukaemias in adults. a3 Describe the required diagnostic methods of adults acute leukaemias a4.discuss diagnostic approach to chronic leukaemia a11 Outline the natural history, presentation and complications of congenital coagulation and platelet disorders, the diagnostic methods used in their assessment and their management a5 describe the diagnostic methods for coagulation and platelet disorders, a6 Describe methods of assessment of anticoagulant therapy a15 Describe the pathophysiology a7 Describe the required diagnostic methods

17 and classification of myeloproliferative disorders, the required diagnostic methods and the therapeutic options. for myeloproliferative disorders a8 Describe the investigations required for myelodysplatic syndrome B. Intellectual skills b3 Interpret laboratory testing results and advise on the initial management of common haematological disorders. b1 Interpret laboratory testing results of anaemia and bleeding disorder b2 Interpret laboratory testing results of malignant blood disorders C.Professional and Practical Skills D. General Skills c1 Analyze and interpret blood films and bone marrow smears c3 Select and evaluate appropriate laboratory investigations to establish diagnosis. C15 Perform and interpret blood film, marrow aspirate and trephine biopsy under supervision. c1 interpret blood films c2 Interpret bone marrow aspirate c3 Select laboratory investigations for appropriate diagnosis of benign blood diseases c4 Select laboratory investigations for proper diagnosis of malignant blood diseases C5-Perform blood picture under guide C6-perform bone marrow aspirate and trephine biopsy under guide. Course Content (Units/Topics) Sampling in hematology Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others How to approach a case of anemia Investigations of Aplastic anemia Investigations of Hemolytic anemia Investigations of Iron deficiency and megaloblastic anemia

18 Classification and diagnosis of Acute leukemia Chronic lymphoproliferative disorders I Chronic lymphoproliferative disorders II Principles of flow cytometry and immunophenotyping I Principles of flow cytometry and immunophenotyping II Classification and diagnosis of Myelodysplastic syndromes Chronic myeloproliferative disorders Plasma cell disorders How to approach a case of bleeding disorder How to approach a case of hypercoagulable state Complete blood picture (normal pattern, anemias and malignancies) Bone marrow aspirate and trephine biopsy Investigations of hemolytic anemias ( Coomb s test, osmotic fragility and ham s test) Electrophoresis Investigations of bleeding disorders: PT,PTT, FDP s, Factor assay Cytochemistry and Iron stain Serology and blood transfusion Please check () the appropriate method.

19 Student Assessment Methods of Assessment Essay Objective questions Case Assignment Others Schedule of Assessment Mid-term % OSCE/OSPE Logbook fulfillment End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Dacie and Lewis Practical Haematology Suggested Extra Reading Journals and Periodicals, others Course Instructor Name: Prof. Nahla Farahat Signature: Program Coordinator Name: Prof. Nahla A.M. Hamed Signature: Program Director (Head of Department) Name: Prof. Tarek Thabet Signature:

20 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: Haemostasis Program in which the Course is Given Master Degree in Hematology Number of Credit Hours 1 Theoretical 1/2 Clinical/Practical 1/2 Course Aims to provide candidates with the basic facts and skills that allow them to diagnose and manage successfully haemostatic disorders Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a11 Outline the natural history, presentation and complications of congenital coagulation and platelet disorders, the diagnostic methods used in their assessment and their management Course ILOs a1 Identify basic facts in the diagnosis and management of haemostatic disorders a2 Outline basic data regarding the drugs used in treatment of haemostatic disorders a3 Outline the complications of haemophilias B. Intellectual skills b1 Perform collection of entry and follow up data. b2 Conduct history and examination competently. b3 Interpret laboratory testing results and advise on the initial management of common haematological disorders. b1 Collects data of patients on admission b2 Collect follow up data. b3 perform efficient history taking b4 Conduct full clinical examination. b3 Analyze & evaluate laboratory information to establish diagnosis and appropriate treatment planning of haemostatic disorders. b4 solve problems related to haemostatic disorders according to the available data C.Professional and Practical c2 Interpret presenting features and conduct history and C1- conduct full history taking C2- perform clinical examination competently

21 Skills D. General Skills examination competently c3 Select and evaluate appropriate laboratory investigations to establish diagnosis. c4 Interpret and apply laboratory results to patient management. c9 Interpret and evaluate monitoring of anticoagulation and advises appropriately d4- Communicate effectively with colleagues in other specialties for proper diagnosis and treatment of the patients. d6- Refer the patient to seniors whenever indicated. c3 Select the investigations appropriate for diagnosis in a systematic manner. c4 Interpret laboratory results appropriately c5 interrelate results of laboratory investigations to patient treatment. c6 Select appropriate investigations for follow up patients C7-Evaluate methods and tools used in management of haemostatic disorders c8-evaluate anticoagulant monitoring d1- Communicate with colleagues in other specialties for data interpretation d2- know appropriate time for referral d3- consult seniors in difficult cases. d4-get benefit from senior opinion Course Content(Units/Topics) Normal haemostasis: Blood vessels. Platelets. Coagulation factors. Naturally occurring inhibitors. Fibrinolysis. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease. Congenital platelet disorders Acquired coagulation, platelet & vascular bleeding: Disseminated intravascular coagulation.

22 Coagulopathy & massive blood loss. Vitamin K deficiency. Idiopathic thrombocytophric purpura. vascularpurpuras. Inherited thrombophilia. Acquired venous thrombosis. TTP. Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Mohamed El-Dafrawy Signature:

23 Program Coordinator Name: Nahla AM Hamed Signature: Program Director (Head of Department) Name: Tarek Thabet Signature:

24 University: Alexandria Faculty: Medicine Course Specifications Department: Course Information Course Code: Course Name: integrated hematology Program in which the Course is Given: master program of hematology Number of Credit Hours 3 Theoretical Clinical/Practical Course Aims to provide candidates with the skills that allow them to Diagnose and manage successfully common diseases of blood and bone marrow Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) B. Intellectual skills Interpret and correlate clinical data to make diagnostic and therapeutic decisions based on best evidence Interact with patients in a respected and sympathetic manner. Cooperate appropriately with members of medical staff. Course ILOs b3 Perform collection of entry and follow up data. b4 Conduct history and examination competently. b5 Interpret laboratory-testing results and advise on the initial management of common hematological disorders. b7 Correlate the examination, differential diagnosis and investigations to establish the diagnosis and appropriate treatment planning. b8 Explain planned treatment clearly to the patient b9 Contribute to work of multidisciplinary team for managing complication through an appropriate writing of letter of referral b10apply evidence-based medicine from updated reference.

25 C.Professional and Practical Skills D. General Skills Apply specific maneuvers required by haematologist Perform laboratory tests and interpret reports. Graduate should: Perfect communication skills with patients. Integrate information from different sources. c1 Analyze and interpret blood films and bone marrow smears c2 Interpret presenting features and conduct history and examination competently c3 Select and evaluate appropriate laboratory investigations to establish diagnosis. c4 Interpret and apply laboratory results to patient management. c5 Formulate an appropriate management plan and offer full explanation to patients. c6 Prescribe combination chemotherapy regimens appropriately. c10 Assess suitability for stem cell transplantation d4-communicate effectively with colleagues in other specialties for proper diagnosis and treatment of the patients. d5-perform leadership responsibilities in his work d6- Refer the patient to seniors whenever indicated. d7- Write appropriate reports. d8-recognize the value of continuous self lifelong learning d9-upgrade his scientific information utilizing all available printed and electronic sources. Course Content (Units/Topics) Teaching/Learning Methods Lectures self learning Practical/ Clinical Case presentation Small group discussion Others Please check () the appropriate method.

26 Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 100 % Practical/Clinical Exam % Others % Perquisites : List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Postgraduate haematology William haematology Blood haematological Course Instructor Name: Prof. Dr Manal sorady Prof.Dr ashraf alghandour Signature: Program Coordinator Name: Prof.Dr. Nahla A. Hamed Signature: Program Director (Head of Department) Name: Prof. Dr. Hassan Nafea Signature:

27 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: General Pathology Program in which the Course is Given Master Degree in Hematology Number of Credit Hours 1 Theoretical Clinical/Practical Course Aims 1. Study the basics of general pathology that allow understanding the different pathologic changes in the diseases that will be studied in the course. 2. Understanding the pathology of different lesions affecting the lymphoid system including: etiology, pathogenesis, morphology, complications, clinical picture and prognosis. 3. Acquiring skills needed to interpret pathologic findings in correlation with the clinical findings. Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a8 Describe the classification, natural history, molecular biology, presentation, staging and therapeutic modalities of hematological malignancies. Course ILOs a1summarize the relevant anatomy and functional histology of the lymphoid system a2. Illustrate the ontogeny of the lymphoid system a3. Describe the changes that occur in a lymph node upon antigenic stimulation a4. Recognize the normal immunohistochemical profile of different lymphoid cells a5. Identify the information that should be included in the request for a lymph node biopsy a6. Recognize prerequisits for a proper diagnosis of a case of lymphoid disorder

28 a7. Explain the importance of proper grossing of lymph node biopsy a8. Identify the role of immunohistochemistry in the diagnosis of lymphoid disorders a9. Explain the principles of immunophenotyping in detecting molecules on the surface of different types of lymphoid cells through antibodies that are given cluster designation or CD numbers a10. Identify the three methods of immunophenotyping : Immunohistochemistry, immunofluorescence and flow cytometry a11. Appreciate common applications for cytogenetics in NHL a12. Identify the role of lymph node aspiration in diagnosis of lymphoid disorder a13. List the causes of leukocytosis with examples a14. Distinguish reactive from neoplastic leukocytosis a15. Relate these changes to various etiologic factors a16. Mention the causes of enlargement of lymph nodes a17. Classify inflammatory disorders of lymphoid tissue and discuss key points about the different types of inflammatory lymphadenitis a18. Classify granulomas. affecting lymph nodes a19. Describe the microscopic patterns of reactive lymphadenopathy and relate them to the etiology a20. Mention the different classification schemes of lymphoma a9 Outline the most recent histological classification of lymphomas approved by the WHO. a21. Explain the most recent classification of lymphoma a22. Identify different types of lymphoma

29 B. Intellectual skills C.Professional b5. Correlate the examination, differential diagnosis and investigations to establish the diagnosis and appropriate treatment planning. C3 Select and evaluate appropriate a23. Determine the lymphoma category to which it belongs a24. Determine and categorize indolent and aggressive lymphomas a25. Distinguish between NHL and HL a26. Distinguish between non- Hodgkin s lymphoma (NHL) and Hodgkin's lymphoma (HL) a27. Describe the morphological features of NHL and HL a28. State the staging system of NHL and HL a29. Mention the causes of enlargement of the spleen a30. Discuss the pathology of histiocytosis X a31. Classify anemia a32. Summarize the pathologic features of anemia a33. Classify leukemia a34. Summarize the principle pathologic features of leukemia a35. Outline a proper workup of a case of lymphoid disorder A. Clinical Picture B. Laboratory Investigations C. Radiodiagnosis D. Tissue Biopsy : morphologic approach, immunophenotyping E. Cytogenetics F. Molecular diagnostic G. Bone marrow biopsy b1-recognize the most important causes of lymph node enlargement b2.evaluate the malignancy of a lymphoid proliferation b3.recognize the most common types of lymphomas in Egypt b4. Select the proper situation to recommend a lymph node biopsy b5. Formulate a logarithm for diagnosis of a case b6. Critically appraise the different classification schemes of lymphoma

30 and Practical Skills D. General Skills laboratory investigations to establish diagnosis. C4 Interpret and apply laboratory results to patient management. d7 Write appropriate reports. d8-recognize the value of continuous self lifelong learning C1.Properly deal with a lymph node biopsy and spleen c2. Apply proper grossing techniques of the lymph node and spleen. C3. Properly Interpret a lymph node biopsy c4. Use the proper tools for proper diagnosis of a lymphoid disorder c5. Select the proper panel of immunohistochemistry for diagnosing a specific condition. c6. Practice proper interpretation of immunohistochemical staining patterns of the different cases. c7. Properly utilize the WHO classification of malignant lymphomas d1. Actively participate and interact in group discussions d2. Develop self-directed learning abilities. d3. Develop presentation skills d4. Communicate effectively with his/her colleagues and teaching staff. d5. Cooperate with colleagues to effectively accomplish group work activities. d6. Develop decision making, and problem solving skills (analyzing, evaluating evidence, logical reasoning and synthesizing). d7. Practice self and peer-to-peer appraisal and evaluation. d8. Able to manage time effectively on personal and team basis.

31 Course Content (Units/Topics) Histology of the lymphoid system Development and ontogeny of the lymphoid tissue Define leukocytosis Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion assignments Causes of leukocytosis with examples Causes of enlargement of lymph nodes Causes of acute and chronic lymphadenitis Gross and microscopic morphology of acute and chronic lymphadenitis Classification systems of lymphomas Small lymphocytic lymphoma Mantle cell lymphoma MALT lymphoma Large cell lymphoma Burkitt s lymphoma Lymphoblastic lymphoma Hodgkin's lymphoma T cell lymphoma Staging of lymphoma Causes of enlargement of spleen Pathogenesis of splenomegaly in different conditions. Histiocytosis X Classification of leukemia Classification of anemia Pathologic aspects of anemia

32 Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others quiz Drill Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam % Others oral % Assignment 30% List of Textbooks and References Lecture Notes Course Text Books Robbins and Cotran: Pathologic Basis of Disease Suggested Extra Reading Journals and Periodicals, others Course Instructor Name: Professor Nagwa Mashali Signature: Nagwa Mashali Program Coordinator Name: Prof. Nahla A.M. Hamed Signature: Program Director (Head of Department) Name: Prof. Tarek Thabet Signature:

33 Course Specifications University: Alexandria Faculty: Medicine Department: Course Information Course Code: Course Name lymphoma II Program in which the Course is Given: doctorate program in hematology Number of Credit Hours2 Theoretical 1 Clinical/Practical 1 Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and manage successfully Lymphomas Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a5 Identify recent advances in the classification, natural history, molecular biology, and therapeutic modalities of hematological malignancies. a6 Identify recent advances in the histological classification of lymphomas approved by the WHO. Course ILOs a3 update his knowledge in WHO classification of lymphoma a4 Identify recent advances in the drugs used in Lymphomas according to WHO classification B. Intellectual skills b1 Analyze, deduce, extrapolate & evaluate laboratory testing results for the initial management of common and unusual hematological disorders. b1 Analyze & evaluate available laboratory information to establish treatment plan of Lymphomas. b2 Analyze & deduce laboratory tests to establish treatment of uncommon types of Lymphomas. b2 Take decision in the diagnosis and appropriate treatment planning. b3 Take decisions in various situations in lymphoma professional b5 Apply evidence based medicine b5 Refer to evidence based medicine in

34 from updated printed and electronic reference. managing cases b6 Refer to updated reference in dealing with difficult cases. C.Professionaland Practical Skills C1-Plan professional courses of combination chemotherapy regimens D. General Skills d1- perform full explanation of the side effects of chemotherapy to patients. C1-Evaluate and improve methods and tools used in management of Lymphomas C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate treatment of Lymphomas d1-performleadership responsibilities in explaining complications of chemotherapy to patients d2- upgrade his scientific information utilizing all available printed and electronic sources to manage side effects of chemotherapy Course Content(Units/Topics) Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics& oncogenes. Clinical features. Investigations. Staging. Treatment. Specific types. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy.

35 Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof.Signature: Prof. Nabil El-Halawani Program Coordinator Name: Prof. Signature: Program Director (Head of Department) Name: Prof. Signature: Yehia Ghanem

36 Course Specifications University: Alexandria Faculty: Medicine Department: Course Information Course Code: Course Name:myeloma II Program in which the Course is Given: MD in hematology Number of Credit Hours 2 Theoretical 1 Clinical/Practical 1 Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and manage successfully Myeloma Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a1 Identify Recent advances in the field of molecular biology in myeloma a2 Identify recent advanes in diagnosis and management of Myeloma Course ILOs a5 Identify recent advances in the classification, natural history, molecular biology, and therapeutic modalities of hematological malignancies. B. Intellectual skills b1 Analyze & evaluate available laboratory information to establish treatment plan of Myeloma. b2 Analyze & deduce laboratory tests to establish treatment of uncommon types of Myeloma. b4 Solve professional problems related to Myeloma according to the available data b5 Refer to evidence based medicine in managing cases b6 Refer to updated reference in dealing with difficult cases. b1 Analyze, deduce, extrapolate & evaluate laboratory testing results for the initial management of common and unusual hematological disorders. b2 Take decision in the diagnosis and appropriate treatment planning. b5 Apply evidence based medicine from updated printed and electronic reference.

37 C.Professionaland Practical Skills C1-Evaluate and improve methods and tools used in management of Myeloma C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate treatment of Myeloma D. General Skills d1-perform leadership responsibilities in explaining complications of chemotherapy to patients d2- upgrade his scientific information utilizing all available printed and electronic sources to manage side effects of chemotherapy C1-Plan professional courses of combination chemotherapy regimens d1-perform full explanation of the effects of chemotherapy to patients. side Course Content(Units/Topics) Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal gammopathy of uncertain significance. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Special types of myeloma: Plasma cell leukemia. Non-secretory myeloma. Waldenstrommacroglobulinaemia. Heavy-chain diseases. Please check () the appropriate method.

38 Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 10 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof.Signature:Nahla AM Hamed Program Coordinator Name: Prof. Signature: Program Director (Head of Department) Name: Prof. Signature:YehiaGhanem

39 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: Stem Cell Disorders Program in which the Course is Given Master Degree in Hematology Number of Credit Hours 1 Theoretical 1/2 Clinical/Practical 1/2 Course Aims to provide candidates with the basic data and skills that allow them to diagnose and manage successfully stem cell disorders Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding B. Intellectual skills a15 Describe the pathophysiology and classification of myeloproliferative disorders, the required diagnostic methods and the therapeutic options. b1 Perform collection of entry and follow up data. Course ILOs a1 outline the classification of myeloproliferative disorder a2 describe basic facts in the field of diagnosis and management of stem cell disorders a3 describe fundamentals regarding the drugs used in treating stem cell disorders b1 Perform data collection b2 Perform collection of follow up data. b2 Conduct history and examination competently. b3 Perform history data and full examination of myelodysplastic syndrome. b4 Perform history data and full examination of myeloproliferative disorders. b3 Interpret laboratory testing results and advise on the initial management of common hematological disorders. b5 solve problems related to stem cell disorders according to the available data b6 Correlate the examination, differential diagnosis and investigations to establish the diagnosis and appropriate treatment planning. C.Professional c2 Interpret presenting features C1- Interpret presenting clinical features

40 and Practical Skills D. General Skills and conduct history and examination competently c3 Select and evaluate appropriate laboratory investigations to establish diagnosis. c4 Interpret and apply laboratory results to patient management. d1-offer full explanation of the side effects of chemotherapy to patients. d6- Refer the patient to seniors whenever indicated. C2 conduct history taking and clinical examination efficiently C3-Select the appropriate investigations to diagnose myelodysplastic syndrome. C4-Select the required investigations to diagnose myeloproliferative disorder. C3 apply laboratory results to patient management. C4-Evaluate methods used in management of stem cell disorders d1- discuss side effects of chemotherapy to patients. d2- deal with side effects of chemotherapy efficiently d3- Communicate effectively with colleagues in other specialties d4- refer cases to seniors in the appropriate time for proper diagnosis and treatment of the patients.. Course Content(Units/Topics) Myelodysplastic syndromes. Cytogenetics. Investigations. Classifcation. Pathogenesis. Prognosis. Management. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Myeloproliferative disorders: The polycythaemia. Polycythaemiarubravera. Essential thrombocythaemia. Idiopathic myelofibrosis. Please check () the appropriate method.

41 Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood Haematologica Course Instructor Name: Prof. Nahla AM Hamed Signature: Program Coordinator Name: Prof. Nahla AM Hamed Signature:

42 Program Director (Head of Department) Name: Prof. Tarek Thabet Signature:

43 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: Internal Medicine for Haematology ll Program in which the Course is Given Master Degree in Hematology Number of Credit Hours 4 Theoretical 2 Clinical/Practical 2 Course Aims To provide the students with data concerning clinical presentation and diagnosis of systemic diseases characterized by haematological manifestations, Outline the impact of systemic disease on the blood and bone marrow. in addition to study the effect of chemotherapy on different organs as well systemic paraneoplastic manifestations Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a16 Outline the impact of systemic disease on the blood and bone marrow. Course ILOs a1 Outline the effect of kidney on blood a2 Outline the paraneoplastic manifestations a3 Describe haematological changes in the elderly a4 Outline enteral and parenteral nutrition B. Intellectual skills b7 Contribute to work of multidisciplinary team for managing complication through an appropriate writing of letter of referral b1 Contribute multidisciplinary team work for early referral, diagnosing and treating complications in other systems b2 Write an appropriate letter of referral C.Professional and Practical Skills c2 Interpret presenting features and conduct history and examination competently c1 Interpret clinical data appropriately c2 Conduct history taking and clinical examination in the appropriate way