University: Alexandria Faculty : Medicine Program Specifications (Academic year: 2015)

Transcription

1 الهيئة القومية لضمان جودة التعليم واالعتماد University: Alexandria Faculty : Medicine Program Specifications (Academic year: 2015)

2 الهيئة القومية لضمان جودة التعليم واالعتماد A. Basic Information: 1. Program title: : Doctor Degree in Hematology 2. Department offering the program; Internal medicine ( Clinical Hematology Unit) 3. Program Coordinator: Prof. Dr. Nahla A. Hamed. 4. External evaluator(s): Prof Dr Sameh Shamaa 5. Type of the program: Single 6. Date of most recent program specifications approval: October 2015 B. Professional Information: 1- Program Aims: This program is designed to provide candidates with the updated knowledge and skills that allow them to: 1.1. Deal successfully with common and difficult cases with diseases of blood and bone marrow Interpret hematological manifestations of medical diseases and solid tumors Take decisions with emergency situation in hematology Apply evidence based medicine from updated reference. 1.5 Perform continuous self life-long learning 2- Acdemic reference standards (ARS)& ILOs: Academic reference standards of Doctor Degree in Hematology designed and approved by Department of Internal Medicine (Hematology Unit) Faculty of Medicine. Alexandria University. Based on: Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt (2009). Published by National Authority for Quality Assurance and Accreditation of Education (NAQAAE) National [ Adapted from; Specialty Training Curriculum for Hematology by Joint Royal Colleges of Physicians Training Board ( Domain A. Knowledge and understanding Academic Reference Standards (ARS) Identify Recent advances in the field of diagnosis and management of haematological diseases including anaemia, coagulation disturbance and haematological malignancies. a1 a2 a3 ILOs Identify recent advances in the causes, presentation, complications, diagnosis and management of different types of anemia. Identify recent advances in haematopoiesis and stem cell research. Identify recent advances in diagnosis and management of inherited and acquired bone marrow failure.

3 الهيئة القومية لضمان جودة التعليم واالعتماد update his knowledge regarding the drugs used in the field of haematology, as well as blood and blood products a4 a5 a6 Identify recent advances in diagnosis, classification and management of acute and chronic leukemias in adults. Identify recent advances in the classification, natural history, molecular biology, and therapeutic modalities of hematological malignancies. Identify recent advances in the histological classification of lymphomas approved by the WHO. a7 Identify recent advances in the diagnostic methods used in the assessment and the management congenital coagulation and platelet disorders, a8 update his knowledge in the pharmaceuticals and blood products available for the management of excessive bleeding. a9 update his knowledge in the field of blood transfusion. a10 update his knowledge in classification of myeloproliferative disorders, the required diagnostic methods and the therapeutic options. a11 update his knowledge on the impact of systemic disease on the blood and bone marrow. a12 update his knowledge in haemostatic problems in pregnancy and solid tumors a13 update his knowledge regarding indications and management of bone marrow transplantation a14 update his knowledge regarding chemotherapy regimens used in the management of hematological malignancies.

4 الهيئة القومية لضمان جودة التعليم واالعتماد B. Intellectual skills Analyze, deduce, extrapolate & evaluate laboratory information to establish diagnosis and appropriate treatment planning. Take decisions in various professional situations of haematological problems according to the available data b1 Analyze laboratory testing results for the initial management of common and unusual hematological disorders. b2 Take decision in the diagnosis and appropriate treatment planning. b3 Explain planned treatment clearly to junior staff b4 apply multidisciplinary team work for managing complication C. Professional skills Apply evidence based medicine from updated reference. Evaluate and improve methods and tools used in patient management. Plan professional courses to improve practice and enhance performance of juniors as regards appropriate use of antibiotic regimens for treatment and prophylaxis in immunosuppresse d patient. Management of complications of blood transfusion appropriately monitoring of anticoagulation b5 Apply evidence based medicine from updated printed and electronic reference. c1 - Plan professional courses of combination chemotherapy regimens. c2 Plan professional courses for appropriate use of antibiotic regimens for treatment and prophylaxis in the immunosuppressed patient. c3 Plan professional courses for complications of blood transfusion appropriately c4 Plan professional courses for use and monitoring of anticoagulation c5 Evaluate and improve methods and tools used in stem cell transplantation c6 - Evaluate and improve methods and tools used in diagnosis & management of hematological emergencies.

5 الهيئة القومية لضمان جودة التعليم واالعتماد D. General and transferrable skills E. Attitudes and ethical behavior Communicate with colleagues in other specialties effectively for proper diagnosis and treatment of the patients. -Direct his assistant team throughout the work Write and assess patient s reports -Advance his knowledge and information continuously using different printed and electronic sources. Appreciate ethical, religious and law regulations during his practice. d1- perform full explanation of the side effects of chemotherapy to patients. d2-communicates effectively with patients performing transplantation and their family. d3-communicate effectively with colleagues in other specialties for proper management of the patients. d4-perform leadership responsibilities d5- Write and appraise reports. d6-perform continuous self lifelong learning d7-upgrade his scientific knowledge utilizing all available sources. e1 Appreciates ethical communication of informed consent. e2 -Evaluates the junior staff ability to Communicate with terminal patients and their relatives. e3 Demonstrates the importance of supportive care for successive patient outcome. e4 Conducts and modifies multidisciplinary team working. e5 Evaluates the ability of juniors to conduct sympathetically bad news including terminal progress. Program courses ILOs Matrix ILOs Course title A 1 A 2 Clinical and Chemical pathology for hematology II Hemopoiesis II x A 3 Iron metabolism. And x x A 4 A 5 A 6 A 7 A 8 A 9 A 1 0 A 1 1 A 1 2 A 1 3 A 1 4

6 الهيئة القومية لضمان جودة التعليم واالعتماد anemia, Acute leukemias II x x Chronic leukemias II x x x Stem cell disorders II x Lymphomas II x x Myeloma II x x Hemostasis II x x Blood transfusion II x x Hematological manifestations of medical diseases II Immunodeficiencies Stem cell transplantation Integrated hematology II x x ILOs Course title Clinical and Chemical pathology for hematology II Hemopoiesis II Iron metabolism. And anemia, II Acute leukemias II Chronic leukemias II Stem cell disorders II B 1 B 2 B3 B4 B5 C 1 x C 2 C 3 C4 C5 C6 D 1 x x x x x D2 D 3 D 4 D5 D 6 D7 E1 E 2 x x x x x x x X X X X x x x x x x x x Lymphomas II x x x x x X Myeloma II x x x x x X Hemostasis II x x x x x Blood transfusion II Hematological manifestations of medical diseases II Immunodeficien cies Stem cell transplantation Integrated hematology II x x x x x E 3 E4 E5

7 الهيئة القومية لضمان جودة التعليم واالعتماد 2- Curriculum Structure: -Program duration: This program is fulfilled in not less than 2 years with a maximum of 5 years (4 semesters & thesis). -Program structure: 1. Total hours: 52 Credit hours. 2. Obligatory subjects: 32 Credit Hours. 3. Thesis: 20 Credit Hours Elective Subjects: 2 Credit Hours each = 4 hours. -Program Content: A. Obligatory Courses: Code Course Credit Contact hours hours lectures practical other Clinical and Chemical pathology for hematology II Haemopoiesis II Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis, Megaloblastic Anaemia, Haemolytic Anaemias, Aplastic Anaemia Acute Leukaemias II Chronic Leukaemias II Stem Cell Disorders II Lymphomas II Myeloma II Haemostasis II Blood Transfusion II Haematological manifestation of medical diseases II Immunodeficiencies Stem cell transplantation Integrated hematology II 4 B. Elective Courses: Code Subject Credit hours Prerequisites Biostatistics and Computer Imaging for hematology Molecular Biology 1 - Others According to the Field of the Thesis 1 3- Program Admission Requirements: According to the regulations of the credit hour by laws of the Faculty of Medicine Alexandria University (annex). 4- Regulations for Progression and Program Completion: According to the regulations of the credit hour by laws of the Faculty of Medicine Alexandria University (annex).

8 الهيئة القومية لضمان جودة التعليم واالعتماد 5- Methods of student assessment: Methods Intended Learning outcomes to be assessed 1. Written Exam a1-a14, b1-b2, b5,c2-c3 2. Practical Exam B3-b4, c1,c4-c6 3. Assignments d1 d7 4.Thesis d5-d7,e1-e5 6- Methods of program evaluation: Evaluator Tool Sample 1. Students enrolled in the program Questionnaires. 2. Alumni Stakeholders (Employers) Focus group 4. External Evaluator (s) Prof. Sameh Shamaa 5. Others: Program Director: Prof Dr. Yahia Ganem Program Coordinator: Prof Dr. Nahla A Hamed

9 الهيئة القومية لضمان جودة التعليم واالعتماد COURSE DESCRIPTION 1 Code Credit hours (1) Course Prerequisites Lectures Clinical Clinical and Chemical pathology for hematology II 2 Code Credit hours (2) Course Prerequisites Lectures Clinical Haemopoiesis II 1 1 Introduction. Sites of haemopoiesis. The stromal microenvironment. Stem cell trafficking. Organization of haemopoiesis. Haemopoietic growth factors and receptors. Clinical applications of stem cell research. Selected bibliography. Seminars: update. 3 Code Credit hours (4) Course Prerequisites Lectures Clinical Iron Metabolism, Iron 3 1 Deficiency and Disorders of Haem Synthesis, Megaloblastic Anaemia, Haemolytic Anaemias, Aplastic Anaemia Distribution of body iron. Cellular iron homeostasis. Normal iron balance. Iron absorption. Internal exchange. Haem synthesis. Diagnostic methods for investigating iron metabolism. Iron deficiency anaemia. Causes of iron deficiency. Management of iron deficiency. Pathological alterations in haem synthesis. Selected bibliography. Megaloblastic anaemia: Introduction. Underlying basic science. Clinical features. Haematological findings. Cobalamin. Cobalamin analogues. Causes of cobalamin deficiency. Diagnosis of cobalamin deficiency. Tests for the cause of cobalamin deficiency. Folate. Causes of folate deficiency. Diagnosis of folate deficiency. General management of megaloblastic anaemia. Prophylactic folic acid. Megaloblastic anaemia not due to cobalamin or folate deficiency or altered metabolism. Other nutritional anaemias. Inherited disorders of hemoglobin. Acquired haemolytic anaemias: Introduction. Immune haemolytic anaemias. Warm-type autoimmune haemolytic anaemias. Cold-type autoimmune haemolytic anaemias. The non-immune acquired haemolytic anaemias. Sickle cell disease. Disorders of red cell membrane. Inherited aplastic anaemia/bone marrow failure syndromes: Introduction. Fanconi anaemia. Dyskeratosis congenital. Shwachman-Diamond syndrome. Diamond-Black fan anaemia. Congenital and cyclical neutropenias. Thrombocytopenia with absent radii. Congenital amegakaryocytic thrombocytopenia. Conclusion. PNH. Seminars: update. 4 Code Credit hours (2) Course Prerequisites Lectures Clinical Acute Leukaemias II 1 1

10 الهيئة القومية لضمان جودة التعليم واالعتماد Acute myeloid leukemia. Epidemiology of disease. Pathophysiology. Disease classification. Cytogenetics. Treatment. Future developments. Selected bibliography. Adult acute lymphoblastic leukaemia: Introduction. Diagnosis. Clinical manifestations. Laboratory evaluation. Differential diagnosis. Initial evaluation and supportive therapy. Chemotherapy. Stem Cell transplantation. Outcome of all subtypes and prognostic factors. Minimal residual diseasepractical application in adult ALL. Treatment with monoclonal antibodies. ABL tyrosine kinase inhibitors in Ph/BCR-ABL-positive ALL. Selected bibliography. Seminars: update. 5 Code Credit hours (2) Course Prerequisites Lectures Clinical Chronic Leukaemias II 1 1 Introduction. Classification. Cytokinetics. Cytogenetics. Molecular biology. Clinical features. Haematology. Management of chronic myeloid leukaemia in chronic phase. Treatment decisions for newly diagnosed patients in chronic phase. Management of chronic myeloid leukaemia in advanced phase. Variants of chronic myeloid leukaemia. Selected bibliography. Chronic lymphocytic leukaemia and other B-cell disorders: Introduction. Methodology for diagnosis. Chronic lymphocytic leukaemia. Management. Prolymphocytic leukaemia. Hairy cell leukaemia. The leukaemic phase of low-grade NHL. Selected bibliography. Seminars: update. 6 Code Credit hours (3) Course Prerequisites Lectures Clinical Stem cell disorders II 2 1 Myelodysplastic syndromes. Cytogenetics. Investigations. Classifcation. Pathogenesis. Prognosis. Management. Myeloproliferative disorders: The polycythaemia. Polycythaemia rubra vera. Essential thrombocythaemia. Idiopathic myelofibrosis. Bone marrow transplantation. Seminars: update.

11 الهيئة القومية لضمان جودة التعليم واالعتماد 7 Code Credit hours (2) Course Prerequisites Lectures Clinical Lymphomas 1 1 Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics & oncogenes. Clinical features. Investigations. Staging. Treatment. Specific types. Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy. 8 Code Credit hours (2) Course Prerequisites Lectures Clinical Myeloma 1 1 Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal gammopathy of uncertain significance. Waldenstrom macroglobulinaemia. Plasma cell leukemia. Non-secretory myeloma. Hairy-chain diseases. Seminars: update. 9 Code Credit hours (3) Course Prerequisites Lectures Clinical Haemostasis II 2 1 Overview. Blood vessels. Platelets. Coagulation factors. Naturally occurring inhibitors. Fibrinolysis. Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease. Acquired coagulation, platelet & vascular bleeding: Disseminated intravascular coagulation. Coagulopathy & massive blood loss. Vitamin K deficiency. Idiopathic thrombocytophric purpura. Non-thrombotic vascular purpuras. Inherited thrombophilia. Acquired venous thrombosis. TTP. Congenital platelet disorders. Seminars: update. 10 Code Credit hours (2) Course Prerequisites Lectures Clinical Blood Transfusion II 2 - Blood component transfusion indications and complications. 11 Code Credit hours (2) Course Prerequisites Lectures Clinical Hematological 1 1 Manifestations of Medical Diseases Connective tissue disorders liver disease, renal disease, neurological disorders. 12 Code Credit hours (1) Course Prerequisites Lectures Clinical Immunodeficiencies 13 Code Credit hours (2) Course Prerequisites Lectures Clinical Stem cell transplantation

12 الهيئة القومية لضمان جودة التعليم واالعتماد 14 Code Credit hours (2) Course Lectures Clinical Integrated hematology II

13 Course Specifications University: Alexandria Faculty: Medicine Department: Course Information Course Code: Course Name lymphoma II Program in which the Course is Given: doctorate program in hematology Number of Credit Hours2 Theoretical 1 Clinical/Practical 1 Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and manage successfully Lymphomas Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a5 Identify recent advances in the classification, natural history, molecular biology, and therapeutic modalities of hematological malignancies. a6 Identify recent advances in the histological classification of lymphomas approved by the WHO. Course ILOs a3 update his knowledge in WHO classification of lymphoma a4 Identify recent advances in the drugs used in Lymphomas according to WHO classification B. Intellectual skills b1 Analyze, deduce, extrapolate & evaluate laboratory testing results for the initial management of common and unusual hematological disorders. b1 Analyze & evaluate available laboratory information to establish treatment plan of Lymphomas. b2 Analyze & deduce laboratory tests to establish treatment of uncommon types of Lymphomas. b2 Take decision in the diagnosis and appropriate treatment planning. b3 Take decisions in various situations in lymphoma professional b5 Apply evidence based medicine b5 Refer to evidence based medicine in

14 from updated printed and electronic reference. managing cases b6 Refer to updated reference in dealing with difficult cases. C.Professionaland Practical Skills C1-Plan professional courses of combination chemotherapy regimens D. General Skills d1- perform full explanation of the side effects of chemotherapy to patients. C1-Evaluate and improve methods and tools used in management of Lymphomas C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate treatment of Lymphomas d1-performleadership responsibilities in explaining complications of chemotherapy to patients d2- upgrade his scientific information utilizing all available printed and electronic sources to manage side effects of chemotherapy Course Content(Units/Topics) Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics& oncogenes. Clinical features. Investigations. Staging. Treatment. Specific types. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy.

15 Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Nabil El-Halawani Program Coordinator Name : Nahla Hamed Signature: Program Director (Head of Department) Name: Prof. Signature: Yehia Ghanem

16 Course Specifications University: Alexandria Faculty: Medicine Department:Internal Medicine- Hematology Unit Course Information Course Code: Course Name: stem cell transplantation Program in which the Course is Given: MD in hematology Number of Credit Hours2Theoretical 1.5Clinical/Practical shrs 0.5 Course Aimsto provide candidates with the basic knowledge about the indications of HSC transplantation, stem cell sources, pre transplant evaluation, and management during the transplant procedure and post transplant complications. Intended Learning Outcomes (ILOs) Program ILO (refer to program Course ILOs A. Knowledge and Understanding matrix) -Understanding recent advances in the classification, pathogenesis, molecular biology, diagnosis and therapeutic modalities of hematological diseases. Identify recent advances in the field of HSC transplantation regarding indications, selection of patients, pre-transplant evaluation, the transplant procedure and post-transplant complications. B. Intellectual skills C.Professional and Practical Skills -Analysis and interpretation of clinical data and laboratory results of various hematological disorders. -Decision making in the diagnosis and appropriate treatment planning of hematological diseases which is evidence-based. -Improving the professional skills needed for treatment of various hematological disorders, including experience with use of chemotherapy protocols and management of side effects. -How to select patients for the transplant procedure according to indications, comorbidities, laboratory data and assessment of benefit/risk ratio. -Analysis of clinical and laboratory data of patients during and post-transplantation and suggestion of appropriate measures to be taken accordingly. -Appropriate management of patients before, during the procedure and in the posttransplant period according to recent guidelines. -How to monitor and deal with the adverse effects of conditioning regimens and other medications used during and after transplantation.

17 D. General Skills -Development and improvement of communication and leadership skills. -To enhance communication skills with both the medical team and the patients. Course Content(Units/Topics) Teaching/Learning Methods Lectures self learning Practical/ Clinical Overview of HSCT Stem cell sources Pre-transplant evaluation Conditioning regimens and supportive care GVHD prophylaxis Transfusion medicine Engraftment Infectious Complications Acute GVHD Chronic GVHD Thrombotic Microangiopathies Graft Failure Post-transplant Relapse Small group discussion Others Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case Assignment Others Schedule of Assessment Mid-term --- OSCE/OSPE Logbook fulfillment End of term 100% Distribution of Marks Written Exam 80 % Practical/Clinical Exam --

18 Others log book+assignment20% List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others -Lecture Notes -Postgraduate Hematology -Blood and Marrow Transplant Handbook -The EBMT Handbook Course Instructor Name: Prof.Manal El SoradySignature: Manal El Sorady Program Coordinator Name: Prof. Nahla HamedSignature: Program Director (Head of Department) Name: Prof. Manal El SoradySignature: Manal El Sorady

19 University: Alexandria Faculty: Medicine Course Specifications Department: Course Information Course Code: Course Name: Immune deficiencies Program in which the Course is Given: doctorate program in hematology Number of Credit Hours 1 Theoretical Clinical/Practical Course Aims provide updated knowledge and skills that allow Dealing successfully with common and difficult cases with diseases of blood and bone marrow as well as Interpret hematological manifestations of medical diseases and solid tumors. Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding Identify Recent advances in the field of diagnosis and management of haematological diseases including anaemia, coagulation disturbance and haematological malignancies. Course ILOs a11 update his knowledge on the impact of systemic disease on the blood and bone marrow. B. Intellectual skills Analyze, deduce, extrapolate & evaluate laboratory information to establish diagnosis and appropriate treatment planning. b1 Analyze laboratory testing results for the initial management of common and unusual hematological disorders. b2 Take decision in the diagnosis and appropriate treatment planning. b4 apply multidisciplinary team work for managing complication C.Professional and Practical Skills c1 Plan professional courses to improve practice and enhance performance of juniors as regards c2plan professional courses for appropriate use of antibiotic regimens for treatment and prophylaxis in the immunosuppressed patient.

20 D. General Skills appropriate use of antibiotic regimens for treatment and prophylaxis in immunosuppressed patient. Communicate with colleagues in other specialties effectively for proper diagnosis and treatment of the patients. -Advance his knowledge and information continuously using different printed and electronic sources. d3-communicate effectively with colleagues in other specialties for proper management of the patients. d6-perform continuous self lifelong learning d7-upgrade his scientific knowledge utilizing all available sources. Course Content (Units/Topics) Hereditary immunodeficiency Acquired immunodeficiency Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 %

21 Distribution of Marks Written Exam 100 % Practical/Clinical Exam % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out Postgraduate haematology William haematology Blood Haematologica Course Instructor Name: Prof. Dr Manal sorady Prof.Dr ashraf alghandour Signature: Program Coordinator Name: Prof.Dr. Nahla A. Hamed Signature: Program Director (Head of Department) Name: Prof. Dr. Hassan Nafea Signature:

22 University: Alexandria Faculty: Medicine Course Specifications Department: Course Information Course Code: Course Name: Integrated hematology II Program in which the Course is Given: MD in hematology Number of Credit Hours 4 Theoretical Clinical/Practical Course Aims provide candidates with the updated skills that allow them to Deal successfully with common and difficult cases with diseases of blood and bone marrow as well as Interpret hematological manifestations of medical diseases and solid tumors. Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding Course ILOs B. Intellectual skills Analyze, deduce, extrapolate & evaluate laboratory information to establish diagnosis and appropriate treatment planning. Take decisions in various professional situations of haematological problems according to the available data b1 Analyze laboratory testing results for the initial management of common and unusual hematological disorders. b2 Take decision in the diagnosis and appropriate treatment planning. b3 Explain planned treatment clearly to junior staff Apply evidence based medicine from updated reference. b5 Apply evidence based medicine from updated printed and electronic reference. C.Professional and Practical Skills

23 D. General Skills Communicate with colleagues in other specialties effectively for proper diagnosis and treatment of the patients. Write and assess patient s reports -Advance his knowledge and information continuously using different printed and electronic sources. d3-communicate effectively with colleagues in other specialties for proper management of the patients. d4-perform leadership responsibilities d5- Write and appraise reports. d6-perform continuous self lifelong learning d7-upgrade his scientific knowledge utilizing all available sources. Course Content (Units/Topics) Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others Schedule of Assessment Mid-term %

24 End of term 100 % Distribution of Marks Written Exam % Practical/Clinical Exam 100 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Course Instructor Name: Prof. Dr Manal sorady Prof.Dr ashraf alghandour Postgraduate haematology William haematology Blood haematologica Signature: Program Coordinator Name: Prof.Dr. Nahla A. Hamed Signature: Program Director (Head of Department) Name: Prof. Dr. Hassan Nafea Signature:

25 Course Specifications University: Alexandria Faculty: Medicine Department: Course Information Course Code: Course Name:myeloma II Program in which the Course is Given: MD in hematology Number of Credit Hours 2 Theoretical 1 Clinical/Practical 1 Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and manage successfully Myeloma Intended Learning Outcomes (ILOs) Program ILO (refer to program matrix) A. Knowledge and Understanding a1 Identify Recent advances in the field of molecular biology in myeloma a2 Identify recent advanes in diagnosis and management of Myeloma Course ILOs a5 Identify recent advances in the classification, natural history, molecular biology, and therapeutic modalities of hematological malignancies. B. Intellectual skills b1 Analyze & evaluate available laboratory information to establish treatment plan of Myeloma. b2 Analyze & deduce laboratory tests to establish treatment of uncommon types of Myeloma. b4 Solve professional problems related to Myeloma according to the available data b5 Refer to evidence based medicine in managing cases b6 Refer to updated reference in dealing with difficult cases. b1 Analyze, deduce, extrapolate & evaluate laboratory testing results for the initial management of common and unusual hematological disorders. b2 Take decision in the diagnosis and appropriate treatment planning. b5 Apply evidence based medicine from updated printed and electronic reference.

26 C.Professionaland Practical Skills C1-Evaluate and improve methods and tools used in management of Myeloma C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate treatment of Myeloma D. General Skills d1-perform leadership responsibilities in explaining complications of chemotherapy to patients d2- upgrade his scientific information utilizing all available printed and electronic sources to manage side effects of chemotherapy C1-Plan professional courses of combination chemotherapy regimens d1-perform full explanation of the effects of chemotherapy to patients. side Course Content(Units/Topics) Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal gammopathy of uncertain significance. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Special types of myeloma: Plasma cell leukemia. Non-secretory myeloma. Waldenstrommacroglobulinaemia. Heavy-chain diseases. Please check () the appropriate method.

27 Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 10 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Nahla AM Hamed Signature: Nahla AM Hamed. Program Director (Head of Department) Name: Prof. Signature: YehiaGhanem

28 Course Specifications University: Alexandria Faculty: Medicine Department:Internal Medicine Course Information Course Code: Course Name:Hematological Manifestations of Medical Diseases II Program in which the Course is Given Doctorate Degree in Hematology Number of Credit Hours 2 Theoretical 1 Clinical/Practical 1 Course Aims to provide candidates with the updated knowledge and skills that allow them todiagnose Hematological Manifestations of Medical Diseases Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a11 update his knowledge on the impact of systemic disease on the blood and bone marrow. a12 update his knowledge in haemostatic problems in pregnancy and solid tumors Course ILOs a1 Identify Recent advances in the diagnosis of Hematological Manifestations of Medical Diseases a2 Identify recent advances in treating haematological manifestations of medical disorders a3 Identify updated knowledge in haematological changes accompanying solid tumors a4 Identify recent data in diagnosis and management of haematological abnormalities during pregnancy B. Intellectual skills b4 apply multidisciplinary team work for managing complication b1 Communicates with his collagues in other speciality for early detection of complications of Medical Diseases. b2 Work in multidisciplinary team for best results in treatment of haematological manifestations of systemic disease

29 C.Professional and Practical Skills c2 Plan professional courses for appropriate use of antibiotic regimens for treatment and prophylaxis in the immunosuppressed patient. C1-plan professional course for use of antibiotics in cancer patients C2- plan for professional course for treating infection in HIV D. General Skills d3- Communicate effectively with colleagues in other specialties for proper diagnosis and treatment of the patients. d1- Communicate with different specialties at optimum time for proper managing of the patients. d2- Write and appraise reports Course Content(Units/Topics) Hematological Manifestations of Connective tissue disorders Hematological Manifestations of liver disease Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Hematological Manifestations of renal disease Hematological Manifestations of endocrine disease Please check () the appropriate method.

30 Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Nahla AM Hamed Signature: Nahla AM Hamed Program Coordinator Name: Prof. Nahla AM Hamed Signature: Nahla AM Hamed Program Director (Head of Department) Name: Prof. Yehia Ghanem Signature: Yehia Ghanem

31 Course Specifications University: Alexandria Faculty: Medicine Department:Internal Medicine Course Information Course Code: Course Name: Acute Leukaemias II Program in which the Course is Given Doctorate Degree in Hematology Number of Credit Hours Theoretical 1 Clinical/Practical 1 Course Aims to provide candidates with the updated knowledge and skills that allow them to diagnose and manage successfully acute leukaemic patients Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a4 Identify recent advances in diagnosis, classification and management of acute and chronic leukemias in adults. Course ILOs a1 Identify Recent advances in molecular diagnosis of acute leukaemia a2 Identify Recent advances in prognostic factors and their relation to mananagement B. Intellectual skills a13 update his knowledge regarding indications and management of bone marrow transplantation b3 Explain planned treatment clearly to junior staff a3 update his data concerning indication of bone marrow transplantation a4 update his knowledge regarding posttransplant immunosuppressive drugs b1 Take decisions in treatment plan of patients b2 Explain planed treatment and their side effects to other team member C.Professionaland Practical Skills c2 Plan professional courses for appropriate use of antibiotic regimens for treatment and prophylaxis in the immunosuppressed patient. C1-Evaluate and improve uses of antibiotic during period of aplasia C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate use of antibiotic during aplasia

32 c5 Evaluate and improve methods and tools used in stem cell transplantation c6 - Evaluate and improve methods and tools used in diagnosis & management of hematological emergencies. D. General Skills d2-communicates effectively with patients performing transplantation and their family. C3-Plan professional courses to improve methods used in managing complications of stem cell transplantation C4-evaluate and improve protocols used in stem cell transplantation C5-- Evaluate and improve diagnostic methods of hematological emergencies C6-plan professional courses for management of haematological emergencies d1- Communicate with patients indicated for bone marrow transplantation as well as their families d2- describe complications of bone marrow transplantation to patients d4-perform responsibilities leadership d3-describe detailed follow up for junior staff d4- assess jobs ascribed to nursing staff d5- Write and appraise reports. d3- Write referral medical reports. d4- assess medical reports written by junior staff Course Content(Units/Topics) Acute myeloid leukemia. Epidemiology of disease. Pathophysiology. Disease classification. Cytogenetics. Treatment. Future developments. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Adult acute lymphoblastic leukaemia: Introduction. Diagnosis. Clinical manifestations. Laboratory evaluation. Differential diagnosis. Initial evaluation and supportive

33 therapy. Chemotherapy. Stem Cell transplantation. Outcome of all subtypes and prognostic factors. Minimal residual disease-practical application in adult ALL. Treatment with monoclonal antibodies. ABL tyrosine kinase inhibitors in Ph/BCR-ABL-positive ALL. Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Print out of lectures

34 Course Text Books Suggested Extra Reading Journals and Periodicals, others Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Hashim neanaa Signature: Program Coordinator Name: Prof. Nahla AM Hamed Signature: Program Director (Head of Department) Name: Prof. Yehia Ghanem Signature: Yehia Ghanem

35 Course Specifications University: Alexandria Faculty: Medicine Department:Internal Medicine Course Information Course Code: Course Name: Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis, MegaloblasticAnaemia,HaemolyticAnaemias, Aplastic Anaemia Program in which the Course is GivenDoctorate Degree in Hematology Number of Credit Hours 4 Theoretical 3 Clinical/Practical 1 Course Aims to provide candidates with the updated knowledge and skills that allow them to Diagnose and manage successfully anaemic patients Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a1 Identify recent advances in the causes, presentation, complications, diagnosis and management of different types of anemia. Course ILOs a1 Identify Recent advances in genetic basis of thalassaemia a2 Update his knowledge in the field of diagnosis of anaemia a3 Update his knowledge in management of different types of anaemia a4 Update his knowledge regarding treatment of paroxysmal nocturnal haemoglobinuria a5 update his knowledge regarding recent drugs used in the field of anaemia a6 Update his knowledge in the use of hydroxyurea a7 Update his knwoldge regarding screening for thalassemia a8 Update his knowledge regarding drug induced haemolytic anaemia a9 Identify recent advances in Molecular mechanisms of normal iron a10 identify recent advances in invasive

36 assessment of tissue iron overload a11update his knowledge in the use of iron chelation therapy B. Intellectual skills a3 Identify recent advances in diagnosis and management of inherited and acquired bone marrow failure. b5 Apply evidence based medicine from updated printed and electronic reference. a12update his data in use of immunosuppressive therapy in aplastic anaemia a13update his knowledge in use of bone marrow transplantation in aplastic anaemia b1 Take decisions in various professional situations related to anaemic patients according to evidence based medicine b2 Solve advanced problems related to treatment of sickle cell anaemia b3 Solve advanced problems related to diagnosis of pancytopenia b4 Take decisions in treatment of infections in aplastic anaemia b5 Solve problems related to diagnosis of iron overload C.Professional and Practical Skills D. General Skills c5 Evaluate and improve methods and tools used in stem cell transplantation c6 - Evaluate and improve methods and tools used in diagnosis & management of hematological emergencies. d6-perform continuous self lifelong learning d7-upgrade his scientific knowledge utilizing all available sources C1-evaluate the tools used in use of bone marrow transplantation in thalassaemia C2-evaluate and improve methods use in transplanting hepatitis c positive patients C3-improve methods used in preventing sickle cell crisis C4- improves methods used in treating sickle cell crisis d1-perform self learning all through his life d2- Plan courses for junior staff d3-shares in scientific conferences d4-upgrade his scientific knowledge continuously using available printed sources d5- perform updating his knowledge through electronic sources. d5-perform researches in his field Course Content(Units/Topics) Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others

37 Distribution of body iron. Cellular iron homeostasis. Normal iron balance. Iron absorption. Internal exchange. Diagnostic methods for investigating iron metabolism. Iron deficiency anaemia. Causes of iron deficiency. Management of iron deficiency. Haem synthesis. Pathological alterations in haem synthesis. Megaloblasticanaemia: Introduction. Underlying basic science. Clinical features. Haematological findings. Cobalamin. Cobalamin analogues. Causes of cobalamin deficiency. Diagnosis of cobalamin deficiency. Tests for the cause of cobalamin deficiency. Folate. Causes of folate deficiency. Diagnosis of folate deficiency. General management of megaloblasticanaemia. Prophylactic folic acid. Megaloblasticanaemia not due to cobalamin or folate deficiency or altered metabolism. Other nutritional anaemias. Haemolyticanaemias Disorders of red cell membrane. Inherited disorders of hemoglobin. Sickle cell disease. Acquired haemolyticanaemias Immune haemolyticanaemias. Warm-type autoimmune haemolyticanaemias. Cold-type autoimmune haemolyticanaemias. The non-immune acquired haemolyticanaemias. Inherited aplastic anaemia/bone marrow failure syndromes: Introduction.

38 Fanconianaemia. Dyskeratosis congenital. Shwachman-Diamond syndrome. Diamond- Blackfananaemia. Congenital and cyclical neutropenias. Thrombocytopenia with absent radii. Congenital amegakaryocytic thrombocytopenia. PNH Acquired aplastic anaemia Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Hassan Nafea Hassan Nafea

39 Program Coordinator Name: Prof. Nahla AM Hamed Nahla AM Hamed Program Director (Head of Department) Name: Prof. Yehia Ghanem Yehia Ghanem

40 Course Specifications University: Alexandria Faculty: Medicine Department: Internal Medicine Course Information Course Code: Course Name: Blood Transfusion II Program in which the Course is Given Doctorate Degree in Hematology Number of Credit Hours 2 Theoretical 2 Clinical/Practical Course Aims to provide candidates with the Recent advances inthe field of blood transfusion Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a8 update his knowledge in the pharmaceuticals and blood products available for the management of excessive bleeding. Course ILOs a1 Identify Recent advances in the indication of blood transfusion. a2 Identify recent advances in managing complications of blood transfusion a3 Identify recent advances in Transfusion- Related Acute Lung Injury B. Intellectual skills a9 update his knowledge in the field of blood transfusion. b2 Take decision in the diagnosis and appropriate treatment planning. a4 update his knowledge in artificial platelet substitutes a5 Identify recent advances in therapeutic apheresis a6 Update his knowledge in alternative to blood transfusion a7 Update his knowledge in use of anti D a8 Update his knowledge in platelet refractoriness b1- take decision in early diagnosis of complications of blood transfusion b2- take decision in treatment of complication of blood transfusion

41 C.Professional and Practical Skills C3-Plan professional courses for complications of blood transfusion appropriately C1-Plan advanced courses for junior staff concerning management of complications of blood transfusion C2-solve problems related to complications of blood transfusion D. General Skills Course Content(Units/Topics) Blood component transfusion indications Complications of blood transfusion Alternative to blood transfusion Therapeutic apheresis Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case Assignment OSCE/OSPE Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 100 % Practical/Clinical Exam % Others %

42 List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Ass. Prof. Nadia Zaki Signature: Program Coordinator Name: Prof. Nahla AM Hamed Signature: Program Director (Head of Department) Name: Prof. Yehia Ghanem Signature: Yehia Ghanem

43 Course Specifications University: Alexandria Faculty: Medicine Department:Internal Medicine Course Information Course Code: Course Name: Homeostasis II Program in which the Course is GivenDoctorate Degree in Hematology Number of Credit Hours 3 Theoretical 2 Clinical/Practical 1 Course Aims to provide candidates with the updated knowledge and skills that allow them todiagnose and manage successfully haemostatic disorders Intended Learning Outcomes (ILOs) Program ILO(refer to program matrix) A. Knowledge and Understanding a7 Identify recent advances in the diagnostic methods used in the assessment and the management congenital coagulation and platelet disorders. Course ILOs a1 Identify Recent advances in the field of diagnosis of haemostasis a2 Identify updated knowledge in the management of haemostatic disorders a3 Updating his knowledge regarding treatment of von Willebrand disease according to molecular data B. Intellectual skills a8 update his knowledge in the pharmaceuticals and blood products available for the management of excessive bleeding. b1 Analyze, deduce, extrapolate & evaluate laboratory testing results for the initial management of common and unusual hematological disorders. a4 update his knowledge regarding the drugs used in the field of haemostatic disorders a5 Update his knowledge in indication and side effects of blood products a6 Update his data regarding management of bleeding disorders during pregnancy a7 Identify recent advances in drug induced thrombocytopenia b1 Analyze & evaluate laboratory data to plan for treating platelet disorders b2 Analyze & evaluate results of laboratory tests to treat coagulation abnormalities b2 Take decision in the diagnosis b3 Take decisions in various professional

44 and appropriate treatment planning. situations of haemostatic disorders b4 solve problems related to haemostatic disorders according to the available data b5 Apply evidence based medicine from updated printed and electronic reference. b5 Apply treatment according to evidence based medicine b6 Refer to updated referencein rare presentations C.Professionaland Practical Skills c4 Plan professional courses for use and monitoring of anticoagulation D. General Skills d7-upgrade his scientific knowledge utilizing all available sources. C1-Evaluate and improve methods and tools used in management of haemostatic disorders C2 Plan professional courses to improve practice and enhance performance of juniors as regards appropriate treatment of haemostatic disordersand monitoring of anticoagulants d1- Upgrade his scientific data using recent textbooks and journals. d2- select appropriate idea for research work Course Content(Units/Topics) Normal haemostasis: Blood vessels. Platelets. Coagulation factors. Naturally occurring inhibitors. Fibrinolysis. Teaching/Learning Methods Lectures self learning Practical/ Clinical Small group discussion Others Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease. Congenital platelet disorders Acquired coagulation, platelet & vascular bleeding: Disseminated intravascular coagulation. Coagulopathy & massive blood loss.

45 Vitamin K deficiency. Idiopathic thrombocytophricpurpura. vascularpurpuras. Inherited thrombophilia.. Acquired venous thrombosis. TTP. Please check () the appropriate method. Student Assessment Methods of Assessment Essay Objective questions Case OSCE/OSPE Assignment Logbook fulfillment Others Schedule of Assessment Mid-term % End of term 100 % Distribution of Marks Written Exam 70 % Practical/Clinical Exam 30 % Others % List of Textbooks and References Lecture Notes Course Text Books Suggested Extra Reading Journals and Periodicals, others Print out of lectures Postgraduate haematology William haematology Blood haematologica Course Instructor Name: Prof. Mohamed El-Dafrawy Signature: