CEVAC CEVAC BROILER ND K / 5000 doses

Transcription

1 CEVAC BROILER ND K / 5 doses

2 CEVAC BROILER ND K Newcastle disease a permanent threat Newcastle Disease is highly contagious and exists in a wide range of forms. It is one of the four major poultry diseases worldwide. It takes its toll in all areas where poultry farming is intensive and spreads practically everywhere. Despite health control programmes and extensive vaccination, Newcastle Disease is enzootic in all continents, and also epizootic in many of the world regions. In epizootic situations, it is recommended to combine a live vaccine with an inactivated one to actively immunise young chicks from 1 day old onwards. To achieve this goal, CEVA SANTE ANIMALE offers the high technology vaccine:. Confirmed outbreaks of velogenic Newcastle Disease in 2-21

3 n outstanding, efficient and innovative technology Innovative An exceptional balance CEVA SANTE ANIMALE's formulation expertise enables to combine a high antigenic concentration with a small volume (.1ml). Beyond the small volume of the dose and its antigenic concentration, also has exceptional fluidity, making it easy to inject, and is perfectly tolerated at the injection site. VACCINE The Best in its generation VISCOSITY at 5 C and 12 rpm (in mpas) A 48.3 B 51.3 Combined inactivated vaccine 8-11 A et B : competitors Oily phase Aqueous phase Vaccine antigens Conventional inactivated vaccine.1 ml / dose is totally safe 34.2

4 formulation Effective inactivation process Inactivation is one of the key steps in the inactivated vaccine manufacturing process. The objective is to neutralise or kill the virus by removing its capacity to replicate itself, while maintaining its antigenic characteristics. Binary Ethylene Imine (BEI) has been selected as inactivation agent for the CEVAC K inactivated range. Unlike other inactivation agents such as formaldehyde, BEI neutralises the virus by acting on its nucleic acids without modifying its antigenic structure.** offers the best antigenic quality for a better immune response BEI Inactivation Formaldehyde Destruction of ADN or RNA, but no modification of surface antigens. Denaturation of surface antigens simple to use Intramuscular or subcutaneous is remarkably easy to use both intramuscularly and subcutaneously. It can be administered bothwith automatic injection systems and manual syringes. Manual injection Manual vaccination practices are similar to those employed for the vaccination of future layers or future breeders via the subcutaneous or intramuscular route. Automatic vaccination systems Automatic vaccination systems are in most cases set up in the hatchery, enabling fast, accurate injection of all types of vaccine into 1-day-old chicks. They carry out sub cutaneous or intramuscular injection using interchangeable syringes that cannot be deregulated. **Buonavoglia C et al 1988 Veterinary Research Communications, 12,2-3 :

5 n outstanding, efficient and innovative technology % protection Challenge 3 weeks Strenghten your protection from 1 day old onwards 25 offers the best protection in the face of high viral challenge. The combination of injected at one day old, with an attenuated live vaccine, produces protection and antibody levels that are significantly higher than those reached from the use of each vaccine individually. This combined vaccination is especially suitable for epidemiological situations where the risks of infection are high.* 5 Challenge 6 weeks + CEVAC Vitapest L Comparison of protection (%) in a virulent ND challenge to commercial chickens at 3 and 6 weeks given by alone and in combination with CEVAC Vitapest L (Ceva 2). % of protection A B C * Bennejean G, Avian Pathology, 7 : Mean HI titre (log2) Age (days) + CEVAC Vitapest L Mean ND titres observed after vaccination with alone or in combination with CEVAC Vitapest L in commercial chicks vaccinated at 1 day of age (Ceva 2) guarantees a highly significant, lasting protection and serological response, up to 5 days old, that exceed those of its competitors. % protection Unvaccinated controls Live vaccine Inactivated vaccine Live + inactivated vaccines Âge (days) Evolution of protection procured by live and inactivated vaccines administered individually or combined, to 1-day-old commercial chicks (Bennejean et al., 1978). Efficacy to withstand any challenge 21 days 28 days 42 days Comparison of the (%) protection procured by and that of 3 competitor vaccines (A, B, C) against virulent challenge at 21, 28 and 42 days in commercial chicks (Ceva 21). Mean HI titre (log2) Âge (days) A B C Average ND antibody rates after vaccination with or 3 competitor vaccines (A, B, C) in commercial chicks (Ceva 21).

6 Cevac Broiler ND K Vaccination programmes These vaccination programmes are given for information only and should be adapted to the local epidemiological context, the local choices for implementation and according to the other vaccinations that have already been recommended. Age Vaccines Route 1 day old in the hatchery Cevac Broiler ND K + Cevac Vitapest L On farms, Cevac Broiler ND K can be injected from 1 to 7 days old. IM or SC for.1 ml Spray Live vaccines are ideally combined with inactivated vaccines in one-day-olds in the hatchery. In cases where injection cannot be carried out in the hatchery, the recommended age limit is 7 days old. It is important that the inactivated vaccine is administered in the same week as the live one. The other vaccinations against Newcastle Disease using live vaccines remain unchanged. Efficacy to stand any test from one day old Remarkably easy to use Totally safe in young chicks Exceptional antigenic quality COMPOSITION: contains La Sota strain of Newcastle Disease virus in inactivated form, homogenized with oily adjuvant and merthiolate as a preservative. INDICATIONS: is recommended for the vaccination of young chickens, especially dayold chicks, against Newcastle Disease (ND). can be used alone or together with a live ND vaccine. ADMINISTRATION AND DOSAGE: should be injected subcutaneously (under the skin of the neck) or by intramuscular route (thigh muscles) at the dose of.1 ml per bird. GENERAL PRECAUTION: Satisfactory protection can be achieved in healthy birds only. Use sterile injection equipment. Keep the vaccine at room temperature (15 to 25 C) for 3 to 4 hours before use. Shake the bottle well before and during use. Check the accuracy of the syringe to ensure that the correct dose is delivered. Once a bottle has been opened, its content must be used up within 24 hours; otherwise, it should be discarded. WARNING: If the vaccine is accidentally injected to the operator, urgent medical attention is required. STORAGE: between 2 C and 8 C protected from light, do not freeze. PRESENTATION: plastic vials of ml ( doses) and 5 ml (5 doses). CEVAC AVIAN BIOLOGICAL RANGE CEVA SANTE ANIMALE S.A. - La Ballastière - B.P Libourne Cedex - France - Tél. 33 () Fax 33 () contact@ceva.com -