AT THE INTERSECTION OF METABOLIC AND CVD PREVENTION

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1 October 5-8, 2016 AT THE INTERSECTION OF METABOLIC AND CVD PREVENTION EARN UP TO CME/CE CREDITS! CVD PREVENTION DIABETES DYSLIPIDEMIA HYPERTENSION OBESITY This activity is jointly provided by Medical Education Resources (MER) and Tarsus Cardio Inc. dba Cardiometabolic Health Congress. Copyright Cardiometabolic Health Congress. All rights reserved.

2 TABLE OF CONTENTS More than one-third of the US population has at least one cardiometabolic disorder such as diabetes, dyslipidemia, obesity, or hypertension, with an ever-increasing presence that continues to create major challenges for healthcare providers. Employing aggressive strategies for early identification and comprehensive management of patients presenting with multiple cardiometabolic risk factors is key to stemming the future burden of cardiovascular and metabolic disease. KEYNOTE SPEAKERS 3 CMHC CHAIRPERSONS 3 PROGRAM AGENDA 4-5 CALL FOR PATIENT CASES 6 ACCREDITATION 6 ASSOCIATION PARTNERS 7 MEDIA PARTNERS 7 REGISTRATION 7 Now, in its 11th year, the Cardiometabolic Health Congress continues its dedication to translating late-breaking clinical research on cardiometabolic syndrome risk reduction into practical and targeted education that can easily be applied to real-world clinical scenarios. UP TO 2 REGISTER TODAY

3 KEYNOTE SPEAKERS STEVEN E. NISSEN, MD, MACC Chairman, Department of Cardiovascular Medicine Cleveland Clinic INTRAVASCULAR ULTRASOUND INSIGHTS INTO THE REGRESSION AND PROGRESSION OF CORONARY ATHEROSCLEROSIS SUZANNE OPARIL, MD Distinguished Professor of Medicine University of Alabama UPDATE AND CLINICAL IMPLICATIONS OF THE SPRINT TRIAL C. RONALD KAHN, MD Mary K. Iacocca Professor of Medicine Harvard Medical School Joslin Diabetes Center THE GUT MICROBIOME AS A MODIFIER OF INSULIN RESISTANCE AND METABOLIC SYNDROME PETER LIBBY, MD Mallinckrodt Professor of Medicine Harvard Medical School TRIGLYCERIDES ON THE RISE: SHOULD WE SWAP SEATS ON THE SEESAW? SUBODH VERMA, MD, PHD Cardiac Surgeon, St. Michael s Hospital OBESITY FAT DISTRIBUTION AND CARDIOVASCULAR RISK TO VIEW FULL FACULTY LISTING org/2016/chairfaculty.html CMHC CHAIRPERSONS CHRISTIE M. BALLANTYNE, MD Professor of Medicine Chief, Section of Cardiovascular Research Chief, Section of Cardiology Department of Medicine, Baylor College of Medicine Director, Center for Cardiovascular Disease Prevention Baylor College of Medicine Methodist DeBakey Heart Center Houston, TX GEORGE L. BAKRIS, MD Professor of Medicine Director, ASH Comprehensive Hypertension Center University of Chicago Medicine Pritzker School of Medicine Chicago, IL ROBERT H. ECKEL, MD Professor of Medicine Division of Endocrinology, Metabolism and Diabetes Division of Cardiology Professor of Physiology and Biophysics Charles A. Boettcher II Chair in Atherosclerosis Director, T32 in Obesity and Cardiovascular Disease University of Colorado Anschutz Medical Campus Director, Lipid Clinic, University Hospital Aurora, CO JAY S. SKYLER, MD Professor of Medicine, Pediatrics, & Psychology Division of Endocrinology, Diabetes & Metabolism University of Miami Miller School of Medicine Deputy Director for Clinical & Academic Programs Diabetes Research Institute Miami, FL REGISTER TODAY

4 AGENDA PROGRAM WEDNESDAY, OCTOBER 5, 2016 CMHC GENERAL SESSIONS 9AM 8:30 PM Capital What Healthcare Professionals Need to Know About Money (workshop registration fees apply) David Joyce MD, MBA; Paul A. Gurny, MBA, MS Leadership and Management For Healthcare Professionals (workshop registration fees apply) David Joyce MD, MBA; Paul A. Gurny, MBA, MS Non CME Lunch Symposium Insights on Repatha (evolocumab): A Clinical Perspective Yehuda Handelsman, MD, FACP, FACE, FNLA Sponsored by Amgen, Inc. Non-CME Session CME Workshop A Wolf in Sheep s Clothing: Diagnostic and Treatment Challenges of Rare Lipid Disorders 1 James A. Underberg, MD OPENING SESSIONS 4:00 PM ; Robert H. Eckel, MD; Intravascular Ultrasound Insights into the Regression and Progression of Coronary Atherosclerosis Steven E. Nissen, MD, MACC Non CME Session Non CME Dinner Reception Examining Options to Go Further in the Treatment of Adults with T2DM Sponsored by Janssen Pharmaceuticals, Inc. CME Symposium Nutritional Interventions in Clinical Practice: What Every Provider Needs to Know 2 Stephen Devries, MD, FACC CME Breakfast Symposium The New Face of Lipid Management for Hypercholesterolemia Patients with Statin Intolerance 3 Chairperson: Steven E. Nissen, MD, MACC Presenters: Michael H. Davidson, MD; Robert H. Eckel, MD CME Breakfast Workshop Handling the Challenging Cases: Identifying and Managing Hyponatremia in Heart Failure Patients 4 Michael Emmett, MD, MACP; Stephen Gottlieb, MD SESSION I. DYSLIPIDEMIA, ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE RISK REDUCTION Opening Remarks 8:00 AM Late Breaking Clinical Trials and FDA Update Moderator: Panelists: Deepak L. Bhatt, MD, MPH; Robert H. Eckel, MD; Keith C. Ferdinand, MD; Triglycerides on the Rise: Should We Swap Seats on the Seesaw? Peter Libby, MD Morning Break/Meet the Experts Exhibit Hall Lipid-Modifying Therapies 2016: What You Need to Know Challenging Lipid Cases, Panel Discussion, and Q&A Moderator: Panelists: Robert H. Eckel, MD; Pam Morris, MD CME Lunch Symposium New Developments in Insulin Therapy: Expert Insights in Individualizing Treatment 5 Chairperson: Bernard Zinman, MD Presenters: Anne L. Peters, MD; Athena Philis-Tsimikas, MD; Jean-François Yale, MD CME Lunch Symposium Patient-focused LDL-C Management and Risk Reduction in Clinical Practice: The Utility of PCSK9 Inhibitors 6 Chairperson: Presenters: Henry A. Ginsberg, MD; Michael J. Koren, MD; James A. Underberg, MD Cardiometabolic Challenges: Cases from Clinical Practice Moderator: Panelists: THURSDAY, OCTOBER 6, 2016 CMHC GENERAL SESSIONS 6:30 AM 8:00 PM George L. Bakris, MD; Deepak L. Bhatt, MD, MPH; Robert H. Eckel, MD; Afternoon Break/Meet the Experts Exhibit Hall The Latest in Antithrombotic Therapy: The Experts Take Sides Moderator: Deepak L. Bhatt, MD, MPH Panelist: Kenneth Mahaffey, MD; Gregg W. Stone, MD Closing Remarks Welcome Reception/Meet the Experts Exhibit Hall Exhibitor Showcase Closes Exhibit Hall Non-CME Session Widespread Lack or Loss of Adipose Tissue and Metabolic Abnormalities Could it Be Generalized Lipodystrophy? Sponsored by Aegerion Pharmaceuticals, Inc. Non-CME Session Pure EPA: Mechanism and Clinical Data Sponsored by Amarin Pharma, Inc. CME Dinner Symposium Managing Inflammation: A Novel Approach for Secondary Prevention of CVD Risks 7 Chairperson: (Chair) Presenters: Peter Libby, MD; Paul M. Ridker, MD 4 REGISTER TODAY

5 CME Breakfast Symposium Consider the Comorbidities and Clinical Challenges: Individualizing Stroke Prevention Therapy in Complex Patients with NVAF 8 Chairperson: Deepak L. Bhatt, MD, MPH Presenters: Elaine Hylek, MD; Christian T. Ruff, MD, MPH SESSION II: HYPERTENSION, CARDIO RENAL, HEART FAILURE Opening Remarks 8:00 AM George L. Bakris, MD Update and Clinical Implications of the SPRINT Trial Suzanne Oparil, MD Patient Case Discussion: SPRINT Slowly to Lower BP in Everyone Moderator: George L. Bakris, MD Panelists: Paul Muntner, PhD; Clyde W. Yancy, MD Heart Failure in the Context of SPRINT: What Has Changed? Clyde W. Yancy, MD Morning Break/Meet the Experts Exhibit Hall SGLT2s: Should They Be Second Line Therapy? George L. Bakris, MD Panel Discussion and Q&A: Case Consults in Hypertension Moderator: George L. Bakris, MD Panelists: Keith C. Ferdinand, MD; Suzanne Oparil, MD; Clyde W. Yancy, MD CME Lunch Symposium Evolving Therapeutic Paradigms for the Management of Hyperkalemia 9 Chairperson: George L. Bakris, MD Presenters: Rajiv Agarwal, MD; Joanne Lindenfeld, MD; Robert Toto, MD CME Lunch Workshop New Frontiers in the Prevention and Management of Heart Failure 10 Chairperson: Clyde W. Yancy, MD Presenters: Javed Butler, MD, MPH; Keith C. Ferdinand, MD; Joel Kahn, MD SESSION III. DIABETES MANAGEMENT Opening Remarks The Gut Microbiome as a Modifier of Insulin Resistance and Metabolic Syndrome C. Ronald Kahn, MD CV Outcomes Trials and Diabetes Afternoon Break/Meet the Experts Exhibit Hall Insulin Therapy Options: What s in Store for 2017? Irl Hirsch, MD Non-insulin Therapy Options: A Look Ahead for 2017 Robert E. Ratner, MD Panel Discussion and Q&A: Case Consults in Diabetes Moderator: Panelists: FRIDAY, OCTOBER 7, 2016 CMHC GENERAL SESSIONS 6:30 AM 8:00 PM George L. Bakris, MD; Robert H. Eckel, MD; Irl Hirsch, MD; Robert E. Ratner, MD Implications of Recent Trials on Management of Diabetes: Should the Algorithms be Changed? Moderator: Panelists: Christie Ballantyne, MD; George L. Bakris, MD; Robert H. Eckel, MD; Irl Hirsch, MD; Robert E. Ratner, MD Closing Remarks Networking Reception/Meet the Experts Exhibit Hall CME Dinner Symposia or Non-CME Session SATURDAY, OCTOBER 8, 2016 CMHC GENERAL SESSIONS 6:30 AM-11:45 AM CME Breakfast Symposium SESSION IV: OBESITY, LIFESTYLE MANAGEMENT AND CARDIOVASCULAR DISEASE Opening Remarks 8:05 AM Robert H. Eckel, MD Obesity Fat Distribution and Cardiovascular Risk Subodh Verma, MD, PhD A Dialogue Between the Experts: the Newest Evidence on Metabolic Surgery Lee Kaplan, MD; Francesco Rubino, MD Morning Break/Meet the Experts Exhibit Hall Managing the Obesity Epidemic: Lifestyle, Behavioral, and Pharmacological Approaches Caroline Apovian, MD Panel Discussion and Q&A: Case Consults on Lifestyle and Obesity Management of CVD Moderator: Robert H. Eckel, MD Panelists: Caroline Apovian, MD; Lee Kaplan, MD; Francesco Rubino, MD Closing Remarks Robert H. Eckel, MD SYMPOSIA EDUCATIONAL GRANT SUPPORT 1. Supported in part by an educational grant from Alexion Pharmaceuticals, Inc. Endorsed by the FH Foundation. 2. Supported by educational funding from Tarsus Cardio Inc. dba Cardiometabolic Health Congress. 3. Supported in part by educational funding donations provided by Amgen and Esperion Therapeutics, Inc. 4. Supported by an educational grant from Otsuka America Pharmaceutical Inc. 5. Supported by an educational grant from Novo Nordisk. 6. Supported by an educational grant from Sanofi US and Regeneron Pharmaceuticals. 7. Supported by an educational grant from Novartis. 8. Supported in part by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc. 9. Supported by an educational grant from Relypsa, Inc. 10. Supported by an educational grant from Arbor Pharmaceuticals, LLC and Metabolic Medical Institute. REGISTER TODAY

6 NEW THIS YEAR: Call for Patient Cases! The Cardiometabolic Health Congress is calling for healthcare practitioners to submit a challenging patient case in the following areas: DYSLIPIDEMIA CARDIOVASCULAR DISEASE HYPERTENSION HEART FAILURE TYPE 2 DIABETES OBESITY MANAGEMENT Selected cases (2 to 3) will be discussed by our expert faculty during each of the 4 session tracks during the 11th Annual CMHC. Participants who submit a case will earn a discounted registration rate ($200 OFF) to the meeting; participants whose case is selected will earn FREE registration and acknowledgment from the presenting faculty. This discount cannot be applied to previous registrations associated with other pricing discounts ACCREDITATION Note: Credit hours are not final and are subject to change. PHYSICIAN CREDIT This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of Medical Education Resources and Tarsus Cardio Inc. dba Cardiometabolic Health Congress. Medical Education Resources is accredited by the ACCME to provide continuing medical education for physicians. CREDIT DESIGNATION Medical Education Resources designates this live activity for a maximum of AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AAFP (AMERICAN ACADEMY OF FAMILY PHYSICIANS) CREDIT Pending approval from the American Academy of Family Physicians. NURSING CREDIT (ANCC) Medical Education Resources is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. This CE activity provides contact hours of continuing nursing education. Medical Education Resources is a provider of continuing nursing education by the California Board of Registered Nursing, Provider #CEP 12299, for contact hours. REGISTERED DIETITIAN CREDIT Medical Education Resources (Provider Number ME110) is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). Registered dietitians (RDs) and dietetic technicians, registered (DTRs) will receive 27 continuing professional education units (CPEUs) for completion of this program/material. PHARMACY CREDIT Medical Education Resources (MER) is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. MER designates this continuing education activity for contact hours (0.275 CEUs) of the Accreditation Council for Pharmacy Education. (Universal Program Number - TBD) This activity is certified as Knowledge based CPE. Attention Certified Diabetes Educators: The 11th Annual Cardiometabolic Health Congress (CMHC) is accredited by Medical Education Resources (MER). MER is accredited by the ACCME, ANCC, ACPE, and the CDR to provide continuing medical education. All of these accredited organizations are recognized by the AADE when applying for CDE renewal of certification or for initial certification. For more information please visit Recognized Provider List NCBDE DISCLOSURE OF CONFLICTS OF INTEREST It is the policy of Medical Education Resources (MER) to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, MER identifies conflicts of interest with its instructors, content managers, and other individuals who are in a position to control the content of an activity. Conflicts are resolved by MER to ensure that all scientific research referred to, reported, or used in a CME activity conforms to the generally accepted standards of experimental design, data collection, and analysis. MER is committed to providing its learners with high quality activities that promote improvements or quality in health care and not the business interest of a commercial interest. STATEMENT OF NEED The ever increasing presence of cardiometabolic risk continues to be a major challenge for health care providers in the United States. Current estimates suggest approximately 23% - 38% of all U.S. adults have metabolic syndrome, a constellation of cardiometabolic risk factors, including excessive abdominal fat, insulin resistance, inflammation, dyslipidemia, and hypertension. Patients with multiple cardiometabolic risk factors have twice the likelihood of developing and dying from cardiovascular disease and more than seven times the risk of developing diabetes compared to those with no cardiometabolic risk factors. Cardiovascular disease already affects approximately 83.6 million U.S. adults (> 1 in 3) and is the leading cause of U.S. deaths; however, this CVD burden can be expected to increase. This sampling of sobering statistics points to a rapidly growing epidemic of cardiovascular and metabolic disease and calls to the forefront the need for medical education focused on all aspects of cardiometabolic risk. The CMHC presents an especially valuable venue for this educational outreach with sessions fostering a collaborative, multidisciplinary approach to care. The 2016 Cardiometabolic Health Congress will translate the latest cutting edge medical research into practical, clinical strategies for preventing, delaying, and managing cardiovascular and metabolic disorders. The goal is to provide the medical community with evidence based interventions to improve health outcomes and quality of life for the growing numbers of patients at increased cardiometabolic risk. TARGET AUDIENCE & LEARNING OBJECTIVES The CMHC is designed for advanced level clinicians responsible for the prevention, diagnosis, and management of cardiometabolic risk. At the end of the congress, participants will be able to: Explain the interrelationships among the various cardiometabolic risk factors, their impact on cardiovascular health, and their common comorbidities. Translate evidence based strategies for prevention, screening, and treatment of cardiometabolic risk factors and their comorbidities to their clinical practice. Identify which interventions, including lifestyle changes and various drugs in combination, are most appropriate for particular patients based on their risk profiles. Identify how novel and emerging therapies can be integrated into clinical practice to reduce morbidity and mortality from cardiovascular and metabolic disease. EDUCATIONAL GRANT SUPPORT The 11th Annual CMHC general sessions are supported in part by educational grants from Amgen, AstraZeneca and Pfizer. Please continue to check online for updates. DISCLAIMER The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of Medical Education Resources, Tarsus Cardio Inc. dba Cardiometabolic Health Congress and/or the various industry supporters. The authors have disclosed if there is any discussion of published and/or investigational uses of agents that are not indicated by the FDA in their presentations. The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Medical Education Resources, Tarsus Cardio Inc. dba Cardiometabolic Health Congress and/or the various industry supporters. MER s ANCC accreditation status does not imply endorsement by MER or ANCC of any commercial products displayed in conjunction with this activity. Before prescribing any medicine, primary references and full prescribing information should be consulted. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient s conditions and possible contraindications on dangers in use, review of any applicable manufacturer s product information, and comparison with recommendations of other authorities. The information presented in this activity is not meant to serve as a guideline for patient management This activity is jointly provided by Medical Education Resources (MER) and Tarsus Cardio Inc. dba Cardiometabolic Health Congress. 6 REGISTER TODAY

7 ASSOCIATION PARTNERS Members Receive a $100 Discount on Registration! Accreditation Council for Clinical Lipidology American Board of Clinical Lipidology American Society of Endocrine Physician Assistants Asian Pacific Society of Cardiology FH Foundation Massachusetts Coordinating Body AADE Northern Indiana Assoc of Diabetes Educators Obesity Medicine Association San Francisco Bay Area Assoc of Diabetes Educators Society for the Study of Ingestive Behavior World Obesity PLATINUM MEDIA PARTNERS Cardiology Today and Healio.com by SLACK Incorporated Postgraduate Medicine MEDIA PARTNERS Bentham Science Publishers Cardiology CardioRenal Medicine Clinical Nephrology Current Cardiology Reviews Diabetes Technology & Therapeutics Dustri-Verlag Publishers Future Cardiology Kidney and Blood Pressure Research Mary Ann Liebert Inc. Publishers Metabolic Syndrome and Related Disorders Nutrition Today PharmaVOICE Wolters Kluwer REGISTRATION FORM Physicians FIRST NAME DEGREE(S) ADDRESS REGISTRATION FEES LAST NAME Allied Health Professionals AFFILIATION / COMPANY Fellows/Residents/Students Industry Register By 08/19/16 $695 $595 $295 $1,195 CITY STATE ZIP CODE HOME/OFFICE PHONE TOTAL AMOUNT DUE DISCOUNT CODE: METHOD OF PAYMENT: CHECK VISA MASTERCARD AMERICAN EXPRESS DISCOVER ACCOUNT NUMBER CARDHOLDER NAME EXPIRATION DATE CARDHOLDER SIGNATURE BILLING ZIP CODE Cancellation Policy Cancellations must be made in writing via fax to or to info@cardiometabolichealth.org. Refunds, less a $100 service fee, will be given if written cancellation is received no later than August 31, No refunds will be given after August 31, To send a substitute, please call or request to info@cardiometabolichealth.org. * Must be engaged in clinical practice and not employed by a pharmaceutical, medical device, medical education/advertising agency, or similar company to be eligible for the physician or allied health professional discounted registration fees. ** ID card from school, residency, or fellowship program is required for verification. Please fax information to No other discounts apply. REGISTRATION OPTIONS VISIT: CALL: FAX: REGISTER TODAY

8 1801 N Military Trail, Ste 200 Boca Raton, FL, EARN UP TO CME/CE CREDITS! Of all the national conferences, the CMHC is the best at having the right combination of medical experts and interactive audiences to crystalize key teaching points that allow both faculty and attendees to elevate their game in cardiometabolic medicine. Peter A. McCullough, MD FOLLOW US ONLINE HOTEL INFORMATION SHERATON BOSTON HOTEL 39 Dalton Street. Boston, MA Tel: Discounted Rate: $299/night Expires: September 12, 2016 AT THE INTERSECTION OF METABOLIC AND CVD PREVENTION REGISTRATION OPTIONS VISIT: CALL: FAX: This activity is jointly provided by Medical Education Resources (MER) and Tarsus Cardio Inc. dba Cardiometabolic Health Congress. Copyright Cardiometabolic Health Congress. All rights reserved.

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