Chapter 2: Studies of Human Learning and Memory. From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.

Transcription

1 Chapter 2: Studies of Human Learning and Memory From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.

2 Medium Spiny Neuron

3 A Current Conception of the major memory systems in the brain Figure 1

4 Figure 2 Major Brain Regions and Temporal Lobe System

5 Hippocampal Connectivity in the CNS Somatosensory Visual Sensory Regions Of Cortex Olfactory Auditory Perirhinal/ Entorhinal Cortex Perirhinal Cortex Entorhinal Cortex Hippocampal Formation CA3 Dentate Gyrus CA1 Figure 3

6 Figure 4 Hippocampal Pyramidal Neuron

7 Hippocampal Output Pathway & Intrinsic Circuit A Entorhinal Cortex Perforant Pathway B CA3 CA1 Dentate Gyrus Entorhinal Cortex CA1 Outputs CA3 Mossy Fibers C CA1 Axon Schaffer Collaterals GABAergic Interneuron CA1 Norepinephrine Acetylcholine Subiculum/ Entorhinal Cortex Lateral Septum Amygdala, Cortex Schaffer Collaterals Serotonin Figure 5

8 MRI scan of H.M. and control brain H.M. Control Figure 6

9 MRI of HM s Brain lesions Surgeon s Estimate of H.M. s lesions Revised Estimate based on MRI Figure 7

10 Virtual Reality Town used in episodic memory studies E F Figure 8

11 London Taxi driver study A B Figure 9

12 Figure 10 Excellence in motor learning and memory

13 Summary Scheme of interaction between motor centers Figure 11

14 Figure 12 Basal Ganglia in the Human Brain

15 The Striatal Motor Learning System Cortex Motor Pre-Motor Pre-Frontal (Sensory) Striatum Caudate/Putamen/ Accumbens Substantia Nigra Globus Pallidus Subthalamic Nucleus Thalamus Ventral Anterior & Ventral Lateral Nuclei Figure 13

16 Figure 14 Rajan Srinavasen Mahadevan

17 1000 Decimal places of pi Figure 15

18 Figure 16 Kim Peek

19 Neuroimaging of the retrieval of the Spatial Context of an Event Blue Box 1

20 Movies Using Amnesia as a Plot Device Movie Director (plus Notable Actors) Year Anterograde Amnesia: Memento Christopher Nolan (Guy Pearce) 2001 Finding Nemo Andrew Stanton (Animated - Ellen DeGeneris as Dory) First Dates Peter Segal (Adam Sandler) 2004 Retrograde Amnesia: The Bourne Identity Doug Liman (Matt Damon) 2002 Total Recall Paul Verhoeven (Arnold Schwarzenegger, Sharon Stone) 1990 Spellbound Alfred Hitchcock (Ingrid Bergman, Gregory Peck) 1945 Eternal Sunshine Michel Gondry (Jim Carrey, Kate Winslet) 2004 of the Spotless Mind The Forgotten Joseph Ruben (Julianne Moore) 2004 Men in Black Barry Sonnenfeld (Tommy Lee Jones, Will Smith) 1997 Not Sure: Mulholland Drive David Lynch (Michael J. Anderson, Diane Baker) 2001 Table 1

21 Multiple Memory Systems in the Human CNS Memory Subtype Working Memory Declarative, Episodic, and Spatial Memory Habits, Motor Skills, Procedural Memory Priming Aversive Associative Conditioning Motoric Associative Conditioning Olfactory and Taste Conditioning Sensitization, Habituation Circadian Rhythm Reward, Positive Reinforcement, Addiction Corresponding CNS Subregion Prefrontal Cortex, contributions from Caudate Nucleus Medial Temporal Lobe system including the Hippocampus, Dentate Gyrus, Ento-rhinal and Perirhinal cortices Striatum (Caudate Nucleus and Putamen), Globus Pallidus*, and Cerebellum Occipital Cortex, Neocortex in general Amygdala Cerebellum Olfactory Bulb, Insular Cortex, Nucleus Tractus Solitarius (NTS), positive and negative reinforcement systems (Amygdala or Nucleus Accumbens) Spinal Cord, Brainstem Nuclei, Amygdala Hypothalamus Suprachiasmatic Nucleus (SCN) Nucleus Accumbens, Ventral Tegmental Area (VTA) *Collectively the Caudate Nucleus, Putamen, and Globus Pallidus are referred to as the Basal Ganglia. Table 2

22 Memory-associated Cognitive Dysfunction in Humans Disease or Syndrome Type of Memory Affected Likely Anatomical Locus or Involved* Schizophrenia Working Memory Prefrontal Cortex Major Depression Declarative Memory? Aging-related Dementias Long-term Declarative and Temporal Lobe Hippocampal Episodic Memory System Korsakoff s Syndrome Long-term Declarative and Mamillary Bodies, Limbic (Alcoholism, Malnutrition) Episodic Memory System, Thalamus Huntington s Disease and Motor Learning, Habit Learning Nigro-striatal System Parkinson s Disease Attention Deficit Generalized or Specific Learning Frontal Lobes? Hyperactivity Disorder (ADHD) Disabilities, Dyslexia Basal Ganglia? Post-traumatic Aversive Associative Conditioning, Amygdala, Hippocampus Stress Disorder* (PTSD) Lack of Extinction Table 3

23 Major Neurotransmitters in the Hippocampus Neurotransmitter Abbreviation, Synonym General role Serotonin 5HT, 5-hydroxytryptamine neuromodulation Dopamine DA neuromodulation Acetylcholine ACh neuromodulation Norepinephrine NE neuromodulation Gamma-amino GABA inhibitory transmission Butyric Acid Glutamate Glu excitatory transmission Table 4