No. Code TEST SPECIMEN TAT TO Aldolase 3 ml Plain Blood/Serum (10-12 hour fasting

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Evelyn McDonald
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1 B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST (* updated:20/03/2018) Note: If any test(s) in esoteric list below is included in campaign profile, outlet/requester must notify processing lab at least 2-3 weeks in advanced for reagent and consumables preparation. Failure to pre-notify lab will cause delay in TAT. Preferred specimen collection on Monday to Wednesday excluding Thursday, Friday, Saturday, Sunday and public holiday. Special request form required for samples to Thomson and Parkway No Aldolase 3 ml Plain Blood/Serum (10-12 hour fasting sample) Aldosterone 3 ml Plain Blood/Serum (Another Option available 2 weeks SGH Amoebic Ab 3 ml Plain Blood/Serum 2-3 weeks NUH S'pore Amniotic Fluid Cells Chromosome Culture 25 ml Sterile Amniotic Fluid (Another Option available 3 weeks Thomson S'pore (Karyotyping) at Prince Court Medical Center with cheaper price) (Pre-arrange with Lab) Amniotic Fluid QF-PCR (AMNIO-PCR Screen) 25 ml Sterile Amniotic Fluid (Another option available at Thomson S'pore, Amniotic Fluid QF-PCR (AMNIO-PCR Screen) 25 ml Sterile Amniotic Fluid (Another option available at Parkway S'pore, Amniotic Fluid QF-PCR & Chromosome Culture 25 ml Sterile Amniotic Fluid (Another option available at Thomson S'pore, 3 days Parkway S'pore 3 days Thomson S'pore 3 d + 3 wks Parkway S'pore

2 Amniotic Fluid QF-PCR & Chromosome Culture 25 ml Sterile Amniotic Fluid (Another option available 3 d + 3 wks Thomson S'pore at Parkway S'pore, Amniotic Fluid Thalassaemia Genotyping Father:5ml EDTA blood, Mother:5ml EDTA 3 weeks Thomson S'pore blood, Child:20ml Amniotic fluid or 20mg CVS sample Angiotensin Converting Enzyme (ACE) 3 ml Plain Blood/Serum (Fasting) (Spin and send sample in plastic tube) Page 1 of Anti-ACH Receptor 3 ml Plain Blood/Serum 3 weeks NUH S'pore Anti-Cardiolipin Antibody IgM 3 ml Plain Blood/Serum (Frozen) Anti-GAD (Glutamic acid decarboxylase) 3 ml Plain Blood/Serum 2 weeks SGH Anti-Glomerular Basement Membrane (GBMA) 3 ml Plain Blood/Serum 1 week SGH Anti Liver Antibodies Profile (M2, LKM-1, LC-1, 3 ml Plain Blood/Serum 1 week SGH SLA/LP) Array CGH 3 ml EDTA blood 1 month Thomson S'pore Aspergillus Galactomannan Antigen 5ml Serum (preferred)/1ml BAL/CSF(but not recommended) (Frozen) Beta-2-Glycoprotein I IgG 3 ml Plain Serum (Frozen) Temporary Suspended 3 weeks NUH S'pore (Please call lab) Beta-2-Glycoprotein I IgM 3 ml Plain Serum (Frozen) 3 weeks NUH S'pore Beta Crosslaps (B-Tx) 3ml EDTA plasma (fasting) 5 days SGH Bence Jones Protein, Immunofixation Ep 20 ml Urine. Preferred 24hr urine collection or (Another Option available early morning fasting urine specimen.(no preservative) at UMMC using different method) Benzodiazepines, Serum/Plasma 3 ml serum/heparin plasma Borrelia (Lyme) IgG Ab 3 ml Plain Blood/Serum 1 week SGH Borrelia (Lyme) IgM Ab 3 ml Plain Blood/Serum 1 week SGH C-Telopeptides (CTx) 3 ml Plain Blood/Serum (Fasting)(Frozen) 3 ml Plain Blood/Serum (Fasting) (Send with C1 Esterase Inhibitor Antigen separated serum in frozen) Calcitonin 3 ml Plain Blood/Serum (Fasting) (Send with 2 weeks SGH Catecholamines, Urine (Epinephrine/Adrenaline & Norepinephrine/Noradrenaline, Dopamine) separated serum in frozen) 24 hrs Urine with 20ml conc. HCL (Separate at least 15 ml of urine and provide total urine volume) (Please call lab) (Another option available price) 3 weeks NUH S'pore CH 50 (Total Serum Complement Assay) 3 ml Plain Blood/Serum 1 week SGH

3 Chlamydia trachomatis (PCR, qualitative) 15 ml First Catch Urine/Dry Swab (Specimen stability: 2-8 C for 48 hours) Chlamydia trachomatis/neisseria gonorrhoeae panel (PCR) 15 ml First Catch Urine/Dry Swab (Specimen stability: 2-8 C for 48 hours) Cholinesterase, RBC (Acetylcholinesterase) Chromosome Studies (Cytogenetics) 5 ml EDTA Whole Blood 1 week SGH (Karyotyping) 5 ml Heparin Whole Blood 3 weeks Thomson S'pore Chromogranin A 3 ml Plain Blood/Serum (Fasting) 1-2 weeks SGH CK Isoenzyme 3 ml Plain Blood/Serum Coproporphyrin, Qualitative, Urine 20 ml Urine (Protect from light) 1 week SGH Coxiella Burnetii Ab, CFT (Q-Fever) 3 ml Plain Blood/Serum (Send paired sera taken two weeks apart for rising titre) 2 weeks (For SGH each Cytomegalovirus (PCR, Quantitative) sample) 3 ml whole EDTA blood (Lavender top) 1 week 1ml CSF/ sputum or bronchial lavage in NUH S'pore plain tube/ 1ml eye acqueous or vitreous/ Tissue biopsies in sterile saline Dengue Virus RNA (RT-PCR, Qualitative) & 5 ml Fresh EDTA Whole Blood (Lavender typing Top) (Specimen stability: 2-8 C for 48 hours) Dihydrotestosterone (DHT) 3 ml Plain Blood/Serum Page 2 of DNA Diagnostic Test Huntington's disease 3-5ml Fresh EDTA Blood 5-7weeks Thomson S'pore Epstein-Barr Virus, EA IgA Ab 3 ml Plain Blood/Serum 2 weeks SGH Epstein-Barr Virus, EA IgG Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, EA IgM Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, VCA IgG Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, VCA IgM Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, Quant, Real Time PCR 3 ml EDTA Whole Blood (Lavender Top) Factor V Leiden 5 ml EDTA Whole Blood (Lavender Top) Fibroblast Growth Factor 23 (FGF23) 3 ml EDTA whole blood (Lavender top) (Spin 3-5 weeks NUH S'pore and send Plasma in plastic tube) Free Testosterone (RIA-Measured) 3 ml Plain Blood/Serum 2 weeks SGH G6PD, RBC (Quantitative) 5 ml EDTA Whole Blood 1 week SGH Gastrin 3 ml Plain Blood/Serum (Morning sampling after a hour fasting) (Frozen) Gene mapping alpha thalassaemia prenatal Amniotic Fluid & parent's EDTA (3ml each) (Lanvender Top) Heparin Assay (Anti-Xa), Unfractionated 2 tubes of 3 ml Fresh Citrated Plasma (Frozen) Hep B Drug Resistance Test 3 ml Plain Blood/Serum Hep C Virus Ab (Anti-HCV) RIBA 3 ml Plain Blood/Serum (Frozen) 4 weeks NUH S'pore Hep C Virus Genotyping 5 ml Fresh Plain Blood/Serum 3 weeks NUH S'pore

4 Hep D (Delta) Virus Ab, Total (Anti-HDV) 3 ml Plain Blood/Serum 2-3 weeks SGH Hep E Virus IgM Ab (Anti-HEV IgM) 3 ml Plain Blood/Serum 1 month SGH Herpes simplex virus (PCR), CSF 2 ml CSF HIV-1 Proviral DNA PCR 5 ml EDTA Whole Blood 2 weeks SGH HLA -B27 typing (PCR) 3 ml fresh EDTA whole blood (Lavender Top) H5N1 RT PCR Throat, Nasopharyngeal swab (dry swab in sterile container) / aspirate) (Specimen stability: 2-8 C for 72 hours) Homovanillic Acid (HVA), Urine 30 ml Urine/24 hrs Urine with 15 ml 50 % HCl 2 weeks SGH (Vanillyl-free diet) Hydroxyindolacetic Acid (5-HIAA) 24 hrs Urine with 20ml conc. HCL 2-3 weeks NUH S'pore Hydroxyprogesterone 3 ml Plain Blood/Serum (Indicate patient s age (Another option available and sex) (Frozen) Hydroxyprogesterone (< 1 year old) 3 ml Plain Blood/Serum (Indicate patient s age (For patient < 1 year old) 3-5 weeks NUH S'pore and sex) (Frozen) Inhibin A & B, Tumor Marker 5ml Plain Serum Refrigerated 7 days (preferred) Inhibin B Frozen 90 days 5ml Plain Serum Refrigerated 7 days (preferred) Frozen 90 days Interleukin-6 (IL-6) 3 ml Plain Blood/Serum (Spin down within weeks NUH S'pore Immunofixation Electrophoresis hours and send serum in separated tube, keep frozen) 3 ml Plain Blood/Serum/20 ml urine (Preferred 24hr urine collection or early morning fasting urine specimen.(no preservative) Immunoglobulin D (IgD) 3 ml Plain Blood/Serum Intrinsic factor antibody 3 ml plain Blood/Serum (Fasting) 1-2 weeks SGH Page 3 of Islet Cell Antibody 3 ml Plain Blood/Serum 2 weeks SGH LDH Isoenzymes (LD1, LD2, LD3, LD4, & LD5) 3 ml Plain Blood/Serum (Ambient Ep Lipase temperature) 3 ml Plain Blood/Serum Lipoprotein (a) [LP (a)] 3 ml Plain Blood/Serum 1 week SGH Lupus Anticoagulant Screen 2 tubes of 3 ml Fresh Citrated Plasma (Frozen)

5 Metanephrines (& Normetanephrines) 24 hrs Urine with 20ml conc. HCL (Another option available Metanephrines Plasma 3ml EDTA Whole Blood (Lavender Top) (Spin 3-5 weeks NUH S'pore Mitotane (Lysodren) and 3-5ml send Plain EDTA Blood/Serum Plasma in (Gel frozen) tube is not acceptable)(spin and separate serum in 3 weeks NUH S'pore plastic tube) MTHFR variant 3 ml EDTA whole blood (Lavender top) 3 weeks NUH S'pore Myeloma Protein Study, Urine 20ml urine (No preservative) Preferred 24 hr urine collection or early morning fasting urine specimen (No preservative) 2 Weeks NUH S'pore Myoglobin, Serum 3 ml Plain Blood/Serum Myoglobin, Urine 20 ml Fresh Urine 1 week SGH Neisseria gonorrhoeae (PCR, Qualitative) 15 ml First Catch Urine (Patient must not have Neuron Specific Enolase, Serum urinated during the previous 2 hours)/ Gel Swab 3ml Plain Blood (Spin and separate serum, 3-5 weeks NUH S'pore NT-proBNP send in plastic tube) 3ml Plain Blood/Serum 1 week SGH Oligoclonal Bands, CSF 3 ml CSF & 3 ml Plain Blood Oxalate, Urine 20ml 24 hrs Urine with 20ml conc. HCL (Keep refrigerated during collection) Parvovirus B19 IgG Ab 3 ml Plain Blood/Serum 3-4 weeks SGH Porphyrin Screen 20 ml Random Urine without preservative (Keep refrigerated during collection. Collect urine in dark brown bottle or wrap container with aluminium foil. Protect from light) Prader-Willi/Angelman Syndrome 5 ml EDTA Whole Blood 6-7 weeks Thomson S'pore Prealbumin (Transthyretin) 3 ml Plain Blood/Serum (Fasting) (Frozen) Procalcitonin 3 ml Plain Blood/Serum (Frozen) Protein Test (CSF) 1 ml CSF (Frozen) 3-5 weeks NUH S'pore Protein Electrophoresis, Serum 3 ml Plain Blood/Serum Protein Electrophoresis, Urine 20 ml Urine (Preferred 24 hr urine collection or early morning fasting urine specimen (No preservative) Renin 3-4 weeks NUH S'pore 5 ml Frozen EDTA Plasma (Another option available Rickettsia IgG Panel 3ml plain blood/serum Rickettsia typi IgG 3 ml Plain Blood/Serum Page 4 of 5

6 ROMA using HE4 & CA125 3 ml Plain Blood/Serum (Spin and separate 1- serum, send in frozen) Sickling Test 3 ml EDTA blood (send to lab under 2-8 C) 1 week SGH Skeletal Muscle Ab 3 ml Plain Blood/Serum 1 week SGH Smooth Muscle Ab 3 ml Plain Blood/Serum (Frozen) Spinocerebellar Ataxia (SCA) DNA Testing Preferred 3 tubes of 3ml EDTA blood 7-8 weeks Thomson S'pore (minimum 2 tubes EDTA) S. pneumoniae Antigen Test Squamous Cell Carcinoma (SCC) 5ml Urine (At least 1ml) 3 ml Plain Blood/Serum 1-2 weeks 3-4 weeks SGH SGH Thalassaemia Genotyping (alpha & beta 10 ml Fresh EDTA Blood (Lavender Top) mutations) Thyroglobulin Panel (Tg with TgAb) 3 ml Plain Blood/Serum (Spin and separate Another option available serum, send in frozen) at SGH, please ask doctor preference for patient monitoring) Thyroglobulin (Tg) Panel (Tg with TgAb) 3 ml Plain Blood/Serum (Another option available 2 weeks SGH at NUH S'pore, please ask doctor preference for patient monitoring) Thyroid Stimulating Immunoglobulins (TSI)/TSAb 5 ml Plain Blood/Serum 3 weeks SGH Tissue transglutaminase IgA 3 ml Plain Blood/Serum 5-6 weeks NUH S'pore Toxoplasma gondii PCR 3ml EDTA (Whole blood) / Tissue Biopsy 2-5 ml Amniotic Fluid (Specimen stability: 2-8 C for 72 hours) Tricyclic Anti-Depressants (TAD) 3 ml Plain Blood/Serum Vanillyl Mandelic Acid (VMA) 24 hrs Urine with 20ml conc. HCL (Keep refrigerated) (Vanillyl-free diet) (Another option available at UMMC) VDRL-CSF 1ml CSF 1-2 weeks SGH Y-chromosome deletions 3ml EDTA Whole blood (Lavender top) 2-4 weeks NUH S'pore Page 5 of 5

B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST

B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST (* updated:28/03/2017) Note: If any test(s) in esoteric list below is included in campaign profile, outlet/requester must notify processing lab at least 2-3