B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST

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Willa Tucker
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1 B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST (* updated:28/03/2017) Note: If any test(s) in esoteric list below is included in campaign profile, outlet/requester must notify processing lab at least 2-3 weeks in advanced for reagent and consumables preparation. Failure to pre-notify lab will cause delay in TAT. Preferred specimen collection on Monday to Wednesday excluding Thursday, Friday, Saturday, Sunday and public holiday. Special request form required for samples to Thomson and Parkway Anti Mullerian Hormone (AMH) 3 ml Plain Blood/Serum Aldolase 3 ml Plain Blood/Serum (10-12 hour fasting sample) Aldosterone 3 ml Plain Blood/Serum Amniotic Fluid Cells Chromosome Culture 2 weeks (Karyotyping) 25 ml Sterile Amniotic Fluid (Pre-arrange with Lab) 3 weeks Thomson S'pore Amniotic Fluid QF-PCR (AMNIO-PCR Screen) 25 ml Sterile Amniotic Fluid (Pre-arrange with Lab) 3 days Parkway S'pore Amniotic Fluid QF-PCR (AMNIO-PCR Screen) 25 ml Sterile Amniotic Fluid (Pre-arrange with Lab) 3 days Thomson S'pore Amniotic Fluid QF-PCR & Chromosome Culture 25 ml Sterile Amniotic Fluid (Pre-arrange with Lab) 3 d + 3 wks Parkway S'pore Amniotic Fluid QF-PCR & Chromosome Culture 25 ml Sterile Amniotic Fluid Father:5ml EDTA blood, Mother:5ml EDTA (Pre-arrange with Lab) 3 d + 3 wks Thomson S'pore Amniotic Fluid Thalassaemia Genotyping blood, Child:20ml Amniotic fluid or 20mg CVS sample (Pre-arrange with Lab) 3 weeks Thomson S'pore Angiotensin Converting Enzyme (ACE) 3 ml Plain Blood/Serum (Fasting) (Spin and Anti-ACH Receptor send sample in plastic tube) 3 ml Plain Blood/Serum 3 weeks NUH S'pore Anti-Cardiolipin Antibody IgM 3 ml Plain Blood/Serum (Frozen) Anti-GAD (Glutamic acid decarboxylase) 3 ml Plain Blood/Serum 2 weeks Anti-Glomerular Basement Membrane (GBMA) Anti Liver Antibodies Profile (M2, LKM-1, LC-1, 3 ml Plain Blood/Serum 1 week SLA/LP) 3 ml Plain Blood/Serum 1 week Anti-Neutrophil Cytoplasmic Ab 5 ml Plain Blood/Serum (Includes panca/mpo, canca/pr3) Array CGH 3 ml EDTA blood 1 month Thomson S'pore Aspergillus Galactomannan Antigen 5ml Serum (preferred)/1ml BAL/CSF(but not Beta-2-Glycoprotein I IgG recommended) (Frozen) 3 ml Plain Serum (Frozen) 3 weeks NUH S'pore Beta-2-Glycoprotein I IgM 3 ml Plain Serum (Frozen) 3 weeks NUH S'pore Beta Crosslaps (B-Tx) 3ml EDTA plasma (fasting) 5 days Bence Jones Protein, Immunofixation Ep 20 ml Urine. Preferred 24hr urine collection or Benzodiazepines, Serum/Plasma early morning fasting urine specimen.(no 3 ml serum/heparin plasma Borrelia (Lyme) IgG Ab 3 ml Plain Blood/Serum 1 week Borrelia (Lyme) IgM Ab 3 ml Plain Blood/Serum 1 week

2 C-Telopeptides (CTx) 3 ml Plain Blood/Serum (Fasting)(Frozen) 3 ml Plain Blood/Serum (Fasting) (Send with C1 Esterase Inhibitor Antigen separated serum in frozen) Page 1 of Calcitonin 3 ml Plain Blood/Serum (Fasting) (Send with 2 weeks separated serum in frozen) Catecholamines, Urine 24 hrs Urine with 10ml conc. HCL 3 weeks NUH S'pore (Epinephrine/Adrenaline & Norepinephrine/Noradrenaline, Dopamine) CH 50 (Total Serum Complement Assay) (Separate at least 15 ml of urine and provide total urine volume) 3 ml Plain Blood/Serum 1 week Chlamydia trachomatis (PCR, qualitative) 15 ml First Catch Urine/Dry Swab (Specimen Chlamydia trachomatis/neisseria gonorrhoeae stability: 2-8 C for 48 hours) 15 ml First Catch Urine/Dry Swab (Specimen panel (PCR) stability: 2-8 C for 48 hours) Cholinesterase, RBC (Acetylcholinesterase) Chromosome Studies (Cytogenetics) 5 ml EDTA Whole Blood (Pre-arrange with Lab) 1 week (Karyotyping) 5 ml Heparin Whole Blood (Pre-arrange with Lab) 3 weeks Thomson S'pore Chromogranin A 3 ml Plain Blood/Serum (Fasting) 1-2 weeks CK Isoenzyme 3 ml Plain Blood/Serum Coproporphyrin, Qualitative, Urine 20 ml Urine (Protect from light) 1 week Coxiella Burnetii Ab, CFT (Q-Fever) 3 ml Plain Blood/Serum (Send paired sera taken two weeks apart for rising titre) 2 weeks (For each sample) Crouzon Syndrome Test 3 ml EDTA Blood 1 month Thomson S'pore Cyanide Toxicology Test 5 ml Heparin Whole Blood 2-3 weeks NUH S'pore Cytomegalovirus (PCR, Quantitative) 3 ml whole EDTA blood (Lavender top) 1ml CSF/ sputum or bronchial lavage in plain tube/ 1ml eye acqueous or vitreous/ Tissue biopsies in sterile saline Dengue Virus RNA (RT-PCR, Qualitative) & 5 ml Fresh EDTA Whole Blood (Lavender typing Dihydrotestosterone (DHT) Top) (Specimen stability: 2-8 C for 48 hours) 3 ml Plain Blood/Serum DNA Diagnostic Test Huntington's disease 3-5ml Fresh EDTA Blood 5-7weeks Thomson S'pore Epstein-Barr Virus, EA IgA Ab 3 ml Plain Blood/Serum 2 weeks Epstein-Barr Virus, EA IgG Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, EA IgM Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, VCA IgG Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, VCA IgM Ab 3 ml Plain Blood/Serum Epstein-Barr Virus, Quant, Real Time PCR 3 ml EDTA Whole Blood (Lavender Top) Factor V Leiden 5 ml EDTA Whole Blood (Lavender Top) (Pre-arrange with Lab)

3 Fibroblast Growth Factor 23 (FGF23) 3 ml EDTA whole blood (Lavender top) (Spin (Pre-arrange with Lab) 3-5 weeks NUH S'pore Free Testosterone (RIA-Measured) and send Plasma in plastic tube) 3 ml Plain Blood/Serum 2 weeks G6PD, RBC (Quantitative) 5 ml EDTA Whole Blood (Pre-arrange with Lab) 1 week Gastrin 3 ml Plain Blood/Serum (Morning sampling after a hour fasting) (Frozen) Gene mapping alpha thalassaemia prenatal Amniotic Fluid & parent's EDTA (3ml each) (Lanvender Top) Heparin Assay (Anti-Xa), Unfractionated 2 tubes of 3 ml Fresh Citrated Plasma (Pre-arrange with Lab) Hep B Drug Resistance Test (Frozen) 3 ml Plain Blood/Serum Hep C Virus Ab (Anti-HCV) RIBA 3 ml Plain Blood/Serum (Frozen) (Pre-arrange with Lab) 4 weeks NUH S'pore Hep C Virus Genotyping 5 ml Fresh Plain Blood/Serum (Pre-arrange with Lab) 3 weeks NUH S'pore Hep D (Delta) Virus Ab, Total (Anti-HDV) 3 ml Plain Blood/Serum 2-3 weeks Hep E Virus IgM Ab (Anti-HEV IgM) 3 ml Plain Blood/Serum 1 month Page 2 of Herpes simplex virus (PCR), CSF 2 ml CSF HIV-1 Proviral DNA PCR 5 ml EDTA Whole Blood (Pre-arrange with Lab) 2 weeks HIV -1 RNA (Roche Quantitative) 5 ml EDTA Whole Blood (Lavender Top) (Pre-arrange with Lab) HLA -B27 typing (PCR) 3 ml fresh EDTA whole blood (Lavender Top) H5N1 RT PCR Throat, Nasopharyngeal swab (dry swab in sterile container) / aspirate) (Specimen stability: 2-8 C for 72 hours) Homovanillic Acid (HVA), Urine 30 ml Urine/24 hrs Urine with 15 ml 50 % HCl 2 weeks (Vanillyl-free diet) Hydroxyindolacetic Acid (5-HIAA) 24 hrs Urine with 10ml conc. HCL Hydroxyprogesterone 3 ml Plain Blood/Serum (Indicate patient s age and sex) (Frozen) Hydroxyprogesterone (< 1 year old) 3 ml Plain Blood/Serum (Indicate patient s age 3-5 weeks NUH S'pore Inhibin A & B, Tumor Marker and 5ml Plain sex) (Frozen) Serum Refrigerated 7 days (preferred) Inhibin B Frozen 90 days 5ml Plain Serum Refrigerated 7 days (preferred) Frozen 90 days Interleukin-6 (IL-6) 3 ml Plain Blood/Serum (Spin down within weeks NUH S'pore Immunofixation Electrophoresis hours and send serum in separated tube, keep frozen) 3 ml Plain Blood/Serum/20 ml urine (Preferred 24hr urine collection or early morning fasting urine specimen.(no Immunoglobulin D (IgD) 3 ml Plain Blood/Serum

4 Intrinsic factor antibody 3 ml plain Blood/Serum (Fasting) 1-2 weeks Islet Cell Antibody 3 ml Plain Blood/Serum 2 weeks LDH Isoenzymes (LD1, LD2, LD3, LD4, & LD5) 3 ml Plain Blood/Serum (Ambient Ep Leptospira IgM Ab temperature) 3 ml Plain Blood/Serum (Frozen) Lipase 3 ml Plain Blood/Serum Lipoprotein (a) [LP (a)] 3 ml Plain Blood/Serum 1 week Lupus Anticoagulant Screen 2 tubes of 3 ml Fresh Citrated Plasma (Pre-arrange with Lab) Magnesium, Urine (Frozen) 24 hrs Urine with 10ml conc. HCL Metanephrines (& Normetanephrines) 24 hrs Urine with 10ml conc. HCL Metanephrines Plasma 3ml EDTA Whole Blood (Lavender Top) (Spin (Pre-arrange with Lab) 3-5 weeks NUH S'pore MTHFR variant and send EDTA Plasma in frozen) 3 ml EDTA whole blood (Lavender top) 3 weeks NUH S'pore Myeloma Protein Study, Urine 20ml urine (No Preferred 24 hr urine collection or early morning fasting urine specimen (No 2 Weeks NUH S'pore Myoglobin, Serum 3 ml Plain Blood/Serum Myoglobin, Urine 20 ml Fresh Urine 1 week Neisseria gonorrhoeae (PCR, Qualitative) 15 ml First Catch Urine (Patient must not have Neuron Specific Enolase, Serum urinated during the previous 2 hours)/ Gel Swab 3ml Plain Blood (Spin and separate serum, 3-5 weeks NUH S'pore NT-proBNP send in plastic tube) 3ml Plain Blood/Serum 1 week Oligoclonal Bands, CSF 3 ml CSF & 3 ml Plain Blood Oxalate, Urine 20ml 24 hrs Urine with 10ml conc. HCL (Keep refrigerated during collection) Page 3 of Parvovirus B19 IgG Ab 3 ml Plain Blood/Serum 3-4 weeks Porphyrin Screen 20 ml Random Urine without preservative (Keep refrigerated during collection. Collect urine in dark brown bottle or wrap container (Pre-arrange with Lab) with aluminium foil. Protect from light) Prader-Willi/Angelman Syndrome 5 ml EDTA Whole Blood (Pre-arrange with Lab) 6-7 weeks Thomson S'pore Prealbumin (Transthyretin) 3 ml Plain Blood/Serum (Fasting) (Frozen) Procalcitonin 3 ml Plain Blood/Serum (Frozen) Protein Test (CSF) 1 ml CSF (Frozen) 3-5 weeks NUH S'pore Protein Electrophoresis, Serum 3 ml Plain Blood/Serum Protein Electrophoresis, Urine 20 ml Urine (Preferred 24 hr urine collection or early morning fasting urine specimen (No

5 Renin 5 ml Frozen EDTA Plasma (Pre-arrange with Lab) Rickettsia IgG Panel 3ml plain blood/serum Rickettsia typi IgG 3 ml Plain Blood/Serum ROMA using HE4 & CA125 3 ml Plain Blood/Serum (Spin and separate Sickling Test serum, send in frozen) 3 ml EDTA blood (send to lab under 2-8 C) 1 week Skeletal Muscle Ab 3 ml Plain Blood/Serum 1 week Smooth Muscle Ab 3 ml Plain Blood/Serum (Frozen) Spinocerebellar Ataxia (SCA) DNA Testing Preferred 3 tubes of 3ml EDTA blood 7-8 weeks Thomson S'pore (minimum 2 tubes EDTA) S. pneumoniae Antigen Test Squamous Cell Carcinoma (SCC) 5ml Urine (At least 1ml) 3 ml Plain Blood/Serum 1-2 weeks 3-4 weeks Thalassaemia Genotyping (alpha & beta 10 ml Fresh EDTA Blood (Lavender Top) (Pre-arrange with Lab) mutations) Thyroglobulin Panel (Tg with TgAb) 3 ml Plain Blood/Serum (Spin and separate serum, send in frozen) Thyroglobulin (Tg) Panel (Tg with TgAb) Thyroid Stimulating Immunoglobulins (TSI)/TSAb 3 ml Plain Blood/Serum 5 ml Plain Blood/Serum 2 weeks 3 weeks Tissue transglutaminase IgA 3 ml Plain Blood/Serum 5-6 weeks NUH S'pore Toxoplasma gondii PCR 3ml EDTA (Whole blood) / Tissue Biopsy 2-5 ml Amniotic Fluid (Specimen stability: 2-8 C for 72 hours) Tricyclic Anti-Depressants (TAD) 3 ml Plain Blood/Serum Vanillyl Mandelic Acid (VMA) 24 hrs Urine with 10ml conc. HCL (Keep (Vanillyl-free diet) VDRL-CSF refrigerated) 1ml CSF 1-2 weeks Page 4 of 4

No. Code TEST SPECIMEN TAT TO Aldolase 3 ml Plain Blood/Serum (10-12 hour fasting

No. Code TEST SPECIMEN TAT TO Aldolase 3 ml Plain Blood/Serum (10-12 hour fasting B.P. CLINICAL LAB SDN. BHD. ESOTERIC TEST LIST (* updated:20/03/2018) Note: If any test(s) in esoteric list below is included in campaign profile, outlet/requester must notify processing lab at least 2-3