REACTOME: Nonsense Mediated Decay (NMD) REACTOME:72764 Eukaryotic Translation Termination. REACTOME:72737 Cap dependent Translation Initiation
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1 A REACTOME: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) REACTOME:72764 Eukaryotic Translation Termination REACTOME:72737 Cap dependent Translation Initiation REACTOME:72706 GTP hydrolysis and joining of the 60S ribosomal subunit REACTOME:72689 Formation of a pool of free S subunits REACTOME:72613 Eukaryotic Translation Initiation REACTOME:6115 Respiratory electron transport* REACTOME:56635 Infectious disease REACTOME: Viral mrna Translation REACTOME: Influenza Viral RNA Transcription and Replication REACTOME: Influenza Life Cycle REACTOME:1630 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.* REACTOME: ' UTR mediated translational regulation REACTOME: Peptide chain elongation REACTOME: Eukaryotic Translation Elongation REACTOME: L13a mediated translational silencing of Ceruloplasmin expression REACTOME: The citric acid (TCA) cycle and respiratory electron transport* KEGG:hsa00190 Oxidative phosphorylation* UP: human_dm
2 REACTOME: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) REACTOME:72766 Translation* REACTOME:72764 Eukaryotic Translation Termination* REACTOME:72737 Cap dependent Translation Initiation* REACTOME:72706 GTP hydrolysis and joining of the 60S ribosomal subunit* REACTOME:72689 Formation of a pool of free S subunits* REACTOME:72613 Eukaryotic Translation Initiation* REACTOME: Viral mrna Translation* REACTOME: SRP dependent cotranslational protein targeting to membrane* REACTOME: Influenza Viral RNA Transcription and Replication* REACTOME: Influenza Life Cycle* REACTOME: Influenza Infection* REACTOME:1630 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.* REACTOME: ' UTR mediated translational regulation REACTOME: Peptide chain elongation* REACTOME: Eukaryotic Translation Elongation* REACTOME: L13a mediated translational silencing of Ceruloplasmin expression* KEGG:hsa030 Ribosome* UP: human_ms
3 UP: human_ra REACTOME:76005 Response to elevated platelet cytosolic Ca2+* REACTOME:76002 Platelet activation, signaling and aggregation* REACTOME: Cytokine Signaling in Immune system* REACTOME: Platelet degranulation REACTOME:9582 Hemostasis* KEGG:hsa05322 Systemic lupus erythematosus KEGG:hsa05219 Bladder cancer* KEGG:hsa052 Transcriptional misregulation in cancer* KEGG:hsa05164 Influenza A* KEGG:hsa05144 Malaria* KEGG:hsa04668 TNF signaling pathway* KEGG:hsa046 Hematopoietic cell lineage* KEGG:hsa046 Complement and coagulation cascades* KEGG:hsa04380 Osteoclast differentiation* KEGG:hsa042 Apoptosis*
4 UP: human_sle REACTOME: Growth hormone receptor signaling* REACTOME: Interferon Signaling* REACTOME: Interferon alpha/beta signaling* REACTOME: Interferon gamma signaling* REACTOME: The NLRP3 inflammasome REACTOME: Inflammasomes* REACTOME: IRAK4 deficiency (TLR2/4) REACTOME: MyD88 deficiency (TLR2/4) REACTOME: Toll Like Receptors Cascades REACTOME: Nucleotide binding domain, leucine rich repeat containing receptor (NLR) signaling pathways* REACTOME: Innate Immune System REACTOME: Cytokine Signaling in Immune system* KEGG:hsa05168 Herpes simplex infection* KEGG:hsa05164 Influenza A* KEGG:hsa05162 Measles* KEGG:hsa05144 Malaria* KEGG:hsa051 Leishmaniasis* KEGG:hsa05134 Legionellosis* KEGG:hsa05133 Pertussis* KEGG:hsa04621 NOD like receptor signaling pathway*
5 UP: mouse_dm1 REACTOME: Interferon gamma signaling* REACTOME: GPCR ligand binding* REACTOME:3808 Chemokine receptors bind chemokines* REACTOME: Peptide ligand binding receptors* REACTOME: Class A/1 (Rhodopsin like receptors)* REACTOME: Immunoregulatory interactions between a Lymphoid and a non Lymphoid cell* REACTOME: Extracellular matrix organization* KEGG:hsa053 Primary immunodeficiency* KEGG:hsa05332 Graft versus host disease* KEGG:hsa05330 Allograft rejection* KEGG:hsa05323 Rheumatoid arthritis* KEGG:hsa05321 Inflammatory bowel disease (IBD)* KEGG:hsa053 Autoimmune thyroid disease* KEGG:hsa05150 Staphylococcus aureus infection* KEGG:hsa04672 Intestinal immune network for IgA production* KEGG:hsa04612 Antigen processing and presentation* KEGG:hsa04514 Cell adhesion molecules (CAMs)* KEGG:hsa04145 Phagosome* KEGG:hsa04142 Lysosome* KEGG:hsa060 Cytokine cytokine receptor interaction*
6 UP: mouse_ms REACTOME: Class I MHC mediated antigen processing & presentation* REACTOME: Interferon Signaling* REACTOME: Interferon alpha/beta signaling* REACTOME: Interferon gamma signaling* REACTOME: RHO GTPases Activate NADPH Oxidases REACTOME: Cytokine Signaling in Immune system* REACTOME: Antigen processing Cross presentation* REACTOME: Cross presentation of particulate exogenous antigens (phagosomes)* REACTOME: Phagosomal maturation (early endosomal stage) REACTOME: Latent infection of Homo sapiens with Mycobacterium tuberculosis KEGG:hsa05322 Systemic lupus erythematosus* KEGG:hsa05168 Herpes simplex infection* KEGG:hsa05152 Tuberculosis* KEGG:hsa05150 Staphylococcus aureus infection* KEGG:hsa051 Leishmaniasis* KEGG:hsa05133 Pertussis* KEGG:hsa04612 Antigen processing and presentation* KEGG:hsa046 Complement and coagulation cascades* KEGG:hsa04380 Osteoclast differentiation* KEGG:hsa04145 Phagosome*
7 UP: mouse_ra REACTOME:3808 Chemokine receptors bind chemokines* REACTOME: Defective B4GALT1 causes B4GALT1 CDG (CDG 2d) REACTOME: Defective CHST6 causes MCDC1 REACTOME: Diseases associated with glycosaminoglycan metabolism REACTOME:22857 Keratan sulfate degradation* REACTOME: Keratan sulfate/keratin metabolism* REACTOME: Glycosaminoglycan metabolism* REACTOME: Activation of Matrix Metalloproteinases* REACTOME: Extracellular matrix organization* REACTOME: Degradation of the extracellular matrix* REACTOME: Collagen degradation* KEGG:hsa05323 Rheumatoid arthritis* KEGG:hsa054 Chemical carcinogenesis* KEGG:hsa05152 Tuberculosis* KEGG:hsa05150 Staphylococcus aureus infection* KEGG:hsa05144 Malaria* KEGG:hsa04668 TNF signaling pathway* KEGG:hsa046 Complement and coagulation cascades* KEGG:hsa060 Cytokine cytokine receptor interaction* KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450*
8 UP: mouse_sle REACTOME: GPCR ligand binding REACTOME:3808 Chemokine receptors bind chemokines* REACTOME: Peptide ligand binding receptors* REACTOME: Class A/1 (Rhodopsin like receptors)* REACTOME: Extracellular matrix organization* KEGG:hsa05323 Rheumatoid arthritis* KEGG:hsa05321 Inflammatory bowel disease (IBD)* KEGG:hsa053 Autoimmune thyroid disease KEGG:hsa060 Cytokine cytokine receptor interaction*
9 B DOWN: human_dm1 REACTOME: IRAK4 deficiency (TLR2/4) REACTOME: MyD88 deficiency (TLR2/4) REACTOME: Signaling by Interleukins* REACTOME: Toll Like Receptor 2 (TLR2) Cascade REACTOME: Toll Like Receptors Cascades REACTOME: Innate Immune System REACTOME: Toll Like Receptor TLR6:TLR2 Cascade REACTOME: Toll Like Receptor TLR1:TLR2 Cascade REACTOME: MyD88:Mal cascade initiated on plasma membrane REACTOME: Toll Like Receptor 4 (TLR4) Cascade REACTOME: Adaptive Immune System* REACTOME: Cytokine Signaling in Immune system* REACTOME: Endosomal/Vacuolar pathway* KEGG:hsa05416 Viral myocarditis* KEGG:hsa05332 Graft versus host disease* KEGG:hsa05168 Herpes simplex infection* KEGG:hsa05164 Influenza A* KEGG:hsa05152 Tuberculosis* KEGG:hsa051 Leishmaniasis* KEGG:hsa04145 Phagosome*
10 DOWN: human_ms REACTOME: GPCR ligand binding* REACTOME: G alpha (i) signalling events REACTOME: GPCR downstream signaling REACTOME:3808 Chemokine receptors bind chemokines REACTOME: Peptide ligand binding receptors* REACTOME: Class A/1 (Rhodopsin like receptors) REACTOME: Signaling by GPCR REACTOME: ECM proteoglycans REACTOME: Laminin interactions REACTOME: Phase 1 Functionalization of compounds REACTOME: Cytochrome P450 arranged by substrate type REACTOME: Extracellular matrix organization* REACTOME: Degradation of the extracellular matrix REACTOME: Neuronal System KEGG:hsa04925 Aldosterone synthesis and secretion KEGG:hsa04913 Ovarian steroidogenesis* KEGG:hsa04750 Inflammatory mediator regulation of TRP channels KEGG:hsa04512 ECM receptor interaction* KEGG:hsa080 Neuroactive ligand receptor interaction KEGG:hsa024 camp signaling pathway
11 DOWN: human_ra REACTOME:73894 DNA Repair* REACTOME:73864 RNA Polymerase I Transcription REACTOME:73863 RNA Polymerase I Transcription Termination REACTOME:73777 RNA Polymerase I Chain Elongation REACTOME: Mitochondrial translation termination REACTOME:53898 Mitochondrial translation elongation REACTOME: Mitochondrial translation REACTOME: Mitochondrial translation initiation REACTOME: Negative epigenetic regulation of rrna expression REACTOME:5046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription REACTOME: SIRT1 negatively regulates rrna Expression REACTOME:2430 Translocation of ZAP 70 to Immunological synapse REACTOME: Immunoregulatory interactions between a Lymphoid and a non Lymphoid cell REACTOME: Organelle biogenesis and maintenance KEGG:hsa053 Primary immunodeficiency*
12 REACTOME: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers REACTOME: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) REACTOME: Nonsense Mediated Decay (NMD) REACTOME:72766 Translation* REACTOME:72764 Eukaryotic Translation Termination* REACTOME:72737 Cap dependent Translation Initiation* REACTOME:72706 GTP hydrolysis and joining of the 60S ribosomal subunit* REACTOME:72689 Formation of a pool of free S subunits* REACTOME:72649 Translation initiation complex formation* REACTOME:72613 Eukaryotic Translation Initiation* REACTOME:2433 Generation of second messenger molecules* REACTOME:2430 Translocation of ZAP 70 to Immunological synapse* REACTOME:2427 Phosphorylation of CD3 and TCR zeta chains* REACTOME:23 TCR signaling* REACTOME: Viral mrna Translation* REACTOME: ' UTR mediated translational regulation REACTOME: Peptide chain elongation* REACTOME: Eukaryotic Translation Elongation* REACTOME: L13a mediated translational silencing of Ceruloplasmin expression* DOWN: human_sle
13 DOWN: mouse_dm1 REACTOME:69278 Cell Cycle, Mitotic* REACTOME:69190 DNA strand elongation* REACTOME:69186 Lagging Strand Synthesis* REACTOME:699 Leading Strand Synthesis* REACTOME:69091 Polymerase switching* REACTOME:68962 Activation of the pre replicative complex* REACTOME: ATF4 activates genes REACTOME: Biological oxidations REACTOME: Regulation of beta cell development* REACTOME: Unwinding of DNA* REACTOME: Polymerase switching on the C strand of the telomere* KEGG:hsa04950 Maturity onset diabetes of the young* KEGG:hsa041 Cell cycle* KEGG:hsa03030 DNA replication* KEGG:hsa00982 Drug metabolism cytochrome P450 KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450 KEGG:hsa00380 Tryptophan metabolism* KEGG:hsa00350 Tyrosine metabolism* KEGG:hsa00330 Arginine and proline metabolism* KEGG:hsa00260 Glycine, serine and threonine metabolism*
14 DOWN: mouse_ms REACTOME: Muscle contraction* REACTOME: Striated Muscle Contraction* REACTOME: Extracellular matrix organization*
15 DOWN: mouse_ra REACTOME: Cell junction organization* REACTOME:4467 Type I hemidesmosome assembly* REACTOME: Laminin interactions* REACTOME: Activation of gene expression by SREBF (SREBP) REACTOME:22143 Anchoring fibril formation REACTOME: Integrin cell surface interactions* REACTOME:290 Assembly of collagen fibrils and other multimeric structures* REACTOME: VEGF binds to VEGFR leading to receptor dimerization* REACTOME: VEGF ligand receptor interactions* REACTOME: Cholesterol biosynthesis* REACTOME: Regulation of cholesterol biosynthesis by SREBP (SREBF) REACTOME: Cell Cell communication* REACTOME: O2/CO2 exchange in erythrocytes* REACTOME: Collagen formation* REACTOME: Erythrocytes take up oxygen and release carbon dioxide REACTOME: Erythrocytes take up carbon dioxide and release oxygen KEGG:hsa045 Focal adhesion* KEGG:hsa000 Steroid biosynthesis*
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