T. gondii. P. knowlesi

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1 KEGG - Citrate cycle (TCA cycle) KEGG - Fatty acid biosynthesis KEGG - Glutathione metabolism KEGG - Fatty acid metabolism KEGG - Polyketide sugar unit biosynthesis KEGG - Folate biosynthesis KEGG - Urea cycle and metabolism of amino groups KEGG - Glyoxylate and dicarboxylate metabolism KEGG - Novobiocin biosynthesis KEGG - Glutamate metabolism KEGG - Streptomycin biosynthesis KEGG - Nucleotide sugars metabolism KEGG - Thiamine metabolism KEGG - Nitrogen metabolism KEGG - Alanine and aspartate metabolism KEGG - Pentose phosphate pathway KEGG - Stilbene, coumarine and lignin biosynthesis KEGG - Oxidative phosphorylation KEGG - Sulfur metabolism KEGG - Methionine metabolism KEGG - Starch and sucrose metabolism KEGG - Arginine and proline metabolism KEGG - Styrene degradation KEGG - Riboflavin metabolism KEGG - Purine metabolism

2 KEGG - Methane metabolism KEGG - O-Glycan biosynthesis KEGG - Ubiquinone biosynthesis KEGG - Glycine, serine and threonine metabolism KEGG - Valine, leucine and isoleucine degradation KEGG - D-Arginine and D-ornithine metabolism KEGG - Carbazole degradation KEGG - Biphenyl degradation KEGG - 1,1,1-Trichloro-2,2-bis(4- chlorophenyl)ethane (DDT) degradation KEGG - Pyrimidine metabolism KEGG - Phenylalanine, tyrosine and tryptophan biosynthesis KEGG - gamma-hexachlorocyclohexane degradation KEGG - Toluene and xylene degradation KEGG - D-Alanine metabolism KEGG - Propanoate metabolism KEGG - Tyrosine metabolism KEGG - Valine, leucine and isoleucine biosynthesis KEGG - N-Glycan biosynthesis KEGG - Cysteine metabolism KEGG - beta-alanine metabolism KEGG - Ascorbate and aldarate metabolism KEGG - Inositol phosphate metabolism KEGG - Glycerolipid metabolism KEGG - 1,4-Dichlorobenzene degradation KEGG - Synthesis and degradation of ketone bodies

3 KEGG - Aminosugars metabolism KEGG - Terpenoid biosynthesis KEGG - Reductive carboxylate cycle (CO2 fixation) KEGG - Glycerophospholipid metabolism KEGG - Aminophosphonate metabolism KEGG - Indole and ipecac alkaloid biosynthesis KEGG - Pentose and glucuronate interconversions KEGG - Fluorene degradation KEGG - D-Glutamine and D-glutamate metabolism KEGG - Benzoate degradation via hydroxylation KEGG - Inositol metabolism KEGG - Vitamin B6 metabolism KEGG - Glycosphingolipid metabolism KEGG - 3-Chloroacrylic acid degradation KEGG - Lysine degradation KEGG - Lysine biosynthesis KEGG - Benzoate degradation via CoA ligation KEGG - Ethylbenzene degradation KEGG - Butanoate metabolism KEGG - Aminoacyl-tRNA biosynthesis KEGG - Penicillins and cephalosporins biosynthesis KEGG - Galactose metabolism KEGG - Phenylalanine metabolism KEGG - Biosynthesis of steroids KEGG - 1- and 2-Methylnaphthalene degradation

4 Ahr Signal Transduction Pathway KEGG - Glycolysis / Gluconeogenesis KEGG - Pantothenate and CoA biosynthesis KEGG - Bile acid biosynthesis KEGG - Selenoamino acid metabolism KEGG - C21-Steroid hormone metabolism KEGG - Carbon fixation KEGG - Histidine metabolism KEGG - Pyruvate metabolism KEGG - Fructose and mannose metabolism KEGG - Androgen and estrogen metabolism KEGG - Limonene and pinene degradation ADP-Ribosylation Factor AKAP95 role in mitosis and chromosome dynamics AKT Signaling Pathway ALK in cardiac myocytes ATM Signaling Pathway Acetylation and Deacetylation of RelA in The Nucleus Actions of Nitric Oxide in the Heart Activation of Csk by camp-dependent Protein Kinase Inhibits Signaling through the T Cell [...] Activation of PKC through G protein coupled receptor Activation of Src by Proteintyrosine phosphatase alpha Activation of campdependent protein kinase, PKA Acute Myocardial Infarction Adhesion Molecules on Lymphocyte

5 Alpha-synuclein and Parkinmediated proteolysis in Parkinson s disease Alternative Complement Pathway Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling Angiotensinconverting enzyme 2 regulates heart function Anthrax Toxin Mechanism of Action Antigen Dependent B Cell Activation Apoptotic DNA fragmentation and tissue homeostasis Apoptotic Signaling in Response to DNA Damage Aspirin Blocks Signaling Pathway Involved in Platelet Activation Attenuation of GPCR Signaling B Cell Receptor Complex B Lymphocyte Cell Surface Molecules BCR Signaling Pathway Basic Mechanisms of SUMOylation Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression Bioactive Peptide Induced Signaling Pathway Blockade of Neurotransmitter Relase by Botulinum Toxin Bone Remodelling Bystander B Cell Activation CARM1 and Regulation of the Estrogen Receptor CBL mediated ligandinduced downregulation of EGF receptors CCR3 signaling in Eosinophils CD40L Signaling Pathway CTL mediated immune response against target cells CXCR4 Signaling Pathway

6 Cytokines and Inflammatory Response Ca++/ Calmodulindependent Protein Kinase Activation Cadmium induces DNA synthesis and proliferation in macrophages Calcium Signaling by HBx of Hepatitis B virus Cardiac Protection Against ROS Caspase Cascade in Apoptosis Catabolic Pathways for Arginine, Histidine, Glutamate, Glutamine, and Proline Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine Cell Cycle: G1/S Check Point Cell Cycle: G2/M Checkpoint Cell to Cell Adhesion Signaling Cells and Molecules involved in local acute inflammatory response Ceramide Signaling Pathway ChREBP regulation by carbohydrates and camp Chaperones modulate interferon Signaling Pathway Circadian Rhythms Classical Complement Pathway Complement Pathway Control of skeletal myogenesis by HDAC & calcium/calmodulindependent kinase (CaMK) Corticosteroids and cardioprotection Cyclin E Destruction Pathway Cycling of Ran in nucleocytoplasmic transport Cyclins and Cell Cycle Regulation Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathwa [...] Cytokine Network

7 Function of SLRP in Bone: An Integrated View D4-GDI Signaling Pathway Degradation of the RAR and RXR by the proteasome Dendritic cells in regulating TH1 and TH2 Development Deregulation of CDK5 in Alzheimers Disease Double Stranded RNA Induced Gene Expression Downregulated of MTA-3 in ERnegative Breast Tumors E2F1 Destruction Pathway EGF Signaling Pathway EPO Signaling Pathway Effects of calcineurin in Keratinocyte Differentiation Electron Transport Reaction in Mitochondria Endocytotic role of NDK, Phosphins and Dynamin Eph Kinases and ephrins support platelet aggregation Erk and PI- 3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia Erk1/Erk2 Mapk Signaling pathway Erythrocyte Differentiation Pathway Erythropoietin mediated neuroprotection through NF-kB Extrinsic Prothrombin Activation Pathway FAS signaling pathway ( CD95 ) FOSB gene expression and drug abuse FXR and LXR Regulation of Cholesterol Metabolism Fc Epsilon Receptor I Signaling in Mast Cells Fibrinolysis Pathway Free Radical Induced Apoptosis

8 IL 4 signaling pathway G-Protein Signaling Through Tubby Proteins GATA3 participate in activating the Th2 cytokine genes expression Gamma-aminobutyric Acid Receptor Life Cycle Generation of amyloid b-peptide by PS1 Glycolysis Pathway Granzyme A mediated Apoptosis Pathway Growth Hormone Signaling Pathway HIV Induced T Cell Apoptosis HIV-1 defeats host-mediated resistance by CEM15 HIV-I Nef: negative effector of Fas and TNF Hemoglobin s Chaperone Hop Pathway in Cardiac Development How Progesterone Initiates the Oocyte Maturation How does salmonella hijack a cell Human Cytomegalovirus and Map Kinase Pathways Hypoxia and p53 in the Cardiovascular system Hypoxia- Inducible Factor in the Cardiovascular System IFN alpha signaling pathway IFN gamma signaling pathway IGF-1 Signaling Pathway IL 17 Signaling Pathway IL 18 Signaling Pathway IL 2 signaling pathway IL 3 signaling pathway

9 METS affect on Macrophage Differentiation IL 5 Signaling Pathway IL 6 signaling pathway IL-10 Anti-inflammatory Signaling Pathway IL-2 Receptor Beta Chain in T cell Activation IL-7 Signal Transduction IL12 and Stat4 Dependent Signaling Pathway in Th1 Development IL22 Soluble Receptor Signaling Pathway Inactivation of Gsk3 by AKT causes accumulation of b- catenin in Alveolar Macrophages Induction of apoptosis through DR3 and DR4/5 Death Receptors Influence of Ras and Rho proteins on G1 to S Transition Inhibition of Cellular Proliferation by Gleevec Inhibition of Huntington s disease neurodegeneration by histone deacetylase inhibitors Inhibition of Matrix Metalloproteinases Insulin Signaling Pathway Integrin Signaling Pathway Intrinsic Prothrombin Activation Pathway Ion Channel and Phorbal Esters Signaling Pathway Keratinocyte Differentiation Lck and Fyn tyrosine kinases in initiation of TCR Activation Lectin Induced Complement Pathway Leloir pathway of galactose metabolism Links between Pyk2 and Map Kinases Lowdensity lipoprotein (LDL) pathway during atherogenesis MAPKinase Signaling Pathway

10 Oxidative Stress Induced Gene Expression Via Nrf2 Malate-aspartate shuttle Map Kinase Inactivation of SMRT Corepressor Mechanism of Acetaminophen Activity and Toxicity Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) Mitochondrial Carnitine Palmitoyltransferase (CPT) System Monocyte and its Surface Molecules Msp/Ron Receptor Signaling Pathway Multi-Drug Resistance Factors Multi-step Regulation of Transcription by Pitx2 Multiple antiapoptotic pathways from IGF- 1R signaling lead to BAD phosphorylation NF-kB Signaling Pathway NFAT and Hypertrophy of the heart (Transcription in the broken heart) NFkB activation by Nontypeable Hemophilus influenzae NO2-dependent IL 12 Pathway in NK cells Nerve growth factor pathway (NGF) Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells Neuroregulin receptor degredation protein- 1 Controls ErbB3 receptor recycling Neutrophil and Its Surface Molecules Nitric Oxide Signaling Pathway Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactiv [...] OX40 Signaling Pathway Opposing roles of AIF in Apoptosis and Cell Survival Overview of telomerase RNA component gene hterc Transcriptional Regulation Overview of telomerase protein component gene htert Transcriptional Regulation

11 PDGF Signaling Pathway PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase PTEN dependent cell cycle arrest and apoptosis Pelp1 Modulation of Estrogen Receptor Activity Pertussis toxininsensitive CCR5 Signaling in Macrophage Phosphoinositides and their downstream targets. Phospholipase C Signaling Pathway Phospholipase C d1 in phospholipid associated cell signaling Phospholipase C-epsilon pathway Phospholipids as signalling intermediaries Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway Presenilin action in Notch and Wnt signaling Proepithelin Conversion to Epithelin and Wound Repair Control Protein Kinase A at the Centrosome Proteolysis and Signaling Pathway of Notch RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage Rab GTPases Mark Targets In The Endocytotic Machinery Rac 1 cell motility signaling pathway Ras Signaling Pathway Ras-Independent pathway in NK cellmediated cytotoxicity Reelin Signaling Pathway Regulation of BAD phosphorylation Regulation of PGC-1a Regulation of Spermatogenesis by CREM Regulation of cell cycle progression by Plk3

12 Regulation of ck1/cdk5 by type 1 glutamate receptors Regulation of eif2 Regulation of eif4e and p70 S6 Kinase Regulation of hematopoiesis by cytokines Regulation of p27 Phosphorylation during Cell Cycle Progression Regulation of transcriptional activity by PML Repression of Pain Sensation by the Transcriptional Regulator DREAM Reversal of Insulin Resistance by Leptin Rho cell motility signaling pathway Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy Role of Erk5 in Neuronal Survival Role of MEF2D in T-cell Apoptosis Role of Mitochondria in Apoptotic Signaling Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration Role of PPARgamma Coactivators in Obesity and Thermogenesis Role of Parkin in the Ubiquitin- Proteasomal Pathway Role of Tob in T-cell activation Role of nicotinic acetylcholine receptors in the regulation of apoptosis SARS Coronavirus Protease SODD/TNFR1 Signaling Pathway SREBP control of lipid synthesis Selective expression of chemokine receptors during T- cell polarization Shuttle for transfer of acetyl groups from mitochondria to the cytosol

13 The 4-1BB-dependent immune response Signal Dependent Regulation of Myogenesis by Corepressor MITR Signal transduction through IL1R Signaling Pathway from G-Protein Families Signaling of Hepatocyte Growth Factor Receptor Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway Small Leucine-rich Proteoglycan (SLRP) molecules Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle Sonic Hedgehog (Shh) Pathway Sprouty regulation of tyrosine kinase signals Stat3 Signaling Pathway Stress Induction of HSP Regulation T Cell Receptor Signaling Pathway T Cell Receptor and CD3 Complex T Cytotoxic Cell Surface Molecules T Helper Cell Surface Molecules TACI and BCMA stimulation of B cell immune responses. TGF beta signaling pathway TNF/Stress Related Signaling TNFR1 Signaling Pathway TNFR2 Signaling Pathway TPO Signaling Pathway TSP- 1 Induced Apoptosis in Microvascular Endothelial Cell Telomeres, Telomerase, Cellular Aging, and Immortality Th1/Th2 Differentiation

14 The Co-Stimulatory Signal During T- cell Activation The IGF-1 Receptor and Longevity The Role of Eosinophils in the Chemokine Network of Allergy The role of FYVEfinger proteins in vesicle transport Thrombin signaling and proteaseactivated receptors Toll-Like Receptor Pathway Transcription Regulation by Methyltransferase of CARM1 Transcription factor CREB and its extracellular signals Transcriptional activation of dbpb from mrna Trka Receptor Signaling Pathway Tumor Suppressor Arf Inhibits Ribosomal Biogenesis VEGF, Hypoxia, and Angiogenesis Visceral Fat Deposits and the Metabolic Syndrome Vitamin C in the Brain WNT Signaling Pathway Y branching of actin filaments cdc25 and chk1 Regulatory Pathway in response to DNA damage fmlp induced chemokine gene expression in HMC-1 cells g-secretase mediated ErbB4 Signaling Pathway mcalpain and friends in Cell motility mtor Signaling Pathway p38 MAPK Signaling Pathway p53 Signaling Pathway ucalpain and friends in Cell spread KEGG - 1,2-Dichloroethane degradation

15 KEGG - Cholera - Colonization KEGG - 2,4-Dichlorobenzoate degradation KEGG - ABC transporters, prokaryotic KEGG - ATP synthesis KEGG - Adherens junction KEGG - Alkaloid biosynthesis KEGG - Alzheimer s disease KEGG - Amyotrophic lateral sclerosis (ALS) KEGG - Apoptosis KEGG - Atrazine degradation KEGG - Bacterial chemotaxis KEGG - Basal transcription factors KEGG - Biosynthesis of 12-, 14- and 16-membered macrolides KEGG - Biosynthesis of ansamycins KEGG - Biosynthesis of siderophore group nonribosomal peptides KEGG - Biosynthesis of type II polyketide backbone KEGG - Biosynthesis of type II polyketide products KEGG - Biotin metabolism KEGG - Bisphenol A degradation KEGG - Blood group glycolipid biosynthesis-lactoseries KEGG - Blood group glycolipid biosynthesis-neolactoseries KEGG - C5-Branched dibasic acid metabolism KEGG - Calcium signaling pathway KEGG - Caprolactam degradation KEGG - Cell cycle

16 KEGG - Jak-STAT signaling pathway KEGG - Cholera - Diarrhea KEGG - Cholera - Environment KEGG - Cholera - Infection KEGG - Cholera - Life cycle KEGG - Chondroitin / Heparan sulfate biosynthesis KEGG - Circadian rhythm KEGG - Complement and coagulation cascades KEGG - Cyanoamino acid metabolism KEGG - Cytokine-cytokine receptor interaction KEGG - DNA polymerase KEGG - Dentatorubropallidoluysian atrophy (DRPLA) KEGG - Diterpenoid biosynthesis KEGG - Dorso-ventral axis formation KEGG - ECM-receptor interaction KEGG - Flagellar assembly KEGG - Flavonoid biosynthesis KEGG - Focal adhesion KEGG - Ganglioside biosynthesis KEGG - Globoside metabolism KEGG - Glycosaminoglycan degradation KEGG - Glycosylphosphatidylinositol(GPI)-anchor biosynthesis KEGG - Hedgehog signaling pathway KEGG - High-mannose type N-glycan biosynthesis KEGG - Huntington s disease

17 KEGG - Regulation of actin cytoskeleton KEGG - Keratan sulfate biosynthesis KEGG - Lipopolysaccharide biosynthesis KEGG - MAPK signaling pathway KEGG - Monoterpenoid biosynthesis KEGG - N-Glycan degradation KEGG - Neuroactive ligand-receptor interaction KEGG - Neurodegenerative Disorders KEGG - Nicotinate and nicotinamide metabolism KEGG - Nitrobenzene degradation KEGG - None KEGG - Nonribosomal peptide structures KEGG - Notch signaling pathway KEGG - One carbon pool by folate KEGG - Parkinson s disease KEGG - Peptidoglycan biosynthesis KEGG - Phosphatidylinositol signaling system KEGG - Phosphotransferase system (PTS) KEGG - Photosynthesis KEGG - Porphyrin and chlorophyll metabolism KEGG - Prion disease KEGG - Prostaglandin and leukotriene metabolism KEGG - Proteasome KEGG - Protein export KEGG - RNA polymerase

18 KEGG - beta-lactam resistanse KEGG - Retinol metabolism KEGG - Ribosome KEGG - TGF-beta signaling pathway KEGG - Taurine and hypotaurine metabolism KEGG - Tetrachloroethene degradation KEGG - Tight junction KEGG - Toll-like receptor signaling pathway KEGG - Tryptophan metabolism KEGG - Two-component system KEGG - Type I polyketide structures KEGG - Type II secretion system KEGG - Type III secretion system KEGG - Type IV secretion system KEGG - Ubiquitin mediated proteolysis KEGG - Wnt signaling pathway

Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers

Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers ListHits ListTotal PopulationHits PopulationTotal Terms 3 72 10 1429 Glycolysis Pathway 3 72 11 1429 Regulation