STIMU-TEX AS. Immediate relief for sensitive & irritated skin

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1 Immediate relief for sensitive & irritated skin

2 Feel comfortable again in your skin Mechanisms Up to % of consumers claim that their skin feels sensitive or even itchy. In order to feel good, our skin needs something to counterbalance the aggravating stimuli present in our everyday environment. Just as a cool breeze provides that instant feeling of relief on a warm summer evening, skin sensation and appearance can be significantly improved with a touch of soothing, wholesome care and repair. Dry and sensitive skin is characterized by a weak barrier function and a low threshold for allergic reactions, which can be triggered by different stimuli present in our environment. In response, DSM has developed, which effectively eases sensitive skin complaints thanks to the complementary skin-care properties of its three compounds. In answer to this, DSM developed, a unique mixture of high-quality spent grain wax, cold-processed argan oil, and shea butter. Well-known for centuries for their beneficial effects on the skin, these natural substances have been combined for the first time to deliver effective relief to sensitive skin. visibly reduces histamine-related symptoms like irritation and itching within 5 minutes. The result is a truly soothed and flawless skin. Key facts Unique product features Optimized mixture of spent grain wax, argan oil, and shea butter, processed by high-performing technologies in vitro proven nearly complete inhibition of the bioactivity effects of histamine Significantly ex vivo decrease of inflammation by 58% Benefits Effective relief within 5 minutes for a truly soothed and flawless skin Liberating feeling of ultimate skin comfort by significant reduction of itching and reddening effectively helps to inhibit epidermal inflammation processes. helps to strongly reduce the effects of histamine release. visibly regenerates irritated skin. Stressed skin s red appearance and itchy sensation are substantially alleviated, leaving the skin looking healthy and feeling soothed. is ECOCERT approved and NATRUE certified. Raw material approved by ECOCERT GREENLIFE, conform to the ECOCERT Natural and Organic Cosmetics Standard complies with the NATRUE Criteria. 99.9% Natural (% Organic) % Water.1% Derived natural % Nature-identical Cosmetic application Stress relief cosmetic lines for sensitive and irritated skin Intense soothing cosmetics to alleviate itchy skin Nourishing and regenerating day and night creams Suggested concentration 1 5% in cosmetic formulations INCI name (active) Spent grain wax, Butyrospermum parkii (shea butter) extract, Argania spinosa kernel oil

3 Science meets tradition Consumers around the world are increasingly looking for authentic products with scientifically proven efficacy. Rediscovering heritage ingredients for use in our modern world is proving popular among those who want to nourish their skin and soul for a naturally flawless look. Individually, the three natural compounds that make up have been protecting skin down through the ages. But only now have they been combined to address the needs of sensitive and irritated skin. Argan oil has been valued for its numerous health and beauty benefits for centuries. This oil is obtained from the seeds of Argania spinosa, a tree endemic to southwest Morocco. It is known to the Berbers living there as the Tree of Life. Moroccan women have traditionally regarded argan oil as a beauty elixir, using it daily in topical applications for skin, hair and nail care, and also integrating it into their diet. is ECOCERT approved and NATRUE certified. Spent grain wax - the key ingredient of For generations, beer brewers have been aware of the ability of spent grain wax to soothe skin and relieve itching. Dermatological studies 1 performed on skin with atopic conditions have confirmed this traditional knowledge. Equally outstanding results were achieved when a spent grain extract was applied to skin through baththerapy or in a cosmetic cream. These treatments not only alleviated itching significantly, they also stopped it recurring. But what exactly is spent grain wax? It is what remains once pure barley (Hordeum vulgare) has been progressively transformed into malt through several stages of physical and fermentative processing. DSM obtains spent grain wax through extraction from malt using supercritical CO2. This high-tech extraction process is particularly gentle and produces golden, 1%-pure spent grain wax which is free from organic solvents and preservatives. It contains large amounts of unsaturated fatty acids, which are essential for the regeneration of the epidermal barrier and for maintaining homeostasis in the skin. Our gentle cold-pressing process provides a perfectly balanced oil which is highly concentrated in active compounds. Up to 8% unsaturated fatty acids, combined with polyphenols, tocopherols, phenolic acids, and squalene give it a unique profile and make it highly valuable for skin care. Its nourishing, regenerating, and protecting qualities help maintain skin s youthful assets. Shea butter, the African wonder, has been used in Egypt for at least 2, years for its soothing properties. It is believed that Queen Nefertiti owed the magnificence of her beauty to the daily use of shea butter, which contains extraordinary skin healing, regenerating, and emollient components. The shea tree itself can live for as long as years. The extraction of the fruit s kernels provides the butter, which consists mostly of fatty acids linoleic acid in particular and unsaponifiables such as phytosterols called sheasterols, which stimulate healthy cellular processes and cell regeneration. 1 Entwicklung und Prüfung eines neuen dermatologisch-kosmetischen Wirkstoffes aus Gerstentreber (development and testing of a new dermatological-cosmetic active ingredient from barley grains), H. Tronnier, P. Haas and L. Motitschke, Ärztliche Kosmetologie 17, (1987)

4 Efficacy in vitro Efficacy ex vivo Histamine effect blocking assay Anti-inflammatory assay Histamine is a marker for allergic reactions. Histamine-blocking products inhibit the symptoms of allergy such as itching, swelling, and red skin. An in vitro assay with human endothelial cells was developed to quantify histamine effects: Histamine combined with TNF (Tissue Necrosis Factor) enhances the induction of E-selectin on endothelial cells. E-selectin induction is the starting point of an inflammatory reaction. 7 Histamine blocking activity 66.2 Determination of the inflammation marker interleukin-1α, released in the supernatants of stripped human skin disks. A human skin fragment was taken after abdominal plastic surgery and stripped 1 times. was tested on the skin surface at a concentration of 1 mg/cm2. Dexamethasone is a glucocorticoid, used as positive control. Anti-inflammatory activity * p < % E-selectin positive cells IL-1α [pg] -58% * Medium + TNF TNF + Histamine TNF + Histamine + Result: nearly completely blocks E-selectin expression on endothelial cells, a downstream target of histamine. Blank, stripped Dexamethasone 1μM Result: significantly decreases the expression of IL-1α by 58%, a marker for inflammatory reactions.

5 Anti-inflammatory activity Histamine blocking activity 7 Efficacy in vivo % Histamine alleviating efficacy The release of histamine induces a vasodilatation, an increase of vascular permeability, inflammation, and skin redness. Laser Doppler flow measurements enable this increased blood flow to be quantified. Histamine was applied on the inner forearm of 1 healthy female volunteers between the ages of 18 and 39. Penetration of histamine 1 skin was stimulated non-invasively by iontophoresis in into the order to produce a mild reaction. Results for distilled water 1.1 histamine alone (positive control), and 5% (negative control), STIMU-TEX AS with histamine were compared. Medium + STIMU-TEX AS TNF + Histamine + AS STIMU-TEX The reactions were determined non-invasively as perfusion TNF TNF + Histamine modification by means of a laser Doppler imager and as wheal formation by computerized surface measurement. Mean wheal extent 18 1 * p <.5 ** p <.1 Water Iontophoresis Histamine Iontophoresis STIMU-TEX AS + Histamine * Wheal area [mm2] 1 ** mins Spent grain wax the key ingredient of STIMU-TEX AS 5 mins mins Result: A 5% STIMU-TEX AS formulation significantly reduces histaminerelated symptoms by % after as little as 5 minutes. IL-1α [pg] % E-selectin positive cells * p < * 1 Liberating feeling of ultimate skin comfort by significant reduction of itching and reddening Blank, stripped Dexamethasone 1μM STIMU-TEX AS

6 Europe DSM Nutritional Products Europe Ltd. P.O. Box 2676, 2 Basel Switzerland Phone: Fax: info.pc-emea@dsm.com Asia Pacific DSM Singapore Industrial Pte Ltd. trading as DSM Nutritional Products Asia Pacific Pasir Panjang Road Mapletree Business City #13-31 Singapore 1174 Phone: Fax: info.pc-apac@dsm.com North America DSM Nutritional Products, LLC 45 Waterview Boulevard, Parsippany, NJ 754 United States of America Phone: Fax: info.pc-na@dsm.com Latin America DSM Produtos Nutricionais Brasil S.A. Avenida Engenheiro Billings, 1729 Prédio 31 Sala A - CEP:5321-1, São Paulo SP Brasil Phone: Fax: info.pc-latam@dsm.com 15 DSM Nutritional Products, 2 Basel, Switzerland. All rights reserved. No part of this brochure may be reproduced, distributed or translated in any form or by any means, or stored in a database or retrieval system, without the prior written permission of DSM Nutritional Products AG ( DSM ). While making reasonable efforts to ensure that all information in this brochure is accurate and up to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. Use of this information shall be at your discretion and risk. Nothing herein relieves you from carrying out your own suitability determinations and tests and from your obligation to comply with all applicable laws and regulations and to observe all third party rights. The uses and claims for DSM s products recommended in the brochure should be adapted to the current local regulatory environment. We disclaim any and all liability in connection with your product or its use. P