Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells

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1 Chinese Journal of Tissue Engineering Research October 1, 2015 Vol.19, No.41 ( ) 1 2 3, PubMed(CNKI) Articular cartilage injury Bone marrow mesenchymal stem cells :R318 :A : (2015) [J] (41): doi: /j.issn Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells Hou Wei-yu, Cheng Yan-wei, Xiang Chuan (Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China) Abstract BACKGROUND: Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles have been confirmed in various tissue repairs, which are expected to become more effective and safe therapy for articular cartilage repair. OBJECTIVE: To overall understand the research progress in the use of induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles in articular cartilage repair. METHODS: A computer-based search of PubMed and CNKI was performed by the first author for articles related to stem cell treatment of osteoarthritis published from 2003 to The keywords were articular cartilage injury, bone marrow mesenchymal stem cells in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. RESULTS AND CONCLUSION: Articular cartilage injury is still a difficulty in the orthopedics. Many repair methods have been reported, but they all have limitations. Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles bring a new hope for patients with articular cartilage injury. However, there are still many problems to be solved, such as extracting and purifying a large amount of cells, proliferation and differentiation potentials, and mechanism underlying cartilage repair. Subject headings: Cartilage Diseases; Cartilage, Articular; Induced Pluripotent Stem Cells; Mesenchymal Stem Cells; Tissue Engineering Hou Wei-yu, Master, Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Corresponding author: Xiang Chuan, M.D., Associate professor, Second Affiliated Hospital of Shanxi Medical University, Taiyuan , Shanxi Province, China Accepted: P.O. Box 10002, Shenyang

2 . Hou WY, Cheng YW, Xiang C. Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(41): Introduction 5% 22% 50% [1] [2] 1 Data and methods 1.1 PubMed (CNKI) PubMed Articular cartilage injury, Bone marrow mesenchymal stem cellsand Results % 80% 10% 15% [3] [4] 2.2 ( ) ( 80% 90%) [5] [6] [7] [8] [9] Noble [10] 1995 [10-13] [14-15] [16-17] 2.3 (MSCs-MVs) () nm ISSN CN /R CODEN: ZLKHAH 6707

3 . [18] 1967 Wolf ( mrna sirna microrna ) [19] [20] P53 [19] [21] Bruno [22-23] 2009 SCID 2011 RNA [24] mrna Zhang [25] Zhu [26] Mokarizadeh [27] Wistar Strassburg [28] ( 1) Diao [29] 1 A 1 µm B T T [30] [31] [32] [33] [22] Takahashi [34] Oct4 Sox2 c-myc Klf4 4 [35] Hou [36] P.O. Box 10002, Shenyang

4 Zou [37] 2012 Diekman [38] [39-40] [41] Yamashita [42] 3 Conclusion ( ) ( ) 4 References [1] Piasecki DP, Spindler KP, Warren TA, et al. Intraarticular injuries associated with anterior cruciate ligament tear: findings at ligament reconstruction in high school and recreational athletes. An analysis of sex-based differences. Am J Sports Med. 2003;31(4): [2]. [J]., 2006,19(7): [3].[J].,1995,10(1): [4]. [J].,2008,10(3): ISSN CN /R CODEN: ZLKHAH 6709

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