The OpenGATE Collaboration

Transcription

1 GATE Simulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy The OpenGATE Collaboration Introduction Short History Code Status GATE Training, INSTN-Saclay, October 2015 Irène Buvat SHFJ CEA Orsay, France

2 What is GATE? GATE: Geant4 Application for Emission Tomography, Transmission Tomography, Radiotherapy and Optical Imaging GATE is an Opensource software dedicated to the simulation of imaging (SPECT, PET, CT, Optical) and radiotherapy, and based on the Geant4 toolbox First release of GATE in May releases since that date Currently GATE V6.2, very soon GATE V7 Broad range of applications: - Detector design - Optimisation of acquisition and processing protocols - Assessment of quantification methods - Estimation of the system matrix used in tomographic reconstruction - Dosimetry - 2

3 A brief history of GATE Initial idea under the leadership of Christian Morel (EPFL Lausanne) in 2001 at a Monte Carlo simulation workshop organized by Irène Buvat (U494 Inserm) in Paris First developments end of 2001, by 4 labs: EPFL Lausanne, LPC Clermont-Ferrand, University of Ghent, U494 Inserm Creation of the OpenGATE collaboration in 2002 First release of GATE in May releases since that date (2 releases/year) Currently GATE V6.2 2nd major release of GATE in February 2010: GATE V6 Increasing range of applications 3

4 The OpenGATE collaboration 19 labs, sharing developments and validation studies regarding GATE, and working together to make these developments publicly available France U892 Inserm, Nantes U1101 Inserm, Brest IMNC CNRS, Orsay LPC CNRS, Clermont Ferrand IPHC CNRS, Strasbourg UMR5515 CNRS, CREATIS, Lyon CPPM CNRS, Marseille Subatech CNRS, Nantes SHFJ CEA, Orsay U1037 Inserm, Toulouse Europe Delft University of Technology, Delft, The Netherlands Forschungszentrum Juelich, Germany National Technical University of Athens, Greece Medical University Vienna, Wien, Austria MedAustron, Wiener Neustadt, Wien, Austria Rest of the world Memorial Sloan-Kettering Cancer Center, New York, USA UC Davis, Davis, USA University of Santiago of Chile, Chile Sungkyunkwan University School of Medicine, Seoul, South Korea 4

5 The OpenGATE collaboration OpenGATE collaborators meet twice a year, and communicate any time via a gate-devel mailing list The OpenGATE collaboration steering committee consists of one representative of each of the 19 labs OpenGATE collaboration organization: A spokesperson (Christian Morel , Irène Buvat since 2005) A technical coordinator (Daniel Strul , Sébastien Jan since 2003) A GATE-dedicated engineer (Didier Benoit , Albertine Dubois since 2013) 5

6 Role of the OpenGATE collaboration Upgrade GATE to follow the Geant4 releases Add new functionalities to GATE Organize training Publish articles demonstrating the usefulness of GATE: > 80 peer-reviewed GATE-related papers produced by members of the collaboration 6

7 GATE landmarks Official initial GATE publication in Physics in Medicine and Biology 7

8 GATE landmarks Second publication related to the 2nd major GATE release 8

9 GATE landmarks Recent publication related to the extension of GATE to support Optical Imaging simulations 9

10 GATE landmarks A review of the applications of GATE for dosimetry and radiation therapy A review of the potential of GATE for radiation therapy and dosimetry applications David Sarrut, 1 Manuel Bardiès, 2 Nicolas Boussion, 3 Nicolas Freud, 1 Sébastien Jan, 4 Jean- Michel Létang, 1 George Loudos, 5 Lydia Maigne, 6 Sara Marcatili, 2 Thibault Mauxion, 2 PanagiotisPapadimitroulas, 5 Yann Perrot, 6 Uwe Pietrzyk, 7, 8 Charlotte Robert, 9 Dennis R. Schaart, 10 DimitrisVisvikis, 3 and Irène Buvat, 4 To be published in Medical Physics 2014 Whenever you use GATE in your work, please cite these papers because this helps us find funding to support the collaboration on the long term 10

11 GATE landmarks GATE URL: GATE user mailing list: GATE documentation (wiki): To install GATE: To use GATE: GATE publications: 11

12 GATE funding French Research Agency: fgate : Contract number ANR 06-CIS ( ) hgate: Contract number ANR 09-COSINUS ( ) French Research Cancer Institute : Physicancer IMADRON ( ) European Commission: FP Cooperation: ENVISION project ( ) 12

13 Main technical features of GATE (1) GATE is based on Geant4: GATE is written in C++ GATE is user-friendly as simulations can be designed and controlled using macros, without any C++ writing GATE can simulate SPECT, PET, CT and optical scans and radiotherapy treatments GATE is flexible enough to model almost any detector design, including prototypes GATE explicitly models time, hence makes it possible to model detector motion, patient motion, radioactive decay, optical photon tracking, dead time, time of flight, tracer kinetics GATE can handle analytical or voxelized phantoms GATE can run on a cluster architecture and on a grid 13

14 Main technical features of GATE (2) GATE can be freely downloaded, including sources GATE can be run on many platforms (Linux, MAC OS, Windows) Online documentation about GATE, including FAQ Help about the use of GATE can be obtained through the gate-user mailing list (more than 1500 subscribers) Archives of the gate-user posts on Many commercial or prototype systems have already been modeled using GATE and most models have been thoroughly validated (list available on The GATE project is mostly based on volunteer participation and on the active contribution of GATE developers and users 14

15 Geant4 & GATE releases: Overview & Summary Geant4 Geant4 version Date release CLHEP version Gcc version 9.5.p02 10/ x to p02 05/ x to beta 06/ x to GATE V6.2: current GATE release from 09/2012 Recommended platform: 1 Validated for Geant4 releases: 9.5.p01/p02 2 CLHEP version: recommended by the Geant4 version 3 gcc 4.1 to gcc Mac OS: OK 5 ROOT: last versions (according to the ROOT install specificities) 15

16 Based on Geant4 9.5 & 9.6 GATE V7.0 Supporting optical imaging simulations, including bioluminescence and fluorescence Supporting PET and CT simulations on a GPU engine Unification of image readers and navigators between imaging applications and radiation therapy applications Geant4 DNA processes & physics list mechanism Washout model for hadrontherapy applications (Mizuno et al model, PMB 2003) To be released in April 2014 First patch to be released in summer Including Optical GPU modules - Possibly including Dosimetry modules 16