GATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT
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1 GATE MONTE CARLO DOSIMETRY SIMULATION OF MARS SPECTRAL CT R Aamir, C Lowe, J Damet, P Carbonez, A P H Butler, N Schleich, N G Anderson MARFO, Emmanuel Geant4 User Workshop 2017, Wollongong
2 Overview MARS scanner and its applications In-silico modelling of MARS scanner using GATE Monte Carlo toolkit Validation of MARS scanner x-ray spectrum in GATE
3 INTRODUCTION(1/4) MARS Scanner Identification of Multiple High Z materials (a) MARS small bore animal scanner. (b) Inside view showing a phantom mounted on a sample holder between the x-ray source and MARS camera. (c) MARS gantry removed from the scanner. Detector 3
4 INTRODUCTION(2/4) Areas of preclinical research using MARS-CT Soft tissue quantification Biological specimen imaging(multiple targeted agents) Cancer research Dosimetry 4
5 INTRODUCTION(3/4) Areas of preclinical research using MARS-CT Dosimetry 5
6 INTRODUCTION(4/4) GATE: Geant4 Application for Emission Tomography Why GATE was Chosen Open source software and User-friendly Imaging application, Radiation therapy and Dosimetry Widely validated and frequently used 6
7 SIGNIFICANCE OF STUDY Implementation of MARS scanner into GATE platform Understand the radiation deposition through simulation and actual measurement Reduce experimental (dosimetry) and time cost 7
8 OBJECTIVES To implement a MARS scanner model into GATE To validate the simulated results with the experimental data. To integrate a voxelised phantom from MARS scans into GATE for 3D spatial dose mapping. 8
9 MATERIALS AND METHODS(1/10) Specification of MARS scanner X-ray tube 1 mm Tungsten target 20 anode angle Cathode Anode 1.8 mm Aluminium equivalent inherent filtration at 120 kvp mm electron focal spot KVp range x-ray tube in the source unit (Adapted from Manez, 2012) ua range 9
10 MATERIALS AND METHODS (2/10) GATE TOOLKIT(v7.2) MAIN STEPS IN GATE DOSIMETRIC APPLICATION Four major steps 10
11 MATERIALS AND METHODS (3/10) GATE TOOLKIT(v7.2) MAIN STEPS IN GATE DOSIMETRIC APPLICATION Phantom description TLD and CTDI PMMA phantom Source description Actors Energy Physics spectrum definition Calculated x-ray energy spectrum emstandard_opt3 actor from BeamNRC as Dose actor GPS in GATE 11
12 MATERIALS AND METHODS(4/10) ION CHAMBER AND CTDI PHANTOM CTDI Phantom CTDI Phantom specification PMMA 30 mm outer diameter and 12 mm inner diameter and 100 mm long Red: CTDI ion chamber, Cyan: CTDI phantom Unfors Raysafe Solo CT detector Ion chamber specification ~6 mm diameter and 100 mm long 12
13 MATERIALS AND METHODS(5/10) PHANTOM WITH TLD100 TLD and Phantom Specification Phantom TLD TLD100(3.2mm 3.2mm 0.9mm) Composition(2.635g/cm3, Li(0.26), F(0.73) 28mm diameter phantom 13
14 MATERIALS AND METHODS (6/10) GATE TOOLKIT(v7.2) MAIN STEPS IN GATE DOSIMETRIC APPLICATION Physics definition emstandard_opt3 Source Actors description Energy Calculated x-ray spectrum energy actor spectrum Dose from actor BeamNRC as GPS in GATE 14
15 MATERIALS AND METHODS (7/10) GATE TOOLKIT(v7.2) MAIN STEPS IN GATE DOSIMETRIC APPLICATION Actors Energy spectrum actor Dose actor 15
16 MATERIALS AND METHODS (8/10) GATE TOOLKIT(v7.2) MAIN STEPS IN GATE DOSIMETRIC APPLICATION Actors Phantom description Energy spectrum actor TLD and CTDI PMMA phantom Dose actor Source description Calculated x-ray energy spectrum from BeamNRC as GPS in GATE 16
17 MATERIALS AND METHODS (9/10) HELICAL AND CIRCULAR SCANNING TCR = N p DT + ET (1) RR = 360 TCR (2) S TR = L B CL TCR SL +B CL (3) Where; TCR= total time for complete rotation(s/rotation) N p =Number of projection frames DT=detector dead time per step (ms) ET=exposure time per step (ms) RR= rotation rate (deg/s) TR= translation rate (mm/s) S L = sample scan length (mm) B CL = beam collimation width (mm) 17
18 COMMON SCAN PARAMETERS Brass filter protocol 118 kvp SDD = 250mm Exposure time = 220ms Circular Projections = 720 Scan parameters CTDI detector/tld Tube current(µa) MATERIALS AND METHODS(10/10) SCAN PARAMETERS X-ray Photon source Collimator Phantom y z X-ray photons x TLD 24,34,44,54 GUI OF GATE dosimetry of MARS scanner CTDI detector 65,70,80 18
19 RESULTS AND DICUSSIONS VALIDATION OF GATE SPECTRUM 19
20 RESULTS AND DICUSSIONS EXPERIMENTAL RESULTS VS SIMULATED RESULTS Phantom with TLD Tube current(ua) Experimental Absorbed dose(mgy) Simulated Absorbed dose(mgy)
21 SUMMARY COMPLETED TASK UNCOMPLETED TASK To implement a MARS-CT model into GATE Implementation of source model Implementation of scanner geometry To validate the simulated results with the experimental data. To integrate a patient data from MARS scans into GATE for 3D spatial dose mapping. Scatter dose in voxelised phantom(patient data) 21
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