RAMATHIBODI CANCER REPORT

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2 RAMATHIBODI CANCER REPORT 2016 Ramathibodi Cancer Registry : A subsidiary of Ramathibodi Comprehensive Cancer Center Faculty of Medicine, Ramathibodi Hospital Mahidol University

3 Table of content INTRODUCTION...III ACKNOWLEDGEMENTS...IV RAMATHIBODI HOSPITAL CANCER COMMITTEE, V RAMATHIBODI HOSPITAL CANCER REGISTRY COMMITTEE, VI CHAPTER I... 1 REGISTRY PROCEDURE AND STATISTICAL METHODS Purpose of the registry Data collection Statistical Methods... 2 CHAPTER II... 3 OVERALL CANCERS... 3 Table 2.1 Most valid method of diagnosis Table 2.2 Number of cancer case by staging of present extent of disease.. Error! Bookmark not defined. Table 2.3 Number of cancer case by age and sex, CHAPTER III... 6 TEN LEADING SITES OF CANCER, Table 3.1 Ten leading sites of cancer in both sexes Table 3.2 Ten leading sites of cancer in male Table 3.3 Ten leading sites of cancer in female Table 3.4 Site of cancer in childhood by ICCC, age<15, both sexes CHAPTER IV RAMATHIBODI CANCER REGISTRY Table 4.1 Annual reports Table 4.2 Percentage of morphologically verified and death certificate only case Table 4.3 Number of cancer case by site, sex and age Table 4.4 Number of cancer case by primary site Table 4.5 Number of cancer case by pathology according to site CHAPTER V THE MOST COMMON CANCER SITES BREAST LUNG AND BRONCHUS CERVIX UTERI LIVER ANDINTRAHEPATIC BILE DUCTS BILE DUCTS COLORECTAL HEMATOPOIETIC AND RETICULOENDOTHELIAL CHILDHOOD CANCER CHAPTER VI Distribution by Regional of Thailand CHAPTER VII...71 Kaplan-Meier Survival Curve and the Log rank test...71

4 INTRODUCTION Ramathibodi Cancer Registry 2016 is the result of the fruitful collaboration between units and departments of the faculty of medicine, Ramathibodi Hospital, Mahidol University. I would like to thank all of our collaborators for their help in providing data presented in this volume of Cancer Registry. Ramathibodi Comprehensive Cancer Registry provides the hospital-based cancer data of new cancer cases each year. This data provides important base is information in the field of research and policy making. I hope that the data from this Cancer Registry will benefit health personals, physicians, medical students researchers, patients, relatives and eventually general population. Association. Professor. Surasak Leelaudomlipi Director of Ramathibodi Hospital Faculty of medicine, Ramathibodi Hospital Mahidol University III

5 ACKNOWLEDGEMENTS We would like to express our gratitude to: The dean of Faculty of Medicine Ramathibodi Hospital; Professor Piyamitr Sritara, for his support and providing resources for this Cancer Registry. The former chairman of Ramathibodi Comprehensive Cancer Registry Committee; Assistant Professor SomjaiDangprasert for her initiation and advice in preparing this report. The director of Ramathibodi Hospital, Associate Professor Surasak Leelaudomlipifor all his support and advise. The Ramathibodi Hospital Cancer Committee members and Cancer Registry Committee members for their hard work in contribution to the preparation of the Cancer Registry manuscript. Medical Informatics unit staffs of the Faculty of Medicine, Ramathibodi Hospital for their continuous support in the data collection. And finally, we would like to give a special thank to the Cancer Registry Coordinators and her team who have pushed their maximum efforts in contribution to the good quality cancer data. Professor Sarikapan Wilailak Chairman, Cancer Registry Committee Ramathibodi hospital, Mahidol University IV

6 RAMATHIBODI HOSPITAL CANCER COMMITTEE, 2016 CHAIRMAN: Asst.Prof.Somjai Dangprasert, M.D. Department of Radiology COMMITTEE: Prof.Sarikapan Wilailak, M.D. Prof.Suradej Hongeng, M.D. Assoc.Prof.Sansanee Wongwaisayawan, M.D. Assoc.Prof.Artit Ungkanont, M.D. Assoc.Prof.Arb-Aroon Lertkhachonsuk, M.D. Asst.Prof.Thongchai Bhongmakapat, M.D. Asst.Prof.Ekapob Sirachainant, M.D. Prakasit Chirappapha, M.D. Saran Subhadrabandhu, M.D. Narongrit Masayaanon, M.D. Duangnate Rojanaponrn, M.D. Natini Jinawat, M.D.,PhD Manmana Jirajarus Jitprapa Konmun, BCOPS, BCP Department of Obstetrics and Gynecology Department of Pediatrics Department of Pathology Department of Medicine Department of Obstetrics and Gynecology Department of Otolaryngology Department of Medicine Department of Medicine Department of Orthopedics Ramathibodi Hospital Department of Ophthalmology Tumor Biobank Nursing Affairs Pharmacy Division COMMITTEE AND SECRETARY: Sarunporn Pramyothin, M.D. Nintita Sripaiboonkij Thokanit, Dr.PH Ramathibodi Hospital Ramathibodi Comprehensive Cancer Center V

7 RAMATHIBODI HOSPITAL CANCER REGISTRY COMMITTEE, 2016 CHAIRMAN: Prof. Sarikapan Wilailak, M.D. Department of Obstetrics and Gynecology COMMITTEE: Prof. Suradej Hongeng, M.D. Assoc.Prof.Sansanee Wongwaisayawan, M.D. Assoc.Prof.Arb-Aroon Lertkhachonsuk, M.D. Department of Pediatrics Department of Pathology Department of Obstetrics and Gynecology Asst.Prof.Ekapob Sirachainant, M.D. Assoc.Prof.Chomporn Sitathanee, M.D. Assoc.Prof.Panuwat Lertsithichai, M.D. Panus Binsirawanich, M.D. Miss Manmana Jirajarus Department of Medicine Department of Radiology Department of Surgery Department of Otolaryngology Nursing Affairs COMMITTEE AND SECRETORY: Nintita Sripaiboonkij Thokanit, Dr.Ph Ramathibodi Comprehensive Cancer Center CANCER REGISTRY TEAM: Nintita Sripaiboonkij Thokanit, Dr.PH Miss Sopit Promchana Mr. Tanapol Thonkamdee Miss Pornsuda Jitkasikorn Mr. Jakkapong Pongsachai Miss Chanpen Preedee Miss Pisamai Srinaka Medical Statistics officer Medical Statistician Medical Statistician Medical Statistician General Affairs Officer General Affairs Officer High Vocational Certificate VI

8 CHAPTER I REGISTRY PROCEDURE AND STATISTICAL METHODS 1.1 Purpose of the registry The Ramathibodi Cancer Registry (RCR) is a hospital-based cancer registry. The epidemiology including incidence and survival data of all cancer patients who are diagnosed and/or treated for cancer in the Ramathibodi hospital are collocated. The goods of the RCR are to: determine the incidence of cancer in Ramathibodi hospital with demographic and social characteristics. evaluate the outcome including the survival and prognostic factors affecting the survival and mortality. provide data in planning effectively plan services, measure prevention and intervention strategies. provide a database and serve as a resource in conducting epidemiologic studies. provide data to assist public health officers and hospital administrators in planning health policy. 1.2 Data collection Each department in Ramathibodi hospital including surgical out patient, radiation outpatient and pathology laboratory is responsible to complete all data on cancer diagnosed and treated within six months of diagnosis. Sources for identifying eligible cases include: all types of malignancies including skin cancer, pre-invasive cancer or carcinoma in situ, neoplasm with malignant potential all types of myeloproliferative disorders all types of malignant histiocytosis carcinomatosisperitonei without detectable primary thymoma-both benign and malignant all type of CNS tumors (intracranial & spinal cord) both benign and malignant gastrointestinal stomach tumor 1

9 Exclusion criteria 1. Benign tumors 2. Pre-malignant Remarks: When a cancer case is reported form more than on department, the information is consolidate into one record Reported cases contain the following data: Patient characteristics (including demographic data at the time of cancer diagnosis) Descriptive data of cancer (including date of diagnosis, primary site*, histology, metastatic sites, extent of disease, staging etc.) * Primary site, behavior, grade, and histology were coded 1.3 Statistical Methods Morphologically Verified Cases (%MV): The percentage of cases whose diagnosis were based on cytology or histology examination of tissue form primary site or metastasis site, peripheral blood and bone marrow aspiration, including autopsy specimens. Childhood cancer: The results for cancer in the childhood are presented according to the diagnostic groups defined in International Classification of Childhood Cancer 1996 this was done by simply adding together the cases in age between 0-14 years old 2

10 Table 2.1Most valid method of diagnosis. CANCER REGISTRY, RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY CHAPTER II OVERALL CANCERS Basis of diagnosis Number Percentage Histology or metastasis Histology of primary 3, Total 3, Figure 2.1 Most valid method of diagnosis. 3

11 Table 2.2Number of cancer case by staging of present extent of disease Staging Male Female Total Number % Number % Number % Localized Regional LN Distant metastasis Unknown Total Figure 2.2 Number of cancer case by present extent of disease 4

12 Table 2.3Number of cancer case by age and sex, 2016 Age group Male Female Both sexes Number % Number % Number % Total 1, , , Mean S.D Figure 2.3 Patient pyramids, 01/01/ /12/2016 5

13 CHAPTER III TEN LEADING SITES OF CANCER, 2016 Table 3.1Ten leading sites of cancer in both sexes. Site ICD-O Number of cases % 1. BREAST C LIVER AND INTRAHEPATIC BILE DUCTS C LUNG AND BRONCHUS C COLON C THYROID GLAND C PROSTATE GLAND C HEMATOPOIETIC AND C RETICULOENDOTHELIAL SYSTEMS 8. RECTUM C CORPUS UTERI C LYMPH NODES C Other 1, Total 3, Figure3.1Ten leading sites of cancer in both sexes. 6

14 Table 3.2 Ten leading sites of cancer in male. Site ICD-O Number of cases % 1. LIVER AND INTRAHEPATIC BILE DUCTS C PROSTATE GLAND C LUNG AND BRONCHUS C COLON C HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS C RECTUM C URINARY BLADDER C LYMPH NODES C ESOPHAGUS C NASOPHARYNX C Other Total 1, Figure 3.2 Ten leading sites of cancer in male. 7

15 Table 3.3 Ten leading sites of cancer in female. Site ICD-O Number of cases 1. BREAST C THYROID GLAND C CORPUS UTERI C COLON C LUNG AND BRONCHUS C CERVIX UTERI C LIVER AND INTRAHEPATIC BILE DUCTS C RECTUM C HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS % C OVARY C Other Total 1, Figure 3.3 Ten leading sites of cancer in female. 8

16 Table 3.4 Site of cancer in childhood by ICCC, age<15, both sexes. Site Male Female Total Number % Number % Number % Leukemias-I Lymphomas-II Brain/CNS-III Sympathetics NER.-IV Retinoblastoma-V Renal-VI Hepatic-VII Malignant bone-viii Soft-tissue-IX Germ cell-x Carcinomas-XI Total *ICCC: International childhood cancer Classification Figure 3.4 Site of cancer in childhood by ICCC, age<15, both sexes. 9

17 Table 4.1 Annual reports CHAPTER IV RAMATHIBODI CANCER REGISTRY Site Male Female Total ICD O N (%) N (%) N (%) Lip C00 Tongue C01-C02 Mouth C03-C06 Salivary gland C07-C08 Oropharynx C09-C10 Nasopharynx C11 Hypopharynx C12-C13 Pharynx unspecified C14 Esophagus C15 Stomach C16 Small intestine C17 Colon C18 Rectum C19-C21 Liver C22 Gallbladder and other parts of billiary tract C23-C24 Pancreas C25 Nose, sinuses etc C30-C31 Larynx C32 Trachea,Bronchus& lung C33-C34 Thymus mediastinum C37-C38 Bone C40-C41 Haematopoetic and Reticuloendothelial C42 Other skin C44 Peripheral and Autonomic nervous C47 Retroperitonium and peritoneum C48 Connective, Subcu.& Soft tissue C49 Breast C50 Other female genital C51,C52,C57 Cervix uteri C53 Corpus uteri C54 Uterus unspecified C55 Ovary C56 Penis C60 Prostate C61 Testis C62 Bladder C67 Kidney etc C64-C66,C68 Eye C69 Brain, nervous system C71 Spinal cord and nervous system C72 Thyroid C73 Adrenal gland C74 Other endocrine gland C75 Other and ill-defined site C76 Lymphnodes C77 Unknown primary site C80 All sites ALL 10

18 Table 4.2 Percentage of morphologically verified and death certificate only case Site Male Female Total ICD O Case %MV Case %MV Case %MV Lip C00 Tongue C01-C02 Mouth C03-C06 Salivary gland C07-C08 Oropharynx C09-C10 Nasopharynx C11 Hypopharynx C12-C13 Pharynx unspecified C14 Esophagus C15 Stomach C16 Small intestine C17 Colon C18 Rectum C19-C21 Liver C22 Gallbladder and other parts of billiary tract C23-C24 Pancreas C25 Nose, sinuses etc C30-C31 Larynx C32 Trachea,Bronchus& lung C33-C34 Thymus mediastinum C37-C38 Bone C40-C41 Haematopoetic and Reticuloendothelial C42 Other skin C44 Peripheral and Autonomic nervous C47 Retroperitonium and peritoneum C48 Connective, Subcu.& Soft tissue C49 Breast C50 Other female genital C51,C52,C57 Cervix uteri C53 Corpus uteri C54 Uterus unspecified C55 Ovary C56 Penis C60 Prostate C61 Testis C62 Bladder C67 Kidney etc C64-C66,C68 Eye C69 Brain, nervous system C71 Spinal cord and nervous system C72 Thyroid C73 Adrenal gland C74 Other endocrine gland C75 Other and ill-defined site C76 Lymphnodes C77 Unknown primary site C80 All sites ALL 11

19 Table 4.3 Number of cancer case by site, sex and age Site/age Total Mean S.D. GRAND TOTAL M F T C00 LIP M F T C01 BASE OF TOUNGUE M T C02 OTHER AND UNSPECIFIED PART OF TONGUE M F T C03 GUM M F T C04 FLOOR OF MOUTH M F T C05 PALATE M F T C06 OTHER AND UNSPECIFIED PART OF MOUTH M F T C07 PAROTID GLAND M F T C08 OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS M F T C09 TONSIL M F T C10 OROPHARYNX M T

20 Site/age Total Mean S.D. C11 NASOPHARYNX M F T C12 PYRIFORM SINUS M T C13 HYPOPHARYNX M T C14 ILL-DEFINED SITES IN LIP, ORAL CAVITY AND PHARYNX AND OTHER F T C15 ESOPHAGUS M F T C16 STOMACH M F T C17 SMALL INTESTINE M F T C18 COLON M F T C19 RECTOSIGMOID JUNCTION M F T C20 RECTUM M F T C21 ANUS AND ANAL CANAL F T C22 LIVER AND INTRAHEPATIC BILE DUCTS M F T C23 GALLBLADDER M F T

21 Site/age Total Mean S.D. C24 OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT M F T C25 PANCREAS M F T C26 ILL-DEFINED DIGESTIVE ORGANS AND OTHER F T C30 NASAL CAVITY AND MIDDLE EAR M F T C31 ACCESSORY SINUSES M F T C32 LARYNX M F T C34 LUNG AND BRONCHUS M F T C37 THYMUS M F T C38 HEART, MEDIASTINUM AND PLEURA M F T C40 BONES, JOINTS AND ARTICULAR CARTILAGE OF LIMBS M F T C41 BONE, JOIN AND ARTICULAR CARTILAGE OF OTHER AND UNSPECIFIED SITES M F T C42 HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS M F T

22 Site/age Total Mean S.D. C44 SKIN M F T C47 PERIPHERAL NERVES AND AUTONOMIC NERVOUS SYNSTEM M F T C48 RETROPERITONEUM AND PERITONEUM M F T C49 CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES M F T C50 BREAST M F T C51 VULVA F T C52 VAGINA F T C53 CERVIX UTERI F T C54 CORPUS UTERI F T C55 UTERUS, NOS F T C56 OVARY F T C57 OTHER AND UNSPECIFIED FEMALE GENITAL ORGANS F T C60 PENIS M T C61 PROSTATE GLAND M T

23 Site/age Total Mean S.D. C62 TESTIS M T C63 EPIDIDYMIS, SPERMATIC CORD, MALE GENITAL ORGANS M T C64 KIDNEY M F T C65 RENAL PELVIS M F T C66 URETER M F T C67 URINARY BLADDER M F T C68 OTHER AND UNSPECIFIED URINARY ORGANS F T C69 EYE AND ADNEXA M F T C70 MENINGES F T C71 BRAIN M F T C72 SPINAL CORD, CRANIAL NERVES AND OTHER PARTS OF CENTRAL NERVOUS SYSTEM M T C73 THYROID GLAND M F T C74 ADRENAL GLAND M F T

24 Site/age Total Mean S.D. C75 OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES M F T C76 OTHER AND ILL-DEFINED SITES M F T C77 LYMPH NODES M F T C80 UNKNOWN PRIMARY SITE M F T

25 Table 4.4 Number of cancer case by primary site. ICD-O SITE AND HISTOPATHOLOGY Male Female Total C00 LIP C00.1 External lower lip C00.3 Mucosa of upper lip C00.4 Mucosa of lower lip C00.5 Mucosa of lip, NOS C01 BASE OF TOUNGUE C01.9 Base of tongue, NOS C02 OTHER AND UNSPECIFIED PART OF TONGUE C02.1 Border of tongue C02.2 Ventral surface of tongue, NOS C02.3 Anterior 2/3 of tongue, NOS C02.8 Overl. lesion of tongue C02.9 Tongue, NOS C03 GUM C03.1 Lower gum C03.9 Gum, NOS C04 FLOOR OF MOUTH C04.9 Floor of mouth, NOS C05 PALATE C05.0 Hard palate C05.1 Soft palate, NOS C06 OTHER AND UNSPECIFIED PART OF MOUTH C06.0 Cheek mucosa C06.2 Retromolar area C06.9 Mouth, NOS C07 PAROTID GLAND C07.9 Parotid gland C08 OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS C08.0 Submandibular gland C08.9 Major salivary gland, NOS C09 TONSIL C09.1 Tonsillar pillar C09.9 Tonsil, NOS C10 OROPHARYNX C10.9 Oropharynx, NOS C11 NASOPHARYNX C11.1 Posterior wall of nasopharynx C11.2 Lateral wall of nasopharynx C11.9 Nasopharynx, NOS C12 PYRIFORM SINUS C12.9 Pyriform sinus C13 HYPOPHARYNX C13.9 Hypopharynx, NOS C14 ILL-DEFINED SITES IN LIP, ORAL CAVITY AND PHARYNX AND OTHER C14.0 Pharynx, NOS

26 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C15 ESOPHAGUS C15.0 Cervical esophagus C15.1 Thoracic esophagus C15.3 Upper third of esophagus C15.4 Middle third of esophagus C15.5 Lower third of esophagus C15.8 Overl. lesion of esophagus C15.9 Esophagus, NOS C16 STOMACH C16.0 Cardia, NOS C16.1 Fundus of stomach C16.2 Body of stomach C16.3 Gastric antrum C16.4 Pylorus C16.9 Stomach, NOS C17 SMALL INTESTINE C17.0 Duodenum C17.1 Jejunum C17.2 Ileum C17.9 Small intestine C18 COLON C18.0 Cecum C18.1 Appendix C18.2 Ascending colon C18.3 Hepatic flexure of colon C18.4 Transverse colon C18.5 Splenic flexure of colon C18.6 Descending colon C18.7 Sigmoid colon C18.9 Colon, NOS C19 RECTOSIGMOID JUNCTION C19.9 Rectosigmoid junction C20 RECTUM C20.9 Rectum, NOS C21 ANUS AND ANAL CANAL C21.0 Anus, NOS C21.1 Anal canal C22 LIVER AND INTRAHEPATIC BILE DUCTS C22.0 Liver C22.1 Intrahepatic bile duct C23 GALLBLADDER C23.9 Gallbladder C24 OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT C24.0 Extrahepatic bile duct C24.1 Ampulla of Vater

27 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C25 PANCREAS C25.0 Head of pancreas C25.1 Body of pancreas C25.2 Tail of pancreas C25.9 Pancreas, NOS C26 ILL-DEFINED DIGESTIVE ORGANS AND OTHER C26.0 Intestinal tract, NOS C26.9 Gastrointestinal tract, NOS C30 NASAL CAVITY AND MIDDLE EAR C30.0 Nasal cavity C31 ACCESSORY SINUSES C31.0 Maxillary sinus C31.1 Ethmoid sinus C31.3 Sphenoid sinus C32 LARYNX C32.0 Glottis C32.1 Supraglottis C32.2 Subglottis C32.9 Larynx, NOS C34 LUNG AND BRONCHUS C34.1 Upper lobe, lung C34.2 Middle lobe, lung C34.3 Lower lobe, lung C34.8 Overl. lesion of lung C34.9 Lung, NOS C37 THYMUS C37.9 Thymus C38 HEART, MEDIASTINUM AND PLEURA C38.1 Anterior mediastinum C38.3 Mediastinum, NOS C38.4 Pleura, NOS C40 BONES, JOINTS AND ARTICULAR CARTILAGE OF LIMBS C40.0 Long bones of upper limb, scapula and associated joints C40.2 Long bones of lower limb and associated joints C41 BONE, JOIN AND ARTICULAR CARTILAGE OF OTHER AND UNSPECIFIED SITES C41.0 Bones of skull and face and associated joints C41.1 Mandible C41.2 Vertebral column C41.3 Rib, sternum, clavicle and associated joints C41.4 Pelvic bones, sacrum, coccyx and associated joints C42 HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS C42.0 Blood C42.1 Bone marrow C44 SKIN C44.1 Eyelid C44.2 External ear C44.3 Skin, other and unspecified parts of face

28 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C44.4 Skin of scalp and neck C44.5 Skin of trunk C44.6 Skin of upper limb and shoulder C44.7 Skin of lower limb and hip C44.8 Overl. lesion of skin C44.9 Skin, NOS C47 PERIPHERAL NERVES AND AUTONOMIC NERVOUS SYNSTEM C47.4 Per. nerves & A.N.S. of abdomen C47.9 Autonomic nervous system, NOS C48 RETROPERITONEUM AND PERITONEUM C48.0 Retroperitoneum C48.1 Specified parts of peritoneum C48.2 Peritoneum, NOS C49 CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES C49.0 Connec., subcut. and other soft tissues of head, face, and neck C49.1 Connec., subcut. and other soft tissues of upper limb and shoulder C49.2 Connec., subcut. and other soft tissues of lower limb and hip C49.4 Connec., subcut. and other soft tissues of abdomen C49.5 Connec., subcut. and other soft tissues of pelvis C49.6 Connec., subcut. and other soft tissues of trunk C50 BREAST C50.0 Nipple C50.1 Central portion of breast C50.2 Upper-inner quadrant of breast C50.3 Lower-inner quadrant of breast C50.4 Upper-outer quadrant of breast C50.5 Lower-outer quadrant of breast C50.6 Axillary tail of breast C50.8 Overl. lesion of breast C50.9 Breast, NOS C51 VULVA C51.9 Vulva, NOS C52 VAGINA C52.9 Vagina, NOS C53 CERVIX UTERI C53.0 Endocervix C53.1 Exocervix C53.8 Overl. lesion of cervix uteri C53.9 Cervix uteri C54 CORPUS UTERI C54.1 Endometrium C54.2 Myometrium C55 UTERUS, NOS C55.9 Uterus, NOS

29 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C56 OVARY C56.9 Ovary C57 OTHER AND UNSPECIFIED FEMALE GENITAL ORGANS C57.0 Fallopian tube C60 PENIS C60.0 Prepuce C60.1 Glans penis C60.2 Body of penis C60.9 Penis, NOS C61 PROSTATE GLAND C61.9 Prostate gland C62 TESTIS C62.1 Descended testis C62.9 Testis, NOS C63 EPIDIDYMIS, SPERMATIC CORD, MALE GENITAL ORGANS C63.2 Scrotum, NOS C64 KIDNEY C64.9 Kidney C65 RENAL PELVIS C65.9 Renal pelvis C66 URETER C66.9 Ureter C67 URINARY BLADDER C67.2 Lateral wall of urinary bladder C67.3 Anterior wall of urinary bladder C67.4 Posterior wall of urinary bladder C67.5 Bladder neck C67.6 Ureteric orifice C67.8 Overl. lesion of bladder C67.9 Bladder, NOS C68 OTHER AND UNSPECIFIED URINARY ORGANS C68.0 Urethra C69 EYE AND ADNEXA C69.0 Conjunctiva C69.2 Retina C69.3 Choroid C69.4 Eyeball C69.5 Lacrimal gland, NOS C69.6 Orbit, NOS C69.9 Eye, NOS C71 BRAIN C71.0 Cerebrum C71.1 Frontal lobe C71.2 Temporal lobe C71.3 Parietal lobe C71.4 Occipital lobe C71.6 Cerebellum, NOS

30 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C71.7 Brain stem C71.9 Brain, NOS C72 SPINAL CORD, CRANIAL NERVES AND OTHER PARTS OF CENTRAL NERVOUS SYSTEM C72.3 Optic nerve C73 THYROID GLAND C73.9 Thyroid gland C74 ADRENAL GLAND C74.0 Cortex of adrenal gland C74.9 Adrenal gland, NOS C75 OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES C75.1 Pituitary gland C75.3 Pineal gland C76 OTHER AND ILL-DEFINED SITES C76.0 Head, face or neck, NOS C76.2 Abdomen, NOS C76.5 Lower limb, NOS C77 LYMPH NODES C77.0 Lymph nodes of head, face and neck C77.1 Intrathoracic lymph nodes C77.2 Intra-abdominal lymph nodes C77.3 Lymph nodes of axilla or arm C77.4 Lymph nodes, inguinal region or leg C77.9 Lymph node, NOS C80 UNKNOWN PRIMARY SITE C80.9 Unknown primary site

31 Table 4.5 Number of cancer case by pathology according to site. ICD-O SITE AND HISTOPATHOLOGY Male Female Total C00 LIP C00.1 External lower lip M 8070/3 Squamous cell carcinoma, NOS C00.3 Mucosa of upper lip M 8070/3 Squamous cell carcinoma, NOS C00.4 Mucosa of lower lip M 8430/3 Mucoepidermoid carcinoma C00.5 Mucosa of lip, NOS M 8200/3 Adenoid cystic carcinoma C01 BASE OF TOUNGUE C01.9 Base of tongue, NOS M 8070/3 Squamous cell carcinoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C02 OTHER AND UNSPECIFIED PART OF TONGUE C02.1 Border of tongue M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS C02.2 Ventral surface of tongue, NOS M 8070/3 Squamous cell carcinoma, NOS C02.3 Anterior 2/3 of tongue, NOS M 8070/3 Squamous cell carcinoma, NOS C02.8 Overl. lesion of tongue M 8070/3 Squamous cell carcinoma, NOS C02.9 Tongue, NOS M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS C03 GUM C03.1 Lower gum M 8070/3 Squamous cell carcinoma, NOS C03.9 Gum, NOS M 8076/3 Squamous cell carcinoma, microinvasive C04 FLOOR OF MOUTH C04.9 Floor of mouth, NOS M 8010/3 Carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS C05 PALATE C05.0 Hard palate M 9590/3 Malignant lymphoma, NOS C05.1 Soft palate, NOS M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS

32 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C06 OTHER AND UNSPECIFIED PART OF MOUTH C06.0 Cheek mucosa M 8070/3 Squamous cell carcinoma, NOS M 8200/3 Adenoid cystic carcinoma C06.2 Retromolar area M 8070/3 Squamous cell carcinoma, NOS C06.9 Mouth, NOS M 9687/3 Burkitt lymphoma, NOS C07 PAROTID GLAND C07.9 Parotid gland M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8200/3 Adenoid cystic carcinoma M 8430/3 Mucoepidermoid carcinoma M 8982/3 Malignant myoepithelioma C08 OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS C08.0 Submandibular gland M 8140/3 Adenocarcinoma, NOS M 8550/3 Acinar cell carcinoma C08.9 Major salivary gland, NOS M 8200/3 Adenoid cystic carcinoma C09 TONSIL C09.1 Tonsillar pillar M 8070/3 Squamous cell carcinoma, NOS C09.9 Tonsil, NOS M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8082/3 Lymphoepithelial carcinoma M 8083/3 Basaloid squamous cell carcinoma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C10 OROPHARYNX C10.9 Oropharynx, NOS M 8070/3 Squamous cell carcinoma, NOS C11 NASOPHARYNX C11.1 Posterior wall of nasopharynx M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8200/3 Adenoid cystic carcinoma C11.2 Lateral wall of nasopharynx M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS C11.9 Nasopharynx, NOS M 8020/3 Carcinoma, undifferentiated, NOS M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8200/3 Adenoid cystic carcinoma

33 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C12 PYRIFORM SINUS C12.9 Pyriform sinus M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS M 9590/3 Malignant lymphoma, NOS C13 HYPOPHARYNX C13.9 Hypopharynx, NOS M 8070/3 Squamous cell carcinoma, NOS C14 ILL-DEFINED SITES IN LIP, ORAL CAVITY AND PHARYNX AND OTHER C14.0 Pharynx, NOS M 9370/3 Chordoma, NOS C15 ESOPHAGUS C15.0 Cervical esophagus M 8070/3 Squamous cell carcinoma, NOS C15.1 Thoracic esophagus M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8076/3 Squamous cell carcinoma, microinvasive C15.3 Upper third of esophagus M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8140/3 Adenocarcinoma, NOS C15.4 Middle third of esophagus M 8070/3 Squamous cell carcinoma, NOS C15.5 Lower third of esophagus M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS C15.8 Overl. lesion of esophagus M 8070/3 Squamous cell carcinoma, NOS C15.9 Esophagus, NOS M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8560/3 Adenosquamous carcinoma C16 STOMACH C16.0 Cardia, NOS M 8140/3 Adenocarcinoma, NOS C16.1 Fundus of stomach M 8140/3 Adenocarcinoma, NOS M 9590/3 Malignant lymphoma, NOS C16.2 Body of stomach M 8004/3 Malignant tumor, spindle cell type M 8140/3 Adenocarcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma M 8720/3 Malignant melanoma, NOS (except juvenile melanoma)

34 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C16.3 Gastric antrum M 8140/3 Adenocarcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma M 8936/3 Gastrointestinal stromal sarcoma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C16.4 Pylorus M 8140/3 Adenocarcinoma, NOS C16.9 Stomach, NOS M 8004/3 Malignant tumor, spindle cell type M 8140/3 Adenocarcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma M 8800/3 Sarcoma, NOS M 8936/3 Gastrointestinal stromal sarcoma M 9590/3 Malignant lymphoma, NOS M 9671/3 Malignant lymphoma, lymphoplasmacytic M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C17 SMALL INTESTINE C17.0 Duodenum M 8140/3 Adenocarcinoma, NOS M 8936/3 Gastrointestinal stromal sarcoma C17.1 Jejunum M 8140/3 Adenocarcinoma, NOS C17.2 Ileum M 8140/3 Adenocarcinoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C17.9 Small intestine M 8936/3 Gastrointestinal stromal sarcoma M 9698/3 Follicular lymphoma, grade C18 COLON C18.0 Cecum M 8013/3 Large cell neuroendocrine carcinoma M 8140/3 Adenocarcinoma, NOS M 8246/3 Neuroendocrine carcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma C18.1 Appendix M 8140/3 Adenocarcinoma, NOS C18.2 Ascending colon M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8246/3 Neuroendocrine carcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma C18.3 Hepatic flexure of colon M 8140/3 Adenocarcinoma, NOS C18.4 Transverse colon M 8140/3 Adenocarcinoma, NOS

35 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C18.5 Splenic flexure of colon M 8140/3 Adenocarcinoma, NOS C18.6 Descending colon M 8140/3 Adenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma C18.7 Sigmoid colon M 8140/3 Adenocarcinoma, NOS C18.9 Colon, NOS M 8140/3 Adenocarcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma C19 RECTOSIGMOID JUNCTION C19.9 Rectosigmoid junction M 8140/3 Adenocarcinoma, NOS C20 RECTUM C20.9 Rectum, NOS M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8200/3 Adenoid cystic carcinoma M 8246/3 Neuroendocrine carcinoma, NOS M 8480/3 Mucinous adenocarcinoma M 8490/3 Metastatic signet ring cell carcinoma M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 8936/3 Gastrointestinal stromal sarcoma C21 ANUS AND ANAL CANAL C21.0 Anus, NOS M 8004/3 Malignant tumor, spindle cell type M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8140/3 Adenocarcinoma, NOS C21.1 Anal canal M 8070/3 Squamous cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) C22 LIVER AND INTRAHEPATIC BILE DUCTS C22.0 Liver M 8170/3 Hepatocellular carcinoma, NOS M 8970/3 Hepatoblastoma M 8991/3 Embryonal sarcoma M 9120/3 Hemangiosarcoma C22.1 Intrahepaic bile duct M 8140/3 Adenocarcinoma, NOS M 8160/3 Cholangiocarcinoma C23 GALLBLADDER C23.9 Gallbladder M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS

36 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C24 OTHER AND UNSPECIFIED PARTS OF BILIARY TRACT C24.0 Extrahepatic bile duct M 8140/3 Adenocarcinoma, NOS M 8160/3 Cholangiocarcinoma M 8560/3 Adenosquamous carcinoma C24.1 Ampulla of Vater M 8140/3 Adenocarcinoma, NOS M 8160/3 Cholangiocarcinoma C25 PANCREAS C25.0 Head of pancreas M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 9071/3 Yolk sac tumor M 9473/3 Primitive neuroectodermal tumor, NOS C25.1 Body of pancreas M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8500/3 Infiltrating duct carcinoma, NOS C25.2 Tail of pancreas M 8140/3 Adenocarcinoma, NOS C25.9 Pancreas, NOS M 8010/3 Carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 9687/3 Burkitt lymphoma, NOS C26 ILL-DEFINED DIGESTIVE ORGANS AND OTHER C26.0 Intestinal tract, NOS M 8480/3 Mucinous adenocarcinoma C26.9 Gastrointestinal tract, NOS M 8246/3 Neuroendocrine carcinoma, NOS C30 NASAL CAVITY AND MIDDLE EAR C30.0 Nasal cavity M 8070/3 Squamous cell carcinoma, NOS M 8310/3 Clear cell adenocarcinoma, mesonephroid M 9251/3 Malignant giant cell tumor of soft parts M 9473/3 Primitive neuroectodermal tumor, NOS M 9522/3 Olfactory neuroblastoma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9719/3 NK/T-cell lymphoma, nasal and nasal-type M 9734/3 Plasmacytoma, extramedullary (not occurring in bone) C31 ACCESSORY SINUSES C31.0 Maxillary sinus M 8070/3 Squamous cell carcinoma, NOS M 8200/3 Adenoid cystic carcinoma

37 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 8810/3 Fibrosarcoma, NOS M 8890/3 Leiomyosarcoma, NOS M 9180/3 Osteosarcoma, NOS M 9719/3 NK/T-cell lymphoma, nasal and nasal-type C31.1 Ethmoid sinus M 8046/3 Non-small cell carcinoma M 8070/3 Squamous cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) C31.3 Sphenoid sinus M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS C32 LARYNX C32.0 Glottis M 8010/3 Carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS M 8076/3 Squamous cell carcinoma, microinvasive C32.1 Supraglottis M 8070/3 Squamous cell carcinoma, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS C32.2 Subglottis M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS C32.9 Larynx, NOS M 8070/3 Squamous cell carcinoma, NOS C33 TRACHEA C33.9 Trachea C34 LUNG AND BRONCHUS C34.0 Main bronchus C34.1 Upper lobe, lung M 8022/3 Pleomorphic carcinoma M 8041/3 Small cell carcinoma, NOS M 8046/3 Non-small cell carcinoma M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8200/3 Adenoid cystic carcinoma M 8430/3 Mucoepidermoid carcinoma M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9699/3 Marginal zone B-cell lymphoma, NOS C34.2 Middle lobe, lung M 8046/3 Non-small cell carcinoma M 8140/3 Adenocarcinoma, NOS C34.3 Lower lobe, lung M 8010/3 Carcinoma, NOS M 8013/3 Large cell neuroendocrine carcinoma M 8041/3 Small cell carcinoma, NOS M 8046/3 Non-small cell carcinoma

38 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma M 8550/3 Acinar cell carcinoma C34.8 Overl. lesion of lung M 8046/3 Non-small cell carcinoma C34.9 Lung, NOS M 8010/3 Carcinoma, NOS M 8041/3 Small cell carcinoma, NOS M 8046/3 Non-small cell carcinoma M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8550/3 Acinar cell carcinoma C37 THYMUS C37.9 Thymus M 8246/3 Neuroendocrine carcinoma, NOS M 8582/3 Thymoma, type AB, malignant M 8584/3 Thymoma, type B2, malignant M 8585/3 Thymoma, type B3, malignant M 8586/3 Thymic carcinoma, NOS C38 HEART, MEDIASTINUM AND PLEURA C38.1 Anterior mediastinum M 9064/3 Germinoma M 9065/3 Germ cell tumor, nonseminomatous M 9070/3 Embryonal carcinoma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS C38.3 Mediastinum, NOS M 8850/3 Liposarcoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C38.4 Pleura, NOS M 8046/3 Non-small cell carcinoma M 8140/3 Adenocarcinoma, NOS M 9050/3 Mesothelioma, malignant C40 BONES, JOINTS AND ARTICULAR CARTILAGE OF LIMBS C40.0 Long bones of upper limb, scapula and associated joints M 9220/3 Chondrosarcoma, NOS M 9260/3 Ewing sarcoma C40.2 Long bones of lower limb and associated joints M 8542/3 Paget disease, extramammary (except Paget disease of bone ) M 8801/3 Spindle cell sarcoma M 9180/3 Osteosarcoma, NOS M 9260/3 Ewing sarcoma

39 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C41 BONE, JOIN AND ARTICULAR CARTILAGE OF OTHER AND UNSPECIFIED SITES C41.0 Bones of skull and face and associated joints M 8810/3 Fibrosarcoma, NOS M 9370/3 Chordoma, NOS M 9753/3 Langerhans cell histiocytosis, multifocal C41.1 Mandible M 8830/3 Malignant fibrous hitiocytoma M 9270/3 Odontogenic tumor, malignant M 9310/3 Ameloblastoma, malignant C41.2 Vertebral column M 9260/3 Ewing sarcoma M 9370/3 Chordoma, NOS C41.3 Rib, sternum, clavicle and associated joints M 8740/3 Malignant melanoma in a junctional nevus C41.4 Pelvic bones, sacrum, coccyx and associated joints M 9180/3 Osteosarcoma, NOS M 9220/3 Chondrosarcoma, NOS C42 HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS C44 SKIN C42.0 Blood M 9761/3 Waldenstrom macroglobulinemia C42.1 Bone marrow M 8830/3 Malignant fibrous hitiocytoma M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9732/3 Multiple myeloma M 9800/3 Leukemia, NOS M 9823/3 B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma M 9835/3 Precursor cell lymphoblastic leukemia, NOS M 9836/3 Precursor B cell lymphoblastic leukemia M 9837/3 Precursor T-cell lymphoblastic leukemia M 9861/3 Acute myeloid leukemia, NOS M 9863/3 Chronic myeloid leukemia, NOS M 9867/3 Acute myelomonocytic leukemia M 9940/3 Hairy cell leukemia M 9946/3 Juvenile myelomonocytic leukemia M 9950/3 Polycythemia vera M 9962/3 Essential thrombocythemia M 9989/3 Myelodysplastic syndrome, NOS C44.1 Eyelid M 8070/3 Squamous cell carcinoma, NOS M 8090/3 Basal cell carcinoma, NOS M 8410/3 Sebaceous adenocarcinoma M 8720/3 Malignant melanoma, NOS (except juvenile melanoma)

40 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C44.2 External ear M 8070/3 Squamous cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) C44.3 Skin, other and unspecified parts of face M 8070/3 Squamous cell carcinoma, NOS M 8090/3 Basal cell carcinoma, NOS M 8832/3 Dermatofibrosarcoma, NOS C44.4 Skin of scalp and neck M 8070/3 Squamous cell carcinoma, NOS M 8090/3 Basal cell carcinoma, NOS M 8413/3 Eccrine adenocarcinoma M 9754/3 Langerhans cell histiocytosis, disseminated C44.5 Skin of trunk M 8070/3 Squamous cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 8832/3 Dermatofibrosarcoma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS C44.6 Skin of upper limb and shoulder M 8070/3 Squamous cell carcinoma, NOS M 8090/3 Basal cell carcinoma, NOS M 9140/3 Kaposi sarcoma C44.7 Skin of lower limb and hip M 8051/3 Verrucous carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8090/3 Basal cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 8801/3 Spindle cell sarcoma M 9044/3 Clear cell sarcoma, NOS (except of kidney) M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9708/3 Subcutaneous panniculitis-like T-cell lymphoma C44.8 Overl. lesion of skin M 9591/3 Malignant lymphoma, non-hodgkin, NOS C44.9 Skin, NOS M 9140/3 Kaposi sarcoma M 9754/3 Langerhans cell histiocytosis, disseminated C47 PERIPHERAL NERVES AND AUTONOMIC NERVOUS SYNSTEM C47.4 Per. nerves & A.N.S. of abdomen M 9540/3 Malignant peripheral nerve sheath tumor C47.9 Autonomic nervous system, NOS M 9540/3 Malignant peripheral nerve sheath tumor C48 RETROPERITONEUM AND PERITONEUM C48.0 Retroperitoneum M 8010/3 Carcinoma, NOS M 8800/3 Sarcoma, NOS M 8850/3 Liposarcoma, NOS

41 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 8890/3 Leiomyosarcoma, NOS M 9540/3 Malignant peripheral nerve sheath tumor C48.1 Specified parts of peritoneum M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C48.2 Peritoneum, NOS M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8260/3 Papillary adenocarcinoma, NOS C49 CONNECTIVE, SUBCUTANEOUS AND OTHER SOFT TISSUES C49.0 Connec., subcut. and other soft tissues of head, face, and neck M 8070/3 Squamous cell carcinoma, NOS M 8900/3 Rhabdomyosarcoma, NOS M 8910/3 Embryonal rhabdomayosarcoma, NOS M 9260/3 Ewing sarcoma C49.1 Connec., subcut. and other soft tissues of upper limb and shoulder M 8811/3 Fibromyxosarcoma M 8852/3 Myxoid liposarcoma C49.2 Connec., subcut. and other soft tissues of lower limb and hip M 8801/3 Spindle cell sarcoma M 8811/3 Fibromyxosarcoma M 8830/3 Malignant fibrous hitiocytoma M 8850/3 Liposarcoma, NOS M 8890/3 Leiomyosarcoma, NOS M 9040/3 Synovial sarcoma, NOS M 9044/3 Clear cell sarcoma, NOS (except of kidney) M 9581/3 Alveolar soft part sarcoma C49.4 Connec., subcut. and other soft tissues of abdomen M 8800/3 Sarcoma, NOS M 8806/3 Desmopoastic small round cell tumor M 8850/3 Liposarcoma, NOS M 8900/3 Rhabdomyosarcoma, NOS C49.5 Connec., subcut. and other soft tissues of pelvis M 8810/3 Fibrosarcoma, NOS M 8830/3 Malignant fibrous hitiocytoma M 8832/3 Dermatofibrosarcoma, NOS M 8900/3 Rhabdomyosarcoma, NOS C49.6 Connec., subcut. and other soft tissues of trunk M 8830/3 Malignant fibrous hitiocytoma C50 BREAST C50.0 Nipple M 8004/3 Malignant tumor, spindle cell type M 8480/3 Mucinous adenocarcinoma M 8500/3 Infiltrating duct carcinoma, NOS

42 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C50.1 Central portion of breast M 8140/3 Adenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma M 8500/3 Infiltrating duct carcinoma, NOS M 8503/3 Intraductal paillary adenocarcinoma with invasion M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C50.2 Upper-inner quadrant of breast M 8010/3 Carcinoma, NOS M 8500/3 Infiltrating duct carcinoma, NOS M 8503/3 Intraductal paillary adenocarcinoma with invasion C50.3 Lower-inner quadrant of breast M 8500/3 Infiltrating duct carcinoma, NOS M 8503/3 Intraductal paillary adenocarcinoma with invasion M 9020/3 Phyllodes tumor, malignant C50.4 Upper-outer quadrant of breast M 8050/3 Papillary carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma M 8500/3 Infiltrating duct carcinoma, NOS M 8503/3 Intraductal paillary adenocarcinoma with invasion M 8507/3 Invasive micropapillary carcinoma M 8520/3 Lobular carcinoma, NOS M 8600/3 Thecoma, malignant C50.5 Lower-outer quadrant of breast M 8480/3 Mucinous adenocarcinoma M 8500/3 Infiltrating duct carcinoma, NOS M 8520/3 Lobular carcinoma, NOS C50.6 Axillary tail of breast M 8500/3 Infiltrating duct carcinoma, NOS C50.8 Overl. lesion of breast M 8500/3 Infiltrating duct carcinoma, NOS C50.9 Breast, NOS M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8343/3 Papillary carcinoma, encapsulate M 8500/3 Infiltrating duct carcinoma, NOS M 8520/3 Lobular carcinoma, NOS C51 VULVA C51.9 Vulva, NOS M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS M 8542/3 Paget disease, extramammary (except Paget disease of bone )

43 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C52 VAGINA C52.9 Vagina, NOS M 8041/3 Small cell carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS C53 CERVIX UTERI C53.0 Endocervix M 8140/3 Adenocarcinoma, NOS M 8380/3 Endometrioid adenocarcinoma, NOS M 8384/3 Adenocarcinoma, endocervical type M 8441/3 Serous cystadenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma C53.1 Exocervix M 8052/3 Papillary squamous cell carcinoma M 8070/3 Squamous cell carcinoma, NOS M 8071/3 Squamous cell carcinoma, keratinizing, NOS M 8072/3 Squamous cell carcinoma, large cell, nonkeratinizing, NOS M 8076/3 Squamous cell carcinoma, microinvasive C53.8 Overl. lesion of cervix uteri M 8560/3 Adenosquamous carcinoma C53.9 Cervix uteri M 8010/3 Carcinoma, NOS M 8560/3 Adenosquamous carcinoma C54 CORPUS UTERI C54.1 Endometrium M 8013/3 Large cell neuroendocrine carcinoma M 8020/3 Carcinoma, undifferentiated, NOS M 8083/3 Basaloid squamous cell carcinoma M 8140/3 Adenocarcinoma, NOS M 8310/3 Clear cell adenocarcinoma, mesonephroid M 8380/3 Endometrioid adenocarcinoma, NOS M 8441/3 Serous cystadenocarcinoma, NOS M 8890/3 Leiomyosarcoma, NOS M 8930/3 Endometrial stromal sarcoma, NOS M 8980/3 Carcinosarcoma, NOS C54.2 Myometrium M 8890/3 Leiomyosarcoma, NOS C55 UTERUS, NOS C55.9 Uterus, NOS M 8890/3 Leiomyosarcoma, NOS M 8930/3 Endometrial stromal sarcoma, NOS M 8980/3 Carcinosarcoma, NOS C56 OVARY C56.9 Ovary M 8010/3 Carcinoma, NOS M 8140/3 Adenocarcinoma, NOS

44 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 8310/3 Clear cell adenocarcinoma, mesonephroid M 8380/3 Endometrioid adenocarcinoma, NOS M 8441/3 Serous cystadenocarcinoma, NOS M 8460/3 Papillary serous cystadenocarcinoma M 8470/3 Mucinous cystadenocarcinoma, NOS M 8480/3 Mucinous adenocarcinoma M 8980/3 Carcinosarcoma, NOS M 9000/3 Brenner tumor, malignant M 9064/3 Germinoma M 9080/3 Teratoma, malignant, NOS M 9084/3 Teratoma with malignant transformation M 9580/3 Granular cell tumor, malignant C57 OTHER AND UNSPECIFIED FEMALE GENITAL ORGANS C60 PENIS C57.0 Fallopian tube M 8140/3 Adenocarcinoma, NOS C60.0 Prepuce M 8070/3 Squamous cell carcinoma, NOS C60.1 Glans penis M 8070/3 Squamous cell carcinoma, NOS C60.2 Body of penis M 8560/3 Adenosquamous carcinoma C60.9 Penis, NOS C61 PROSTATE GLAND C62 TESTIS M 8070/3 Squamous cell carcinoma, NOS M 8076/3 Squamous cell carcinoma, microinvasive C61.9 Prostate gland M 8140/3 Adenocarcinoma, NOS M 8246/3 Neuroendocrine carcinoma, NOS M 8550/3 Acinar cell carcinoma M 8900/3 Rhabdomyosarcoma, NOS C62.1 Descended testis M 9071/3 Yolk sac tumor C62.9 Testis, NOS M 9061/3 Seminoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C63 EPIDIDYMIS, SPERMATIC CORD, MALE GENITAL ORGANS C64 KIDNEY C63.2 Scrotum, NOS M 8542/3 Paget disease, extramammary (except Paget disease of bone ) M 8890/3 Leiomyosarcoma, NOS C64.9 Kidney M 8120/3 Transition cell carcinoma, NOS M 8260/3 Papillary adenocarcinoma, NOS M 8310/3 Clear cell adenocarcinoma, mesonephroid

45 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 8312/3 Renal cell carcinoma, NOS M 8318/3 Renal cell carcinoma, sarcomatoid M 8319/3 Coilecting duct carcinoma M 8960/3 Nephroblastoma, NOS M 9500/3 Neuroblastoma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS C65 RENAL PELVIS C65.9 Renal pelvis M 8120/3 Transition cell carcinoma, NOS C66 URETER C66.9 Ureter M 8120/3 Transition cell carcinoma, NOS C67 URINARY BLADDER C67.2 Lateral wall of urinary bladder M 8120/3 Transition cell carcinoma, NOS C67.3 Anterior wall of urinary bladder M 8120/3 Transition cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS C67.4 Posterior wall of urinary bladder M 8120/3 Transition cell carcinoma, NOS C67.5 Bladder neck M 8010/3 Carcinoma, NOS M 8120/3 Transition cell carcinoma, NOS M 8246/3 Neuroendocrine carcinoma, NOS C67.6 Ureteric orifice M 8120/3 Transition cell carcinoma, NOS C67.8 Overl. lesion of bladder M 8120/3 Transition cell carcinoma, NOS C67.9 Bladder, NOS M 8032/3 Spindle cell carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8120/3 Transition cell carcinoma, NOS M 8130/3 Papillary transitional cell carcinoma M 8246/3 Neuroendocrine carcinoma, NOS M 8490/3 Metastatic signet ring cell carcinoma M 8806/3 Desmopoastic small round cell tumor M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C68 OTHER AND UNSPECIFIED URINARY ORGANS C68.0 Urethra M 8140/3 Adenocarcinoma, NOS C69 EYE AND ADNEXA C69.0 Conjunctiva M 8083/3 Basaloid squamous cell carcinoma M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 9591/3 Malignant lymphoma, non-hodgkin, NOS

46 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C69.2 Retina M 9510/3 Retinoblastoma, NOS C69.3 Choroid M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) C69.4 Eyeball M 9591/3 Malignant lymphoma, non-hodgkin, NOS C69.5 Lacrimal gland, NOS M 8200/3 Adenoid cystic carcinoma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9699/3 Marginal zone B-cell lymphoma, NOS C69.6 Orbit, NOS M 8140/3 Adenocarcinoma, NOS M 8901/3 Pleomorphic rhabdomyosarcoma, adult type M 9540/3 Malignant peripheral nerve sheath tumor M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9687/3 Burkitt lymphoma, NOS C69.9 Eye, NOS M 9180/3 Osteosarcoma, NOS M 9699/3 Marginal zone B-cell lymphoma, NOS C71 BRAIN C71.0 Cerebrum M 9064/3 Germinoma M 9380/3 Glioma, malignant M 9400/3 Astrocytoma, NOS M 9401/3 Astrocytoma, anaplastic M 9440/3 Glioblastoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C71.1 Frontal lobe M 9380/3 Glioma, malignant M 9392/3 Ependymoma, anaplastic M 9400/3 Astrocytoma, NOS M 9401/3 Astrocytoma, anaplastic M 9440/3 Glioblastoma, NOS M 9450/3 Oligodendroglioma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C71.2 Temporal lobe M 9380/3 Glioma, malignant M 9400/3 Astrocytoma, NOS M 9401/3 Astrocytoma, anaplastic M 9440/3 Glioblastoma, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C71.3 Parietal lobe M 9380/3 Glioma, malignant M 9392/3 Ependymoma, anaplastic

47 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 9440/3 Glioblastoma, NOS M 9473/3 Primitive neuroectodermal tumor, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C71.4 Occipital lobe M 9401/3 Astrocytoma, anaplastic M 9440/3 Glioblastoma, NOS C71.6 Cerebellum, NOS M 9391/3 Ependymoma, NOS M 9440/3 Glioblastoma, NOS M 9470/3 Medulloblastoma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS C71.7 Brain stem M 9380/3 Glioma, malignant M 9391/3 Ependymoma, NOS M 9400/3 Astrocytoma, NOS C71.9 Brain, NOS M 9064/3 Germinoma C72 SPINAL CORD, CRANIAL NERVES AND OTHER PARTS OF CENTRAL NERVOUS SYSTEM C72.3 Optic nerve C73 THYROID GLAND M 9380/3 Glioma, malignant C73.9 Thyroid gland C74 ADRENAL GLAND M 8021/3 Carcinoma, anaplastic, NOS M 8070/3 Squamous cell carcinoma, NOS M 8260/3 Papillary adenocarcinoma, NOS M 8290/3 Oxyphilic adenocarcinoma M 8330/3 Follicular adenocarcinoma, NOS M 8340/3 Papillary carcinoma, follicular variant M 8341/3 Papillary microcarcinoma M 8345/3 Medullary carcinoma with amyloid stroma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C74.0 Cortex of adrenal gland M 8370/3 Adrenal cortical carcinoma C74.9 Adrenal gland, NOS M 8370/3 Adrenal cortical carcinoma M 9500/3 Neuroblastoma, NOS C75 OTHER ENDOCRINE GLANDS AND RELATED STRUCTURES C75.1 Pituitary gland M 9064/3 Germinoma C75.3 Pineal gland M 9064/3 Germinoma M 9080/3 Teratoma, malignant, NOS M 9085/3 Mixed germ cell tumor M 9362/3 Pineoblastoma

48 ICD-O SITE AND HISTOPATHOLOGY Male Female Total C76 OTHER AND ILL-DEFINED SITES C76.0 Head, face or neck, NOS M 8070/3 Squamous cell carcinoma, NOS M 8963/3 Mlignant rhabdoid tumor C76.2 Abdomen, NOS M 8246/3 Neuroendocrine carcinoma, NOS M 9560/3 Neurilemoma, malignant C76.5 Lower limb, NOS M 8070/3 Squamous cell carcinoma, NOS M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 8811/3 Fibromyxosarcoma C77 LYMPH NODES C77.0 Lymph nodes of head, face and neck M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9650/3 Hodgkin lymphoma, NOS M 9673/3 Mantle cell lymphoma M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9687/3 Burkitt lymphoma, NOS M 9690/3 Follicular lymphoma, NOS M 9835/3 Precursor cell lymphoblastic leukemia, NOS C77.1 Intrathoracic lymph nodes M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9729/3 Precursor T-cell lymphoblastic lymphoma C77.2 Intra-abdominal lymph nodes M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9652/3 Hodgkin lymphoma, mixed cellularity, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9687/3 Burkitt lymphoma, NOS M 9719/3 NK/T-cell lymphoma, nasal and nasal-type C77.3 Lymph nodes of axilla or arm M 8720/3 Malignant melanoma, NOS (except juvenile melanoma) M 9652/3 Hodgkin lymphoma, mixed cellularity, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS C77.4 Lymph nodes, inguinal region or leg M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9698/3 Follicular lymphoma, grade C77.9 Lymph node, NOS M 9590/3 Malignant lymphoma, NOS M 9591/3 Malignant lymphoma, non-hodgkin, NOS M 9650/3 Hodgkin lymphoma, NOS M 9663/3 Hodgkin lymphoma, nodular sclerosis, NOS M 9670/3 Malignant lymphoma, small B lymphocytic, NOS M 9673/3 Mantle cell lymphoma

49 ICD-O SITE AND HISTOPATHOLOGY Male Female Total M 9680/3 Malignant lymphoma, large B-cell, diffuse, NOS M 9687/3 Burkitt lymphoma, NOS M 9690/3 Follicular lymphoma, NOS M 9691/3 Follicular lymphoma, grade M 9695/3 Follicular lymphoma, grade M 9698/3 Follicular lymphoma, grade M 9699/3 Marginal zone B-cell lymphoma, NOS M 9702/3 Mature T-cell lymphoma, NOS M 9714/3 Anaplastic large cell lymphoma, T-cell and null cell type M 9729/3 Precursor T-cell lymphoblastic lymphoma C80 UNKNOWN PRIMARY SITE C80.9 Unknown primary site M 8010/3 Carcinoma, NOS M 8070/3 Squamous cell carcinoma, NOS M 8140/3 Adenocarcinoma, NOS

50 CHAPTER V THE MOST COMMON CANCER SITES BREAST LUNG AND BRONCHUS CERVIX UTERI LIVER ANDINTRAHEPATIC BILE DUCTS COLORECTAL HEMATOPOIETIC AND RETICULOENDOTHELIAL CHILDHOOD CANCER 43

51 BREAST Table 5.1 Age and gender of breast cancer. Special Notes Age Mean and standard deviation age at diagnosis (years) 54.2 (12.0) Median and range age at diagnosis 53 (23:89) % of the patient is lower than 15 year of age at diagnosis 0.0% Gender Male 1 (0.2%) Female 502(99.8%) Sex ratio (male: female) 0.00:1 Table 5.2 Most valid method of diagnosis for breast cancer. Basis of diagnosis Male Female Total N % N % N % Histology or metastasis Histology of primary Total Figure 5.1 Age at diagnosis of breast cancer, 2016, by sex. 44

52 Figure 5.2 Distribution of staging for breast cancer. Figure 5.3 Distribution of metastasis for breast cancer. 45

53 LUNG AND BRONCHUS Table 5.3 Age and gender of lung cancer, by sex Age Special Notes Mean and standard deviation age at diagnosis (years) 63.2 (11.4) Median and range age at diagnosis 64 (32:89) % of the patient is lower than 15 year of age at diagnosis 0.0% Gender Male 147 (55.5%) Female 118 (44.5%) Sex ratio (male: female) 1.25:1 Table 5.4 Most valid method of diagnosis for lung cancer. Basis of diagnosis Male Female Total N % N % N % Histology or metastasis Histology of primary Total Figure 5.4 Age at diagnosis of lung cancer, 2016, by sex. 46

54 Figure 5.5 Distribution of staging for lung cancer. Figure 5.6 Distribution of metastasis for lung cancer. 47

55 CERVIX UTERI Table 5.5 Age and gender of cervix uteri cancer. Age Special Notes Mean and standard deviation age at diagnosis (years) 55.2 (14.4) Median and range age at diagnosis 55.5 (27:89) % of the patient is lower than 15 year of age at diagnosis 0.0% Gender Male 0 (0.0%) Female 102(100.0%) Sex ratio (male: female) 0.00:1 Table 5.6 Most valid method of diagnosis for cervix uteri cancer. Basis of diagnosis Male Female Total N % N % N % Histology or metastasis Histology of primary Total Figure 5.7 Age at diagnosis of cervix uteri cancer, 2016, by sex. 48

56 Figure 5.8 Distribution of staging for cervix uteri cancer. Figure 5.9 Distribution of metastasis for cervix uteri cancer. 49

57 LIVER ANDINTRAHEPATIC BILE DUCTS Table 5.7 Age and gender of liver and bile duct cancer. Age Special Notes Mean and standard deviation age at diagnosis (years) 61.3 (13.7) Median and range age at diagnosis 62 (0:94) % of the patient is lower than 15 year of age at diagnosis 1.7% Gender Male 207 (68.5%) Female 95 (31.5%) Sex ratio (male: female) 2.18:1 Table 5.8 Most valid method of diagnosis for liver and bile duct cancer. Basis of diagnosis Male Female Total N % N % N % Histology of primary Total Figure 5.10 Age at diagnosis of Liver and bile duct cancer, 2016 by sex 50

58 Figure 5.11 Distribution of staging for liver and bile duct cancer. Figure 5.12 Distribution of metastasis for liver and bile duct cancer. 51

59 COLORECTAL Table 5.9 Age and gender of Colon and Rectum cancer. Age Special Notes Mean and standard deviation age at diagnosis (years) 63.9 (12.2) Median and range age at diagnosis 64 (29:91) % of the patient is lower than 15 year of age at diagnosis 0.00% Gender Male 217 (50.9%) Female 209(49.1%) Sex ratio (male: female) 1.04:1 Table 5.10 Most valid method of diagnosis for colorectal cancer. Basis of diagnosis Male Female Total N % N % N % Histology of primary Total Figure 5.13 Age at diagnosis of Colon and Rectum cancer, 2016, by sex. 52

60 Figure 5.14 Distribution of staging for colorectal cancer Figure 5.15 Total case by ICD-O both sex. 53

61 HEMATOPOIETIC AND RETICULOENDOTHELIAL Table 5.11 Age and gender of leukemia cancer. Age Special Notes Mean and standard deviation age at diagnosis (years) 47.3 (26.7) Median and range age at diagnosis 56 (0:92) % of the patient is lower than 15 year of age at diagnosis 21.9% Gender Male 94 (57.3 %) Female 70 (42.7%) Sex ratio (male: female) 1.34:1 Table 5.12 Most valid method of diagnosis. Basis of diagnosis Male Female Total N % N % N % Histology of primary Total Figure Age at diagnosis of Leukemia cancer, 2016, by sex. 54

62 Figure 5.17 Distribution of staging for Leukemia. 55

63 CHILDHOOD CANCER Table 5.13 Type of diagnosis for Childhood Cancer Special Notes Age Mean and standard deviation age at diagnosis (years) 6.4 (4.3) Median and range age at diagnosis 6 (0:14) % of the patient is lower than 15 year of age at diagnosis 100.0% Gender Male 56 (51.4%) Female 53 (48.6%) Sex ratio (male: female) 1.06:1 Figure 5.18 Number of childhood cancer by ICCC group, age<15, both sexes 56

64 Figure 5.19 Number of Cancers in Childhood by ICCC group, age <15 both sexes ICCC GROUP Both sexes Male Female < All < All M:F %MV I Leukemia : II Lymphomas and Reticuloendothelial Neoplasms III CNS and Miscellaneous Intracranial and Intraspinal Neoplasms IV Sympathetic Nervous System Tumors : : : V Retinoblastoma : VI Renal Tumors : VII Hepatic Tumors : VIII Malignant Bone Tumors IX Soft-Tissue Sarcomas X Germ-Cell, Trophoblastic and other Gonadal Neoplasms XI Carcinomas and other Malignant Epithelial Neoplasms : : : : Total :

65 Figure 5.20 Number of Cases of all Childhood Cancers by ICCC and Age Group, both Sexes. 58

66 CHAPTER VI Distribution by Regional of Thailand Table 6.1 Number of cancer cases by region, 2016 Region Freq Percent Northern North-eastern Central 1, Eastern Western Southern Bangkok 1, Total 3, Figure 6.1 Distribution of region,

67 Table 6.2 Number of cancer cases by topography and region, 2016 Topography Northern North-eastern Central Eastern Western Southern Bangkok Total C00-Lip C01-Tongue C02-Other part of Tongue C03-Gum C04-Mouth C05-Palate C06-Other part of mouth C07-Paritid gland C08-Unspecified salivary C09-Tonsil C10-Oropharynx C11-Nasopharynx C12-Pyriform sinus C13-Hypopharynx C14-Pharynx C15-Esophagus C16-Stomach C17-Small intestine C18-Colon C19-Rectosigmoid C20-Rectum C21-Anus,Anal canal C22-Liver and Bile duct C23-Gallbladder C24-Other biliary tract C25-Pancreas C26-Intestinal tract C30-Nasal cavity C31-Accessory sinuses C32-Larynx C34-Lung C37-Thymus C38-Heart C40-Bone of skull and face and associated joint C41-Bone C42-Bone marrow C44-Skin C47-Peripheral nerves C48-Retroperitoneum C49-Soft tissues C50-Breast C51-Vulva C52-Vagina

68 Topography Northern North-eastern Central Eastern Western Southern Bangkok Total C53-Cervix C54-Corpus C55-Uterus C56-Ovary C57-Other female genital C60-Penis C61-Prostate C62-Testis C63-Unspecified male genital organs C64-Kidney C65-Renal C66-Ureter C67-Bladder C68-Unspecified urinary organs C69-Eye C71-Brain C72-Spinal cord C73-Thyroid C74-Adrenal C75-Other Endocrine C76-Ill-defined C77-Lymph node C80-Unknown Total , ,391 3,432 Table 6.3 Distribution of topography by Northern, 2016 Topography Number % C06 Other part of mouth C11 Nasopharynx C15 Esophagus C18 Colon C19 Rectosigmoid C20 Rectum C22 Liver and Bile duct C24 Other biliary tract C25 Pancreas C34 Lung C42 Bone marrow C50 Breast C54 Corpus C61 Prostate C64 Kidney C67 Bladder C69 Eye C73 Thyroid Other Total

69 Figure 6.2 Distribution of topography by Northern, Table 6.4 Distribution of topography by North-eastern, 2016 Topography Number % C11 Nasopharynx C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C24 Other biliary tract C34 Lung C42 Bone marrow C44 Skin C50 Breast C53 Cervix C54 Corpus C61 Prostate C64 Kidney C67 Bladder C69 Eye C71 Brain C73 Thyroid C77 Lymph node Other Total

70 Figure 6.3 Distribution of topography by North-eastern, 2016 Table 6.5 Distribution of topography by Central, 2016 Topography Number % C11 Nasopharynx C15 Esophagus C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C34 Lung C42 Bone marrow C44 Skin C50 Breast C53 Cervix C54 Corpus C61 Prostate C64 Kidney C67 Bladder C71 Brain C73 Thyroid C77 Lymph node Other Total

71 Figure 6.4 Distribution of topography by Central, Table 6.6 Distribution of topography by Eastern, 2016 Topography Number % C11 Nasopharynx C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C25 Pancreas C34 Lung C38 Heart C42 Bone marrow C44 Skin C49 Soft tissues C50 Breast C53 Cervix C61 Prostate C67 Bladder C71 Brain C73 Thyroid C77 Lymph node Other Total

72 Figure 6.5 Distribution of topography by Eastern, 2016 Table 6.7 Distribution of topography by Western, 2016 Topography Number % C02 Other part of Tongue C11 Nasopharynx C15 Esophagus C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C25 Pancreas C34 Lung C42 Bone marrow C44 Skin C50 Breast C53 Cervix C54 Corpus C56 Ovary C61 Prostate C73 Thyroid C77 Lymph node Other Total

73 Figure 6.6 Distribution of topography by Western, Table 6.8 Distribution of topography by Southern, 2016 Topography Number % C11 Nasopharynx C15 Esophagus C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C25 Pancreas C34 Lung C42 Bone marrow C44 Skin C50 Breast C53 Cervix C54 Corpus C67 Bladder C69 Eye C71 Brain C73 Thyroid C77 Lymph node Other Total

74 Figure 6.7 Distribution of topography by Southern, Table 6.9 Distribution of topography by Bangkok, 2016 Topography Number % C15 Esophagus C16 Stomach C18 Colon C20 Rectum C22 Liver and Bile duct C25 Pancreas C34 Lung C42 Bone marrow C50 Breast C53 Cervix C54 Corpus C56 Ovary C61 Prostate C64 Kidney C67 Bladder C71 Brain C73 Thyroid C77 Lymph node Other Total

75 Figure 6.8 Distribution of topography by Bangkok, Figure 6.9 Distribution of staging for breast cancer by region,

76 Figure 6.10 Distribution of staging for lung cancer by region, Stage 1 Stage 2 Stage 3 Stage Figure 6.11 Distribution of staging for colon cancer by region, Stage 1 Stage 2 Stage 3 Stage 4 69

77 Figure 6.12 Distribution of staging for cervix cancer by region, Stage 1 Stage 2 Stage 3 Stage 4 Figure 6.13 Distribution of staging for prostate cancer by region, Stage 1 Stage 2 Stage 3 Stage

78 CHAPTER VII Kaplan-Meier Survival Curve and the Log rank test Cervical cancer Lung cancer Colorectal cancer Liver and bile duct cancer Childhood cancer 71

79 7.1 Cervical cancer Clinical characteristics of 1,937 women diagnosed with cervical cancer between October 2004 and January 2014, follow up till May 2017 Figure Figo stage (n=1713) Survival Probability Estimates at 5 years, 10 years Stage 1, 80.8 %, 73.7 % Stage 2, 64.0%, 53.3 % Stage 3, 44.8 %, 34.9 % Stage 4, 16.6 %, 9.8 % Time (years) 5-yr survival, ACS (cancer.org) Stage I = 93 % Stage II = 63% Stage III = 35% stage IV = 16 Figure Overall Survival Probability by Stage 72

80 7.2 Liver and bile duct cancer Clinical characteristics of 2,578 patient diagnosed with liver and bile duct cancer between 2007 and 2016 Figure age at first diagnosis (n=2,578) 1.00 Survival Probability Estimates at 5 years, 10 years 0.75 P-value < Hepatocarcinoma 23%, 13% Chorangiocarcinoma 9%, 6% time (years) Bile duct adenoma Hepatocarcinoma Figure Overall Survival Probability 73

81 7.3 Colorectal cancer Clinical characteristics of 3,741 patient diagnosed with colorectal cancer between 2007 and survival probability estimates 0.75 P-value < time (years) stage 1, 82% stage 2, 75% stage 3, 62% stage 4, 15% * overall survival at 5 year Figure Overall Survival Probability by Stage 1.00 survival probability estimates P-value < time (years) years survival stage 1, 86% stage 2, 76% stage 3, 61% stage 4, 14% Figure Overall Survival Probability at right colon (Cecum, Ascending, Heppatic flexure,transverse) 74

82 1.00 survival probability estimates P-value < time (years) years survival Stage 1, 82% Stage 2, 75% Stage 3, 63% Stage 4, 15% Figure Overall Survival Probability at right colon (Rectum, Rectosigmoid, Descending colon, Sigmoid colon) 75

83 7.4 Lung cancer Clinical characteristics of 1,739 patient diagnosed with Lung cancer between 2012 and 2016 Figure age at diagnosis and gender Figure Overall Survival Probability for lung cancer by staging 76

84 7.5 Childhood Cancer Clinical characteristics of 945 childhood cancer diagnosed between 2007 and 2016 Figure Age at first diagnosis by ICCC 77

85 Figure Overall survival at 5 years by ICCC 78

86 Title Ramathibodi Cancer Report 2016 Editorial Board Asst.Prof.Somjai Dangprasert Chairman Prof.Sarikapan Wilailak Chairman of Cancer Registry Committee Nintita Sripaiboonkij Thokanit, Dr.PH Cancer Registry Committee All Right reserved Ramathibodi Cancer Registry: A subsidiary of Ramathibodi Comprehensive Cancer Center, Ramathibodi Hospital 270 Rama VI Road, Ratchatewi, Bangkok, Thailand Tel. & Fax. : , Published 2016 Edition Physical 1 st edition 85 Pages ISBN

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