A301 VI- Various cancer tissues with corresponding normal tissues

Transcription

1 A301 VI- Various cancer tissues with (formalin fixed) For research use only Specifications: No. of cases: 28 Tissue type: Various cancer tissues with No. of spots: 2 spots from each cancer case (56 spots) 28 non-neoplastic spots (28 spots) Total spots: 84 Corresponding normal tissues with cancers: Yes Diameter: 1. 0 mm Documents: Product specification: layout, summary of tissue spots H&E stained images Detailed pathological information Layout: P T

2 A301 VI- Various cancer tissues with Summary of tissue spots (formalin fixed) For research use only P T

3 A301 VI- Various cancer tissues with Summary of tissue spots (formalin fixed) For research use only P T

4 A301 VI- Various cancer tissues with (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 A11 A12 B1 B2 B3 B4 B5 B6 B7 B8 B9 B10 B11 B12 P T

5 A301 VI- Various cancer tissues with (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining C1 C2 C3 C4 C5 C6 C7 C8 C9 C10 C11 C12 D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12 P T

6 A301 VI- Various cancer tissues with (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 E11 E12 F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F11 F12 P T

7 A301 VI- Various cancer tissues with (formalin fixed) For research use only QC sheet_lot# Hematoxylin and Eosin staining G1 G2 G3 G4 G5 G6 G7 G8 G9 G10 G11 G12 P T

8 A301 VI: Various cancer tissues with 1 A 1,2 f 52 adrenal gland: pheochromocytoma 2 A 3 f 52 non-neoplastic non-neoplastic from A1,2 1. Adrenal gland, right, adrenalectomy: pheochromocytoma 1) high nuclear grade 2) clear cells: less than 25% 3) presence of capsular invasion, 4) consistent with adrenal cortical carcinoma, by modified Weiss histopathologic criteria. 5) immunohistochemical stain: chromogranin A, NSE, Synaptophysin: (+) 3 A 4,5 m 62 esophagus: squamous cell carcinoma Esophagus and cardia of stomach, esophagectomy and node dissection: 1.Ulcerative squamous cell carcinoma, poorly differentiated, 1) size: 3.3x1cm 2) extension to the outer muscle layer 3) lymphovascular permeation: Positive 2.Resection margins, proximal and distal: Free of tumor. 3.Regional lymph nodes: Free of tumor in all nodes(0/24), in detail, subcarinal(0/10), hilar(0/2), pretracheal(0/6),lower paratracheal(0/3), left paracardial(0/2), 8L(0/1),omental mass(free of tumor). 4 A 6 m 62 non-neoplastic non-neoplastic from A4,5 5 A 7,8 m 35 salivary gland: pleomorphic adenoma 6 A 9 m 35 non-neoplastic non-neoplastic from A7,8 Salivary gland, parotid, right, parotidectomy: Pleomorphic adenoma. 7 A 10,1 1 m 20 terminal ileum: diffuse large cell lymphoma Terminal ileum, segmental resection: diffuse large B cell lymphoma 1) resection margin: lymphoid hyperplasia 2) lymph node: reactive hyperplasia 3) appendix: no pathological diagnosis 4) immunohistochemical staining results: CD20, CD10: diffuse (+), Bcl-6: focal (+), CD3: (-) Ki-67 proliferation index: about 70%. 8 A 12 f 60 non-neoplastic non-neoplastic from A10,11

9 A301 VI: Various cancer tissues with 9 B 1,2 m 59 liver: hepatocellular carcinoma Liver, right lobe, lobectomy: hepatocellular carcinoma 1) size: 8x8x6.8cm 2) edmondson-steiner grade III 3) clear cell(majority) and trabecular histologic type 4) single nodular type with perinodal spreading growth 5) necrosis: less than 10% of total volume 6) microvascular invasion 7) intact intrahepatic resection margin 8) nonneoplastic liver showing: chronic hepatitis, B viral, with mild inflammatory activity(grade II) and early bcirrhosis (stage III). 10 B 3 m 59 non-neoplastic non-neoplastic from B1,2 11 B 4,5 m 51 thyroid gland: papillary carcinoma 12 B 6 m 51 non-neoplastic non-neoplastic from B4,5 13 B 7,8 m 70 soft tissue: diffuse large cell lymphoma 14 B 9 m 70 non-neoplastic non-neoplastic from B7,8 15 B 10,1 1 m 36 skin: invasive squamous cell carcinoma 16 B 12 m 36 non-neoplastic non-neoplastic from B10,11 Thyroid gland, total thyroidectomy with neck node dissection: 1.Papillary carcinoma 1) involving bilateral whole lobe(size: 6.5x3.7cm) 2) extension to perithyroidal fat tissue 2.Regional lymph node: tumor metastasis to 4 out of 20(4/20), in detail, level II(1/2), level III(3/13), level IV(0/5). Soft tissue and lymph node, neck, left, radical neck dissection: 1) soft tissue: diffuse large B cell lymphoma 2) lymph nodes, separately submitted as level ia(0/7), level ib(0/11), level iv(0/16) and level V(0/17): (0/51): reactive hyperplasia 3) salivary gland in level IB: free of tumor 4) tonsil, left, tonsillectomy: chronic follicular tonsillitis 5) immunohistochemical staining results CD20: positive to tumor cells CD3, CD4, CD8, Granzyme, CD30, CD56, ALK: negative to tumor cells 6) EBER ISH (-). Skin, scalp, excision: Invasive squamous cell carcinoma, 1) well-differentiated with extension to the subcutaneous fat tissue (invasion depth: about 3cm) 2) resection margins, all circumference and base: free of tumor 3) lymph nodes, level 2a(0/36), level 2b(0/11), level III(0/25), level IV(0/13) and level V(0/11):(0/96): free of tumor.

10 A301 VI: Various cancer tissues with 17 C 1,2 m 52 urinary bladder: Papillary urothelial carcinoma Urinary bladder including prostate, seminal vesicle and ureter, radical cystectomy: 1. Urinary bladder: Papillary urothelial carcinoma, high grade,with squamous differentiation, with various pathologic state including low grade papillary urothelial carcinoma, urothelial tumor of low malignant potential, carcinoma in situ and papilloma, with extension to the perivesical soft tissue and prostate, and with extensive lymphatic, venous and perineural invasion, incompletely excised. 2. Seminal vesicle: Free of tumor. 3. Ureters, bilateral, resection margins: Free of tumor. 18 C 3 m 52 non-neoplastic non-neoplastic from C1,2 19 C 4,5 m 79 tonsil: squamous cell carcinoma Tonsil, left, wide excision with right neck dissection: squamous cell carcinoma, poorly differentiated 1) size: 3.6x1.5x1.2cm 2) lymphatic permeation: uncertain 3) resection margin, base: free of tumor, margin is very close (less than 1mm) 4) resection margin, lateral: free of tumor 5) lymph node, right, level Ia(0/2), II(0/11), III(0/5), IV(0/4): (0/22): free of tumor 6) lymph node, left, level Ib(0/7), IIa(3/3), IIb(1/2), III(5/7), IV(1/1), V(0/16):(10/36): tumor metastasis, see note. 7) separately submitted lymph node, Ib(0/1), IIb(0/1): free of tumor Note: The largest lymph node involved by tumor measures 1.8x1.3cm in level III of the left side. 20 C 6 m 79 non-neoplastic non-neoplastic from C4,5 21 C 7,8 f 70 lung: squamous cell carcinoma 22 C 9 f 70 non-neoplastic non-neoplastic from C7,8 Lung, right lower lobe, lobectomy: squamous cell carcinoma, moderately differentiated 1) size: 7x5cm 2) extension to the visceral pleura 3) associated obstructive pneumonitis 4) bronchial resection margin: free of tumor.

11 A301 VI: Various cancer tissues with 23 C 10,1 1 m 55 lung: adenocarcinoma 24 C 12 m 55 non-neoplastic non-neoplastic from C10,11 Lung, left lower lobe, lobectomy: adenocarcinoma, acinic and papillary with 1) marked mucin production 2) size: 4.7x4.6cm 3) extension to visceral pleura 4) bronchial resection margin: free of tumor 5) regional lymph node, peribronchial: tumor metastasis(1/1). 25 D 1,2 m 52 Pancreas: Adenocarcinoma Pancreas, distal pancreatectomy: 1.Adenocarcinoma, moderately differentiated 1) Size: 3.5x2.5cm 2) Tumor involvement: Extension to peripancreatic soft tissue and encircling the common hepatic artery without invasion. 3) Vascular invasion: Present 4) Neural and perineural invasion: Frequently present 2.Resection margin, pancreas: Free from tumor 3.Resection margin, circumferential: Free from tumor (margin of clearance: 20um) [Non-neoplastic pancreas] Chronic pancreatitis with parenchymal atrophy at tail portion of pancreas. Lymph nodes, peripancreatic : (4/13) Metastatic carcinoma in 4 out of 13 lymph nodes. 26 D 3 m 52 non-neoplastic non-neoplastic from D1,2 27 D 4,5 m 62 Prostate: adenocarcinoma Prostate, radical prostatectomy: 1.Adenocarcinoma, Gleason score 7(4+3) involving both sides of lobes, multifocally, confined to prostatic parenchyme without capsular involvement. 2.Seminal vesicles, bilateral: Free of tumor. 3.Lymph node, iliac, dissection: Free of tumor in all 14 lymph nodes (0/14), in detail, right(0/7) and left (0/7). 28 D 6 m 62 non-neoplastic non-neoplastic from D4,5

12 A301 VI: Various cancer tissues with 29 D 7,8 m 66 colon: adenocarcinoma 30 D 9 m 66 non-neoplastic non-neoplastic from D7,8 31 D 10,1 1 m 45 colon: adenocarcinoma 32 D 12 m 45 non-neoplastic non-neoplastic from D10,11 33 E 1,2 f 70 stomach: adenocarcinoma 34 E 3 f 70 non-neoplastic non-neoplastic from E1,2 Colon, rectum, lower anterior resection: adenocarcinoma, well differentiated, polypoid 1) size: 4.2x2.5cm 2) confined to the mucosa 3) associated low and high grade tubulo-villous adenoma 4) resection margins, proximal and distal: free of tumor 5) regional lymph nodes: free of tumor in all nodes(0/21), regional(0/21), principal(0/0). Colon, rectum, lower anterior resection: 1.colon: ulcerofungating adenocarcinoma, moderately differentiated, 1) size: 5.5x4.5cm 2) extension to the pericolic fat tissue(pt3c) 3) lateral margin: free of tumor 4) lymphovascular permeation(+) 2.urinary bladder: free of tumor 3.resection margins, proximal and distal: free of tumor 4.regional lymph nodes: tumor metastasis to 4 out of 11(4/11), in detail, regional(4/8), principal(0/3). Stomach, pancreas and spleen, radical total gastrectomy, splenectomy and pancreatectomy: 1.Stomach: ulceroinfiltrative adenocarcinoma, moderately differentiated, 1) size: 10.7x9cm 2) extension to the serosa and pancreas parenchyme 3) lymphovascular permeation: positive 4) Intestinal type by Lauren's classification 2.Resection margins, proximal and distal: free of tumor 3.Resection margin, pancreas: free of tumor 4.Regional lymph nodes: tumor metastasis to 2 out of 47(2/47), in detail, N1(0/5), N3(0/5), N4(0/8), N5(0/2), N6(1/16), N7(0/2), N8(1/4), N9(0/2), N10(0/3) 5.Pancreas: tumor extension 6.Spleen: congestion.

13 A301 VI: Various cancer tissues with 35 E 4,5 m 67 stomach: signet ring cell carcinoma 36 E 6 m 67 non-neoplastic non-neoplastic from E4,5 37 E 7,8 f 65 kidney: renal cell carcinoma 38 E 9 f 65 non-neoplastic non-neoplastic from E7,8 39 E 10,1 1 m 52 kidney: renal cell carcinoma Stomach, subtotal gastrectomy: 1.ulceroinfiltrative signet ring cell carcinoma 1) size: 4.5x4cm 2) extension to the serosa(serosa attached) 3) lymphovascular permeation: positive 4) perineural invasion: positive 5) diffuse type by lauren's classification 2. resection margins, proximal and distal: free of tumor 3. regional lymph nodes: tumor metastasis to 3 out of 31(3/31), in detail, N3(0/6), N4(0/7), N5(1/2), N6(2/5), N7(0/10), N12(0/1). Kidney, left, radical nephrectomy: 1.Renal cell carcinoma, conventional(clear cell) type 1) Fuhrman's nuclear grade: IV 2) Foci of sarcomatoid differentiation 3) Invasion to the perinephric fat tissue but not to Gerota's fascia 4) Renal vein involvement(pt3b) 2.Resection margin, ureter: Free of tumor. 3.Resection margin, renal vein: Presence of tumor. 4.Lymph nodes, perihilar(0/11), paraaortic(0/2) and left common iliac(0/3): Free of tumor metastasis in all 16 nodes. 5.Adrenal gland: Free of tumor. 1. Kidney, left, nephrectomy: renal cell carcinoma, clear cell type 1) size: 4x4cm 2) confined within the renal capsule 3) nuclear grade II 4) renal artery and vein: free of tumor 2. Ureter resection margin: free of tumor 3. Adrenal gland: free of tumor. 40 E 12 m 52 non-neoplastic non-neoplastic from E10,11 41 F 1,2 f 21 parotid gland: pleomorphid adenoma Parotid gland, right, parotidectomy: 1.Pleomorphic adenoma. 2.Lymph node: Reactive hyperplasia. 42 F 3 f 21 non-neoplastic non-neoplastic from F1,2

14 A301 VI: Various cancer tissues with 43 F 4,5 f 15 ovary: yolk sac tumor 44 F 6 f 15 non-neoplastic non-neoplastic from F4,5 45 F 7,8 f 47 uterus: adenocarcinoma 46 F 9 f 47 non-neoplastic non-neoplastic from F7,8 47 F 10,1 1 f 40 uterus: squamous cell carcinoma 48 F 12 f 40 non-neoplastic non-neoplastic from F10,11 49 G 1,2 f 52 breast: Invasive lobular carcinoma. 50 G 3 f 52 non-neoplastic non-neoplastic from G1,2 Ovary and fallopian tube, right, right salpingooophorectomy: 1) ovary: malignant germ cell tumor, probably yolk sac tumor (endodermal sinus tumor) 2) fallopian tube: paraovarian cyst 3) result of special stain: AFP(+), HCG(-), PAS(+), D-PAS(-). Uterus with right adnexa, total abdominal hysterectomy with right salpingooophorectomy: 1.Cervix: Invasive squamous cell carcinoma, moderately differentiated, mixed with adenocarcinoma, moderately differentiated 1) size: 4x3cm 2) extension to lower 1/3 of the wall (invasion depth: 1.9cm) 3) lymphatic permeation: positive 4) lateral margin: Free of tumor. 2.Endometrium: Secretory phase. 3.Myometrium : 1. Leiomyomas, intramural. Uterus with lymph nodes, pelvic, radical abdominal hysterectomy with dissection: 1.Cervix: Invasive squamous cell carcinoma, large cell, keratinizing (invasion depth: 1.1cm) with focal lymphovascular permeation. 2.Endometrium: Proliferative phase. 3.Myometrium : Adenomyosis. 4.Parametria, bilateral: Free of tumor. 5.Vaginal cuff: Free of tumor. 6.Lymph nodes, right pelvic(0/4), left pelvic(0/6), regional(0/2):(0/12): Free of tumor. Breast, left, lumpectomy: Invasive lobular carcinoma.

15 A301 VI: Various cancer tissues with 51 G 4,5 m 52 cecum: adenocarcinoma 52 G 6 m 52 non-neoplastic non-neoplastic from G4,5 53 G 7,8 m 36 Testis:Seminoma 54 G 9 m 36 non-neoplastic non-neoplastic from G7,8 55 G 10,1 1 m 31 Thymus: thymoma 56 G 12 m 31 non-neoplastic non-neoplastic from G10,11 Cecum, ascending colon, terminal ileum and appendix, right hemicolectomy: 1.Ulcerofungating adenocarcinoma, moderately differentiated, inascending colon 1) size: 5x4cm 2) expanding growth 3) invasion to pericolic soft tissue. 4) vascular invasion. 5) intact proximal (terminal ileum) and distal (colon) resection margins. 6) metastasis to 2 out of 32 pericolic lymph nodes. 7) a tubular adenoma with low grade dysplasia in the surrounding mucosa. 8) Terminal ileum: Prominent peyer's patch. 9) Appendix: Free from tumor extension. Testis, left, orchiectomy: 1.Seminoma with invasion beyond tunica albuginea(pt2) and associated with intratubular germ cell neoplasia. 2.Spermatic cord: Free of tumor Thymus, thymectomy: 1.Type B2 thymoma (cortical thymoma by Muller-Hermelink scheme) 1) size: 8x5.5cm 2) confined to the thymic capsule(pt1) (Masaoka's stage I). 3) multilocular thymic cyst 4) resection margin: Free of tumor. 2. Adenomyosis. 3.Ovary: No pathological diagnosis. 4.Fallopian tube: Paratubal cyst. 5.Parametrium, bilateral: Free of tumor. 6.Vaginal cuff: Free of tumor. 7.Regional lymph nodes: Free of tumor in all nodes(0/4), in detail, paraaortic(0/0), left pelvic(0/2), right pelvic(0/2).