Pharmacokinetic analysis on drug causing lung cancer

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Volume 119 No. 12 2018, 103-114 ISSN: 1314-3395 (on-line version) url: http://www.ijpam.eu ijpam.eu Abstract Pharmacokinetic analysis on drug causing lung cancer 1 Jayalakshmi.T, 2 MG.

1 Volume 119 No , ISSN: (on-line version) url: ijpam.eu Abstract Pharmacokinetic analysis on drug causing lung cancer 1 Jayalakshmi.T, 2 MG.Amarnath Reddy Associate Professor, 2 UG Student Dept. of Genetic Engineering BIHER, BIST, Bharath University Chennai jayalakshmit.gen@bharathuniv.ac.in Pharmacokinetic properties has been developed where the metabolism, production and pathogenicity was identified. The present study compares low binding lead compounds and their potential binding attraction leads to the identification of main pathogenic diseases such as lung cancer. It performs an experimental study to identify the similarities between normal lung cancer to contagious lung cancer. It has been proved by clinical studies to identify a difference between them and the inflammatory prostate cancer has been identified. Key words: Enzymes, Inhibitors, Lung cancer, target drug. Introduction Cancer (medical term: malignant neoplasm) which is having undefined growth has been divided through normal metastatic method which can spread from normal cell to dead cells and protrude [1]into it to destroy adjacent tissues and cells. In some cases, the contagious cells can spread to other parts of the body through blood [1]. The properties of malignant cancer can be varied from normal cells in many criteria but having slight variations with benign tumors. Lung cancer Lung cancer mainly affects lungs where the uncontrolled growth takes place in the lining of the lung. It grows by the mechanism of metastasis where [2]it affects adjacent tissues of the lung and beyond it. Initially, the lung cancer can initiate in epithelial layer of cells and causes death in all ages of people annually from The most commonly occuring symptoms include weezing, cold, cough and loss of weight

2 Types of lung cancer Lung cancer can be treated by using radiotheraphy and chemotherapeutic agents can be used. In terms of preliminary to contagious lung cancer radiation theraphy can be used rather than chemotheraphy.[3,4] Larger airways usually refers to Oat cell carcinoma and the small cells leads to paraneoplastic syndrome association [5]. Treatment Surgery: Surgery is limited based on non-small cell lung carcinoma limited to one lung, up to critical stage [6]. Chemotherapy: Chemotheraphy can be given to 5 or 10% and applied in most severe cases[7]. Radiotherapy: Radiotherapy can be given instead of chemotheraphy and in carcinoma cases.[8-12] 2 104

3 Materials and methods: PUBMED: Fig 1. Pubmed snapshot 3 105

4 PUBCHEM: PDB(Protein data bank): Fig. 2 Pubchem snapshot Fig 3. pdb page snapshot 4 106

5 Results: Fig1.TOPOTECAN structure retrival from Pubchem 5 107

6 Fig 2. Structure of TOPOTECAN in PUBMED Fig 3. Shows 3d Structure with Energy Value 6 108

7 Docking score value: sno Name of the molecule G-value 1 acetogenins Allicin Allixin allylsulphides Apigenin Artesunate Betaglucan Capsaicin Catechin Combretastatin A Diallyl disulfide Ellagic acid Ferulic acid Glutathione Hydroxytyrosol Discussion and Summary The molecules were allowed[13-18] for receptor-ligand interaction by using docking tools. The score was identified and the molecules were showed by showing better interactions. It also finds the better score which results in receptor-ligand interaction by docking technique.[19-45] References : 1. Nimal, R.J.G.R., Hussain, J.H., Effect of deep cryogenic treatment on EN24 steel,, V-116, I-17, PP , Parameswari, D., Khanaa, V., Deploying lamport clocks and linked lists, International Journal of Pharmacy and Technology, V-8, I-3, PP , Parameswari, D., Khanaa, V., Case for massive multiplayer online role-playing games, International Journal of Pharmacy and Technology, V-8, I-3, PP ,

8 4. Parameswari, D., Khanaa, V., Deconstructing model checking with hueddot, International Journal of Pharmacy and Technology, V-8, I-3, PP , Parameswari, D., Khanaa, V., The effect of self-learning epistemologies on theory, International Journal of Pharmacy and Technology, V-8, I-3, PP , Pavithra, J., Peter, M., GowthamAashirwad, K., A study on business process in IT and systems through extranet, International Journal of Pure and Applied Mathematics, V-116, I-19, PP , Pavithra, J., Ramamoorthy, R., Satyapira Das, S., A report on evaluating the effectiveness of working capital management in googolsoft technologies, Chennai,, V-116, I-14, PP , Pavithra, J., Thooyamani, K.P., A cram on consumer behaviour on Mahindra two wheelers in Chennai,, V- 116, I-18, PP-55-57, Pavithra, J., Thooyamani, K.P., Dkhar, K., A study on the air freight customer satisfaction,, V-116, I-14, PP , Pavithra, J., Thooyamani, K.P., Dkhar, K., A study on the working capital management of TVS credit services limited, International Journal of Pure and Applied Mathematics, V-116, I-14, PP , Pavithra, J., Thooyamani, K.P., Dkhar, K., A study on the analysis of financial performance with reference to Jeppiaar Cements Pvt Ltd, International Journal of Pure and Applied Mathematics, V-116, I-14, PP , Peter, M., Dayakar, P., Gupta, C., A study on employee motivation at Banalari World Cars Pvt Ltd Shillong, International Journal of Pure and Applied Mathematics, V-116, I-18, PP , Peter, M., Kausalya, R., A study on capital budgeting with reference to signware technologies,, V-116, I-18, PP-71-74, Peter, M., Kausalya, R., Akash, R., A study on career development with reference to premheerasurgicals,, V- 116, I-14, PP , Peter, M., Kausalya, R., Mohanta, S., A study on awareness about the cost reduction and elimination of waste among employees in life line multispeciality hospital,, V-116, I-14, PP , Peter, M., Srinivasan, V., Vignesh, A., A study on working capital management at deccan Finance Pvt Limited Chennai, International Journal of Pure and Applied Mathematics, V-116, I-14, PP ,

9 17. Peter, M., Thooyamani, K.P., Srinivasan, V., A study on performance of the commodity market based on technicalanalysis, International Journal of Pure and Applied Mathematics, V-116, I-18, PP , Philomina, S., Karthik, B., Wi-Fi energy meter implementation using embedded linux in ARM 9, Middle - East Journal of Scientific Research, V-20, I-12, PP , Philomina, S., Subbulakshmi, K., Efficient wireless message transfer system,, V-116, I-20, PP , Philomina, S., Subbulakshmi, K., Ignition system for vechiles on the basis of GSM,, V-116, I-20, PP , Philomina, S., Subbulakshmi, K., Avoidance of fire accident by wireless sensor network,, V-116, I-20, PP , Pothumani, S., Anuradha, C., Monitoring android mobiles in an industry,, V-116, I-20, PP , Pothumani, S., Anuradha, C., Decoy method on various environments - A survey,, V-116, I-10, PP , Pothumani, S., Anuradha, C., Priya, N., Study on apple icloud, International Journal of Pure and Applied Mathematics, V-116, I-8, PP , Pothumani, S., Hameed Hussain, J., A novel economic framework for cloud and grid computing,, V-116, I- 13, PP-5-8, Pothumani, S., Hameed Hussain, J., A novel method to manage network requirements,, V-116, I-13, PP-9-15, Pradeep, R., Vikram, C.J., Naveenchandra, P., Experimental evaluation and finite element analysis of composite leaf spring for automotive vehicle, Middle - East Journal of Scientific Research, V-12, I-12, PP , Pradeep, R., Vikram, C.J., Naveenchandran, P., Experimental evaluation and finite element analysis of composite leaf spring for automotive vehicle, Middle - East Journal of Scientific Research, V-17, I-12, PP , Prakash, S., Jayalakshmi, V., Power quality improvement using matrix converter,, V-116, I-19, PP-95-98, Prakash, S., Jayalakshmi, V., Power quality analysis & power system study in high voltage systems,, V-116, I-19, PP-47-52,

10 31. Prakash, S., Sherine, S., Control of BLDC motor powered electric vehicle using indirect vector control and sliding mode observer, International Journal of Pure and Applied Mathematics, V-116, I-19, PP , Prakesh, S., Sherine, S., Forecasting methodologies of solar resource and PV power for smart grid energy management, International Journal of Pure and Applied Mathematics, V-116, I-18, PP , Prasanna, D., Arulselvi, S., Decoupling smalltalk from rpcs in access points,, V-116, I-16, PP-1-4, Prasanna, D., Arulselvi, S., Exploring gigabit switches and journaling file systems,, V-116, I-16, PP-13-17, Prasanna, D., Arulselvi, S., Collaborative configurations for wireless sensor networks systems,, V-116, I-15, PP , Priya, N., Anuradha, C., Kavitha, R., Li-Fi science transmission of knowledge by way of light,, V-116, I-9, PP , Priya, N., Pothumani, S., Kavitha, R., Merging of e-commerce and e-market-a novel approach,, V-116, I- 9, PP , Raj, R.M., Karthik, B., Effective demining based on statistical modeling for detecting thermal infrared,, V-116, I-20, PP , Raj, R.M., Karthik, B., Energy sag mitigation for chopper, International Journal of Pure and Applied Mathematics, V-116, I-20, PP , Raj, R.M., Karthik, B., Efficient survey in CDMA system on the basis of error revealing,, V-116, I-20, PP , Rajasulochana, P., Krishnamoorthy, P., Ramesh Babu, P., Datta, R., Innovative business modeling towards sustainable E-Health applications, International Journal of Pharmacy and Technology, V-4, I-4, PP , Rama, A., Nalini, C., Shanthi, E., An iris based authentication system by eye localization, International Journal of Pharmacy and Technology, V-8, I-4, PP , Rama, A., Nalini, C., Shanthi, E., Effective collaborative target tracking in wireless sensor networks, International Journal of Pharmacy and Technology, V-8, I-4, PP , Ramamoorthy, R., Kanagasabai, V., Irshad Khan, S., Budget and budgetary control,, V-116, I-20, PP ,

11 45. Ramamoorthy, R., Kanagasabai, V., Jivandan, S., A study on training and development process at Vantec Logistics India Pvt Ltd, International Journal of Pure and Applied Mathematics, V-116, I-14, PP ,

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HARD EXUDATES DETECTION SYSTEM FOR RETINOPATHY PATIENTS

Applied Mathematics Volume 119 No. 12 2018, 5061-5067 ISSN: 1314-3395 (on-line version) url: http://www.ijpam.eu ijpam.eu HARD EXUDATES DETECTION SYSTEM FOR RETINOPATHY PATIENTS 1 E.Kanniga 2 Senthur Pandian.S