8th Course on Epigenetics : March Programme Training Unit - International Course - Open conferences (in blue)

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1 8th Course on Epigenetics : March Programme Training Unit - International Course - Open conferences (in blue) Wednesday March 14th Chair: Nathalie Dostatni / Geneviève Almouzni Jacqueline Legras/Mélanie Herrbach (Institut Curie, Training Unit, Paris, France) Welcome, practical aspects & student poster set-up 08:45 Geneviève Almouzni/Nathalie Dostatni Presentation of the module by the organizers & scientific committee 09:00-10:00 10:00 10:30 Students presentation/ personal work POSTERS SET-UP Short presentation of background and research interest (1 mn each) - Andrew Moore Optimise your chances of publication and recognition: See your paper 11:45 (BioEssays, Weinheim, Germany) from the other side 12:00-12:45 Nathalie Dostatni Position effect variegation in Drosophila : a paradigm for epigenetics 15:45 16:00 16:30-17:30 Brad Cairns (Huntsman Cancer Institute, Salt Lake City, USA) Michiel Vermeulen (Molecular Cancer Research, Utrecht, The Netherlands) BREAK "BDD Hall" Tony Kouzarides (Gurdon Institute, Cambridge, UK) Chromatin dynamics in the vertebrate germline and early embryo Quantitative proteomics for epigenetics Chromatin modifying enzymes in transcription and cancer 17:30-19:30 POSTER SESSION & Workshop on Presentation/communication skills Animated by Andrew Moore and Valérie Borde 19:30 Welcome reception at the "Green Café" 12, rue Lhomond -

2 Thursday March 15th Chair: Patricia Le Baccon / Angela Taddei NUCLEAR ORGANIZATION 9:30-10:30 - Patricia Le Baccon Article presentation by Adriana Gonzalez & Spyridon Merkouris Microscopy, high-resolution microscopy and epigenetics. Domain topology of nucleoporin Nup98 within the nuclear pore complex. Journal of Structural Biology (2012). 177, Proposed by Patricia Le Baccon Reviewed by Tomasz Chelmiki & Kamal al Zaman Serhal Peter Meister (University of Bern, Switzerland) Sequences and Signals for Genome Nuclear Organization in C. elegans 12:30 - Article presentation by Maria-Joao Silva & Noa Oded Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation. Molecular Cell (2010). 38, Proposed by Peter Meister & Reviewed by Sophie Ajjan & André Eid Edouard Bertrand (Institute of Molecular Genetics, Montpellier, France) Gene expression viewed from the microscope Article presentation by Matteo Vietri Rudan & An-Yun Chang Real-Time Observation of Transcription Initiation and Elongation on an Endogenous Yeast Gene. Science (2011). 332, Proposed by Edouard Bertrand Reviewed by Ekaterina Gracheva & Julianne Schmidt "The hidden life of our genes" 16:30 17:45 Angela Taddei Compartmentalisation and dynamics of nuclear functions in budding yeast 18:00-18:20 Article presentation by Scott Berry & Anne Laugesen Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome. Cell (2012).148, Proposed by Angela Taddei Reviewed by Rahul Sharma & Michael Moffat

3 Friday March 16th Chair: Manolis Papamichos-Chronakis / Arturo Londono-Vallejo CHROMATIN DYNAMICS 9:30- Geneviève Almouzni Variations on the theme of chromatin assembly 10:30- Article presentation by Marie Clémot & Arsenios Vlassis Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression. Developmental Cell (2012). 22, Proposed by Ekaterina Boyarchuk Reviewed by Marta Tepereck-Tkacz & Paulina Marzec Andreas Ladurner (EMBL, Heidelberg, Germany) Rapid nuclear remodeling and signaling upon DNA damage 12:30- Article presentation by Tomasz Chelmiki & Beata Wyspianska Poly(ADP-ribose) Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science (2009). 325, Proposed by Andreas Ladurner Reviewed by Neus Cantarino and Maria-Joao Silva Arturo Londono-Vallejo (UMR 3344, Institut Curie/CNRS, Paris, France) Epigenetics at the tips of mammalian chromosomes 15:20 Article presentation by Nathalie Côté & Antoine Campagne A role for heterochromatin protein 1γ at human telomeres. Genes & Development (2011). 25, Proposed by Arturo Londono-Vallejo Reviewed by Sara Jaber & Adriana Gonzalez 16:00-16:45 Manolis Papamichos-Chronakis Chromatin dynamics in genome stability 17:20 Article presentation by Ekaterina Gracheva & Emilie Montellier Chromatin Signaling to Kinetochores: Transregulation of Dam1 Methylation by Histone H2B Ubiquitination. Cell (2011). 146, Proposed by Manolis Papamichos-Chronakis Reviewed by Ava Handley and Karina Jouravleva 17:30-18:00 Alex Eccleston (Nature, London, UK) Inside Nature: an editor s view of the journal and peer review process 18:15 Epigenetic Imagin(in)g workshop with Paul Harrison "Chez Marie" room 12, rue Lhomond Paris

4 Saturday March 17th BRUNCH DEDICATED TO CAREER DEVELOPMENT - Organized by PhD students/post-docs (UMR 218, Institut Curie/CNRS, Paris) Invited participants: President: Dan Filipescu Members: Salome Adam, Micol Guidi, Tanguy Lucas, Anne Lafon, Elisabetta Serrentino. Alex Eccleston Senior Editor at Nature, London, UK. Michele Garfinkel Science Policy Programme Manager, EMBO, Germany. Laurent Marrot Head of the Biological Research Department, L Oréal, Paris. Cyril Buhler - Project Manager at DNA therapeutics, Paris. Muriel Derrien - Industrial Property Attorneys, Casalonga&Joss, Paris Self Institut Curie 25, rue d'ulm - 1 st floor Paris. Sylvain Courbet Teacher at high school, Lycée International de Saint Germain en Laye. Gérald Peyroche - Maître de conférences, ENS Cachan. Leanne De Koning, Head of the Technological Platform of Reverse Phase Protein Array at Institut Curie

5 Monday March 19th Chair: Edith Heard / Raphaël Margueron EPIGENETIC PROCESSES & TRANSCRIPTIONAL LANDSCAPE 09:30-10:30- Edith Heard (CNRS/UMR 3215 / Inserm U934, Institut Curie, Paris, France) Article presentation by Julianne Schmidt & Marta Teperek-Tkacz Chromosome structure, nuclear dynamics and epigenetics: lessons from X-chromosome inactivation Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain. Science (2010). 329, High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain. Science (2010). 329, Proposed by Edith Heard Reviewed by Peter Hill and Spyridon Merkouris Caroline Dean (John Innes Center, Norwich, UK) Dissection of cold-induced epigenetic silencing 12:30- Article presentation by Paulina Marzec & Francesca Taglini Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA. Science (2011). 331, Proposed by Caroline Dean Reviewed by Benoit Lahouse & Antoine Campagne Antonin Morillon (UMR 3344, Institut Curie/CNRS, Paris, France) How non-coding (nc)rnas link to histone modifications in budding yeast Curie 15:20 Article presentation by Sophie Ajjan & Kamar al Zaman Serhal RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature (2012). 479, Proposed by Antonin Morillon Reviewed by An-Yun Chang & Scott Berry BREAK "BDD Hall" 16:00-16:45 Raphaël Margueron (CNRS/UMR 3215 / Inserm U934, Institut Curie, Paris, France) Mechanisms of repression by Polycomb Proteins 17:20 Article presentation by André Eid & Marius Van den Beek Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs. Cell Stem Cell (2012). 10, Proposed by Raphaël Margueron Reviewed by Matteo Vietri Rudan & Anne Laugesen 17:30-18:00 Dörthe Nickel (EpiGeneSys) Scientific Funding 18:00 POSTER SESSION - DRINKS - Animated by M. Papamichos -Chronakis

6 Tuesday March 20th Chair: Deborah Bourc'his / Valérie Borde SILENCING & MAINTENANCE OF GENOME INTEGRITY 09:30- Deborah Bourc'his (CNRS/UMR 3215 / Inserm U934, Institut Curie, Paris, France) Epigenetic cooperation against transposons in the mammalian germline 10:30- Article presentation by Michael Moffat & Peter Hill Role for pirnas and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus. Science (2011). 332, Proposed by Deborah Bourc'his Reviewed by Beata Wyspianska & Francesca Taglini Marc Bühler (FMI, Basel, Switzerland) Co-transcriptional gene silencing 12:30- Article presentation by Ava Handley & Karina Jouravleva Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature (2008). 451, Proposed by Marc bühler Reviewed by Marius Van den Beek & Nathalie Côté Philippe Pasero Epigenetic mechanisms controlling DNA replication and genome (Institute of Human Genetics, Montpellier, France) integrity 15:20 16:00-16:45 17:20 Article presentation by Sara Jaber & Neus Cantarino Valérie Borde (UMR 218, Institut Curie/CNRS Paris, France) Article presentation by Benoit Lahouze & Rahul Sharma Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011). 13, Proposed by Philippe Pasero Reviewed by Arsenios Vlassis & Marie Clémot Chromatin dynamics before and after double-strand break formation in meiosis Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature (2011). 472, Proposed by Valérie Borde Reviewed by Emilie Montellier & Noa Oded 17:30 Lucie Sengmanivong OPTIONAL : Visit of Nikon Imaging Center 12, rue Lhomond - 19:30 Farewell Cocktail & Buffet Dinner "Chez Marie" 12, rue Lhomond -

7 Wednesday March 21st Chair: Geneviève Almouzni / Sophie Polo 09:30 10:00-10:45 DEBRIEFING OF THE COURSE Stephan Beck (University College, London, UK) BREAK "BDD Hall" EWAS: The new kid on the block for epigenome-wide association studies 11:30-12:30 Rob Martienssen (CSHL, Cold Spring Harbor, USA) Fission Yeast Heterochromatin 11-13, rue Pierre et Marie Curie Paris 12:30 13:30 Amanda Fisher (Imperial College, London, UK) Resetting the genome how does epigenetic reprogramming work? 14:30 Farewell and departure