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1 Index A Actomyosin, cleavage furrow ingression, AICAR. See Aminoimidazole carboxamide ribonucleotide ALIX, 157 Aminoimidazole carboxamide ribonucleotide (AICAR), 179 Ana2, 74 76, 89 Anaphase chromosome dynamics, sister chromatid separation and dynamics, 60 Anaphase-promoting complex (APC) activation, 18, 22 discovery, 7 8 ubiquitin ligase activity, Aneuploidy effects cell fitness, 171 genome stability, health, transcription and protein composition, molecular mechanisms cohesion defects, merotelic attachments, spindle assembly checkpoint defects, overview, 166 prospects for study, therapeutic targeting, tolerating mutations, tumorigenesis driver, inhibition, Anillin, 152 APC anaphase-promoting complex. See Anaphase-promoting complex tumor suppression, Arf6, 154 Arp2/3, 193 ASE1, metaphase spindle function, 41 Asl, 79, 89 ASPM, 90 Aurora A cilium cycle role, 84 mitosis entry role, Aurora B anaphase function, 60 cytokinesis role, 150 kinetochore regulation, B BAF, 188 Bfa1, 88 BLM, Boveri, Theodor, 4, 67 BRCA1, 90, 169 Bub1, 138, 140, , 191 Bub3, 140, 168 BUBR1, 23, , 178 C CAK. See Cdk-activating kinase CALK, 84 CAP350, 78 CBB, 89 CBF3, 131 CCDK. See Cyclin-dependent kinase CDC10, 8 Cdc14, 24, 87 CDC20, 22 23, 168 Cdc25, mitosis entry role, Cdc31, 71 cdc mutants, history of yeast cell cycle studies, 6 7 Cdk-activating kinase (CAK), mitosis entry role, 16 Cdk2, CDKRAP2, 81 Cell cycle cdc mutants, history of yeast cell cycle studies, 6 7 overview of phases, 1 2 CEN3, 8 CENP-A assembly constitutive centromere proteins in assembly, HJURP chaperone, , 133 Mis18 complex, 117 overview, centromere longevity and CENP-A maintenance during DNA replication, centromere protein recognition of CENP-A chromatin, depletion studies, 111 functional overview, 9 10, 105 histone H3 comparison, 108 nucleosome deposition at centromeres, distribution during DNA replication, 120 structure, prospects for study, 121 CENP-B box,

2 Index This is a free sample of content from Mitosis. CENP-C, , , 121, 134 CENP-E, 137, 140 CENP-H, 113, CENP-N, 108, , 119, 121 CENP-S, 109, 119, 133 CENP-T, 109, 113, 119, 121, CENP-U, 113 CENP-W, 109, 119, 133 CENP-X, 109, 119, 133 Centriole assembly cartwheel structure, elongation, Plk4 role, 73, species comparison, 74 asymmetry and cell fate decisions, duplication cycle, structure, 72 Centromere. See also CENP-A CENPs architecture, CENP-B box, 111 interactions, composition, epigenetic nature, , 131 functional overview, histone modifications, history of study, 8 9, 103 longevity and CENP-A maintenance during DNA replication, prospects for study, 121 Centrosome asymmetry and cell fate decisions, control center activity, disengagement of mother daughter linkage, disjunction at G2/M, duplication cycle, 68 history of study, 67, 69 pericentriolar material assembly, spindle pole body similarity, 69 structure, 68 Cep55, 157 CEP57, 120 CEP63, 90 Cep83, 83 Cep89, 83 Cep97, 78, 83 CEP120, 77 Cep135, 75 Cep152, 75, 79, 90 Cep164, 83 Cep192, 76, 79, 81 CEP290, 77 CFS. See Common fragile site Chk1, 86, 90 CHMP4 proteins, 157 Chromosomal instability (CIN). See also Aneuploidy cohesion defects, measurement, merotelic attachments, overview, 166 Chromosomal passenger complex (CPC), , 194 Cilia, assembly and disassembly cycle, CIN. See Chromosomal instability CIT-K. See Citron kinase Citron kinase (CIT-K), , 156 CLASP, 38, 138, 150, 169 C-Nap1, CNN, Cnp1, 9 Cohesin functional overview, 12 meiosis and stepwise removal, prophase condensation and cohesin release from chromosome arms, sister chromatid adhesion in S phase, subunit organization, Common fragile site (CFS), 61 Condensin condensin I function, 59 60, 62 condensin II function, cytokinesis and chromosome segregation coordination, 62 prophase condensation and cohesin release from chromosome arms, subunit organization, CP110, 77 78, 83 CPAP, 75, 77 78, 90 CPC. See Chromosomal passenger complex CREST syndrome, 105 CUEDC2, 169 Cut2, 8 Cut12, Cyclin A, mitosis entry role, 18 Cyclin B. mitosis entry role, Cyclin-dependent kinase (CDK) history of study, 6 7, 11 kinetochore regulation, 138 meiosis, 186 mitosis entry role, Cyclosome. See Anaphase-promoting complex Cytokinesis chromosome segregation coordination, 62 cleavage furrow ingression, defects and disease, division plane positioning, membrane formation and composition, midbody dynamics, overview, prospects for study, 158 D Dam1, 136 DSCR1, 178 Dynein, metaphase spindle function, DYRK1A,

3 Index E EB1, metaphase spindle function, Eg5, 79 ENSA, mitosis exit role, 24 ESCO1, 55 ESCO2, 55 ESCRT complexes, cytokinesis role, F Fa1, 83 Fa2, 83 FANCD2, FANCI, 62 FBF1, 83 Fbxw5, 77 Fin1, 85 FIP3, 154 FIP4, 154 Flemming, Walther, 2 4, 103 FOP, 78 G g-tubulin ring complex (g-turc), spindle pole body, g-turc. See g-tubulin ring complex GOLPH3, 154 H HDAC6, 83 HDAC8, 55 HEC1, 176 HEF1, 79, Histone H3, CENP-A comparison, 108 HJURP, 108, , 133 HP-1, 9 HRAS, 177 hsav1, 79 HSET, 179 HURP, 191 K K-RAS, 177 Kar1, 71 KIF4, 59 KIF4A, cytokinesis role, KIF14, 156 KIF20A, cytokinesis role, 149 KIF23, cytokinesis role, , 152, KIF2B, Kin4, Kinesin-4, metaphase spindle function, Kinesin-8, metaphase spindle function, 36 Kinesin-13 kinetochore regulation, 138 metaphase spindle function, Kinesin-14, metaphase spindle function, 41 Kinetochore assembly, centromere association, , components, 133 composition, DNA segregation, force generation, regulation microtubule binding, spindle assembly checkpoint signaling, spindle microtubules binding, dynamics, Klo10A, 77 KLP-19, 193 KNL, 140 KNL1, 113 KNL2, 117 L LIS1, 40 Lte1, 88 M Ma31, 140 Mad1, 140, 176 Mad2, , , Maize, history of chromosome studies, 4 5 Maturation-promoting factor (MPF), history of study, 6 7 MCAK, , 191 MCAK. See Mitotic centromere-associated kinesin MCC. See Mitotic checkpoint complex McClintock, Barbara, 4 5 MCPH1, 57 58, 90 MCRS1, 38 Meiosis acentrosomal spindle formation, asymmetric division of oocytes, cell cycle control, chromosomal segregation, cohesin stepwise removal, pairing and recombination, postrecombination events, 188 sister chromatids, monopolar attachment in meiosis I, 188, 190 spindle assembly checkpoint, 194 spindle chromosome interactions, MEN, MET, 177 Metaphase chromosome dynamics,

4 Index This is a free sample of content from Mitosis. Metaphase spindle assembly modeling in Xenopus extracts, forces and functions ASE1, 41 dynein, kinesin-4, kinesin-14, 41 9 PRC1, 41 microtubules amplification, 34 depolymerases, dynamics, 35 minus end stabilizers, nucleation, plus end dynamics, 35 tracking proteins, 37 38) severing, organizers, 32 prospects for study, 44 size control and scaling, MgcRacGAP, 118, 154 Microcephaly, defects in division symmetry, Microtubule. See Metaphase spindle Microtubule-organizing center. See Centrosome Mis12, 9, 113, 121, 134 Mis16, 118 Mis18, 117 Mitotic centromere-associated kinesin (MCAK), 35, , 191 Mitotic checkpoint complex (MCC), components and function, Mitotic spindle, eukaryote distribution, 5 6 MPF. See Maturation-promoting factor Mps1, 19 20, 138 Mps3, 71 Mst2, 79 MUS81, 82 Myosin II, 193 N Ndc80, 113, , 140 NEBD. See Nuclear envelope breakdown Nek2, 76, NHK-1, Nuclear envelope breakdown (NEBD), 19, 59 Nucleosome. See CENP-A NudE, 40 Nuf, 154 NuMA, 191 NuSAP, 191 O Ofd1, 77 Oocyte. See Meiosis P P53, 175, 177, 180 Patronin, metaphase spindle function, 38 PCM. See Pericentriolar material PCM1, 84 Pds1, 8 Pds5, 56 Pericentriolar material (PCM), assembly, PICH, Plk1 anaphase role, 60 centrosome function, cilium cycle role, 84 cytokinesis role, 157 kinetochore regulation, 138 mitosis entry role, pericentriolar material assembly, 81 Plk4 centriole assembly role, 73, pericentriolar material assembly role, 79 PLK4, 170 Plo1, 18, POC5, 77 PP1 inhibition studies, kinetochore regulation, 139 mitosis exit role, 24 PP2A centriole assembly role, 76 inhibition studies, kinetochore regulation, 139 mitosis exit role, 24 PRC1, 41, , 152, 156 Prdm9, 186 Prometaphase, Prophase condensation and cohesin release from chromosome arms, Psh1, 118 Pyp2, 85 R Rab11, 154 Rab35, 154 Rad51, 187 Ran, 32 34, 191 Rec8, RhoA, cytokinesis role, 150 Rootlein, 78 S SA, SAC, Salamander chromosome, history of mitosis studies, 1 4 SAPK. See Stress-activated protein kinase 202

5 Index Sas-4, 79, 89 SAS-5, SAS-6, 73 76, 89 SCLT1, 83 Sea urchin embryo, history of mitosis studies, 4 5 Securin, degradation in mitosis, 7 8 Sfi1, 71 Sgo1, Shugosin, 24 Sister chromatids cohesin and adhesion in S phase, separation and dynamics in anaphase, 60 separation mechanism, Ska1, 136 SLC19A1, 178 SOC. See Spindle orientation checkpoint SPB. See Spindle pole body Spd-2, 76, SPICE1, 77 Spindle. See Metaphase spindle; Mitotic spindle Spindle assembly checkpoint, , , 194 Spindle orientation checkpoint (SOC), 87 Spindle pole body (SPB) asymmetry cellular asymmetry and spindle alignment in budding yeast, extrinsic control and end of budding yeast cell cycle, spindle pole body asymmetry and spindle alignment in budding yeast, 87 centrosome similarity, 69 control center activity, duplication cycle, mitosis entry, 18 structure, STAG2, 170 STIL, 74 75, 77, 90 Stress-activated protein kinase (SAPK), 73 SUN KASH domain, 187 Syndapin, 155 T TACC3, 81 Telomere, isolation from Tetrahymena, 9 Telophase chromosome dynamics, Topoisomerase I, 11 Topoisomerase II, 10, 60, 62 TPX2, 33, 43, 191 TTBK2, 83 U UBCH10, 169 Ubiquitinylation, sister chromatid separation role, 21 UBP6, 175 UFB. See Ultrafine DNA bridge Ultrafine DNA bridge (UFB), W Wap1, 56 Wee1, mitosis entry role, 17 X XIST, 171 XMAP215, metaphase spindle function, 37, 39 Z ZYG-1,

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