strategies in clinical trials. This FOA utilizes the Exploratory/Developmental Phased Award Cooperative Agreement (UG3/UH3) award mechanism.

Transcription

1 NIH-NCI Newsletter Multiple s, including the National Cancer Perception and Cognition Research to Inform Cancer Image Interpretation (R21) PAR html" (FOA) is to facilitate research on the perceptual and cognitive processes underlying the performance of cancer image observers in radiology and pathology, in order to improve the accuracy of cancer detection and diagnosis. This FOA utilizes the Exploratory/Developmental Grant (R21) 2 years $275,000 direct costs for entire period of support Budgetary Notes Up to $200,000 direct costs allowed per year Todd Horowitz Phone: (240) todd.horowitz@nih.gov Multiple s, including the National Cancer Perception and Cognition Research to Inform Cancer Image Interpretation (R01) PAR html" (FOA) is to facilitate research on the perceptual and cognitive processes underlying the performance of cancer image observers in radiology and pathology, in order to improve the accuracy of cancer detection and diagnosis. This FOA utilizes the Research Project Grant (R01) award Application budgets are not limited of the proposed project. Todd Horowitz Phone: (240) todd.horowitz@nih.gov SCCC Research Administration NIH-NCI Newsletter Page 1 of 14 National Cancer Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21) RFA-CA " This funding opportunity announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies offering novel molecular or cellular analysis capabilities for basic or clinical cancer research. The emphasis of this FOA is on supporting the development of novel capabilities involving a high degree of technical innovation for targeting, probing, or assessing molecular and cellular features of cancer biology. Wellsuited applications must offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, control, epidemiology, and/or address issues associated with cancer health disparities. Technologies proposed for development may be intended to have widespread applicability but must be focused on improving molecular and/or cellular characterizations of cancer biology. 3 years $400,000 direct costs for entire period of support Tony Dickherber Phone: (301) dickerberaj@mail.nih.gov National Cancer Quantitative Imaging Tools and Methods for Cancer Therapy Response Assessment (UG3/UH3) PAR html" research project applications under the cooperative agreement (UG3/UH3) mechanism to address the development, optimization and validation of quantitative imaging (QI) software tools and methods for prediction and/or measurement of response to cancer therapies or for planning and validating radiation therapy treatment

2 strategies in clinical trials. This FOA utilizes the Exploratory/Developmental Phased Award Cooperative Agreement (UG3/UH3) award 2 years (UG3) and 3 years (UH3) $300,000 (UG3) and $500,000 (UH3) direct costs per year Robert Nordstom Phone: (240) nordstrr@mail.nih.gov National Cancer Quantitative Imaging Tools and Methods for Cancer Response Assessment (U01) PAR html" This purpose of this funding opportunity announcement (FOA) is to provide a mechanism of support to research organizations interested in clinically translating already optimized quantitative imaging software tools capable of measuring or predicting the response of cancer to clinical therapies, or in translating imaging tools for planning and validating radiation therapy treatment strategies in clinical trials. This FOA utilizes the Research Project - Cooperative Agreements (U01) award $500,000 direct costs per year Robert Nordstom Phone: (240) nordstrr@mail.nih.gov National Cancer Activities to Promote Technology Research Collaborations (APTRC) for Cancer Research (Admin Supp) PA " The National Cancer (NCI) administers two unique programs focused on supporting technology development research that offer transformative potential for advancing cancer research. The Innovative Molecular Analysis Technologies (IMAT) program supports highly innovative, data-generating platforms and methodologies while the Informatics Technologies for Cancer Research (ITCR) program supports powerful data processing and visualization technologies. This FOA is an Administative Supplement. 2 years $50,000 direct costs per year Tony Dickherber Phone: (301) dickherberaj@mail.nih.gov SCCC Research Administration NIH-NCI Newsletter Page 2 of 14 National Cancer Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33) RFA-CA " This funding opportunity announcement (FOA) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies offering novel capabilities for targeting, probing, or assessing molecular and cellular features of cancer biology for basic or clinical cancer research. Wellsuited applications must offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, control, epidemiology, and/or address issues associated with cancer health disparities. This FOA utilizes the Exploratory/ Developmental Grants Phase II (R33) award 3 years $300,000 direct costs per year Tony Dickherber Phone: (301) dickherberaj@mail.nih.gov National Cancer Innovative Technologies for Cancer-Relevant Biospecimen Science (R21) RFA-CA " This funding opportunity announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. This FOA utilizes the Exploratory/ Developmental (R21) award 3 years $400,000 direct costs for entire period of support Budgetary Notes Up to $200,000 direct costs allowed Tony Dickherber Phone: (301) dickerberaj@mail.nih.gov

3 National Cancer Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33) RFA-CA " This funding opportunity announcement (FOA) solicits grant applications proposing exploratory research projects focused on further development and validation of emerging technologies that improve the quality of the samples used for cancer research or clinical care. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA utilizes the exploratory/ developmental (R33) award 3 years $300,000 direct costs per year Tony Dickherber Phone: (301) dickherberaj@mail.nih.gov National Cancer National Cancer Youth Enjoy Science Research Education Program (R25) PAR " The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this National Cancer (NCI) R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. This FOA utilizes the Educations Projects (R25) award $500,000 direct costs per year Alison Lin Phone: (240) linaj@mail.nih.gov Multiple s, including the National Cancer Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44) PA " Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) to develop and validate next-generation single cell analysis technologies and tools. The purpose is to foster the commercialization of innovative single cell analysis technologies for their broad use in biomedical research. The NCI is especially interested in applications for novel tools/technologies that enable the characterization of this heterogeneity among cells in situ or in clinically relevant samples and for clinically testing drug combinations and resistance with minimal invasiveness. This FOA utilizes the Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track. 2 years (Phase I) 3 years (Phase II) $150,000 (Phase I) and $1M (Phase II) total costs for entire period of support Shane Woodward Phone: (240) woodwars@mail.nih.gov Multiple s, including the National Cancer Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42) PA " Small Business Technology Transfer Research (STTR) grant applications from small business concerns (SBCs) to develop and validate next-generation single cell analysis technologies and tools. The purpose is to foster the commercialization of innovative single cell analysis technologies for their broad use in biomedical research. Tumors are highly heterogeneous at the cellular, molecular, and genetic levels. Through this FOA, the NCI is especially interested in applications for novel tools/technologies that enable the characterization of this heterogeneity among cells in situ or in clinically relevant samples and for clinically testing drug combinations and resistance with minimal invasiveness. These tools/technologies include but are not limited to multidimensional single cell imaging, single cell mass cytometry, high throughput technologies for isolation and characterization of DNA and RNA from individual cells either in situ or in clinically relevant samples. This FOA utilizes the Small Business Technology Transfer (STTR) Grant - Phase I, Phase II, and Fast-Track. 2 years (Phase I) and 3 years (Phase II) $150,000 (Phase I) and $1M (Phase II) total costs for entire period of support Shane Woodward SCCC Research Administration NIH-NCI Newsletter Page 3 of 14

4 Phone: (240) Phone: (240) National Cancer Multilevel Interventions in Cancer Care Delivery: Building from the Problem of Follow-up to Abnormal Screening Tests (U01) PAR html" applications that develop and test multilevel interventions to improve follow-up to abnormal screening tests for breast, colorectal, cervical and lung cancers. Improving follow-up to abnormal screening tests is dependent on factors at the individual, team, healthcare system or community setting levels. Appropriate applications for this FOA should propose to intervene at one or more levels, and must measure outcomes at three or more levels, while accounting for interactions that occur between levels. This FOA utilizes the Research Project - Cooperative Agreements (U01) award $500,000 direct costs per year Erica Breslau Phone: (240) breslaue@mail.nih.gov Multiple s, including the National Cancer Tobacco Centers of Regulatory Science for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U54) RFA-OD " (FOA) is to invite applications for Tobacco Centers of Regulatory Science (TCORS) to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). Research results from this FOA are expected to generate findings and data that are directly relevant in informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health. This FOA utilizes the Specialized Center- Cooperative Agreements (U54) award $4M total costs per year Rachel Grana Mayne SCCC Research Administration NIH-NCI Newsletter Page 4 of 14 Multiple s, including the National Cancer Centers for AIDS Research (P30) PAR html" (FOA) is to invite applications for the Centers for AIDS Research (CFAR) program to provide administrative and shared research support to enhance HIV/AIDS research. CFARs provide core facilities, expertise, resources, and services not readily obtained otherwise through more traditional funding mechanisms. The program emphasizes interdisciplinary collaboration across all areas of HIV/AIDS research. Specific NIH s and Centers cosponsoring the CFAR include AMC, ACSR, and NCI- Designated Cancer Centers. This FOA utilizes the Center Core Grants (P30) award $3M total costs per year Geraldina Dominguez Phone: (301) domingug@mail.nih.gov Multiple s, including the National Cancer Developmental Centers for AIDS Research (P30) PAR html" (FOA) is to invite applications for the Developmental Centers for AIDS Research (D-CFAR) program to provide administrative and shared research support to enhance HIV/AIDS research. D-CFARs provide core facilities, expertise, resources, and services not readily obtained otherwise through more traditional funding mechanisms. The program emphasizes interdisciplinary collaboration across all areas of HIV/AIDS research. Specific NIH s and Centers co-sponsoring the D-CFAR include AMC, ACSR, and NCI-Designated Cancer Centers. This FOA utilizes the Center Core Grants (P30) award $750,000 total costs per year Geraldina Dominguez Phone: (301) domingug@mail.nih.gov

5 Multiple s, including the National Cancer Intensive Longitudinal Analysis of Health Behaviors: Leveraging New Technologies to Understand Health Behaviors (U24) RFA-OD " This funding opportunity announcement (FOA) invites applications to establish a Research Coordinating Center (RCC) to facilitate and support the Intensive Longitudinal Health Behaviors Initiative. The goal of this initiative is to support collaborative research projects studying factors that influence key health behaviors at the individual level, using intensive longitudinal data collection and analytic methods, as well as to further advance research through the broad dissemination of data with the research community, as appropriate. This FOA utilizes the Resource-Related Research Projects Cooperative Agreements (U24) award 4 years $300,000 direct costs per year Richard Moser Phone: (240) moserr@mail.nih.gov Multiple s, including the National Cancer Tobacco Centers of Regulatory Science for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U54) RFA-OD " (FOA) is to invite applications for Tobacco Centers of Regulatory Science (TCORS) to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this FOA will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L ). Research results from this FOA are expected to generate findings and data that are directly relevant in informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health. This FOA utilizes the Specialized Center- Cooperative Agreements (U54) award $4M total costs per year SCCC Research Administration NIH-NCI Newsletter Page 5 of 14 Rachel Grana Mayne Phone: (240) Rachel.Grana@nih.gov National Cancer Inter-organelle Communication in Cancer (R01) PAR html" (FOA) is to support research projects that examine how inter organelle communication in cancer cells and/or tumorassociated cells affects cellular function, adaptation, and phenotypic plasticity. This FOA utilizes the Exploratory /Developmental Grant (R21) award Application budgets are not limited of the proposed project. Michael Graham Espey Phone: (240) SP@nih.gov National Cancer Inter-organelle Communication in Cancer (R21) PAR html" (FOA) is to support research projects that examine how inter organelle communication in cancer cells and/or tumorassociated cells affects cellular function, adaptation, and phenotypic plasticity. This FOA utilizes the Exploratory /Developmental Research Grant (R21) award 2 years $275,000 direct costs for entire period of support Budgetary Notes Up to $200,000 direct costs allowed per year Michael Graham Espy Phone: (240) SP@nih.gov National s of Health NIH Director's Early Independence Award (DP5) RFA-RM Application Due Date: September 22, 2017 "

6 The NIH Director s Early Independence Award Program supports exceptional investigators who wish to pursue independent research directly after completion of their terminal doctoral/research degree or clinical residency, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. This FOA utilizes the Early Independence Award/Cooperative Agreement (DP5) award Since the University of Miami may only submit one proposal, this opportunity is a limited submission competition. An expert panel will internally review our candidates to determine which application will be submitted for competition by the program deadline on September 22, Application materials must be sent to Karen Lamper at klamper@miami.edu by May 18, $250,000 direct costs per year Ravi Basavappa Phone: (301) earlyindependence@mail.nih.gov Multiple s, including the National Cancer Tobacco Regulatory Science (R01) RFA-OD " (FOA) is to invite R01 applications to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this FOA will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L ). Research results from this FOA are expected to generate findings and data that are directly relevant in informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health. This FOA utilizes the Research Project Grant (R01) award 3 years $300,000 direct costs per year Rachel Grana Mayne Phone: (240) granar@nih.gov Multiple s, including the National Cancer Tobacco Regulatory Science Small Grant Program for New Investigators (R03) SCCC Research Administration NIH-NCI Newsletter Page 6 of 14 RFA-OD " (FOA) is to invite R03 applications to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this FOA will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L ). This FOA utilizes the Small Grant Program (R03) award 2 years $50,000 direct costs per year Rachel Grana Mayne Phone: (240) granar@nih.gov Multiple s, including the National Cancer Tobacco Regulatory Science (R21) RFA-OD " (FOA) is to invite research project applications to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this FOA will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L ). This FOA utilizes the Exploratory/Developmental (R21) award 2 years $275,000 direct costs for entire period of support Budgetary Notes Up to $200,000 direct costs allowed per year Carol Perry Phone: (240) perryc@nih.gov Multiple s, including the National Cancer Genomic Community Resources (U24) PAR

7 273.html" Awards under this FOA will support the development and distribution of genomic resources that will be valuable for the broad research community, using cost-effective approaches. Such resources include (but are not limited to) databases and informatics resources (such as human and model organism databases, ontologies, and analysis toolsets), comprehensive identification and collections of genomic features (such as functional genomic elements), and standard data types produced using central sets of samples (such as structural variants in 1000 Genomes or GTEx samples). NCI is interested in any of the above types of resources that focus on cancer. This FOA utilizes the Resource-Related Research Projects Cooperative Agreements (U24) award Application budgets are not limited of the proposed project. Leah Mechanic Phone: (240) National Cancer HIV/AIDS and the Tumor Niche (R01) RFA-CA " (FOA) is to advance our understanding of the role of the tumor niche or microenvironment in the risks, development, progression, diagnosis, and treatment of cancer observed in individuals with an underlying HIV infection or Acquired Immune Deficiency Syndrome (AIDS). This FOA utilizes the Research Project Grant (R01) award Application budgets are not limited of the proposed project. Elizabeth Read-Connole Phone: (240) NEW National Cancer Pediatric Early Phase Clinical Trials Network (UM1) RFA-CA " (FOA) is to enhance NCI s program for conducting early phase clinical trials in children with cancer, currently supported as the Children's Oncology Group (COG) Phase 1 & Pilot Consortium. This FOA is designed to enhance the existing program so that the Network can more efficiently and expeditiously develop and implement state-of-the-art early phase clinical trials. This FOA represents a continuation of NCI s commitment to childhood cancer research but with updates to accommodate changes in the landscape of oncology drug development. This FOA utilizes the Research Project with Complex Structure Cooperative Agreement (UM1) award $3.6M direct costs per year Malcolm Smith Phone: (240) Malcolm.Smith@nih.gov NEW Multiple s, including the National Cancer PHS Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) PA " This funding opportunity announcement (FOA), issued by the National s of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA), invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH, CDC, and FDA awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics. This FOA utilizes the Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track I (R43/R44) award 6 month (Phase I) and 2 years (Phase II) $150,000 (Phase I) and $1M (Phase II) total costs NIH SBIR/STTR Program Office Phone: (301) sbir@od.nih.gov NEW Multiple s, including the National Cancer SCCC Research Administration NIH-NCI Newsletter Page 7 of 14

8 PHS Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) PA " This Funding Opportunity Announcement (FOA) issued by the National s of Health (NIH) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics. This FOA utilizes the Small Business Technology Transfer (STTR) Grant - Phase I, Phase II, and Fast-Track I (R41/R42) award 1 year (Phase I) and 2 years (Phase II) $150,000 (Phase I) and $1.5M (Phase II) totals costs NIH SBIR/STTR Program Office Phone: sbir@od.nih.gov (301) Multiple s, including the National Cancer Lasker Clinical Research Scholars Program (Si2/R00) PAR html" This FOA encourages applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers. The program offers the opportunity for a unique bridge between the NIH intramural and extramural research communities and contains two phases. The National Cancer (NCI) is interested in the areas of medical oncology, pediatric hematologyoncology, radiation oncology, surgical oncology, pathology, neuro-oncology, urology and dermatology. Specific areas within these categories include genitourinary oncology, lymphoid malignancies, neuro-oncology, immunotherapy, women's cancers, aeoro digestive cancers, molecular diagnostics, and functional imaging. This FOA utilizes the Intramural Clinical Research Scholar Transition Award (Si2/R00) award 7 years (Phase I) and 3 years (Phase II) Negotiated at the time of award (Phase I) and $499,000 (Phase II) direct costs William Dahut Phone: (301) SCCC Research Administration NIH-NCI Newsletter Page 8 of 14 dahutw@mail.nih.gov National Cancer National Cancer Program Project Applications (P01) PAR " National Cancer (NCI) invites applications for investigator-initiated program project (P01) grants. Proposed program projects may address any of the broad areas of cancer research, including (but not limited to) cancer biology, cancer treatment, cancer diagnosis, cancer prevention, and cancer control. Basic, translational, clinical, and/or population-based studies in all of these research areas are appropriate. Each Program Project application must consist of at least three component projects. The component projects must share a common central theme, focus, and/or overall objective. This FOA will utilize the NIH Program Project (P01) grant Application budgets are not limited but need to reflect actual needs of the proposed project Referral Officer Phone: (240) ncirefof@dea.nci.nih.gov National Cancer Cancer Education Grants Program (R25) PAR " The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation s biomedical, behavioral and clinical research needs. Applications are encouraged that propose innovative, stateof-the-art programs that address the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients, in accordance with the overall mission of the NCI. This FOA utilizes the NIH Education (R25) grant $300,000 direct costs per year Jeannette Korczak Phone: (240) korczakj@mail.nih.gov Multiple s, including the National Cancer

9 Bioengineering Research Partnerships (BRP) (R01) PAR " bioengineering applications that will accelerate the development and adoption of promising tools and technologies that can address important biomedical research problems. The objectives are to establish these tools and technologies as robust, well-characterized solutions that fulfill an unmet need and are capable of enhancing our understanding of life science processes or the practice of medicine. The National Cancer encourages applications for funding on research to gain understanding and achieve mitigations and solutions to cancer problems. This FOA utilizes the NIH Research Project Grant (R01) funding Application budgets are not limited of the proposed project Grants Info Phone: (301) Multiple s, including the National Cancer Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2015, 2016, and 2017 (P50) PAR " This funding opportunity announcement (FOA) invites applications for (P50) Research Center Grants for Specialized Programs of Research Excellence (SPOREs). The program will fund (P50) SPORE grants to support stateof-the art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer (or a related group of cancers). SPOREs are expected not only to conduct a wide spectrum of research activities, but also to contribute significantly to the development of specialized shared resources core facilities, improved research model systems, and collaborative research projects with other institutions. The research supported through this program must be translational in nature and must always be focused upon knowledge of human biology stemming from research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches with the goal of a translational human endpoint within the project period of the grant. This FOA utilizes the NIH Specialized Center (P50) award $2.3M total costs per year Toby Hecht Phone: (301) hechtt@mail.nih.gov Multiple s, including the National Cancer Physical Sciences-Oncology Network (PS-ON): Physical Sciences-Oncology Projects (PS-OP) (U01) PAR " National s of Health (NIH) and its participating s and Centers invite applications for Physical Science Oncology Projects (PS-OP). The goal of the PS- OPs is to foster the convergence of physical sciences approaches and perspectives with cancer research to advance our understanding of cancer biology and oncology by forming small transdisciplinary teams of physical scientists and cancer biologists/physician scientists. The PS-OPs, individually and as a collaborative Network along with other PS-OPs and the Physical Sciences-Oncology Centers (PS-OC), will support transdisciplinary research that: (1) establishes a physical sciences perspective within the cancer research community; (2) facilitates team science and field convergence at the intersection of physical sciences and cancer research; and (3) collectively tests physical sciences-based experimental and theoretical concepts of cancer and promotes innovative solutions to address outstanding questions in cancer research. This program will utilize the NIH Research Project Cooperative Agreements (U01) award $500,000 direct costs per year Nastaran Kuhn Phone: (240) nas.kuhn@nih.gov Multiple s, including the National Cancer Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01) PAR " The goal of this interagency funding opportunity announcement (FOA) is to support the development of multiscale models to accelerate biological, biomedical, behavioral, environmental and clinical research. This FOA supports the development of non-standard modeling methods and experimental approaches to facilitate multiscale modeling, and active participation in communitydriven activities through the Multiscale Modeling (MSM) SCCC Research Administration NIH-NCI Newsletter Page 9 of 14

10 Consortium. The National Cancer (NCI) is interested in supporting the development of predictive multiscale models of cancer processes. This FOA utilizes the NIH Research Project Cooperative Agreements (U01) award $500,000 direct costs per year Carol Perry Phone: (240) National Cancer Multilevel Interventions in Cancer Care Delivery: Building from the Problem of Follow-up to Abnormal Screening Tests (U01) PAR " applications that strengthen the science of multilevel effects of cancer care interventions by addressing the problem of incomplete follow-up to abnormal screening tests for breast, colorectal, cervical and lung cancers. The goals of this FOA are two-fold. First, this FOA seeks to advance the science of multilevel interventions. Second, this FOA encourages applications that test interventions to improve the follow-up of abnormal screening. This FOA utilizes the Research Project Cooperative Agreements (U01) award 4 years $750,000 direct costs per year Stephen Taplin Phone: (240) taplins@mail.nih.gov Multiple s, including the National Cancer Ethical Issues in Research on HIV/AIDS and its Co- Morbidities (R01) PAR " This funding opportunity announcement (FOA) invites applications addressing ethical issues relevant to research on HIV and associated co-morbidities, including research with populations living with or at high risk of HIV acquisition. The bioethics projects supported through this FOA should focus on at least one of the following three goals: 1) Development of the empirical knowledge base for human subjects protection and ethical standards in HIV/AIDS research; HIV/AIDS research; 3) Supporting the integration of bioethics work with ongoing research in HIV/AIDS This FOA utilizes the Research Project Grant (R01) award Application budgets are not limited of the proposed project Budgetary Notes Rebecca Liddell Huppi Phone: (301) liddellr@exchange.nih.gov Multiple s, including the National Cancer Direct Phase II SBIR Grants to Support Work in Biomedical Computing, Informatics, and Big Data Science (R44) PAR " Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose the extended development, maintenance, testing, evaluation, hardening and dissemination of existing biomedical software. This FOA is for applications that have completed the proof of concept Phase I stage-type of research through other (non-sbir) funding sources. The NIH is interested in promoting a broad base of research and development of a broad base of innovative technologies in biomedical computing, informatics, and Big Data Science that will support rapid progress in areas of scientific opportunity in biomedical research. This FOA utilizes the Small Business Innovation Research (SBIR) Grant - Phase II only (R44) award $1.5M total costs for entire period of support Budgetary Notes 2 years Jonathan Franca-Koh Phone: (240) jonathan.franca-koh@nih.gov Multiple s, including the National Cancer SBIR Technology Transfer (R43/R44) PA " 2) Development of conceptual bioethics approaches to advance scholarship on difficult ethical challenges in SCCC Research Administration NIH-NCI Newsletter Page 10 of 14

11 Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for projects to transfer technology out of the NIH intramural research labs into the private sector. If selected for SBIR funding, the SBC will be granted a royalty-free, nonexclusive patent license agreement for internal research use for the term of and within the field of use of the SBIR award to technologies held by NIH with the intent that the SBC will develop the invention into a commercial product to benefit the public. This FOA utilizes the Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track I award 2 years $225,000 (phase I) and $1.5M (phase II) total costs for entire period of support Crystal Wolfrey Phone: (240) wolfreyc@mail.nih.gov National Cancer The Pancreatic Cancer Detection Consortium (U01) PAR " This funding opportunity announcement (FOA) invites applications from multi-disciplinary teams of researchers and clinicians to establish the Pancreatic Cancer Detection Consortium (PCDC) to conduct research to improve the detection of early stage pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions. The PCDC is intended to support research for the development and testing of new molecular and imaging biomarkers for identifying patients at high risk for PDAC (because of genetic factors or the presence of precursor lesions) who could be candidates for early intervention. This FOA utilizes the Research Project - Cooperative Agreements (U01) award Application budgets are not limited of the proposed project Sudhir Srivastava Phone: (240) srivasts@mail.nih.gov National Cancer Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01) PAR " SCCC Research Administration NIH-NCI Newsletter Page 11 of 14 the submission of applications that propose to advance research in cancer etiology and early detection biomarkers, utilizing the advantages of the unique biorepository resources of the NCI-sponsored Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. This FOA supports a wide range of cancer research including, but not limited to, biochemical and genetic analyses of cancer risk, as well as discovery and validation of early detection biomarkers. The proposed research project must involve use of PLCO biospecimens; additionally, it should also take advantage of the unique characteristics of the PLCO biospecimens. Research projects that do not involve the use of PLCO biospecimens will not be supported under this FOA. This FOA utilizes the Research Project - Cooperative Agreements (U01) award Application budgets are not limited of the proposed project. Claire Zhu Phone: (240) zhucla@mail.nih.gov National Cancer Cancer Research Education Grants Program to Promote Diversity - Research Experiences (R25) PAR " The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI (R25) program is to support educational activities that enhance the diversity of the nation's biomedical, behavioral, and clinical research workforce. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients, as well as the cause and reduction of cancer health disparities in accordance with the overall mission of the NCI. This FOA will utilize the Education Projects (R25) award $300,000 direct costs per year Davyd Chung Phone: (240) davyd.chung@nih.gov National Cancer Cancer Research Education Grants Program to Promote Diversity - Courses for Skills

12 Development (R25) PAR " The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that enhance the diversity of the nation's biomedical, behavioral, and clinical research workforce. Applications are encouraged that propose innovative, state-of the-art programs that address the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients, as well as the cause and reduction of cancer health disparities in accordance with the overall mission of the NCI. This FOA utilizes the Education Projects (R25) award $300,000 direct costs per year Davyd Chung Phone: (240) ) Multiple s, including the National Cancer Tools for Cell Line Indentification (SBIR [R43/R44]) PA " This funding opportunity announcement (FOA) is intended to address the problem of misidentified cell lines. This FOA will support SBIR projects to improve existing technologies, and/or develop novel, reliable, and cost effective tools that will make it easier for researchers to confirm the identity and/or sex of the cells that they use in their work. Applications for support of research and development of particular types of complex technologies that require funding levels and durations beyond those reflected in standard SBIR guidelines are encouraged, as are multi- PD/PI applications, including multi-pd/pi applications that arise from academic-industrial partnerships. This FOA utilizes the Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track (R43/R44) award 6 months (Phase I) and 2 years (Phase II) $150,000 (Phase I) and $1M (Phase II) total costs Jonathan Franca-Koh Phone: (240) francakohjc@mail.nih.gov Development in Biomedical Big Data Science (R25) RFA-HG " The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this Big Data to Knowledge (BD2K) R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation s biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development for biomedical researchers who need the requisite knowledge and skills to extract knowledge from biomedical Big Data. This FOA utilizes the Education Projects (R25) award 3 years $200,000 direct costs per year Grants Info Phone: (301) GrantsInfo@nih.gov Multiple s, including the National Cancer Fogarty HIV Research Training Program for Lowand Middle-Income Country Institutions (D43) PAR " The purpose of this FOA is to encourage applications for research training programs to strengthen the scientific capacity of institutions in low- and middle-income countries (LMICs) to conduct HIV research relevant to the evolving HIV epidemic in their country. This FOA can support training for a broad range of HIV research areas including research on HIV co-infections, AIDS-defining and HIVrelated cancers, neurological and neuro-psychiatric morbidities, and other co morbidities and health conditions, both infectious and non-infectious, that contribute to HIV transmission or poor health in HIV-infected individuals, including HIV infected substance (drug and alcohol) users. This FOA utilizes the International Research Training (D43) award $280,000 direct costs for entire period of support Geraldinha Dominguez Phone: (301) Domingug@mail.nih.gov Multiple s, including the National Cancer BD2K Open Education Resources for Skills SCCC Research Administration NIH-NCI Newsletter Page 12 of 14 Multiple s, including the National Cancer Mobile Health: Technology and Outcomes in Low

13 and Middle Income Countries (R21) PAR " (FOA) is to encourage exploratory/developmental research applications that propose to conduct research to develop or adapt innovative mobile health (mhealth) technology specifically suited for low and middle income countries (LMICs) and determine the health-related outcomes associated with implementation of the technology. Of highest interest are innovative, well-designed multidisciplinary projects that aim to generate generalizable knowledge for the field. This FOA utilizes the Exploratory/ Developmental (R21) award 2 years $125,000 direct costs per year Vidya Vedham Phone: (240) vidya.vedham@nih.gov Multiple s, including the National Cancer Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) PA " The purpose of the Kirschstein-NRSA postdoctoral fellowship is to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health related research fields relevant to the missions of the participating NIH s and Centers. This FOA utilizes the Postdoctoral Individual National Research Service (F32) award Award budgets are composed of stipends, tuition and fees, and institutional allowance, as described in the PA Grants Info Phone: (301) GrantsInfo@nih.gov Multiple s, including the National Cancer Ruth L. Kischstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Hlth-Rel Res (Parent F31 - Diversity) PA " SCCC Research Administration NIH-NCI Newsletter Page 13 of 14 The purpose of this Kirschstein-NRSA predoctoral fellowship (F31) award is to enhance the diversity of the health related research workforce by supporting the research training of predoctoral students from population groups that have been shown to be underrepresented in the biomedical, behavioral, or clinical research workforce, including underrepresented racial and ethnic groups and those with disabilities. The proposed mentored research training is expected to clearly enhance the individual s potential to develop into a productive, independent research scientist. This FOA utilizes the Predoctoral Individual National Research Service Grant (F31) award Award budgets are composed of stipends, tuition and fees, and institutional allowance, as described in the PA Grants Info Phone: (301) GrantsInfo@nih.gov Multiple s, including the National Cancer Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) PA " The National s of Health (NIH) awards senior individual research training fellowships to experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators in research fields relevant to the missions of participating NIH s and Centers. This FOA utilizes the National Research Service Awards for Senior Fellows (F33) award Award budgets are composed of stipends, tuition and fees, and institutional allowance, as described in the PA Grants Info Phone: (301) GrantsInfo@nih.gov National Cancer Biological Comparisons in Patient-Derived Models of Cancer (U01) PAR "

14 The purpose of this FOA is to encourage applications wherein similarities and differences in the underlying biological mechanisms that drive cancer phenotype and response to perturbations between two or more patientderived models of cancer originating from a common patient sample are delineated and compared. This FOA utilizes the Research Project - Cooperative Agreements (U01) award Application budgets are not limited, of the proposed project. Michael Graham Espey Phone: (240) SP@nih.gov Multiple s, including the National Cancer Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01) PAR " As part of the Collaborative Research on Addiction at NIH (CRAN) initiative, NIDA, NIAAA, and NCI join to issue this FOA. Applicants may address a range of addiction health services including, but not limited to, tobacco-cessation services, substance use prevention services, medication assisted treatments, HIV/AIDS services, polysubstance use treatment, treatment of co-occurring disorders, etc. Likewise, a wide variety of settings could be targeted, including traditional behavioral health service settings, primary care settings, health care settings where substance use or use disorders are relevant (e.g., cancer treatment). This FOA utilizes the Research Project (R01) award $500,000 direct costs per year Elizabeth Ginexi Phone: (240) Iginexi@mail.nih.gov The purpose of the NIH Research Conference Grant (R13) is to support high quality scientific conferences that are relevant to the NIH's mission and to the public health. A conference is defined as a symposium, seminar, workshop, or any other organized and formal meeting, whether conducted face-to-face or via the internet, where individuals assemble (or meet virtually) for the primary purpose to exchange technical information and views or explore or clarify a defined subject, problem, or area of knowledge, whether or not a published report results from such meeting. This FOA utilizes the Support for Conferences and Scientific Meetings (R13) award Application budgets are not limited of the proposed project. Grants Info Phone: (301) GrantsInfo@nih.gov Multiple s, including the National Cancer NIH Support for Conferences and Scientific Meetings (Parent R13) PA " SCCC Research Administration NIH-NCI Newsletter Page 14 of 14