Page 8 the draw of Histidine There is a Beta-carbon missed; there should be "CH2" attached to the alpha-carbon.

Transcription

1 Sec 1,2,3 : Sheet #1 Page 4 Paragraph 3 The correction is: "(has a plane of symmetry)" The wrong sentence was: "(does not have a plane of symmetry)" Page 8 the draw of Histidine There is a Beta-carbon missed; there should be "CH2" attached to the alpha-carbon. Sheet #3 page 5 First paragraph The correction is: "When the PH becomes = 9 : - 50% of the amino group will be deprotonated "thus has a net charge of ( -1 )", and 50% are protonated "has a net charge of ( Zero )" The wrong sentence was: zero, +1 Page 7 Last line It s written as: pi = (pkr+ pkcooh)/2 = ( )/2=3.58 It shoud be written as: pi = (pkr+ pkcooh)/2 = ( )/2=3.22 The quiz Q.2 At PH = 9, 50% of the molecules will have a net charge of +1 and 50% will have a net charge of zero, thus the net charge of the solution is 0.5 Q.3 At PH = 8, The carboxylic group will be deprotonated, while 50% of the solution amino acids will have the SH group protonated with a net charge of zero and 50% will have it deprotonated with a net charge of -1. Thus at PH = 8 the net charge of the solution will be -0.5 Sheet #4 Page 4 line #10 They are secreted to relieve pain not to feel pain

2 Sheet #7 Page 4 Paragraph 3 "We have several amino acids with Nitrogen in their side chains like:..., Glutamine" instead of Glutamate Sheet #8 The quiz Q.5 the answer is B instead of E Q.7 C- almost entirely of alpha helix* Sheet #10 Page 10 The paragraph talking about Sucrose: The correction is: "α-d-gucopyranosyl-(1->2)- β-d-fructofuranose". The wrong name was: "α-d-gucopyranosyl-(1->4)- β-d-fructofuranose" Sheet #11 Page 12 The last paragraph: The correction is: "a person with a blood type AB can get blood from any other type of blood" The wrong sentence was: "a person with a blood type A or B can get blood from any other type of blood" Sheet #12 Page 3 Lipid functions: The mistake was in point #1 in considering (Glycogen & Starch) as lipids instead of carbohydrates. Page 9 Line #5 It should be " V = K2 * [ES] " Sheet #14 Page 6 Paragraph #2 It s written as: here you have an attachment of 18 carbon fatty acid (cholesterol state) It should be written as: here you have an attachment of 18 carbon fatty acid (cholesterol stearate)

3 Page 7 Last paragraph It is written as: so for example in the outer leaflet we will have phosphotidylcholine, glycoprotein and sphingomyelin. It should be written as: so for example in the outer leaflet we will have phosphotidylcholine, glycolipid and sphingomyelin. Page 8 Paragraph #1 It s written as: (cleaved to produce 2 molecules diacid cholestrol and 3 phosphoinositol pi3 and these 2 molecules induce the release of calcium from inside the cell). It should be as: (cleaved to produce 2 molecules diacyl glycerol (DAG) and 3 phosphoinositol pi3 and these 2 molecules induce the release of calcium from inside the cell). Page 11 Last paragraph RAS is the the name of the protein that gets mutated not the drug name. Sheet #16 Page 5 line 17 ** Ice melting is an endothermic and (exothermic) reaction... It is not exothermic, it is (exergonic) يعني هيك الزم تصير الجملة Ice melting is an ENDOthermic and EXERGONIC rxn... ** lines 19, 20 and 21 in the same page Are wrong! الزم هيك يكونو Endothermic : it absorbs heat from the SURROUNDING (not from the system,as what it's written which is wrong)... كل الجملة خطأ : Exothermic و الزم تكون هيك Exothermic : heat is released to the surrounding when a bond forms Bond BREAKING : ENDOthermic Bond MAKING : EXOthermic

4 Sheet #17 Page 1 line 13 "Rate does not mean thermodynamics, rate means delta G, delta H or delta S" This is wrong and the correct statement is : "Rate does not mean thermodynamics, rate DOESN'T mean delta G, delta H or delta S"... Page 7 lines 5&6 In the classification, it's written that 4- isomerases 5- lyases But the correct is : 4- lyases 5- isomerases Page 7 Last two lines It was written that : "Ligases... Must have at least two reactants and TWO products." But this is wrong.. It must be : "Ligases... Must have at least two reactants and ONE products." Sheet #18 Page 5 This is written "Condensation is the opposite to Dehydration reaction" this is wrong and it should be "Condensation is the opposite to Hydrolysis reaction" Page 13 Lines 5 & 6 It written that : "-Formation of bonds > needs energy. -Breaking of bonds > gives energy." But this is wrong It must be : "-Formation of bonds > GIVES energy. Because it's exothermic -Breaking of bonds > NEEDS energy. Because it's endothermic"

5 Sheet #19 Page 14 Line #5 It's written that : "... If you add two phosphates you get PLP" but this is wrong and the correct is : That PLP has one phosphate not two phophates Page 16 Line 2 NAD: functional group: "C opposite to N" not "N opposite to C" Page 18 Line 5 In FAD two nitrogen of the ring are responsible for accepting 2 H'S NOT the adenosine sheet #20 Page 6 Line 6 It was written that : "Enzymes according to their behavior can be classified into 2 types : simple & complex (conjugated...) This is wrong "It can be classified as simple and complex (allosteric)..." While according to their structure it can be classified as simple and complex (conjugated) Page 19 the example : units are wrong because when we convert from s^-1 to min^-1 the number should be multiplied by 60 not divided by it and the number in the question should be Vmax= 0.6 mol per min because Km in S^-1 should not be more than 10^4 as the turn over number falls in range from 1-10^4 S^-1 sheet #21 Page 14 Line #6 Is was written that "..are all red we call it R..." It must be "...are all red we call it M..."... page 14 Line 13 & 14 &15 It's written that :

6 " In the HEART you don't need lactate, instead you need PYRUVATE... In the MUSCLES you CAN'T produce lactate..." This is wrong And the correct is : "In the HEART you don't need lactate, instead you need PYRUVATE In the MUSCLES you CAN produce lactate..." Not "can't produce lactate..." Sheet #22 Page 9 After : a) allosteric enzymes Line 6 It was written that : " And unlike simple enzymes, they do not follow the michaelis menten equation and their lineweaver burke plots are not hyperbolic." This is wrong And the correct is that : "And unlike simple enzymes, they do not follow the michaelis menten equation and their velocity versus substrate concentration plots are not hyperbolic.... " Because reciprocal plot can't be considered as hyperbolic Sheet #23 Page 3 Line 11 "One of the enzyme that protein kinase A phosphorylate is glycogen phosphorylase kinase which becomes active and causes the splitting of glucose subunit form glycogen ( in the form of glucose 1 phosphate )to produce ATP" phosphrylase kinase activates glycogen phosphorylase, which اللي هو انو Splitting المفروض في شي قبل then causes spiltting of glucose Page 22 After the pic, Line 5 It's written that : "Type 5 in the muscles, type 3 in the liver, type 4 for renal injuries" But the correct is : LDH: "Type 5 in liver and skeletalmuscles, type 4 for renal injuries

7 Sec 4,5,6 : Sheet #1 it has 3 mistakes And here are the details: 1st page 19th & 20th lines "Note: because amino acid has a carboxylic group (WITH +VE CHARGE) and amino group (WITH -VE CHARGE)..." That's wrong and must be: "Note: because amino acid has a carboxylic group (WITH -VE CHARGE) and amino group (WITH +VE CHARGE)..." 5th page under the title : Nonpolar, aliphatic amino acids subtitle : 3-leucine "Put a methylene group (CH3)..." That's wrong and must be: "Put a methylene group (CH2).." 7th page under the title : Polar amino acids and the subtitle : 3- threonine 7th line "*threonine and valine >> threonine looks like valine except: one of the H in CH3 (valine) is replaced by OH in threonine." That's wrong and must be: "*threonine and valine >> threonine looks like valine except that: the omega carbon with the 3 H atoms attached to it (CH3) in (valine) is replaced by OH in threonine." Sheet #2 page 3 Point #2 The sentence talks about the charges of the whole amino acids: "2-The PH increases and when it reaches 2 pka of the carboxyl group : 50% of thecarboxyl group will be pronated and 50% of the carboxyl group will be unprotonated, in other words 50% are +1 charged and 50% are zero." If we talk about the charges of the carboxylic groups in the amino acids they would be 50% -1 and 50% zero charged.

8 Sheet #3 For Oxytocin and Vasopressin, it's written that they are decapeptides (10 amino acids) but the correct is they are nonapeptides (9 amino acids). (the doctor said decapeptides but he migh said it wrong). Sheet #7 Page 4 Paragraph 2 The correction is: "The other one is present in helix E". The wrong sentence was: "The other one is present in helix H". Sheet #11 Page 1 line #7 The wrong sentence is " (Every 6 molecules will bind with one iodine molecule)." The correction is " (Every 36 molecules will bind with one iodine molecule)." Page 3 This pic should be for cellulose not chitin ** You can find these corrected mistakes on facebook on this hashtag: #corrected_sheets Good Luck Doctors