Global list of validated analytes available at ABF (in alphabetic order)
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1 Global list of validated analytes available at ABF (in alphabetic order) Analyte (abbreviation) Chemical name 11-dh-TXB 2 11-dehydro-thromboxane B 2 12-HETE 1-MHBMA 1-OH-Nap 1-OH-Phe 1-OH-Pyr Chemical class / Function of the marker 1,3- butadiene) (PAH) 2,3-dn-8-iso- PGF2α 12-hydroxyeicosa-tetraenoic 1-Hydroxybutene-2-yl mercapturic 1-OH-Naphthalene 1-OH-Phenanthrene 1-OH-Pyrene 2,3-dinor-8-epi/isoprostaglandin F2 alpha Analytical technique Matrix (ox. stress) 2,3-dn-TXB 2 2,3-dinor-thromboxane B 2 2-AN 2-Aminonaphthalene Aromatic amine GC-MS U AN 2-Aminonaphthalene ETS marker GC-MS ETS HPMA 2-Hydroxypropyl-mercapturic propylene oxide) 2-MHBMA 2-Hydroxybutene-1-yl mercapturic 1,3- butadiene) 2-OH-Flu 2-OH-Fluorene 2-OH-Nap 2-OH-Naphthalene 2-OH-Phe 2-OH-Phenanthrene 3-ABP 3-Aminobiphenyl Aromatic amine GC-MS U EP 3-Ethenylpyridine ETS marker GC-MS ETS HPMA 3-Hydroxypropyl-mercapturic acrolein) 3-OH-Butyrate 3-OH-Butyrate Ketone bodies GC-MS P, S, brain OH-Phe 3-OH-Phenanthrene 4-ABP 4-Aminobiphenyl Aromatic amine GC-MS U ABP 4-Aminobiphenyl ETS marker GC-MS ETS 223 Aromatic amine (longterm exposure marker 4-ABP-Hb Hemoglobin adducts of 4- adducts aminobiphenyl for 4-ABP) GC-MS B HNE 4-hydroxy-2-nonenale Aldehyde (lipid GC-MS U, EBC OH-Phe 4-OH-Phenanthrene 5-FU 5-Fluorouracil Cytostatic drug LC-MS/MS W iso-PGF2α 8-epi/iso-prostaglandin-F2 alpha (ox. stress) ABF Method No
2 8-OHdG 8-hydroxy-2-deoxy-guanosine Oidized derivative of deoxyguanisine LC-MS/MS U OH-Phe 9-OH-Phenanthrene AA Acetaldehyde ETS marker HPLC-UV ETS 218 AAMA N-Acetyl-S-(2- carbamoylethyl)-l-cysteine acrylamide) AAVal Carbamoylethyl-valine acrylamide) Acetoacetate Acetoacetate Ketone bodies GC-MS P, S, brain 043 Acetone Acetone Ketone bodies GC-MS P, S, brain 043 ACN Acetonitrile GC-MS B,P,S 022 Acrolein Acrolein ETS marker HPLC-UV ETS 218 ADMA AMCC Amino (ox. stress, inflammation, NO imbalance) dimethylformamide) LC-MS/MS P 032 Arg Arginine Amino LC-MS/MS P 032 BaP Benzo[a]pyrene ETS marker GC-MS ETS 222 Ben Benzene ETS marker GC-MS ETS 220 Benzene (BTX) Benzene GC-MS B,EB 205 Benzole, Toluol, Benzene GC-MS B,EB 205 Xylenes(o, m, p) But 1,3-Butadiene ETS marker GC-MS ETS 219 CA Cholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 CDCA Chenodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 CEMA CEVal Cyanoethyl-mercapturic N-2-Cyanoethyl-valine acrylonitrile) acrylonitrile) Asymmetric Dimethylarginine N-acetyl-S-(Nmethylcarbamoyl)cysteine Cit Citrulline Amino LC-MS/MS P Carboxy-1-ethylethylmercapturic CMEMA crotonaldehyde) CO Carbon monoxide ETS marker IR ETS 215 CO 2 Carbon dioxide ETS marker IR ETS 216 COex Carbon monoxide in exhaled Carbonmonoxide breath CO) ECD EB 207 COHb Carboxyhemoglobin Carbonmonoxide CO) Photometry B 206 Cot Cotinine Nic-metabolite LC-MS/MS Sa 013 Cot Cotinine Nic-metabolite LC-MS/MS P, S 019 Cot Cotinine Nic-metabolite LC-MS/MS F 033 Cot Cotinine Nic-metabolite LC-MS/MS U,P,S, Sa 036 Cot-Gluc Cotinine-glucuronide Nic-metabolite LC-MS/MS F 033 Cot-Gluc Cotinine-glucuronide Nic-metabolite LC-MS/MS U 036 Cot-N-Ox Cotinine-N-oxid Nic-metabolite LC-MS/MS F 033 Cot-N-Ox Cotinine-N-oxid Nic-metabolite LC-MS/MS U 036 CP Cyclophosphamide Cytostatic drug LC-MS/MS W 031
3 DHNMA CREA Normalization of Creatinine urinary concentrations Photometry U 011 CRO Crotonaldehyde ETS marker HPLC-UV ETS 218 DCA Deoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 DHBMA Dihydroxybutyl-mercapturic 1,3- butadiene) 1,4-Dihydroxy-2-nonenemercapturic (Ox. Doce Docetaxel Cytostatic drug LC-MS/MS W 031 eade 1,N 6 -Etheno-adenine DNA Adduct ((Ox. LC-MS/MS U 025 ecyt EMA 3,N 4 -Etheno-cytosine Ethyl-mercapturic DNA Adduct (Ox. ethylating agents) LC-MS/MS U 025 Epi Epirubicin Cytostatic drug LC-MS/MS U,W 225 EtAde 3-Ethyl-adenine DNA Adduct ethylating agent) LC-MS/MS U 004 Ethylbenzene - ETS marker GC-MS ETS 220 FA Formaldehyde ETS marker HPLC-UV ETS 218 F-PM - ETS marker Fluorimetry ETS 214 GAMA acrylamide) GCA Glycocholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 GCDCA Glycochenodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 GDCA Glycodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 Gem Gemcitabin Cytostatic drug LC-MS/MS W 031 GHDCA Glycohyodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 GLCA Glycolithocholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 Glycerol Glycerol Excipient (for e- U,P,S, GC-MS cigarettes) Sa 204 GUDCA Glycoursodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 Hcy Homo-cysteine Amino (CVD risk factor) LC-MS/MS P 032 HDCA Hyodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 HEMA 2-Hydroxy-ethyl-mercapturic ethylene oxide) HMPMA HNALMA HNAMA N-(R,S)-Acetyl-S-(2- carbamoyl-2-hydroxyethyl)-lcystein 3-Hydroxy-1-methylpropylmercapturic 4-Hydroxy-2-nonenelactone mercapturic 4-Hydroxy-2-nonene mercapturic crotonaldehyde) (Ox. (Ox.
4 HNE-MA HOEtVal HPB 4-Hydroxy-2-nonenal mercapturic N-2-Hydroxyethyl-valine 4-hydroxy-1-(3-pyridyl)-1- butanone (Ox. ethylene oxide) DNA adduct to NNK, NNN exposure LC-MS/MS DNA containing matrix HyPyBut 4-hydroxy-(3-pyridyl) butanoic Nic-metabolite LC-MS/MS U 036 IF Ifosfamide Cytostatic drug LC-MS/MS W 031 LCA Lithocholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 L-NMMA L-N-Monomethyl-arginine Amino (ox. stress, inflammation, NO imbalance) LC-MS/MS P 032 LTE 4 Leukotriene E 4 MDA MeAde Malondialdehyde 3-Methyl-adenine Aldehyde (lipid DNA Adduct methylating agents) 044 GC-MS U, EBC 202 LC-MS/MS U 004 Menthol MI Menthol metabolite p-menthane-3,8-diol LC-MS/MS P, S 041 metabolite Met Methionine Amino LC-MS/MS P 032 Identification of new Untargeted Metabolomics U,P, Metabolomics biomarkers ( for effect GC-TOF-MS 224 profiling S,Sa and exposure) MeVal MMA MTCA MTCG N-Methyl-valine Methyl-mercapturic 2-Methylthiazolidine-4- carboxylic 2-Methylthiazolidine-4- carbonyl-glycine methylating agents) methylating agents) Cysteinylglycine Adduct acetaldehyde) Cysteinylglycine Adduct acetaldehyde) MTX Methotrexat Cytostatic drug LC-MS/MS W 031 NAB N-Nitroso-anabasine NAT N-Nitroso-anatabine Nic Nicotine - LC-MS/MS Sa 013 Nic Nicotine - LC-MS/MS P,S 019 Nic Nicotine - LC-MS/MS F 033 Nic Nicotine - LC-MS/MS U 036 Nic Nicotine ETS marker GC-MS ETS 210 Nic-Gluc Nicotine-glucuronide Nic-metabolite LC-MS/MS F 033 Nic-Gluc Nicotine-glucuronide Nic-metabolite LC-MS/MS U 036 Nic-N-Ox Nicotine-N-oxid Nic-metabolite LC-MS/MS F 033
5 Nic-N-Ox Nicotine-N-oxid Nic-metabolite LC-MS/MS U 036 NNAL 4-(Methylnitrosamino)-1-(3- pyridyl)-1-butanol NNAL-Gluc 4-(Methylnitrosamino)-1-(3- pyridyl)-1-butanolglucuronide NNK 4-(Methylnitrosamino)-1-(3- pyridyl)-1-butanone ETS marker LC-MS/MS ETS 221 NNN N-Nitroso-nornicotine LC-MS/MS U, ETS 023 NNN Nornicotine ETS marker LC-MS/MS ETS 221 NO Nitrogen oxide ETS marker Chemoluminescence ETS 217 NO 2 Nitrite Nitric oxide Photometry EBC 208 NO 2 Nitrogen dioxide ETS marker Chemoluminescence ETS 217 NO 3 Nitrate Nitric oxide Photometry EBC 208 NorCot Norcotinine Nic-metabolite LC-MS/MS F 033 NorCot Norcotinine Nic-metabolite LC-MS/MS F 033 NorCot Norcotinine Nic-metabolite LC-MS/MS U 036 NorNic Nornicotine Nic-metabolite LC-MS/MS U 036 Ntyr 3-Nitro-tyrosine Amino (ox. stress) LC-MS/MS EBC 032 o-/m-/p-/xylene - ETS marker GC-MS ETS 220 OH-Cot trans-3'-hydroxy-cotinine Nic-metabolite LC-MS/MS Sa 013 OH-Cot trans-3'-hydroxy-cotinine Nic-metabolite LC-MS/MS F 033 OH-Cot trans-3'-hydroxy-cotinine Nic-metabolite LC-MS/MS U 036 OH-Cot-Gluc 3-Hydroxy-cotinineglucuronide Nic-metabolite LC-MS/MS F 033 OH-Cot-Gluc 3-Hydroxy-cotinineglucuronide Nic-metabolite LC-MS/MS U 036 o-tol o-toluidine Aromatic amine GC-MS U 020 o-tol o-toluidine ETS marker GC-MS ETS 223 PA Propionaldehyde ETS marker HPLC-UV ETS 218 Pacli Paclitaxel Cytostatic drug LC-MS/MS W 031 Particulate matter (PM) - ETS marker Light scattering or gravimetry ETS 211 PC Phosphatidylcholine Lipid (lipid metabolism) LC-MS/MS P,S 203 PE Phosphatidyl-ethanolamine Lipid (lipid metabolism) LC-MS/MS P,S 203 PGD-M tetranor-pgd metabolite PGE-M tetranor-pge metabolite PGF2α prostaglandin F2 alpha (ox. stress PHE Phenanthrene ETS marker GC-MS ETS 222 PHEMA-1 2-hydroxy-1-phenylethyl mercapturic styrene) PHEMA-2 2-hydroxy-2-phenylethyl mercapturic styrene) Propylene glycol Propylene glycol Excipient (for e- U,P,S, GC-MS cigarettes) Sa 204 PYR Pyrene ETS marker GC-MS ETS 222 SBMA S-Benzyl-mercapturic toluene)
6 SCN Thiocyanate Exposure to hydrogen cyanide (and other GC-MS U 012 cyanides) SDMA Symmetric Dimethyl-arginine Amino (ox. stress, inflammation, NO LC-MS/MS P 032 imbalance) Solanesol Solanesol ETS marker HPLC-UV ETS 212 SPMA S-Phenyl-mercapturic benzene) ß-Carotene beta-carotene Vitamine (ox. stress) HPLC-UV P,S 201 TCA Taurocholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 TCA formaldehyde) Thiazolidine-4-carboxylic Cysteinylglycine Adduct TCDCA Taurochenodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 TCG formaldehyde) Thiazolidine-4-carbonylglycine Adduct Cysteinylglycine TDCA Taurodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 THDCA Taurohyodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 Thioether Thioether Exposure to electrophilic compounds Photometry U 008 TLCA Taurolithocholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 Toluene - ETS marker GC-MS ETS 220 tt-ma trans,trans-muconic GC-MS U 001 TUDCA Tauroursodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 UDCA Ursodeoxycholic Lipid (lipid absorption) LC-MS/MS P,S,U 039 UV-PM - ETS marker Photometry ETS 213 Vit C Ascorbic Vitamine (ox. stress) HPLC-UV P,S 201 Vit E alpha-tocopherol Vitamine (ox. stress) HPLC-UV P,S 201 Abbreviations: B: Blood, EB: Exhaled breath, EBC: Exhaled breath condensate, ETS: Environmental tobacco smoke, F: Feces, GC: Gas chromatography, HPLC-UV: High performance liquid chromatography with photospectrometry, LC: Liquid chromatography, MS: Mass spectrometry, MS/MS: Tandem mass spectrometry, P: Plasma, S: Serum, Sa: Saliva, TOF: Time of flight (mass spectrometry), U: Urine, W: Swipe sample
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