Effect of protein intake, hyperglycaemia and micronutrients on DNA damage and mitogen responsiveness of peripheral blood lymphocytes
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1 Nutrition & Dietetics 2008; 65 (Suppl. 3): S27 S32 DOI: /j x ORIGINAL RESEARCH Effect of protein intake, hyperglycaemia and micronutrients on DNA damage and mitogen responsiveness of peripheral blood lymphocytes Michael FENECH, Manny NOAKES, Jane BOWEN and Peter CLIFTON CSIRO Human Nutrition, Adelaide BC, South Australia, Australia Abstract The aim of the study was to comprehensively assess foods differing in protein type (whey vs casein) relative to a low glycaemic index (GI) and high GI carbohydrate (CHO) food for their effects on DNA damage, DNA repair and mitogen response in peripheral blood lymphocytes using the cytokinesis-block micronucleus assay two hours after consumption. We also studied the relationship of these parameters with plasma folate, vitamin B12, zinc, magnesium and selenium immediately before the intervention and change in plasma glucose and plasma insulin during the two-hour period after consumption. There was no effect of protein, CHO or GI on genome damage or immune responsiveness except for a small but significant improvement in resistance to radiation-induced DNA damage in the high-gi CHO food relative to the casein food. Mitogen response was significantly and positively correlated with plasma zinc, magnesium, selenium and folate and baseline genome damage significantly negatively correlated with plasma folate and vitamin B12. There was no significant correlation between plasma micronutrients and change in plasma glucose or insulin except for a positive and significant correlation between change in plasma insulin and plasma selenium. The correlation between change in plasma insulin and change in plasma glucose was weaker. It is apparent from these preliminary data that micronutrient status may have a profound effect on genome stability and immune responsiveness while the effects of short-term changes in glycemia and dietary intake of carbohydrate or protein may have only minor effects on these parameters. Key words: DNA damage, micronutrients, macronutrients, lymphocytes. INTRODUCTION A high rate of damage to DNA is associated with accelerating ageing and increased risk of degenerative diseases such as cancer and Alzheimer disease. 1 Endogenous factors, such as an elevated level of reactive oxygen species (ROS) can cause both base damage and strand breaks in DNA. Repair of such DNA damage depends on the enzymes such as polyadpribosepolymerase (PARP) which requires a high level of NAD bioavailability. In situations of excess glucose, NAD is converted to NADH, generating a high energy state, increased ROS generation in cells and depletion of NAD this may lead to a vicious cycle of increased DNA damage and reduced PARP activity/dna repair. 2 In addition, it has recently been shown that mice on a medium (20%) or high M. Fenech, PhD, Theme Leader, Scientist M. Noakes, PhD, Stream Leader, Scientist J. Bowen, PhD, Project Leader, Scientist P. Clifton, MD PhD, Theme Leader, Scientist Correspondence: M. Fenech, CSIRO Human Nutrition, PO Box 10041, Adelaide BC, SA 5000, Australia. michael.fenech@csiro.au (33%) protein diet exhibited less DNA damage than mice on a low (7%) protein diet when exposed to ionising radiation as a source of ROS. 3 The protective effect of the high-protein diets could be due to an increased plasma concentration of sulfhydryl amino acids, such as cysteine and methionine, which have considerable antioxidant activity, or via increased glutamine which increases tissue antioxidant glutathione. 4 Therefore, it is important to identify foods and diets that do not increase genome instability and/or impair the DNA repair response in cells by depleting NAD and generating excess ROS. The aim of the study was to comprehensively assess foods differing in protein type (whey vs casein), relative to a low glycaemic index (GI) and high-gi carbohydrate (CHO) food for their post-prandial effects on DNA damage, DNA repair and mitogen response in peripheral blood lymphocytes (PBLs), the latter being a biomarker of immune response. Given the potential impact of micronutrients on genome stability, DNA repair, immune response and insulin resistance and glucose metabolism, we also examined the effect of zinc, magnesium, selenium, vitamin B12 and folate status on these parameters. S27
2 M. Fenech et al. Table 1 Macronutrient composition of preloads Preload (liquid food) (a) (b) High glycaemic index (c) Low glycaemic index (d) Energy (kj) Protein (g) (% of energy) 52.2 (83) 52.4 (82) 7.2 (11) 7.2 (11) Fat (g) (% of energy) 0.5 (2) 1 (3) 0.2 (1) 0.2 (1) Carbohydrate (g) (% of energy) 10.3 (15) 10.2 (15) 56.0 (85) 59.8 (85) Energy density (kj/g) (a) protein isolate (MG 2460, Murray Goulburn). (b) Instant calcium caseinate (MG 2954, Murray Goulburn). (c) Glucodin (Boots Healthcare). (d) Lactose (Ace Chemicals). These studies could provide insight into the possible mechanism of action of these dietary components on genome stability in PBLs and immune response. METHODS Study design and protocol The study involved overweight men with impaired fasting glucose participating in four acute studies to assess the effect of isocaloric whey protein or casein or low-gi CHO or high-gi CHO on: (i) markers of glycaemic control; (ii) baseline genome damage rate and mitogenic responsiveness; and (iii) the capacity of blood cells to resist radiation-induced DNA damage before and after consumption of different proteins and carbohydrates. Ten overweight, but otherwise healthy, men with a body mass index (BMI; in kg/m 2 ) of (range: ), high mean fasting glucose concentration of mmol/l (range: mmol/l) and a mean age of years (range: years) were recruited by public advertisement. All subjects had a stable bodyweight during the two months prior to participation, were not seeking to change body weight, nonsmokers and unrestrained eaters. Subjects did not have any medical conditions or take medications known to affect glucose metabolism, gastrointestinal motility or appetite. The study was approved by the Commonwealth Scientific Industrial Research Organisation (CSIRO), Division of Health Sciences and Nutrition Human Ethics Committee. All subjects gave informed, written consent to participate. Subjects attended the research clinic on four occasions for this single-blind, randomised, cross-over designed study comparing liquid foods containing whey, casein, glucose or lactose. There was a seven-day interval between visits. Subjects refrained from exercise, taking paracetamol, paracetamol-containing products or alcohol 24 hours prior to study days and fasted after midnight (water permitted). Upon arrival at the clinic (08:30 hours), subjects height was measured using a stadiometer (Seca, Germany). Weight was measured (Mettler scales, model AMZ14) in light clothing and without shoes. BMI was calculated by weight (kg) divided by height (mz). S28 A cannula was inserted into a vein in the lower arm and a fasting blood sample was taken (-15 minutes). The liquid preload was consumed within five minutes at 09:00 hours (time 0) and was immediately followed by 1500 mg of paracetamol (Glaxo Smith-Klein, Sydney, Australia) dissolved in 100 ml of water, as an indirect marker of liquid gastric emptying. Subsequent blood samples were collected at 15, 30, 45, 60, 90, 120 and 180 minutes after time 0 for analysis of glucose and insulin and paracetamol. Genome damage and mitogen responsiveness in control and irradiated cells (3.0-Gy gamma rays) were measured in blood samples collected before consumption of the test food and two hours later. The order of the test food interventions was fully randomised to avoid effects of habituation to the procedure. Food intake was recorded as were measures of glucose and insulin at eight time points starting immediately before and during the two-hour post-consumption period. Genome damage and mitogen responsiveness in control and irradiated cells (3.0-Gy gamma rays, dose rate 5.0 Gy/minutes) were measured in blood samples collected before consumption of the test food and 2 hours later. Preloads of liquid food (1MJ) were made from a base of water (100 ml), milk (1% fat; 200 ml), artificially sweetened chocolate syrup (50 g) and either whey protein isolate (MG 2460, Murray Goulburn, Melbourne, Australia), calcium caseinate (MG 2954, Murray Goulburn, Melbourne, Australia), glucose (high-gi carbohydrate; Glucodin, Boots Healthcare, Richmond, Australia) or lactose (low-gi carbohydrate; Ace Chemical Company, Camden Park, Australia) (Table 1). The preloads did not contain dietary fibre and were controlled for energy density, palatability, colour and odour. Preloads were prepared on the morning of consumption (except the casein preload that was prepared 24 hours prior to consumption to improve consistency) and served in an opaque container. Energy and nutrient composition of food intake was calculated using Food Works Analysis Package 3.1 (Xyris Software, Highgate Hill, Australia) which is based on data from Australian Food Composition Tables. 5 One dietician conducted all nutrient analysis.
3 Nutrients and DMA damage Biochemistry and genome damage assays Blood for serum was collected in tubes with no additives and allowed to clot at room temperature for 30 minutes. Blood for plasma was collected in sodium fluoride/edta (1 g/l) tubes containing aprotinin (Roche; Indianapolis, IN, USA) 500 KIU/mL blood and stored on ice. Serum and plasma were isolated by centrifugation for 10 minutes at 2000 g (5 C) (Beckman GS-6R Centrifuge, Fullerton, CA, USA) within one hour of collection and aliquots were stored at -80 C. Blood for genome damage assays was collected in lithium heparin tubes. Serum insulin was measured in singleton using a commercial enzyme immunoassay kit (Mercodia, Uppsala, Sweden). 6 Plasma glucose was determined using an enzymatic kit (Hoffman-LaRoche Diagnostics, Basel, Switzerland) and control sera on a Hitachi 902 Automatic Analyser (Roche Diagnostics, Basel, Switzerland). 7 Serum paracetamol (acetaminophen) was measured using a commercial enzymatic kit (Cambridge Life Sciences, Cambridgeshire, England) adapted for a Cobas Bio centrifugal analyser using reagent volumes compatible with this instrument (Roche Diagnostics, Basel, Switzerland). Minerals in plasma were measured by flame atomic absorption spectrophotometry using a Perkin Elmer 5000 Atomic Absorption Spectrophotometer (Perkin Elmer, Melbourne, Australia). 8 Plasma Folate and vitamin B12 were measured by radioimmunoassay (Bio-Rad Quantaphase II, North Ryde, Australia). 9 All biochemical analyses were performed after study completion and all samples for individuals were analysed in the same assay. Intra- and interexperimental variation was less than 8% for all assays. Genome stability was measured using the cytokinesisblock micronucleus assay in human peripheral blood lymphocytes. 10,11 This assay was performed on both untreated lymphocytes and lymphocytes exposed to 3.0-Gy gamma rays to obtain a measure of capacity for DNA repair after oxidative challenge. Lymphocytes were cryopreserved using a standard protocol that preserves viability of cells. 12 Within two months of cryopreservation, the lymphocytes were thawed, washed in culture medium and the CBMN assay performed as previously described. 10,11 Using this assay, we obtained measures of chromosome breakage and loss (micronucleated, MNed, cells) and mitogen responsiveness (nuclear division index, NDI). We also measured plasma Zn, Mg, Se, vitamin B12 and folate in samples collected before the intervention (i.e. at 0 hour) to take into account the possible effect of these micronutrients on measured results. The study on genome stability was done with 10 subjects which, based on historical data on variation in spontaneous MNed cell frequency, should have resulted in 85% power to detect a 12% change in MNed cells at P = Statistical analysis Results for micronutrients, genome damage, NDI, glucose and insulin were normally distributed. We used parametric one-way ANOVA tests to compare effect of treatment followed by Tukey s test to compare pairs of treatments. Correlation between parameters was measured using Pearson s test. Differences were considered to be significant at P < 0.05 (two-tailed). RESULTS The area under the concentration versus time curve (AUC) for plasma glucose was significantly greater in the CHO treatments relative to whey and casein, but there was no difference in AUC for plasma insulin (Figure 1). There was no significant impact of the type of food eaten on baseline genome damage. After correcting for baseline values, it was evident that the observed reduction in radiation-induced genome damage following consumption of the high-gi CHO food was significantly different from the observed change (increase) following consumption of the Plasma glucose AUC (min.nmol/l) Plasma insulin AUC (min.nmol/l) (a) (b) * ** Figure 1 Change in post-prandial plasma concentration measured using area under the plasma concentration versus time curve (AUC) for (a) plasma glucose and (b) plasma insulin during the two-hour post-consumption period. The results show a significant effect of and HI GI CHO on post-prandial plasma glucose concentration relative to whey and casein, and no difference between treatments with respect to effects on insulin and post-prandial insulin concentration. Results represent the mean 1 SEM. n = 10 per group. *P < 0.05 versus whey, casein; **P < 0.01 versus whey, casein. GI, glycaemic index; HI, high; LO, low. S29
4 M. Fenech et al. Difference in frequency of binucleated cells containing micronuclei per 1000 binucleated cells Figure 2 Difference in genome damage induced by 3.0Gy radiation challenge in lymphocytes from blood samples collected two hours post consumption of intervention foods relative to results for lymphocytes from pre-consumption blood samples. DNA damage was measured in peripheral blood lymphocytes using the cytokinesis-block micronucleus assay. Frequency of cells containing micronuclei (i.e. MNed cells) was measured in 1000 binucleated cells. With the exception of casein, all treatments showed a small reduction in radiation-induced DNA damage in samples post consumption. The results also showed that the change in radiation-induced DNA damage post consumption of HI GI CHO was significant relative to the results for casein. n = 10 per group. *P < 0.05 versus casein. GI, glycaemic index; HI, high; LO, low. Difference in NDI casein protein food (Figure 2). The observed changes in radiation-induced genome damage were not significantly correlated with the plasma insulin or plasma glucose AUC (data not shown). We observed a significant post-prandial reduction in NDI with the casein-based food relative to pretreatment NDI levels (P < 0.01; data not shown). However, although the * Figure 3 Difference in nuclear division index (NDI) of peripheral blood lymphocytes measured using the cytokinesis-block micronucleus assay two hours after consumption of test food relative to baseline at time 0 hour. The results show a trend for a reduced NDI in post-prandial samples relative to pre-consumption samples, but differences between groups were not statistically significant. n = 10 per group. S30 difference in NDI relative to baseline was greatest in the casein treatment, it was not significantly different from that of the other treatments which also showed a trend to a reduction in NDI post-prandially (Figure 3). Change in NDI values relative to baseline was not correlated significantly with the plasma insulin and plasma glucose AUC (data not shown). There was: (i) a significant positive correlation between the NDI with plasma Zn, Mg, Se and folate; and (ii) a significant negative correlation between plasma folate and vitamin B12 with baseline MNed cell frequency (Table 2) in fasted samples prior to the intervention. In irradiated cells, only the positive correlation of NDI with plasma magnesium and folate remained significant (Table 3). Also noted were significant correlations between micronutrients such as the positive correlations between Zn, vitamin B12 and folate and the negative correlation between vitamin B12 and magnesium. Micronutrient status was not related to the post-prandial increase in plasma glucose (measured as the area under the plasma concentration vs time curve, AUC). However, the post-prandial increase in plasma insulin concentration (also measured as AUC) was significantly positively correlated with plasma selenium (P = 0.003, R = 0.448) and glucose AUC (P = 0.037, R = 0.327). DISCUSSION The results of the present study do not support the hypothesis that reduced protein intake relative to carbohydrate or increased glycemic load leads to increased genome instability, diminished DNA repair capacity and reduced immune responsiveness in the short-term post-prandial period. Although the results suggest an aggravating effect of casein intake on radiation-induced genome damage and immune responsiveness relative to high-gi CHO, the effects are relatively small. The lack of an effect of glycemic load on genome stability may be due to insufficient time to alter the NAD/NADH ratio in the target PBL cells which are quiescent in vivo. A longerterm intervention coinciding with the in vivo turnover rate of lymphocytes may be required to produce a significant alteration in NAD/NADH ratio sufficient to impact on PARP activity. Another possible explanation could be more than adequate nicotinic acid status in the subjects studied which may compensate for any slight changes in the NAD/NADH ratio. However, we did not measure nicotinic acid or NAD/ NADH ratio, which is a weakness of this preliminary study. The data suggest a marginally improved resistance to radiation-induced genome damage in the high-gi CHO treatment, which, although contrary to expectations, may reflect an adaptive response to low-level increase in oxidative damage that is hypothesised to increase with high-gi diets. Adaptive responses in DNA repair have been observed with pretreatment small doses of radiation or oxidative stress within the time frame of the study protocol (i.e. two hours) using the same model. 13 However, we have no evidence that oxidative stress was actually increased in the high-gi CHO
5 Nutrients and DMA damage Table 2 Correlation matrix of plasma micronutrients, nuclear division index (NDI) and genome damage measured as frequency of binucleated cells containing micronuclei (MNed cells) per 1000 BN cells in control un-irradiated lymphocytes measured just before the intervention Magnesium Selenium Vitamin B12 folate NDI MNed cells Zinc Magnesium Selenium 0.34 Vitamin B Folate NDI Only significant (P < 0.05) correlation values are shown. Data from each intervention arm were included in the analysis. n = 39 (Casewise deletion of missing data). Table 3 Correlation matrix of plasma micronutrients, nuclear division index (NDI) and genome damage measured as frequency of binucleated cells containing micronuclei (MNed cells) per 1000 BN cells in lymphocytes (exposed to 3.0-Gy gamma rays) measured just before the intervention Magnesium Selenium Vitamin B12 folate NDI MNed cells Zinc Magnesium Selenium Vitamin B12 Folate 0.40 NDI Only significant (P < 0.05) correlation values are shown. Data from each intervention arm were included in the analysis; n = 40. treatment and results for baseline MNed cell frequency in non-irradiated lymphocytes suggest no significant change in genome damage with any of the treatments. The observed significant positive correlations between plasma levels of zinc, magnesium, selenium and folate with NDI are in keeping with numerous studies indicating the stimulating effect of these micronutrients on immune function. 14 The negative correlation of plasma folate and B12 with MNed cell frequency is in agreement with our studies showing that folate and its bioavailability are important determinants of chromosomal instability and micronucleus formation in human lymphocytes, and that supplementation with folate and vitamin B12 reduces MNed cell frequency. 15,16 There may be some concern that baseline genome damage rates may have been confounded by the use of paracetamol as a marker of gastric emptying; however, our results show no evidence of increase in MNed cell frequency post food consumption and results from an independent study also showed no effect of paracetamol on MNed cell frequency. 17 The significant positive correlation of plasma selenium concentration with insulin response fits with results from a study on glutathione peroxidase (GPx) overexpression murine model associated with increased insulin resistance and obesity. 18 It is also consistent with the reported positive association between erythrocyte GPx1 activity and levels of insulin resistance in normal pregnant women that are pregnant for at least 16 weeks. 19 It has been hypothesised that increased antioxidant GPx activity may interfere with ROS required for an insulin sensitivity response. 17 It is apparent from these preliminary data that micronutrient status may have a profound effect on genome stability and immune responsiveness while the effects of short-term changes in glycemia and dietary intake of carbohydrate or protein may have only minor effects on these parameters. ACKNOWLEDGEMENTS We are grateful to volunteers without whom the study could not have been completed successfully. Jennifer Keogh, Anne McGuffin, Kathryn Bastiaans, Rosemary MCArthur and other members of the CSIRO clinic are thanked for their role in recruitment, trial management and blood collection. Plasma measures of glucose and insulin were done by Mark Mano and Candita Sullivan. The CBMN assays were performed by Julie Turner and Carolyn Salisbury. Plasma mineral measurements were done by Jenny McInerney and Ben Scherer. The study was partially funded by Australia s National Centre of Excellence for Functional Foods ( CONFLICT OF INTEREST No conflict of interest has been declared by M. Fenech, M. Noakes, J. Bowen or P. Clifton. S31
6 M. Fenech et al. REFERENCES 1 Ames BN, Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer 2002; 2: Hasty P. The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals. Mech Ageing Dev 2001; 122: Shin SJ, Yamada K, Sugisawa A et al. Enhanced oxidative damage induced by total body irradiation in mice fed a low protein diet. Int J Radiat Biol 2002; 78: Jhonson AT, Kaufmann YC, Luo S et al. Effect of glutamine on glutathione, IGF-1 and TGF-beta 1. J Surg Res 2003; 111: Cashel K, English R, Lewis J. Composition of Foods, Australia. Canberra: Australia Government Publishing Service, McReynolds CR, Shah S, Stoffer RP. Computer assisted analysis of insulin response to glucose stimulus. Ann Clin Lab Sci 1973; 3: Kadish AH, Sternberg JC. Determination of urine glucose by measurement of rate of oxygen consumption. Diabetes 1969; 18: Fenech M, Baghurst P, Luderer W et al. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 2005; 26: Fenech M, Noakes M, Clifton P et al. Aleurone flour increases red-cell folate and lowers plasma homocyst(e)ine substantially in man. Br J Nutr 2005; 93: Fenech M. The in vitro micronucleus technique. Mutat Res 2000; 455: Fenech M, Morley AA. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low-dose X-irradiation. Mutat Res 1986; 161: O Donovan MR, Freemantle MR, Hull G et al. Extended-term cultures of human T-lymphocytes: a practical alternative to primary human lymphocytes for use in genotoxicity testing. Mutagenesis 1995; 10: Thierens H, Vral A, Barbe M et al. Chromosomal radiosensitivity study of temporary nuclear workers and the support of the adaptive response induced by occupational exposure. Int J Radiat Biol 2002; 78: Chandra RK. Impact of nutritional status and nutrient supplements on immune responses and incidence of infection in older individuals. Ageing Res Rev 2004; 3: Kimura M, Umegaki K, Higuchi M et al. MTHFR C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr 2004; 134: Fenech M, Aitken C, Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 1998; 19: Kocisova J, Sram RJ. Mutagenicity studies on paracetamol in human volunteers. III. Cytokinesis block micronucleus method. Mutat Res 1990; 244: McClung JP, Roneker CA, Mu W et al. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci USA 2004; 101: Chen X, Scholl TO, Leskiw MJ et al. Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy. J Clin Endocrinol Metab 2003; 88: S32
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