Humanitas University - 2nd Year - 2nd Semester A.A

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1 BAW2-physio Endocrine nervous interaction 02 March 2016 The complement system Seppo Meri L MOD 1 BAW2-physio Hypothalamus and hypophysis 03 March 2016 Introduction to tumors Mantovani/Jaillon L MOD 1 Overview of the adaptive immune system / Antigen processing and presentation Kallikourdis L MOD 1 Antigen presenting cells Bonecchi L MOD 1 Pathogenic Gram-positive bacteria-1 Garlanda L MOD 1 04 March 2016 T cell development and functions Kallikourdis L MOD 1 BAW2-physio The circadian clock 07 March 2016 BAW2-practical Fesce P BW2 1 BAW2-physio Neuro-endocrine control of growth and development Pathogenic Gram-positive bacteria-2 Garlanda L MOD 1 08 March 2016 Bigatello in stand by L BW2 1 Bigatello-Practical in stand by P BW2 1 B cell development and antibodies Kallikourdis L MOD 1

2 9 March March 2016 BAW2-physio Endocrine control of sexual maturation and reproduction Bigatello in stand by L BW2 1 BAW2-Thiroid hormones Bigatello-Practical in stand by P BW2 1 BAW2-Bioch_1- Energy balance in resting and stressed conditions Bussolino L BW2 1 BAW2-Bioch_2- Metabolism of thyroid hormones Bussolino L BW2 1 Immune response polarization and memory Kallikourdis L MOD 1 Pathogenic Gram-positive bacteria-3 Garlanda L MOD 1 11 March 2016 Coagulation and haemodynamics Bigatello L BW2 1 BAW2_Physics_1 - Introduction, static fluids and nonviscous fluids Cozzi L BW2 1 Bigatello-Practical P BW2 1 BAW2-physio Corticosteroids 14 March 2016 BAW2-practical Fesce P BW2 1 Pathogenic Gram-negative cocci and bacilli Garlanda L MOD 1 15 March 2016 Fluids in acute shock management Bigatello L BW2 1 BAW2_Physics_2 - Viscous fluids, the blood system and advanced cases Cozzi L BW2 1 Bigatello-Practical Bigatello P BW2 1

3 16 March 2016 Tolerance and Negative regulators of the immune response Kallikourdis L MOD 1 BAW2_Physics_3 - Viscous fluids, the blood system and advanced cases BAW2-physio Heart volume, pressure, work; the triple product and oxygen consumption Cozzi L BW2 1 Parasitic protozoa -1 Seppo Meri L MOD 1 17 March 2016 Heart 1 Bigatello L BW2 1 Bigatello-Practical Bigatello P BW2 1 Chronic inflammation, fibrosis and tissue renewal Bonecchi L MOD 1 BAW2-Bioch_3 - Metabolism of corticosteroids Bussolino L BW March 2016 Heart 2 Bigatello L BW2 1 Bigatello-Practical Bigatello P BW March 2016 Lecture prof. Berra Berra 22 March 2016

4 BAW2-physio The cardiac cycle: the heart as a pump 23 March 2016 BAW2_Physics_4 - Summary and Tutorial Cozzi L BW March April April 2016 BAW2-Bioch_4- Plasma composition Bussolino L BW2 1 BAW2-Bioch_5- Thrombosis and haemostasis Bussolino L BW2 1 Parasitic protozoa - 1 Seppi Meri L MOD 1 BAW2-Bioch_6 - Energy balance in the heart and cardiac metabolism Bussolino L BW2 1 BAW2-Bioch_7 - Biochemical aspects of vascular functions Bussolino L BW2 1 The immunology of pregnancy - an evolutionary perspective Kallikourdis L MOD 1 BAW2-physio Heart work: the triple product and oxigen consumption BAW2-practical Fesce P BW2 1 Rickettsias, Chlamydias, Spirochetes, Vibrios Garlanda L MOD 1 5 April 2016 Characteristics of benign and malignant tumors Jaillon L MOD 1

5 06 April 2016 BAW2-physio Pressure, resistance, flow - resistance vs capacitance vessels BAW2-physio Microcirculation 07 April 2016 Rickettsias, Chlamydias, Spirochetes, Vibrios Garlanda L MOD 1 08 April 2016 Molecular basis of cancer -1 Jaillon L MOD 1 BAW2-physio The electrical activity in the heart 11 April April 2016 BAW2-practical Fesce P BW2 1 BAW2-physio The Electrocardiogram BAW2-Bioch_8 - Two ways secretion: exocrine and endocrine properties of the GI system Bussolino L BW2 1 BAW2-Bioch_9- Nutritional requirements and food intake Bussolino L BW2 1

6 13 April April April 2016 BAW2-physio The regulation of heart function by the autonomic nervous system Vaccines and their development Mantovani L MOD 1 BAW2-physio Gastrointestinal system: the enteral nervous system, motility and secretion BAW2-Bioch_10 - The metabolic functions of the liver: nutrient processing and biosynthetic activity BAW2-Bioch_11 - The metabolic functions of the liver: catabolic function, detoxification, disposal Bussolino L BW2 1 Bussolino L BW Training PBL (studenti trasferiti) Montagna 1 Group work Flipped classroom P BW2 BAW2_An_The Nephron / Flipped classroom Barajon L BW2 1 1/1/1/1/8/9 /2/5/6/5/6/ BAW2-physio Body fluids and the principles of renal functioning 18 April 2016 BAW2-practical Fesce P BW2 1 BAW2-physio Renal blood flow and glomerular filtration The concept of clearance BAW2-Bioch_12 - The functions of adipose tissue Bussolino L BW April 2016 BAW2-Bioch_13 - Biochemical aspects of renal functions Bussolino L BW2 1 Pasaritic protozoa - 2 Seppo Meri L MOD 1

7 20 April 2016 BAW2-physio The functions of the proximal tubule, Henle's loop and distal tubule Molecular basis of cancer-2 Jaillon L MOD 1 BAW2-physio The regulation of sodium & water balance The kidney & blood pressure Rickettsias, Chlamydias, Spirochetes, Vibrios Garlanda L MOD 1 BAW2-Bioch_14 - Biochemical aspects of renal functions Bussolino L BW2 1 BAW2-Bioch_15 - Biochemistry of senescence Bussolino L BW2 1 PBL Open session group 1 Reggiani Francesco PBL MOD 1 PBL Open session group 2 Citterio Enrico PBL MOD 1 PBL Open session group 3 Marrari Andrea PBL MOD 1 21 April 2016 PBL Open session group 4 Generali Elena PBL MOD 2 PBL Open session group 5 Zavalloni Parenti Dennis PBL MOD 3 PBL Open session group 6 Settepani Fabrizio PBL MOD 5 PBL Open session group 7 Malanchini Giovanni PBL MOD 6 PBL Open session group 8 Lorenzi Elena PBL MOD 8 PBL Open session group 9 Vinci Valeriano PBL MOD 9 PBL Open session group 10 Cornegliani Guido PBL MOD 10 PBL Open session group 11 Laghi Luigi PBL MOD 12 PBL Open session group 12 Peccati Andrea PBL MOD OME

8 Pathogenic fungi-1 Garlanda L MOD 1 22 April 2016 Clinical aspect of patients with tumors Jaillon L MOD 1 Helmints Seppo Meri L MOD 1 26 April 2016 Angiogenesis and tumor angiogenesis Bonecchi L MOD 1 Pathogenic fungi - 2 Garlanda L MOD 1 BAW2-physio Acid-base balance and the regulation of body ph 27 April 2016 Hypersensitivity reactions Jaillon L MOD 1 BAW2-physio Cardio vascular and renal integration in the control of blood pressure Pathogenic DNA viruses-1 Garlanda L MOD 1 28 April April 2016 Group work Flipped classroom P BW2 BAW2_An_Rrespiratory system / Flipped classroom Barajon L BW2 1 BAW2-Bioch_16 - Biochemistry of senescence Bussolino L BW2 1 1/1/1/1/8/9 /2/5/6/5/6/

9 02 May 2016 BAW2-physio The respiratory system pressure-volume curves: lungs and chest wall BAW2-practical Fesce P BW2 1 BAW2-physio The dynamics of the respiratory system and the respiratory muscles Pathogenic DNA viruses-2 Garlanda L MOD 1 Autoimmune diseases Jaillon L MOD 1 PBL Close session group 1 Reggiani Francesco PBL MOD 1 PBL Close session group 2 Citterio Enrico PBL MOD 1 PBL Close session group 3 Marrari Andrea PBL MOD 1 03 May 2016 PBL Close session group 4 Generali Elena PBL MOD 2 PBL Close session group 5 Zavalloni Parenti Dennis PBL MOD 4 PBL Close session group 6 Settepani Fabrizio PBL MOD 4 PBL Close session group 7 Malanchini Giovanni PBL MOD 4 PBL Close session group 8 Lorenzi Elena PBL MOD 5_6 PBL Close session group 9 Vinci Valeriano PBL MOD 10 PBL Close session group 10 Cornegliani Guido PBL MOD 12 PBL Close session group 11 Laghi Luigi PBL MOD ome PBL Open session group 12 Peccati Andrea PBL MOD OME Meeting with the expert Garlanda PBL MOD 1

10 BAW2-physio Gas exchanges at the alveoles; the ventilation/perfusion ratios in the lungs BAW2-physio Control of breathing 04 May 2016 Practical Physical examination of Abdomen Group A Eusebio P BW2 1 Practical Physical examination of Thorax and Heart Group B Ulian P BW2 4 Practical Physical examination of Abdomen Group B Eusebio P BW May 2016 Practical Physical examination of Thorax and Heart Group A Ulian P BW2 4 Group work Flipped classroom P BW2 BAW2_An_Brainstem / Flipped classroom Barajon L BW2 1 1/1/1/1/8/9 /2/5/6/5/6/ Rejection of tissue transplants Jaillon L MOD 1 06 May 2016 Practical Physical examination of Abdomen Group C Eusebio P BW2 1 Practical Physical examination of Thorax and Heart Group D Ulian P BW2 4 Practical Physical examination of Abdomen Group D Eusebio P BW2 1 Practical Physical examination of Thorax and Heart Group C Ulian P BW2 4 BAW2-physio Control of breathing 09 May 2016 BAW2-practical Fesce P BW2 1

11 Pathogenic RNA viruses-1 Garlanda L MOD 1 10 May May 2016 Immunodeficiency syndromes Jaillon L MOD 1 Immune response to tumors Mantovani L MOD 1 BAW2-physio The autonomic nervous system a hierarchical control system Hemostasis and coagulation Bonecchi L MOD 1 BAW2-physio Hypothalamus, amygdala and limbic circuits Emotions Arousal BWA2_an Brainstem Barajon L BW May 2016 Thrombotic diseases Bonecchi L MOD 1 Pathogenic RNA viruses-2 Garlanda L MOD 1 13 May May 2016 Inflammation and cancer Mantovani L MOD 1 BAW2-physio Mesencephalic dopame: pleasure and motivation - Seratonin in the CNS BAW2-practical Fesce P BW BAW2-physio Memory: cellular mechanisms, types of memory, encoding, consolidation, recall Seminario Nehert Nobel prize lecture: Evolutionary perspectives of innate immunity Jules Hoffmann S MOD 1 17 May 2016 Respiratory 1 Bigatello L BW2 1 Bigatello practical Bigatello P BW2 1

12 18 May 2016 BAW2-physio Working memory and planning Primary and extended consciousness Nobel prize lecture: Evolutionary perspectives of innate immunity Jules Hoffmann S MOD Pathogenic RNA viruses-3 Garlanda L MOD 1 19 May 2016 Respiratory 2 Bigatello L BW2 1 Bigatello practical Bigatello P BW2 1 Respiratory 3 Bigatello L BW May May 2016 Bigatello practical Bigatello P BW2 1 Tutorial and practicals Fesce P BW2 1 BAW2-physio The "external" and the internal paths of behavioural control BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW2 1 BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW2 1 Immunosenescence Mantovani L MOD 1 24 May 2016 Bigatello in stand by L BW2 1 Bigatello practical in stand by P BW2 1

13 BAW2-physio Language 25 May May C-maps Group work Zavalloni/Barajon SG Bigatello in stand by L BW2 1 Bigatello practical in stand by P BW2 1 BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW2 1 1_1_1_1_ 5-6_5_6-12_8_9_2 BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW May May 2016 BAW2-Clinical link: the possible disturbances of heart rhythm BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW2 1 BAW2-physio Tutorial and practicals (Electrophysiology Fesce P BW2 1 Microbioma and immune responses Garlanda L MOD 1 31 May 2016 Pain _ Workshop Barajon S BW2 1 Pain _ Workshop Fesce S BW2 1