Anti-diabetic Activities of Chalcones Derived from Ashitaba
|
|
|
- Francis Byron Merritt
- 6 years ago
- Views:
Transcription
1 456 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /1, No. ++,./0.0- (,*+*) 10 Anti-diabetic Activities of Chalcones Derived from Ashitaba Tatsuji Enoki, Hiromu Ohnogi, Eiji Kobaashi and Hiroaki Sagawa Biotechnolog Research Laboratories, Takara Bio Inc., -. +, Seta, Otsu, Shiga /,*,+3- Ashitaba, ( Angelica keiskei), is a perennial belonging to Umbelliferae and has been taken as a healthpromoting vegetable around the Hachijo Island area. Ashitaba has been known to contain about,* kinds of chalcones, and two major chalcones such as xanthoangelol (XA) and.-hdroxderricin (. HD) are more abundantl included than other chalcones. We previousl found that these two chalcones have insulin-like activities such as the induction of adipocte di# erentiation and the enhancement of glucose uptake. Moreover,. HD especiall showed stronger promoting activit of glucose uptake and preventive e# ect on the progression of diabetes in geneticall diabetic mice than the XA. In this report, we tested whether. HD can reduce the blood glucose levels of mice which developed hperglcemia associated with insulin resistance, and the structure-activit relationships of chalcones on glucose uptake using other Ashitaba chalcones and snthetic chalcones. As a result,. HD showed a lowering e# ect of blood glucose levels of diabetic mice, probabl due to the enhancement of glucose uptake. Thus, it is suggested that. HD exert a hpoglcemic action via an insulin-independent pathwa. In the structure-activit relationship, both. - methox group and --large substituted group, such as prenl, geranl, farnesl and benzl of A ring were considered to be essential for glucose uptake promoting activit. (Received Jun.,/,,*+* ; Accepted Jul. +,,,*+*) Kewords : Ashitaba, Angelica keiskei, chalcone, insulin-like activit, diabetes : : Angelica keiskei Koidzumi,- ++ +, * + -,*,,+* + +-,* QOL : xanthoangelol : XA. +. Qualit of Life. -hdroxderricin :. HD. / XA. HD, XA +*. HD /,*, Corresponding author enokit@takara-bio.co.jp,
2 11 : 457. HD, -hdrox-- -methl-. - KK-A methox-ap c,,. -dihdrox---methl-ap. HD 1* +, +*, -hdrox-- -farnesl-. -methox-ap d a, -hdrox-- -benzl-. -methox-ap e. HD b XA. HD AP.-hdroxbenzaldehde AP BP, -hdrox-. -methox- AP - mmol.-hdroxbenzaldehde - mmol +-ml +.*1/ g.*,* +.,, -dihdrox-. -methoxchalcone DHMC +//., AP ae BP a / kg +/ L.,,,. -trihdrox- --farneslchalcone THFC b.,,,. -trihdrox- - -benzl-,/ +.* C+2-OPN chalcone THBC,2./ c.,, -dihdrox- - -methl-. -methoxchalcone DHMMC,.0. -*.* 1/ d.,, -dihdrox-- -farnesl-. -methoxchalcone +** 1/ DHFMC./.. e.,, -dihdrox--- BW--** SP, benzl-. -methoxchalcone DHBMC,3.. : +* : /. NMR F XA-F, 1.+ mg. HD, +2/ mg XA - /3- mg IBC, 0- mg. -T-L - +.* -T--L+ DS : /* / : + -T- -L+ +* DS,** M H XA-H, -0 mg + D-MEM -1 / CO NMR 2*, - +, +* - Lonza,** M + AP D-MEM D-MEM,,. -dihdrox-- -farnesl-ap a,,. -dihdrox- FBS *,/. M +* AP, M KOH gml */. mm farnesl bromide, / g +/./ ml D-MEMFBS,. XA. HD,,. -dihdrox---benzl-ap b,,. -dihdrox-ap benzl bromide +* +.,
3 458 /1 ++,*+* / / -T- -L+ PBS 1 : - :, KK-A Ta E-Test +, CE-, +, 0, / -T--L + *+. D-. HD */. MEM D-MEMBSA. HD + +,** mgkg D-MEMBSA +. +/ HEPES HBSS HBSS./ + gml -* - */. CimL, +,,- H Ameri- can Radiolabeled Chemicals +** M, +. HD XA +*.* M B - + A B XA. HD PBS + NP-.* PBS KK-A + XA. HD XA. HD A B C:XA D:. HD E:XA F:. HD N. * p*.*/ ** p*.*+ v.s. Ctr. Tuke b
4 13 : 459,. HD XA. HD / M XA,* M,. HD XA A. -,. HD KK-A. HD,. HD KK-A KK-A. HD. HD N/ ** p **+. v.s. Ctr. t KK-A -F. HD XA-F. HD IBCXA-H. HD. +2 DHMC,. HD - DHMMC HD +. A -.. HD XA - A -. HD XA. A - - XA-F - A. HD A - XA.. IBC - C. HD. XA. A ; DHFMC, B ; DHBMC, C ; THBC, D ; THFC,. HD, XA, XA-F. HD XA, A. XA-H - B. HD XA-F DHFMC DHBMC. HD, -. HD - THBC THFC -D;DHMC -. -E ; DHMMC
5 460 /1 ++,*+* XA-F A XA-H B, IBC C DHMC D, DHMMC E F N0 * p**/. ** p**+. v.s. Ctr. Tuke b. HD KK-A + +, +. +* KK-A. HD,. HD. HD KK-A in vivo +*. HD
6 15 : 461. DHFMC A DHBMC B, THBC C, THFC D E N0 ** p**+. v.s. Ctr. Tuke b B.. -. HD XA HD XA XA-F IBC XA-F. HD. IBC -. HD XA-F A. XA IBC A. A. -. / B A,
7 462 /1 ++,*+* / A. - XA,. HD XA-F. HD A -. XA. HD XA-F XA-F HD. HD KK-A. HD KK-A + Akihisa, T., Tokuda, H., Ukia, M., Iizuka, M., Schneider, S., Ogasawara, K., Mukainaka, T., Iwatsuki, K., Suzuki, T. and Nishino, H., Chalcones, coumarins, and flavanones from the exudates of Angelica keiskei and their chemopreventive e# ects. Cancer Lett.,,*+, (,**-)., Kozawa, M., Morita, N., Baba, K. and Hata, K., The structure of xanthoangelol, a new chalcone from the roots of Angelica keiskei KOIDZUMI (Umbelliferae). Chem. Pharm. Bull.,,/, /+/ /+0 ( +311). - Foods Food Ingredients J. Jpn., +12, /, 0* Shimizu, E., Haashi, A., Takahashi, R., Aoagi, Y., Murakami, T. and Kimoto, K., E# ects of angiotensin I-converting enzme inhibitor from Ashitaba ( Angelica keiskei) on blood pressure of spontaneousl hpertensive rats. J. Nutr. Sci. Vitaminol.,./, -1/ -2- ( +333). / Kimura, Y. and Baba, K., Antitumor and antimetastatic activities of Angelica keiskei roots, part + : isolation of an active substance, xanthoangelol. Int. J. Cancer., +*0,.,3.-1 (,**-). 0 Kimura, Y., Taniguchi, M. and Baba, K., Antitumor and Antimetastatic activities of.-hdroxderricin isolated from Angelica keiskei roots. Planta Med., 1*,,++,+3 (,**.). 1 Ogawa, H., Ohno, M. and Baba, K., Hpotensive and lipid regulator actions of.-hdroxderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneousl hpertensive rats. Clin. Exp. Pharmacol. Phsiol., -, ( +,), +3,- (,**/). 2 Murakami, S., Kijima, H., Isobe, Y., Muramatsu, M., Aihara, H., Otomo, S., Baba, K. and Nozawa, M., Inhibi- 3 +* ++ tion of gastric H, K -ATPase b chalcone derivatives, xanthoangelol and.-hdroxderricin, from Angelica keiskei Koidzumi. J. Pharm. Pharmacol.,.,, 1,-1,0 ( +33* ). Inamori, Y., Baba, K., Tsujibo, H., Taniguchi, M., Nakata, K. and Kozawa, M., Antibacterial activit of two chal- cones, xanthoangelol and.-hdroxderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem. Pharm. Bull., -3, +0*. +0*/ ( +33+ ). Enoki, T., Ohnogi, H., Nagamine, K., Kudo, Y., Sugiama, K., Tanabe, M., Kobaashi, E., Sagawa, H. and Kato, I., Antidiabetic activities of chalcones isolated from a Japanese herb, Angelica keiskei. J. Agric. Food Chem., //, 0*+-0*+1 (,**1). Saltiel, A.R. and Kahn, R., Insulin signalling and the regulation of glucose and lipid metabolism. Nature,.+., 1332*0 (,**+).
8 17 : 463 +, Zimmet, P., Alberti, K.G.M.M. and Shaw, J., Global and HD societal implications of the diabetes epidemic. Nature, -/ 0.100*,**2.+., 12, 121 (,**+). +1 Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K. and Tobe, K., Adiponectin and adiponectin receptors +. Tripathi, B.K. and Srivastava, A.K., Diabetes mellitus : in insulin resistance, diabetes, and the metabolic sn- Complications and therapeutics. Med. Sci. Monit., +,, RA drome. J. Clin. Invest., ++0, , (,**0). +-* +.1 (,**0). +2 +/ Rubin, C.S., Hirsch, A., Fung, C. and Rosen, O.M., Devel- opment of hormone receptors and hormonal responsive- New Food Industr, /+ ( +* ), ++,+,**3 ness in vitro. J. Biol. Chem.,,/-, 1/1* 1/12 ( +312). +0.,, 0,/,, 1 +,
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects
Cancer Letters 201 (2003) 133 137 www.elsevier.com/locate/canlet Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects Toshihiro Akihisa a, *, Harukuni
Anti-hyperglycemic and Anti-hypercholesterolemic Effects of Angelica keiskei (Ashitaba) Abstract
Anti-hyperglycemic and Anti-hypercholesterolemic Effects of Angelica keiskei (Ashitaba) Aira A. Devanadera, Camille Grace M. Peña and Joy Lhorenz R. Perez Lyceum of the Philippines University (LPU) St.
Inhibition of Fat Digestion by Highly Polymeric Proanthocyanidins from Seed Shells of Japanese Horse Chestnut ( B LUME)
15 Nippon Shokuhin Kagaku Kogaku Kaishi Vol /0 No 3 2 23 (**3) 483 + + + * * * * * * * * * + * * * * Inhibition of Fat Digestion by Highly Polymeric Proanthocyanidins from Seed Shells of Japanese Horse
* * 43 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. /,,./,.3 (,**2)
43 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. /,,./,.3 (,**2) 245 / * * * 0 1 bo * 2 +* Immunostimulating Activity and Molecular Weight Dependence of an Arabinoxylan Derived from Wheat Bran Manami
A Review of the Medicinal Uses and Pharmacology of Ashitaba
1236 Reviews A Review of the Medicinal Uses and Pharmacology of Ashitaba Authors Affiliation Lindsay K. Caesar, Nadja B. Cech Department of Chemistry and Biochemistry, University of North Carolina at Greensboro,
In vitro Analysis on Inhibitory Activity of Amylolytic Enzymes in Deca# ee Bean Extracts and Contributions of Chlorogenic Acids
336 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /0, No. 0, --0-., (,**3) 28 UCC R& D In vitro Analysis on Inhibitory Activity of Amylolytic Enzymes in Deca# einated Green Co# ee Bean Extracts and Contributions
New Developments in Health and Nutritional Function Promoted by Chicken Eggs
65 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /2, No. 1, -.+ -./ (,*++) 341, New Developments in Health and Nutritional Function Promoted by Chicken Eggs Katsumi Imaizumi Trustee and Vice-President Kyushu
The Health and Medicinal Benefits of Ashitaba
The Health and Medicinal Benefits of Ashitaba 1 Copyright BioFoundations All rights reserved. This book is protected by copyright. No portion of this book may be reproduced or distributed in any form or
1 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /1, No. -, 3-33 (,*+*)
1 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /1, No. -, 3-33 (,+) 93 E# ect of Awamori Lees on Growth, Serum and Liver Lipid Concentration in Rats Fed a High Cholesterol Diet Toshitsugu Nohara, Shuntoku
Evaluation of Antioxidant Activity of Vegetable Extracts and Determination of Some Active Compounds
(23)Nippon Shokuhin Kogyo Gakkaishi Vol.41, No.9, 611 `618 (1994) k ñ l611 Evaluation of Antioxidant Activity of Vegetable Extracts and Determination of Some Active Compounds Tojiro TSUSHIDA*, Masahiro
Estimation of Carotenoids, Vitamin C, and Polyphenols in Traditional Okinawan Vegetables
33 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /2, No. -, +*/ ++, (,*++) 105 C * ** * ** Estimation of Carotenoids, Vitamin C, and Polyphenols in Traditional Okinawan Vegetables Goki Maeda, Satoru Iha* and
Cultivar Variation and Anthocyanins and Rutin Content in Sweet Cherries Prunus avium L.
37 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. /,,-3,.. (,**2) 239 * * Cultivar Variation and Anthocyanins and Rutin Content in Sweet Cherries Prunus avium L. Tetsuya Sugawara and Kiharu Igarashi*
Kazumi YAGASAKI, Masato NAGAOKA and Yutaka MIURA
Kazumi YAGASAKI, Masato NAGAOKA and Yutaka MIURA Division of Agriscience and Bioscience, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu 183-8509 ABSTRACT
Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-A y mice
Molecular Medicine REPORTS 3: 449-453, 2010 Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-A y mice Nana Mikami, Masashi Hosokawa
Antidiabetic Action of Low Molecular Weight Chitosan in Genetically Obese Diabetic KK-A y Mice
188 Biol. Pharm. Bull. 25(2) 188 192 (2002) Vol. 25, No. 2 Antidiabetic Action of Low Molecular Weight Chitosan in Genetically Obese Diabetic KK-A y Mice Koji HAYASHI and Mikio ITO* Laboratory of Analytical
96 Chem. Pharm. Bull. 47(1) (1999) Vol. 47, No. 1
96 Chem. Pharm. Bull. 47(1) 96 100 (1999) Vol. 47, No. 1 Antiproliferative Constituents from Umbelliferae Plants. V. 1) A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica
Waist Circumference Measurements in Special Metabolic Syndrome Medical Checkups for Employees of a Japanese University: A Follow-up Study
ORIGINAL ARTICLES Waist Circumference Measurements in Special Metabolic Syndrome Medical Checkups for Employees of a Japanese University: A Follow-up Study Naohito Kawasaki 1, 2) Hisato Tominaga 1), Fumihiko
ect of Protamine from Chum Salmon Milt on Lipid Absorption in Humans
360 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. 2, -0* -00 (,**2) 6 * * The Suppressive E# ect of Protamine from Chum Salmon Milt on Lipid Absorption in Humans Yosuke Hoshino, Yoshinori Takahashi,
Journal of Epidemiology Vol. 17, No. 2 March 2007
Journal of Epidemiology Vol. 7, No. March 7 The harm of smoking has been known for many years and evidences from a cohort study shows that smoking is a prominent risk factor for total mortality,, lung
on Degranulation in RBL-, H- Satoru Horigome, Izumi Yoshida, Chie Tamaki, Akihiro Yamaguchi, Nobuyuki Kibune, Takeshige Kamibe and Masatoshi Watai
19 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. ++, /-/ /.* (,**2) 535 RBL-, H- Simple Screening Method for Inhibitory E# ects of Food Ingredients on Degranulation in RBL-, H- Cells Satoru Horigome,
ect of Long-term Ingestion of Porcine Elastin Peptide on Human Skin Elasticity
23 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /2, No.., +/3 +0- (,*++) 159 * * E# ect of Long-term Ingestion of Porcine Elastin Peptide on Human Skin Elasticity Mikako Sato, Kohji Iwai, Eiichiro Onitsuka,
Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No.1, -/+ -// (,**1) 351. a, b,
39 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No.1, -/+-// (,**1) 351 ao bo * * A Simple Spectrophotometric Method for the Estimation of a-carotene, b-carotene and Lycopene Concentrations in Carrot
CAP FS TNSMS / TNSMS. IgE CAP. cry j 1 cha o 1. IgE. IgE
120833 : : SLIT CAP QOL QOL FS TNSMS : SLIT TNSMS FS0 FS TNSMS / : : cry j 1 cha o 1 IgE IgE CAP IgE 120834 2017 /cm /cm 1 CAP QOL JRQLQ No1 quality of lifeqol QOL QOL JRQLQ No1 total nasal symptom medication
EFFECT OF VOLUNTARY EXERCISE ON PHYSIO LOGICAL FUNCTION AND FEEDING BEHAVIOR OF MICE ON A 20% CASEIN DIET OR A 10% CASEIN DIET
J. Nutr. Sci. Vitaminol., 25, 23-32, 1979 EFFECT OF VOLUNTARY EXERCISE ON PHYSIO LOGICAL FUNCTION AND FEEDING BEHAVIOR OF MICE ON A 20% CASEIN DIET OR A 10% CASEIN DIET Masanori YASHIRO and Shuichi KIMURA1
Simultaneous Treatment of Cancer Cells Lines with the Anticancer Drug Cisplatin and the Antioxidant Fucoxanthin
British Journal of Pharmacology and Toxicology 2(3): 127-131, 2011 ISSN: 2044-2467 Maxwell Scientific Organization, 2011 Received: April 10, 2011 Accepted: May 13, 2011 Published: August 05, 2011 Simultaneous
Patients characteristics associated with better glycemic response to teneligliptin and metformin therapy in type 2 diabetes: a retrospective study
International Journal of Advances in Medicine Gadge PV et al. Int J Adv Med. 2018 Apr;5(2):424-428 http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20181082
ect of Apple Pectin Oligosaccharide on Intestinal Disorders
23 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. +*,.//.0* (,**2) 455 E# ect of Apple Pectin Oligosaccharide on Intestinal Disorders Yoshinori Takahashi, Yasuyuki Masuda, Masahiro Sugimoto and Hiroyuki
Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes
Molecular and Cellular Biochemistry 261: 99 104, 2004. c 2004 Kluwer Academic Publishers. Printed in the Netherlands. Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes
Effect of Acute Exercise on Insulin Binding to Erythrocytes in Type II Diabetes
Endocrinol. Japon. 1982, 29 (5), 561-566 Effect of Acute Exercise on Insulin Binding to Erythrocytes in Type II Diabetes MAKOTO IWASAKI, MASASHI KOBAYASHI, SEIJI OHGAKU, HIROSHI MAEGAWA AND YUKIO SHIGETA
Pharmacological Activities of Glycyrrhetinic Acid Derivatives: Analgesic and Anti-Type IV Allergic Effects
3888 Vol. 35 (1987) Chem. Pharm. Bull. 35( 9 )3888-3893(1987) Pharmacological Activities of Glycyrrhetinic Acid Derivatives: Analgesic and Anti-Type IV Allergic Effects HIDEO INOUE,*, a TAKEO MORI,a SHOJI
Type 2 diabetes in Tuvalu: A drug use and chronic disease management evaluation. Prepared for the Ministry of Health, Tuvalu.
Type 2 diabetes in Tuvalu: A drug use and chronic disease management evaluation Prepared for the Ministry of Health, Tuvalu. 2012 Investigator Alexander Bongers Intern pharmacist, Royal Melbourne Hospital,
Effect of Mixed Fruit and Vegetable Juice on Alcohol Hangovers in Healthy Adults
Prev. Nutr. Food Sci. 2018;23(1):1-7 https://doi.org/10.3746/pnf.2018.23.1.1 pissn 2287-1098 ㆍ eissn 2287-8602 Effect of Mixed Fruit and Vegetable Juice on Alcohol Hangovers in Healthy Adults Min-Ju Kim
Usefulness of a large automated health records database in pharmacoepidemiology
Environ Health Prev Med (2011) 16:313 319 DOI 10.1007/s12199-010-0201-y REGULAR ARTICLE Usefulness of a large automated health records database in pharmacoepidemiology Hirokuni Hashikata Kouji H. Harada
Combined measurement of fasting plasma glucose and HbA1c is effective for the prediction of type 2 diabetes: The Kansai Healthcare Study
Diabetes Care Publish Ahead of Print, published online January 8, 2009 Combined measurement of fasting plasma glucose and HbA1c is effective for the prediction of type 2 diabetes: The Kansai Healthcare
Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells
J Nutr Sci Vitaminol, 63, 193 199, 2017 Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells Kyuichi Kawabata 1, *, Kenji Kitamura 1, Kazuhiro Irie 2, Shoma
Effect of Green Tea Catechins on Plasma Cholesterol Level in Cholesterol-Fed Rats. Keiichiro MURAMATSU,1 Mayumi FUKUYO, and Yukihiko HARA 2
J. Nutr. Sci. VitaminoL, 32, 613-622, 1986 Effect of Green Tea Catechins on Plasma Cholesterol Level in Cholesterol-Fed Rats Keiichiro MURAMATSU,1 Mayumi FUKUYO, and Yukihiko HARA 2 1 Laboratory of Food
Synthesis, stereochemistry, and reactions of 2,5-diphenylsilacyclopentenes
Silicon Chemistry 2: 99 107, 2003. C 2004 Kluwer Academic Publishers. Printed in the Netherlands. 99 Synthesis, stereochemistry, and reactions of 2,5-diphenylsilacyclopentenes Yukinori Nagao 1,, Chikashi
News Release. Identification of the cause of chronic active Epstein Barr virus (EBV) infection and the mechanism by which EBV causes cancer
News Release Title Identification of the cause of chronic active Epstein Barr virus (EBV) infection and the mechanism by which EBV causes cancer Key Points A research group in Japan, led by Dr. Hiroshi
Original paper. Nana Mikami 1,3*, Junko Tsujimura 1, Ayumi Sato 1, Akiko Narasada 1, Mayumi Shigeta 1, Motoshi Kato 1, Shuichi Hata 2 and Eri Hitomi 1
Food Science and Technology Research, 21 (2), 231 _ 240, 2015 Copyright 2015, Japanese Society for Food Science and Technology doi: 10.3136/fstr.21.231 http://www.jsfst.or.jp Original paper Green Rooibos
Umbelliprenin from Ferula szowitsiana Activates both Intrinsic and Extrinsic Pathways of Apoptosis in Jurkat T-CLL Cell Line
Iranian Journal of Pharmaceutical Research (2013), 12 (3): 371-376 Received: May 2012 Accepted: November 2012 Copyright 2013 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health
Crosstalk between Adiponectin and IGF-IR in breast cancer. Prof. Young Jin Suh Department of Surgery The Catholic University of Korea
Crosstalk between Adiponectin and IGF-IR in breast cancer Prof. Young Jin Suh Department of Surgery The Catholic University of Korea Obesity Chronic, multifactorial disorder Hypertrophy and hyperplasia
(Psidium guava Extract) -
347-354 (4 ) 10 1390 -. (Psidium guava Extract) - 5 4 3 2 *2 1 :. -.. 250-180 18 : 10. (STZ) mg/kg 60-1... :. - :. : -1-2 -3-4 -5 09133251067 : : solnep2002@yahoo.com : ... (Psidium guava Extract) - :
Female, years or younger BMI of 30 or less at time of Diabetes diagnosis Prefer no family history of diabetes Took Lipitor consistently for at
Female, 51-70 years or younger BMI of 30 or less at time of Diabetes diagnosis Prefer no family history of diabetes Took Lipitor consistently for at least two months prior to diagnosis or within six months
Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study
Nutrition Research and Practice 2014;8(5):550-557 c2014 The Korean Nutrition Society and the Korean Society of Community Nutrition http://e-nrp.org Bioavailability of plant pigment phytochemicals in Angelica
Pharmacologyonline 1: (2009) HYPOGLYCEMIC EFFECT OF PHOEBE LA CEOLATA O ALLOXA -I DUCED DIABETIC MICE
HYPOGLYCEMIC EFFECT OF PHOEBE LA CEOLATA O ALLOXA -I DUCED DIABETIC MICE SEMWAL DK 1 *, RAWAT U 1, SEMWAL R 2, SINGH K 3, SINGH R 3, SAINI B 3, KRISHAN P 3, SINGH M 4 1 Department of Chemistry, University
Research Article 4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice
Hindawi Publishing Corporation BioMed Research International Volume 214, Article ID 63415, 5 pages http://dx.doi.org/1.1155/214/63415 Research Article 4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation,
HYPOLIPIDEMIC EFFECT OF EXTRACTS FROM ABELMOSCHUS ESCULENTUS L. MALVACEAE ON TYLOXAPOL- INDUCED HYPERLIPIDEMIA IN MICE
HYPOLIPIDEMIC EFFECT OF EXTRACTS FROM ABELMOSCHUS ESCULENTUS L. MALVACEAE ON TYLOXAPOL- INDUCED HYPERLIPIDEMIA IN MICE Huynh Ngoc Trinh 1, Nguyen Ngoc Quynh 1, Tran T Van Anh 2, Vo Phung Nguyen 1 1 Department
About Fermented Guava
About Fermented Guava The Fermented Guava was developed through the joint studies by the following research institutes, including Okinawa Industrial Technology Center, as part of the Okinawa R&D coordinating
Fabrication of Bio-based Polyelectrolyte Capsules and Their Application for Glucose-Triggered Insulin Delivery
Supporting Information for Fabrication of Bio-based Polyelectrolyte Capsules and Their Application for Glucose-Triggered Insulin Delivery Dongjian Shi a*, Maoshuang Ran a, Li Zhang a, He Huang a, Xiaojie
Thomson Reuters 2016 Food Journals Impact Factor List
Thomson Reuters 2016 Food Journals Impact Factor List Rank Full Journal Title Total Cites Journal Impact Factor Eigenfactor Score 366 ANNUAL REVIEW OF FOOD SCIENCE AND 862 6.950 0.003420 373 ANNUAL REVIEW
ENHANCEMENT OF GLUCOSE UPTAKE IN 3T3-L1 ADIPOCYTES BY TOONA SINENSIS LEAF EXTRACT
Effect of Toona sinensis on glucose uptake in adipocytes ENHANCEMENT OF GLUCOSE UPTAKE IN 3T3-L1 ADIPOCYTES BY TOONA SINENSIS LEAF EXTRACT Yu-Chiao Yang, Hseng-Kuang Hsu, 1 Jia-Huae Hwang, and Show-Jen
Sugar-Loaded Beverages and the Impact on Cardiovascular Health. Christina M. Shay, PhD, MA
Sugar-Loaded Beverages and the Impact on Cardiovascular Health Christina M. Shay, PhD, MA 1 Presenter Disclosure Information Christina M. Shay, PhD, MA Sugar-Loaded Beverages and the Impact on Cardiovascular
Factors Associated With Reduced Efficacy of Sitagliptin Therapy: Analysis of 93 Patients With Type 2 Diabetes Treated for 1.
Elmer Original Article ress Factors Associated With Reduced Efficacy of Sitagliptin Therapy: Analysis of 93 Patients With Type 2 Diabetes Treated for 1.5 Years or Longer Akira Kanamori a, Ikuro Matsuba
Pharmacologyonline 3: (2009)
THE EFFECT OF ASTURTIUM OFFICIALE O BLOOD GLUCOSE LEVEL I DIABETIC RATS Hassan Fallah Hoseini 1, Ahmad R. Gohari 2, Soodabeh Saeidnia 2 *, aghi Shahabi Majd 3, Abbass Hadjiakhoondi 2 1- Department of Pharmacology,
NEW PHYTOCHEMICAL BASED COCKTAIL FOR IN VITRO ADIPOCYTES DIFFERENTIATION. Resources Engineering, Universiti Teknologi Malaysia, Skudai, Johor.
NEW PHYTOCHEMICAL BASED COCKTAIL FOR IN VITRO ADIPOCYTES 1 DIFFERENTIATION F.A. ABDUL MAJID 1*, M. TAHER 1 AND M.R. SARMIDI 2 1 Department of Bioprocess, 2 Chemical Engineering Pilot Plant, Faculty of
Studies on Textural and Chemical Changes in Aged Rice Grains
Food Sci. Technol. Res., ++ (.), -2/ -23,,**/ Studies on Textural and Chemical Changes in Aged Rice Grains Toshihisa OHNO and Naganori OHISA Akita Research Institute of Food and Brewing,.,0 Aza-sanuki,
NIH Public Access Author Manuscript Res Commun Chem Pathol Pharmacol. Author manuscript; available in PMC 2010 October 18.
NIH Public Access Author Manuscript Published in final edited form as: Res Commun Chem Pathol Pharmacol. 1986 July ; 53(1): 137 140. EFFECT OF BILE ON CYCLOSPORINE ABSORPTION IN DOGS Raman Venkataramanan
Sunghyen Lee 1, Youngmin Lee 2, Sungjoon Lee 3, Haejeung Lee 4, Hyun Lillehoj 5
Dec 8, 2015 Sunghyen Lee 1, Youngmin Lee 2, Sungjoon Lee 3, Haejeung Lee 4, Hyun Lillehoj 5 1 Functional Food & Nutrition Division, National Institute of Agricultural Science, 2 Seoul Women s Univ, 3 Eulji
Joint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up
1169 Original Article Hypertens Res Vol.30 (2007) No.12 p.1169-1175 Joint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up
Aspects of Hypoglycemia
Aspects of Hypoglycemia Erik T. Paterson 1 M.D. Abstract To two groups of patients the standard six hour oral glucose tolerance test was administered. Over 80 percent of both groups had abnormal responses
Risk factors of gestational diabetes mellitus among the re-birth pregnant women in Xiamen City in
46 6 2017 11 JOURNAL OF HYGIENE RESEARCH Vol. 46 No. 6 Nov. 2017 925 1000-8020 2017 06-0925-05 檾檾檾檾 DANONE INSTITUTE CHINA Young Scientists' Forum 檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾 2015 2016 1 361003 gestational
The Antihypertensive Effect of Sesame Seed-derived Products
Bulletin of saka University of Pharmaceutical Sciences 1 (2007) Brief Reviews *,a b c The Antihypertensive Effect of Sesame Seed-derived Products Daisuke NAKAN, *, a Yoshinobu KIS, b Yasuo MATSUMURA c
Effect of High Intensity Interval Training on Adiponectin Hormone in Women with Diabesity
Med. J. Cairo Univ., Vol. 84, No. 2, December: 225-230, 2016 www.medicaljournalofcairouniversity.net Effect of High Intensity Interval Training on Adiponectin Hormone in Women with Diabesity ESLAM A. ABD
Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests
Endocrine Journal 2011, 58 (1), 13-17 Or i g i n a l Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests Maki Goto
49 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /0, No. +,, 0// 0/3 (,**3)
49 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /0, No. +,, 0// 0/3 (,**3) 655 B,B,C,E +, DPPH ORAC * + *, ++, -Diphenyl-,-picrylhydrazyl Radical-scavenging Capacity and Oxygen Radical Absorbance Capacity
Optimisation of the Post-Harvest Conditions to Produce Chocolate Aroma
Optimisation of the Post-Harvest Conditions to Produce Chocolate Aroma from Jackfruit Seeds Fernanda Papa Spada #*, Lais Masson Zerbeto #, Gabriel Bernardes Cabreira Ragazi #, Érika Maria Roel Gutierrez,
Journal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(1):452-456 Evaluation of anti hyperglycaemic activity
TBP (H) CACAGTGAATCTTGGTTGTAAACTTGA AAACCGCTTGGGATTATATTCG ANGPTL8 (H) CTGGGCCCTGCCTACCGAGA CCGATGCTGCTGTGCCACCA [1]
![TBP (H) CACAGTGAATCTTGGTTGTAAACTTGA AAACCGCTTGGGATTATATTCG ANGPTL8 (H) CTGGGCCCTGCCTACCGAGA CCGATGCTGCTGTGCCACCA [1]](/thumbs/89/99233308.jpg "TBP (H) CACAGTGAATCTTGGTTGTAAACTTGA AAACCGCTTGGGATTATATTCG ANGPTL8 (H) CTGGGCCCTGCCTACCGAGA CCGATGCTGCTGTGCCACCA [1]")
ESM Table 1. Immunoblot antibodies. Primary Supplier Dilution Antibody Akt Cell Signaling 1:1000 Technology Phosphorylated Cell Signaling 1:1000 Akt (Ser 473) Technology PKCε Cell Signaling 1:1000 Technology
Screening Criteria of Diabetes Mellitus and Impaired Glucose Tolerance of the Japanese Population in a Rural Area of Japan: The Tottori-Kofu Study
Yonago Acta medica 2009;52:105 114 Screening Criteria of Diabetes Mellitus and Impaired Glucose Tolerance of the Japanese Population in a Rural Area of Japan: The Tottori-Kofu Study Tsuyoshi Ohkura, Shin-ichi
A systematic study of biochemical profile during the induction and development of an animal model for Metabolic Syndrome
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn: 2278-3008, p-issn:2319-7676. Volume 9, Issue 1, Ver. IV (Jan. 2014), PP 109-113 A systematic study of biochemical profile during the
Subject Index. postprandial glycemia and suppression in serum 51 recommendations 119, 120 supplementation pros and cons 118, 119
Acarbose, diabetes prevention trials 32, 33, 40 42 Accelerator hypothesis accelerators beta cell autoimmunity 140, 141, 147, 150, 151 insulin resistance 140, 142 144, 150 obesity 145 148 diabetes risk
Written By Charles Poliquin of Poliquin Performance
1 Fenuplex A Secret Of My Success Written By Charles Poliquin of Poliquin Performance One of the basic tenets of the Biosignature system is that modulating insulin will always improve your body composition
Vasoprotective Effect of Foods as Treatments: Chicken Collagen Hydrolysate
26 Vasoprotective Effect of Foods as Treatments: Chicken Collagen Hydrolysate Tomomi Kouguchi, Youzuo Zhang, Mikako Sato, Yoshihisa Takahata and Fumiki Morimatsu Nippon Meat Packers, Inc., R & D Center
Glycolipids in Oil Palm Leaf, Crude Palm Oil, Fiber,
502 J. Jpn. Oil Chem. Soc. (YUKAGAKU) ORIGINAL Glycolipids in Oil Palm Leaf, Crude Palm Oil, Fiber, and Empty Bunch Masakazu YAMAOKA*1, Akio TANAKA*1, Wuryaningsih Sri RAHAYU*2, Carmelita Lacap HERNANDEZ*3,
Endocrinology A COMPARISON BETWEEN THE EFFECT OF BLACK TEA AND KOMBUCHA TEA ON BLOOD GLUCOSE LEVEL IN DIABETIC RAT
Endocrinology A COMPARISON BETWEEN THE EFFECT OF BLACK TEA AND KOMBUCHA TEA ON BLOOD GLUCOSE LEVEL IN DIABETIC RAT M. H. DASHTI* A. MORSHEDI* SUMMARY: Diabetes mellitus is a metabolic disorder characterized
Influences of Statins on Glucose Tolerance in Patients with Type 2 Diabetes Mellitus
Original Article 95 Influences of Statins on Glucose Tolerance in Patients with Type 2 Diabetes Mellitus Tatsuro Takano, Tadashi Yamakawa, Mayumi Takahashi, Mari Kimura, and Atsushi Okamura Department
Effects of Starvation on Glycogen Contents of Heart, Skeletal Muscle and Liver in Several Mammals
Effects of Starvation on Glycogen Contents of Heart, Skeletal Muscle and Liver in Several Mammals Mitsuto MATSUMOTO and Tatsuo HAMADA National Institute of Animal Industry, Tsukuba Norindanchi P. O. Box
NATURAL INGREDIENTS TO SUPPORT HEART HEALTH a focus on Mediterranean botanical extracts
NATURAL INGREDIENTS TO SUPPORT HEART HEALTH a focus on Mediterranean botanical extracts Yannick Capelle Product Manager Frutarom Health Cardiovascular Health Risk factors Health conditions with high prevalence
Downloaded from ijdld.tums.ac.ir at 20:15 IRDT on Friday March 22nd 2019
7-15 (1 ) 9 1388. 3 2 1 :.. : :. LDL VLDL LDL. (HDL,LDL,VLDL) :. ( P= / ) VLDL HLD.. (P= / ) :. : -1-2 -3 shirdel_58@yahoo.com: 9155844353 : : * 88/4/15 : 88/3/24 : 87//26: ... : 8... ( ) mg/kg. ( )..[
EFFECT OF BIOCHEMICAL PARAMETERS SHOWING ATHEROGENICITY IN TYPE 2 DIABETIC NEPHROPATHY
EFFECT OF BIOCHEMICAL PARAMETERS SHOWING ATHEROGENICITY IN TYPE 2 DIABETIC NEPHROPATHY *G. Raja and Ivvala Anand Shaker * Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences
EFFECT OF MULBERRY (MORUS INDICA) LEAVES AND BARK ON TYPE 2 DIABETICS
EFFECT OF MULBERRY (MORUS INDICA) LEAVES AND BARK ON TYPE 2 DIABETICS *Johri S. and Chauhan K. Department of Foods and Nutrition, Banasthali University, Banasthali, Rajasthan (India) *Author for Correspondence
E and the heart: Possible role as antioxidant. Acta Vitaminol. Enzymol. 5: 11-22, ) Jolly, S. R., Kane, W. J., Bailie, M. B. et al.
1) Ferrari, R., Visoli, O., Guarnieri, C. et al.: Vitamin E and the heart: Possible role as antioxidant. Acta Vitaminol. Enzymol. 5: 11-22, 1983. 2) Jolly, S. R., Kane, W. J., Bailie, M. B. et al.: Canine
Association of hypothyroidism with metabolic syndrome - A case- control study
Article ID: ISSN 2046-1690 Association of hypothyroidism with metabolic syndrome - A case- control study Peer review status: No Corresponding Author: Dr. Veena K Karanth, Associate Professor, Surgery,
New and Emerging Therapies for Type 2 DM
Dale Clayton MHSc, MD, FRCPC Dalhousie University/Capital Health April 28, 2011 New and Emerging Therapies for Type 2 DM The science of today, is the technology of tomorrow. Edward Teller American Physicist
Characterization of Rutin-rich Bread Made with Manten-Kirari, a Tracerutinosidase Variety of Tartary Buckwheat (Fagopyrum tataricum Gaertn.
Food Science and Technology Research, 21 (5), 733 _ 738, 2015 Copyright 2015, Japanese Society for Food Science and Technology doi: 10.3136/fstr.21.733 http://www.jsfst.or.jp Original paper Characterization
Note Urinary Excretion of Water-Soluble Vitamins Increases in Streptozotocin-Induced Diabetic Rats without Decreases in Liver or Blood Vitamin Content
J Nutr Sci Vitaminol, 58, 54 58, 2012 Note Urinary Excretion of Water-Soluble Vitamins Increases in Streptozotocin-Induced Diabetic Rats without Decreases in Liver or Blood Vitamin Content Eri IMAI, Mitsue
The Low-Dose (7.5 mg/day) Pioglitazone Therapy
Elmer ress Review J Clin Med Res. 2017;9(10):821-825 The Low-Dose (7.5 mg/day) Pioglitazone Therapy Hidekatsu Yanai a, b, Hiroki Adachi a Abstract Pioglitazone is one of thiazolidinedione derivatives,
Roadmap. Diabetes and the Metabolic Syndrome in the Asian Population. Asian. subgroups 8.9. in U.S. (% of total
Diabetes and the Metabolic Syndrome in the Asian Population Alka Kanaya, MD Associate Professor of Medicine, UCSF Feb 26, 2010 Roadmap 1. Diabetes in Asian Americans Prevalence in the U.S. Risk factors
Naohito AOKI, Erina ARAKAWA and Miyuki ITO. Department of Life Science, Graduate School of Bioresources, Mie University Tsu ABSTRACT
Naohito AOKI, Erina ARAKAWA and Miyuki ITO Department of Life Science, Graduate School of Bioresources, Mie University Tsu 514-857 ABSTRACT C57BL/6J mice (male, 4wk old) were fed low fat diet (LF), high
Antidiabetic Activity of Alcoholic Extract of Neem (Azadirachta Indica) Root Bark
RESEARCH ARTICLE Antidiabetic Activity of Alcoholic Extract of Neem (Azadirachta Indica) Root Bark Prabhakar Patil 1, Sudha Patil 2, Abhay Mane 3, Sushilkumar Verma 4 1 Department of Pharmacology, Navodaya
Effects of Exercise and Physical Activity on Diabetes Mellitus and Obesity
1 EXERCISE IS MEDICINE: The Science Behind the Movement Effects of Exercise and Physical Activity on Diabetes Mellitus and Obesity Rosa Allyn G. Sy, MD, FPCP, FPSEDM Endocrinology, Diabetes, Metabolism
No Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. I. Central Depressant Effect of Theanine
No.6 1257 UDC 547,466.64.09:615.21.076.9 Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. I. Central Depressant Effect of Theanine RYOHEI KIMURA and TOSHIRO
Reduction of Catechin Astringency by the Complexation of Gallate-Type Catechins with Pectin
Biosci. Biotechnol. Biochem., 69 (7), 1306 1310, 2005 Reduction of Catechin Astringency by the Complexation of Gallate-Type Catechins with Pectin Nobuyuki HAYASHI, y Tomomi UJIHARA, and Katsunori KOHATA
Takashi Kadowaki Professor, Graduate School of Medicine, The University of Tokyo. for Molecular Basis of Type 2 Diabetes and Metabolic Syndrome
28 Japan Academy Prize to: Takashi Kadowaki Professor, Graduate School of Medicine, The University of Tokyo for Molecular Basis of Type 2 Diabetes and Metabolic Syndrome Outline of the work: Prof. Takashi
Relationship between the Structures and the Antitumor Activities of Tannins
814 Vol. 35 (1987) Chem. Pharm. Bull. 35 (2) 814-822 (1987) Relationship between the Structures and the Antitumor Activities of Tannins KENICHI MIYAMOTO,*,a NOBUHARU KISHI,a RYOZO KOSHIURA,a TAKASHI YOSHIDA,b
Diabetes treatment by the algorithm
Diabetes treatment by the algorithm Joseph Dawley, M.D. Southwest Oklahoma Family Medicine Residency Oklahoma University Health Sciences Center Clinical Assistant Professor Objectives By the end of this
Tadpole-shaped Gene Carrier with Distinct Phase. Segregation in A Ternary Polymeric Micelle
Electronic Supplementary Material (ESI) for Soft Matter. This journal is The Royal Society of Chemistry 2015 Supporting Information Tadpole-shaped Gene Carrier with Distinct Phase Segregation in A Ternary
Pelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2012, 3 (2):266-270 ISSN: 0976-8688 CODEN (USA): PSHIBD Synthesis, characterization and biological screening of novel (E)-1-(3,5-
Tentative Cut Point of High-Sensitivity C-Reactive Protein for a Component of Metabolic Syndrome in Japanese
Tentative Cut Point of High-Sensitivity C-Reactive Protein for a Component of Metabolic Syndrome in Japanese Eiji Oda, MD; Ryu Kawai, MD Background: High-sensitivity C-reactive protein (hs-crp) is an independent
Early diagnosis, early treatment and the new diagnostic criteria of diabetes mellitus
British Journal of Nutrition (2000), 84, Suppl. 2, S177±S181 S177 Early diagnosis, early treatment and the new diagnostic criteria of diabetes mellitus Takeshi Kuzuya* JA Shioya General Hospital, Tomita