EAST-EUROPEAN COURSE ON EPILEPSY (11-13 June 2014) - Cheile Gradistei, Romania -

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1 EAST-EUROPEAN COURSE ON EPILEPSY (11-13 June 2014) - Cheile Gradistei, Romania - This course is supported and endorsed by ILAE-CEA and organized under the umbrella of ILAE Romania, in collaboration with Romanian Society of Pediatric Neurology (SRNP), Romanian Society of Neurology (SNR) and Romanian Foundation for Epilepsy and Neurology (RONEP) with support from Rotary OCTO. Course directors: Dana Craiu, Stanislav Groppa, Alla Guekht Local Organizing committee : Dana Craiu, Ioana Mindruta, Catrinel Iliescu, Laura Popescu; Sectretary : Florentina Grigore (flore.ronep@yahoo.com) Scientific Committee: Sandor Beniczky (Denmark), Meir Bialer (Israel), Dana Craiu (RO), Helen Cross (UK), Petia Dimova (Bulgaria), Kyriakos Garganis (Greece), Stanislav Groppa (Rep Moldova), Alla Guekht (Russia), Hrvoje Hecimovic (Croatia), Hans Holthausen (Germany), Catrinel Iliescu (RO), Volodymyr Karytonov (Ukraine), Ioana Mindruta (RO), Krassimir Minkin (Bulgaria), Lorella Minotti (France), Walter van Emde Boas (Netherlands) Course general information The 2014 Course offers basic knowledge on epilepsy in children and adults based on interactive clinical case-discussions (participants are invited to send their cases related to the announced topics for review and selection at least 1 month before the curse at flore.ronep@yahoo.com). Lectures offered by the faculty will summarize knowledge. This course has international appeal. Topics Semiology related to lobe localization (F, T, P, O), EEG in epilepsy, Differential diagnosis, Imaging epilepsy, Treatment (drug therapy and basic knowledge on epilepsy surgery with cases from East-European countries). Faculty Sandor Beniczky (Denmark), Meir Bialer (Israel), Dana Craiu (RO), Helen Cross (UK), Petia Dimova (Bulgaria), Kyriakos Garganis (Greece), Stanislav Groppa (Rep Moldova), Alla Guekht (Russia), Hrvoje Hecimovic (Croatia), Hans Holthausen (Germany), Catrinel Iliescu (RO), Volodymyr Karytonov (Ukraine), Ioana Mindruta (RO), Krassimir Minkin (Bulgaria), Lorella Minotti (France), Walter van Emde Boas (Netherlands) Target audience Pediatric neurologists and adult neurologists, neurophysiologists, psychiatrists, neurosurgeons with a medium level of expertise in the area of epilepsy care (already dealing with epilepsy patients). The 2014 course aims for participants with possibility of extending to 100 if there is request for it.

2 Venue 2014: Cheile Gradistei, Romania Cheile Gradistei is situated 3 hours driving from Bucharest airport (direct flights from most European cities and UK) and 2.5 hours away from Sibiu airport (directly connected to some European cities). It is situated in the middle of Romania, Transylvanian area, near Brasov city and 5 km near Bran Castle, the so called Dracula s Castle. Cheile Gradistei offers a special advantage of isolation in the middle of splendid nature creating the possibility of good interaction among participants and trainers, premises for future collaboration and friendship. Cheile Gradistei is located 5 km near Bran Castle, the so called Dracula s Castle. Transport to venue: Participant s arrival is expected the evening before the course (June 10 th ). Cheile Gradistei is situated 3 hours driving from Bucharest airport (direct flights from most European cities and UK) and 2.5 hours away from Sibiu airport (directly connected to Munich). Due to distance, arrangements will be made for transportation of all participants and trainers From Bucharest to Cheile Gradistei and back within certain time limits (will be further announced). Accommodation: The course organizers booked 80 rooms in Cheile Gradistei Complex at special prices (included in the course cost). Cost of the whole course: 400 euro covers: - Registration fee - Accommodation: 4 nights in double room (2 participants/room); for single room accommodation, a difference of 20 euro/night should be paid. - Meals (4 x breakfast + 4 x dinner + 3 x lunch) - Social programme during course - Materials for course Bursaries 20 bursaries offered by CEA-ILAE are available and will cover: - Accommodation: 4 nights in double room (2 participants/room) - Meals (4x breakfast + 4 x dinner + 3x lunch) - Social programme during course - Materials for course All bursary recipients will pay a registration fee of 100 euro. For payment see Booking form. Criteria for bursary application will include: 1. Participants from East-European countries (Bulgaria, Romania, Republic of Moldova, Ukraine, Russia); 2. Applicants did not receive an ILAE bursary or do not plan to ask an ILAE bursary during the year Young trainees will have priority (under age 40). Bursary applicants should send a CV and recommendation from the head of their clinic until April 25th. Deadlines 25 May 2014 for final registration - 25 April 2014 bursary applications (results of selected bursary recipients) 30 April 2014.

3 East European Course of Epilepsy Programme: June 2014 Description: This course presents basic knowledge in epilepsy, starting from semiology, syndromes, terminology and etiological diagnosis, differential diagnosis. EEG and imaging aspects in epilepsy will be also presented at basic level. Treatment : when, to whom, what, how to introduce treatment, how to monitor and how to discontinue will be presented discussing drug treatment, alternative treatments (ketogenic diet and VNS) and epilepsy surgery methods. The theoretical issues will be presented mostly starting from practice presenting clinical cases, and involving audience in interactive discussions. Faculty Sandor Beniczky (Denmark), Meir Bialer (Israel), Dana Craiu (RO), Helen Cross (UK), Petia Dimova (Bulgaria), Kyriakos Garganis (Greece), Stanislav Groppa (Rep Moldova), Alla Guekht (Russia), Hrvoje Hecimovic (Croatia), Hans Holthausen (Germany), Catrinel Iliescu (RO), Volodymyr Karytonov (Ukraine), Ioana Mindruta (RO), Krassimir Minkin (Bulgaria), Lorella Minotti (France), Cristina Panea (RO), Adina Roceanu (RO), Walter van Emde Boas (Netherlands) Venue 10 June, departure 14 June : VENUE - 12:00 22:00 Students and Faculty arrival (transport from Bucharest city center / airport to course venue will be organised for all participants and faculty) Welcome get-together dinner

4 Day 1: Epilepsy clinical issues; EEG 08:30 09:00: Opening, faculty and students presentation 09:00 11:00: Seizure semiology depending to lobe. Chairs: Walter van Emde Boas, Dana Craiu. Description: faculty will choose the most eloquent videos to allow students to learn to recognise lobe localization, lateralization (pattern recognition). Presentations of cases sent by participants. Discussions while watching videos and after faculty and students (aim to actively involve students for ad hoc description pointing to localization). Faculty will end every section with short theoretical summary. Faculty: Walter van Emde Boas, Helen Cross, Petia Dimova, Hans Holthausen, Lorella Minotti. - Frontal lobe seizures - H Holthausen - Central ares seizures H Holthausen - Temporal lobe seizures - W v Emde Boas - Parietal lobe seizures L Minotti - Occipital lobe seizures P Dimova, H Ho;lthausen 11:00 11:30: Coffee break 11:30 13:30: Epileptic syndromes, organization and terminology in epilepsy Chairs: Helen Cross, Volodymyr Karitonov TBD Electroclinical epileptic syndromes overview Helen Cross Discussions on definitions, organization of epilepsies and terminology based on clinical cases Volodymyr Karytonov Is it epileptic or non-epileptic? Oana Tarta-Arsene Overview of non-epileptic phenomenon 13:30 15:00: Lunch : Status epilepticus, EEG in epilepsy Chairs: Stanislav Groppa, Sandor Beniczky Stanislav Groppa Status Epilepticus Walter van Emde Boas EEG sensitivity, specificity, indications Sandor Beniczky Getting more info out of the conventional recordings. 16:45 17:15: Coffee break 17:15 18:45: EEG in epilepsy Chairs: Thea Gutter, Bogdan Florea Thea Gutter Practical issues in EEG in epilepsy (electrodes, montages, procedure routine examination) TBD Provocation methods in EEG Bogdan Florea EEG in the intenssive care setting

5 Day 2: Defining etiology in epilepsy; Treatment when, how, what? Defining etiology in epilepsy emphasis on neuroimaging (whom,, when, what to reccommend) Chairs: Alla Guekht, Catrinel Iliescu : Defining etiology in epilepsy (etiological cathegories terminology, concepts) (with examples interactive) Helen Cross Catrinel Iliescu. Imaging epilepsy: whom, when and what to reccommend Dana Craiu, Catrinel Iliescu, Oana Tarta-Arsene, Diana Barca, Cristina Motoescu, Carmen Burloiu, Alice Dica, Carmen Sandu, Nina Butoianu, Cristina Pomeran Structural etiology in epilepsy. During this part there will be small 10 min interactive presentations starting from clinical cases with different etiologies aiming: - Pattern recognition while imaging epilepsy - Understanding what type of imaging, when to reccommend and what for - Understanding causality lesion epilepsy - Thinking cases in day to day practice (TSC, vascular, trauma, inflammatory, immune, infectious, malformative + migration disorders, tumoral, metabolic, HS, HH) : Coffee break Treatment when, how, what? Chairs: Carmen Burloiu, Ioana Mindruta Alla Guekht First seizure management Catrinel Iliescu, Dana Craiu General issues cocerning treatment in epilepsy (When and whom to introduce, what to choose, what to avoid variables to discuss: syndrome, etiology, sex, age) Cristina Panea Resistant epilepsy definition and management Lunch : Antiepileptic drug treatment management Chairs: Dana Craiu, Meir Bialer Adina Roceanu Monitoring the patient with antiepileptic drug treatment (How often? How? If/when to perform lab tests?) Dana Craiu. Compliance to antiepileptic drug treatment Meir Bialer Drug interactions in patients with epilepsy (antiepileptic drugs interactions which are the best/worst combinations and why; interactions of antiepileptic medication with other drugs in patients with other diseases; interactions with contraceptive medication) Coffee break

6 Antiepileptic drug treatment and alternative treatments Chairs: Carmen Sandu, Mircea Gorgan Meir Bialer Original versus generic AEDs Dana Craiu Drug treatment discontinuation when, how and to whom to stop? Carmen Sandu Alternative treatments Ketogenic diet Mircea Gorgan Vagus nerve stimulation (what is it, how does it work, how to implant, results) Day 3: Treatment epilepsy surgery Invited Speakers: Petia Dimova, Kyriakos Garganis, Hans Holthausen, Lorella Minotti, Krassimir Minkin 09:00 11:00 General issues concerning epilepsy surgery. Chairs: Ioana Mindruta, Jean Ciurea Hrvoje Hecimovic Presurgical evaluation what is this about? Steps, team, organization Petia Dimova (BG), Alice Dica (RO), Dana Craiu (RO) The lesion is always the site of epilepsy? Timing in presurgical evaluaton in childhood Hans Holthausen Ioana Mindruta Invasive vs non-invasive presurgical evaluation in epilepsy surgery Coffee break FCD - the most frequent cause of surgically remediable epilepsy? Chairs: Kyriakos Garganis, Petia Dimova Lorella Minotti - Presurgical evaluation in adult patients centered on FCD Hans Holthausen Presurgical evaluation in pediatric patients centered on FCD Kyriakos Garganis Frontal lobe epilepsy related to FCD 13:00 14:00: Lunch 14:00 15:30 - Epilepsy surgery in East European countries were are we? Chairs: Lorella Minotti, Hrvoje Hecimovic Ioana Mindruta Survey Epilepsy surgery in East European countries past and present (Survey participants Petia Dimova (Bulgaria), Kyriakos Garganis (Greece), Stanislav Groppa (Rep Moldova), Alla Guekht (Russia), Hrvoje Hecimovic (Croatia), Volodymyr Karytonov (Ukraine), Dana Craiu (RO), Ioana Mindruta (RO) Krassimir Minkin Bitemporal epilepsy how did we solve it? Ioana Mindruta - Epilepsy related to FCD in functional areas 15: : Coffee break 16:00 17:20 Epilepsy surgery - Learn from mistakes are there such cases as easy cases? Chairs: Krassimir Minkin, I Mindruta

7 Mihai Maliia, Ioana Mindrutra, Andrei Barborica, Jean Ciurea, Cristian Donos, Alin Rasina, Ana Ciurea Clinical Case adult epilepsy surgery O Tarta-Arsene, D Craiu, C Motoescu, C Iliescu, C Pomeran, A Dica Clinical Case Pediatric epilepsy surgery 17:00 17:20 Course closure conclusions, final remarks, course evaluation results 17: 30 19:00 Visit to Bran Castle/ vs Dambovicioara cave 19:00 24:00 Fare well party at Vila Bran with fire outside, barbeque, dancing Breakfast and departure of participants transport to the airport

8 Booking Form PERSONAL DETAILS Title First Name Surname Position Place of Work Address for correspondence Telephone Please write your address very clearly so that we are able to read it. We will information to you before the course. DEADLINES 25 May 2014 for final registration - 25 April 2014 bursary applications (results of selected bursary recipients 30 April 2014) BOOKING I would like to attend the following: COURSE OF EPILEPSY BURSARY 400 Euro 100 Euro Please book accommodation for me (1 place in double room) arriving on and departing on (included in registration fee) Please book accommodation for me (single room) arriving on and departing on for: 4 nights 80 additional fee Gender (important for room allocation): Costs include 4 nights accommodation for course, all meals, registration fee, any course material and social programme.

9 Please arrange for transfers to / from International Airport Henry Coanda Bucharest. My flight details are: Arrival date: Arrival time: Flight number: Flying from: Departure date: Departure time: Flight number: Flying from: Bucharest SPECIAL REQUIREMENTS Please let us know if you have any special dietary requirements (food allergies etc) or if you are a vegetarian or vegan so that we can make provision for you. For vegetarians, please specify if you eat cheese or other products from milk. PAYMENT Payment must be made at the time of your booking. I have paid by bank transfer to "Fundatia Romana de Neurologie si Epileptologie, RONEP" Address: Str Mr Ionescu Atanase nr.43, sector 2, Bucuresti, Romania Bank: BCR Sucursala Mihai Bravu, Bank address: Soseaua Mihai Bravu nr 172 Bl.230, sector 2, Bucuresti Romania IBAN (lei): RO 44 RNCB IBAN (euro): RO 44 RNCB SWIFT code: RNCBROBU Romanian trainees may pay lei at National Bank exchange rate of the day of payment or euro. All the other trainees will only pay euro. PLEASE SEND THIS COMPLETED FORM: By flore.ronep@yahoo.com, by fax or post to: Mrs. Florentina Grigore Pediatric Neurology Clinic Al Obregia Hospital Sos Berceni 10 Sector 4, Bucharest, Romania Fax: