PHARMACOLOGICAL TREATMENT OF EPILEPSY Jerusalem, Israel, October 11-16, 2015

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1 6 th Eilat International Educational Course: PHARMACOLOGICAL TREATMENT OF EPILEPSY Jerusalem, Israel, October 11-16, 2015 Announcement and Call for Abstracts CURE Citizens United for Research in EPILEPSY

2 Dear Colleagues Following the success of the past five Eilat International Educational Courses held in Eilat, September 18-25, 2005, September 2-9, 2007, September 6-13, 2009, September 18-25, 2011 and September 30 - October 6, 2013, it gives us great pleasure to inform you of the forthcoming 6th Eilat International Educational Course: PHARMACOLOGICALTREATMENT OF EPILEPSY, which will take place at Mishkenot Sha ananim, Jerusalem, Israel on October 12-16, The Course is held under the auspices of the ILAE Commission on European Affairs (CEA), Israeli League Against Epilepsy, Citizens United for Research in Epilepsy (CURE) and the Hebrew University of Jerusalem. The program is designed for junior researchers and clinicians (45 years and younger) working in the field of epilepsy treatment and related basic research. It is open to young neurologists, neuropediatricians, pharmacists, pharmacologists, neuropsychologists and neuroscientists. We are happy to inform you that a number of bursaries have been made available towards partially defraying the cost of accommodation expenses of bursary recipients, who will also have their registration fees waived. This year, the course will take place in Jerusalem, at the historic Mishkenot Sha ananim complex in the picturesque Yemin Moshe neighborhood of Jerusalem, which is the ideal venue for this interactive postgraduate teaching program. Jerusalem is an exceptional location for the course. Sacred to the three major Monotheistic faiths, and with a history going back 5000 years, Jerusalem has something to offer everyone, from the colorful narrow alleyways of the bazaars of the old city, to the youthful and vibrant road side cafes and restaurants of modern Jerusalem. The diversity of this beautiful city adds to the unique experience for all participants of this course. We look forward to welcoming you to Jerusalem in October Sincerely TENTATIVE TIMETABLE Sunday, October 11, 2015 All day Arrivals Evening Get-together Reception Monday, October 12, 2015 Full day Welcome Address and Introduction to Course Sessions Tuesday, October 13, 2015 Full day Sessions Wednesday, October 14, 2015 Full day Sessions Late afternoon Walking Tour Thursday, October 15, 2015 Full Day Sessions Friday, October 16, 2015 Full day Sessions Saturday, October 17, 2015 Departures Dr. Svein I. Johannessen on behalf of the Organizing Committee ORGANIZING COMMITTEE S.I. Johannessen, Norway, Chairperson M. Bialer, Israel J.H. Cross, UK A. Guekht, Russia E. Perucca, Italy E. Trinka, Austria 2 3

3 COURSE PROGRAM SUNDAY, OCTOBER 11, 2015 All day Arrival and hotel check-in 16:00 Registration and Distribution of Course Material 19:30 Get-Together, Prima Royale Hotel MONDAY, OCTOBER 12, :30-09:15 Opening Session Auditorium de Button WELCOME ADDRESS AND INTRODUCTION TO THE COURSE S.I. Johannessen, Chair, Organizing Committee, Norway M. Bialer, CEA Chair and Member of the Organizing Committee, Israel INTRODUCTION TO THE COURSE T. Tomson, Organizing Committee, Sweden STUDENT INTRODUCTIONS Each student to present him/herself 09:15-10:00 Introductory Lecture Auditorium de Button Chairpersons: E. Beghi, Italy 09:15 DEFINITIONS, CLASSIFICATION AND EPIDEMIOLOGY OF SEIZURES AND EPILEPSY J.H. Cross, UK (for definition/classification) E. Beghi, Italy (for epidemiology) 09:45 Discussion 10:00-12:15 Session I Auditorium de Button THE PHARMACOLOGY OF AEDs Chairpersons: S.I. Johannessen, Norway C. Johannessen Landmark, Norway 10:00 ANTISEIZURE MEDICINES: MECHANISMS OF ACTION AND RATIONAL POLYPHARMACY H.S. White, USA 10:45 Discussion 11:00 Coffee Break 11:30 EXPERIMENTAL MODELS FOR THE DISCOVERY AND TESTING OF AEDs H.S. White, USA 12:00 Discussion MONDAY, OCTOBER 12, 2015 (continued) 12:15-15:30 Session II Auditorium de Button PHARMACOKINETICS AND THERAPEUTIC DRUG MONITORING Chairpersons: M. Bialer, Israel R.H. Levy, USA 12:15 BASIC PRINCIPLES OF PHARMACOKINETICS M. Bialer, Israel 12:45 Discussion 13:00 Light Lunch 14:00 PHARMACOKINETIC VARIABILITY OF AEDs IN SPECIAL PATIENT POPULATIONS, WITH CLINICAL EXAMPLES C. Johannessen Landmark, Norway 14:30 Discussion 14:45 IMPLEMENTATION OF THERAPEUTIC DRUG MONITORING IN AED THERAPY, WITH CLINICAL EXAMPLES S.I. Johannessen, Norway 15:15 Discussion 15:30 Coffee Break 16:00-17:00 POSTER PRESENTATIONS I (5 minutes each) Auditorium de Button 19:30 Dinner TUESDAY, OCTOBER 13, :30-10:15 Session III Auditorium de Button DRUG INTERACTIONS Chairpersons: H.S. White, USA S.I. Johannessen, Norway 08:30 MECHANISMS AND PREDICTIONS OF PHARMACOKINETIC INTERACTIONS OF AEDs - THEORETICAL ASPECTS R.H. Levy, USA 09:15 Discussion 09:30 CLINICALLY RELEVANT DRUG INTERACTIONS, WITH EXAMPLES R.H. Levy, USA 4 5

4 TUESDAY, OCTOBER 13, 2015 (continued) 10:00 Discussion 10:15 Coffee Break 10:45-12:15 GUIDED CLINICAL PK CASES (IN GROUPS) Auditorium de Button & Fostel Room Tutors: M. Bialer, Israel, S. I. Johannessen, Norway, C. Johannessen Landmark, Norway, R.H Levy, USA, E. Perucca, Italy, 12:15 Light Lunch 13:15-14:15 POSTER PRESENTATIONS II 5 minutes each Auditorium de Button 14:15 Coffee Break 14:45-16:15 GUIDED CASES: DRUG INTERACTIONS AND SPECIAL PATIENT GROUPS (IN GROUPS) Auditorium de Button & Fostel Room Tutors: M. Bialer, Israel, S.I. Johannessen, Norway, C. Johannessen Landmark, Norway, R.H. Levy, USA, E. Perucca, Italy, 19:30 Dinner WEDNESDAY, OCTOBER 14, :30-12:30 Session IV Auditorium de Button ASSESSING EFFICACY AND SAFETY (1) Chairpersons: E. Perucca, Italy 08:30 THE 4 PHASES OF DRUG DEVELOPMENT AND REGULATORY AFFAIRS M. Bialer, Israel 09:15 Discussion 09:30 CONTROLLED AND UNCONTROLLED TRIALS IN EPILEPSY E. Perucca, Italy 10:15 Discussion 10:30 Coffee Break WEDNESDAY, OCTOBER 14, 2015 (continued) 11:00 SPECIFICITIES OF TRIAL DESIGN FOR CHILDREN J.H. Cross, UK 11:30 Discussion 11:45 STATISTICAL PRINCIPLES APPLIED TO DESIGN AND ANALYSIS OF CLINICAL TRIALS M. Bialer, Israel and E. Beghi, Italy 12:15 Discussion 12:30 Light Lunch 13: POSTER PRESENTATIONS III 5 minutes each Auditorium de Button 14:30-16:30 Session V Auditorium de Button ASSESSING EFFICACY AND SAFETY (2) Chairpersons: E. Trinka, Austria 14:30 META-ANALYSIS: ADVANTAGES AND LIMITATIONS E. Beghi, Italy 15:00 Discussion 15:15 CRITICAL INTERPRETATION OF DRUG TRIALS IN EPILEPSY E. Perucca, Italy 16:15 Discussion and assignments for the Journal Club 17:00 Late afternoon walking tour (to depart directly after sessions) 20:00 Dinner THURSDAY, OCTOBER 15, :30-09:15 Session VI Auditorium de Button ASSESSING EFFICACY AND SAFETY (3) Chairpersons: J.H. Cross, UK, M. Neufeld, Israel 08:30 ADVERSE EFFECTS OF ANTIEPILEPTIC (ANTISEIZURE) DRUGS E. Trinka, Austria 09:00 Discussion 09:15-10:15 POSTER PRESENTATIONS IV 5 minutes each Auditorium de Button 10:15 Coffee break 6 7

5 THURSDAY, OCTOBER 15, 2015 (continued) 10:45-17:45 Session VII Auditorium de Button OPTIMIZING MEDICAL MANAGEMENT (1) Chairpersons: J.H. Cross, UK S. Shorvon, UK 10:45 WHEN TO TREAT - AND WITH WHAT DOSAGE? 11:30 Discussion 11:45 SELECTION OF DRUGS FOR INITIAL TREATMENT OF CHILDREN J.H Cross, UK 12:15 Discussion 12:30 Light Lunch 13:30 SELECTION OF DRUGS FOR INITIAL TREATMENT OF ADULTS E. Trinka, Austria 14:00 Discussion 14:15 WHAT STRATEGY WHEN THE INITIAL DRUG FAILS E. Beghi, Italy 14:45 Discussion 15:00 Coffee break 15:30 THE MEDICAL TREATMENT OF CHRONIC EPILEPSY S. Shorvon, UK 16:00 Discussion SEVERE CHILDHOOD EPILEPSIES F. Vigevano, Italy 16:45 Discussion 17:00 SEIZURE AGGRAVATION BY ANTIEPILEPTIC DRUGS E. Perucca, Italy 17:30 Discussion 19:30 Dinner FRIDAY, OCTOBER 16, :30-12:45 Session VIII Auditorium de Button OPTIMIZING MEDICAL MANAGEMENT (2): SPECIAL SITUATIONS/SPECIAL GROUPS Chairpersons: E. Trinka, Austria F. Vigevano, Italy 08:30 TERMINATION OF AED THERAPY IN SEIZURE FREE PATIENTS E. Trinka, Austria 09:00 Discussion 09:15 STATUS EPILEPTICUS AND ACUTE REPETITIVE SEIZURES S. Shorvon, UK 09:45 Discussion 10:00 Coffee break 10:30 PREGNANCY AND BREAST-FEEDING 11:00 Discussion 11:15 PEDIATRICS F. Vigevano, Italy 11:45 Discussion 12:00 EPILEPSY IN THE ELDERLY M. Neufeld, Israel 12:30 Discussion 12:45 Lunch 13:45-14:45 POSTER PRESENTATIONS IV 5 minutes each Auditorium de Button 14:45-16:15 JOURNAL CLUB TUTORIAL Auditorium de Button & Fostel Room Tutors: E. Beghi, Italy, J.H Cross, UK, E. Perucca, Italy, S. Shorvon, UK, F. Vigevano, Italy 19:30 Dinner 8 9

6 APPLICATION FOR BURSARIES Bursaries will be made available to young scientists (45 years and younger). The bursary will include waiver of course registration fee as well as accommodation in a shared room and meals during the course. Potential candidates are kindly requested to submit the following via the online submission link at no later than December 2, CV Letter of application Recommendation letter from head of their department or head of research lab an abstract based on research work Kindly note that submission of an abstract is mandatory and applications will not be considered without an abstract. These documents will be evaluated by the Course Organizing Committee and applicants will be notified of the decision no later than March The number of bursaries is restricted and it is therefore recommended that candidates submit their applications as soon as possible. Deadline for Bursary Submission: December 2, 2014 CALL FOR ABSTRACTS Deadline - May 31, 2015 The target audience for the Course is young neurologists/ epileptologists in training. Submitting an abstract is a good opportunity to present your scientific interest and have the work discussed with faculty members and other students during group sessions. Participants wishing to present a paper are requested to submit an abstract via the online link at All accepted abstracts will be scheduled for poster presentation, although an opportunity to also provide a short oral presentation on the abstract may be offered to certain authors. Inclusion of abstracts in the scientific program is dependent on payment of registration fees. GENERAL INFORMATION VENUE Mishkenot Sha ananim, Yemin Moshe, Jerusalem, is the Course venue. REGISTRATION FEES Before After June 15, 2015 Participant US$ 1,100 US$ 1,300 Accompanying person US$ 450 US$ 450 Registration fees for participants include entrance to all sessions, program and course kit, light lunches and dinners as of evening of October 11 up to and including October 16, as well as participation in the social program. If you are interested in bringing a partner, a registration fee of US$ 450 for your partner will be charged in addition to accommodation. This fee includes participation in the gettogether reception, 5 dinners providing that you have taken accommodation at the Prima Royale Hotel, and a walking tour. LETTER OF INVITATION Upon request, the Secretariat will send a personal invitation to participate in the Course. It should be understood that such an invitation is only meant to assist participants in raising travel funds or obtaining a visa and does not represent a commitment on the part of the Organizing Committee. CLIMATE AND CLOTHING The weather in Jerusalem in October is warm during the day, but cooler at night. Clothing is informal for all occasions. We suggest bringing a light jacket for the evenings and don t forget your sunglasses, hat and comfortable walking shoes. COURSE SECRETARIAT For any additional information, please contact the Secretariat: Target Conferences P.O. Box 51227, Tel Aviv , Israel Tel: Fax: eilatedu@target-conferences.com 10 11

7 TRAVEL AND ACCOMMODATION Target Conferences Ltd. PO Box 51227, Tel Aviv, Israel Tel: Fax: eilatedu.reg@target-conferences.com Target Conferences is the official travel agent of the 6 th Eilat International Educational Course: PHARMACOLOGICAL TREATMENT OF EPILEPSY and will be offering special reduced rates for accommodation and conference tours as well as a choice of pre and post tours specifically designed for participants and accompanying persons. Hotel space has been blocked by Target Conferences at the Prima Royal Hotel, Jerusalem, a five minute walk from Mishkenot Sha ananim, the course venue. Single room (one person) US$ 180 Double room (two people) US$ 210 Rates are per night, per room, and include Israeli buffet style breakfast and service charge. Rooms can only be guaranteed up until September 15, It is therefore advisable to reserve your accommodation well before this date. HOW TO BOOK In order to benefit from the special rate please register online at as soon as possible. AIR TRAVEL Direct flights exist from most major airports in North America, Europe, India, China, Thailand and Africa, by El Al Israel Airlines as well as by other international carriers. It is recommended to book your international air travel to/from Ben Gurion International Airport (Tel Aviv) with your local travel agent and/or on the internet. GROUND TRANSPORTATION BETWEEN BEN GURION INTERNATIONAL AIRPORT AND CONGRESS HOTELS Taxi Service - The cost for a one-way trip is approximately US$ 88, depending on time of day and number of pieces of luggage. The trip should take approximately minutes depending on time of day. Nesher shared transfer service is available from Ben-Gurion Airport. There may be a waiting time as the driver only departs when there are 10 passengers. Rate per person: NIS 64 - approximately US$ 18. There is a Nesher information desk at the airport. Self-parking is available at no charge at the Prima Royale. IMPORTANT NOTES Personal travel, luggage and health insurance are recommended. Please purchase this from your local travel agent. Kindly note the organizers and other sponsors cannot be responsible for participants lacking appropriate insurance coverage. All tours are booked on the express condition that Target Conferences shall not be held responsible for and shall be exempt from all liability in respect of any loss, damage, injury or accident, to any person or his or her luggage or any other property, for any reason whatsoever. OPTIONAL PRE and POST COURSE TOURS Pre-Course Day Tour A One Day Sightseeing MASADA AND THE DEAD SEA Saturday, October 10, 2015 Full day tour to include Massada, the last stronghold of the Zealots against Rome and a dip in the Dead Sea. Rate per person: US$ Pre-Course Day Tour B One Day Sightseeing JERUSALEM - THE OLD AND THE NEW Sunday, October 11, 2015 Tour includes a topographical view and explanation of Jerusalem, the Old and the New, as well as the Old City of Jerusalem with the Western (Wailing) Wall, the colorful Arab Market and the Church of Holy Sepulchre. Rate per person: US$

8 Rates for both tours include: Travel by air-conditioned coach with the services of a government licensed tour guide Entrance fees to sites, as per itinerary Pick-up and drop-offs at the official Course Hotel Not including: Lunch en route Tips to guide and driver Transfers from Ben-Gurion Airport to Jerusalem Rates are based on a minimum of 15 participants Post-Course Day Tour C One Day Sightseeing Nazareth, Tiberias, Sea of Galilee Saturday, October 17, 2015 Start in Nazareth with the Church of Annunciation one of the largest churches in the Middle East, on to Tiberias where you will also enjoy a boat trip on the Sea of Galilee. Visit Tabgha, site of the miracle with the Loaves and Fish. Return to Jerusalem Rate per person: US$ 100 Rate for tour includes: Travel by air-conditioned coach with the services of a government licensed tour guide Entrance fees to sites, as per itinerary Pick-up and drop-offs at the official Course Hotel Not including: Lunch en route Tips to guide and driver Transfers from Ben-Gurion Airport to Jerusalem Rate is based on a minimum of 20 participants Information can also be obtained from the Course Organizers: Target Conferences, PO Box 51227, Tel Aviv Tel: , Fax: eilatedu.reg@target-conferences.com 14

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