The Human Immunoglobulin Kappa Variable (IGKV) Genes and Joining (IGKJ) Segments
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1 IMGT Locus on Focus Exp Clin Immunogenet 1998;15: Received: June 13, 1998 Valérie Barbié Marie-Paule Lefranc Laboratoire d ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France The Human Immunoglobulin Kappa Variable (IGKV) Genes and Joining (IGKJ) Segments OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Human IMGT Immunoglobulin Kappa OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Abstract Human Immunoglobulin Kappa Variable (IGKV) Genes and Joining (IGKJ) Segments, second report of the IMGT Locus on Focus section, comprises five tables entitled: (1) Number of human germline IGKV genes at 2p12 and potential repertoire ; (2) Human germline IGKV gene table ; (3) Human IGKV allele table ; (4) Human germline IGKJ table and (5) Human IGKJ allele table. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database ( created by Marie-Paule Lefranc, CNRS, Université Montpellier II, Montpellier, France. OOOOOOOOOOOOOOOOO Introduction Human Immunoglobulin Kappa Variable (IGKV) Genes and Joining (IGKJ) Segments is the second report of the IMGT Locus on Focus section launched in the April 1998 issue of Experimental and Clinical Immunogenetics [1] with the first report on the human IGLV genes and IGLJ segments [2]. This second report on human IGKV genes and IGKJ segments comprises five tables entitled: (1) Number of human germline IGKV genes at 2p12 and potential repertoire ; (2) Human germline IGKV gene table ; (3) Human IGKV allele table ; (4) Human germline IGKJ table and (5) Human IGKJ allele table. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database ( imgt.cnusc.fr:8104) created by Marie-Paule Lefranc, CNRS, Université Montpellier II, Montpellier, France [3, 4]. Description of functionality (FUNCTIONAL, ORF, PSEU- DOGENE) and description of mutations [1] are according to the IMGT scientific chart available at the IMGT Marie-Paule page. Nucleotide and amino acid numbering of the IGKV alleles (table 3) is according to the IMGT unique numbering [1, 5]. ABC Fax karger@karger.ch S. Karger AG, Basel /98/ $15.00/0 Accessible online at: Prof. Marie-Paule Lefranc Laboratoire d ImmunoGénétique Moléculaire, UPR CNRS 1142, IGH 141, rue de la Cardonille, F Montpellier Cedex 5 (France) Tel. +33 (0) , Fax +33 (0) lefranc@ligm.igh.cnrs.fr, IMGT
2 Table Exp Clin Immunogenet 1998;15: Barbié/Lefranc
3 Table 2 + Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
4 2 174 Exp Clin Immunogenet 1998;15: Barbié/Lefranc
5 2 + Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
6 2 176 Exp Clin Immunogenet 1998;15: Barbié/Lefranc
7 2 + Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
8 2 178 Exp Clin Immunogenet 1998;15: Barbié/Lefranc
9 2 Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
10 Table Exp Clin Immunogenet 1998;15: Barbié/Lefranc
11 3 Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
12 Table Exp Clin Immunogenet 1998;15: Barbié/Lefranc
13 Table 5 Acknowledgments IMGT is funded by IMGT the European Union s BIOTECH programme (BIO4CT ), Centre National de la Recherche Scientifique and Ministère de l Education Nationale, de la Recherche et de la Technologie. Subventions have been received from Association pour la Recherche sur le Cancer, Association de la Recherche sur la Polyarthrite, Fondation pour la Recherche Médicale, Ligue Nationale contre le Cancer and the Région Languedoc-Roussillon. OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO References 1 Lefranc MP: IMGT Locus on Focus. Exp Clin Immunogenet 1998;15: Pallarès N, Frippiat JP, Giudicelli V, Lefranc MP: The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments. Exp Clin Immunogenet 1998;15: Giudicelli V, Chaume D, Bodmer J, Müller W, Busin C, Marsh S, Bontrop R, Lemaitre M, Malik A, Lefranc MP: IMGT, the international ImMunoGeneTics database. Nucleic Acids Res 1997;25: Lefranc MP, Giudicelli V, Busin C, Bodmer J, Müller W, Bontrop R, Lemaitre M, Malik A, Chaume D: IMGT, the international ImMuno- GeneTics database. Nucleic Acids Res 1998;26: Lefranc MP: Unique database numbering system for immunogenetics. Immunol Today 1997;18:509. Human IGKV Genes and IGKJ Segments Exp Clin Immunogenet 1998;15:
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