Catheter Based Therapy for PE: Who and How?
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1 Catheter Based Therapy for PE: Who and How? Jay Giri, MD MPH Assistant Professor of Medicine Director, Pulmonary Embolism Response Team Associate Director, Penn Cardiovascular Quality, Outcomes & Evaluative Research Center Hospital of the University of Pennsylvania 1
2 Disclosures PERT Consortium (501c3): Board of Directors AHA: Writing Committee Chair BEST-CLI trial: Independent Medical Reviewer St. Jude: Research Funds to the Institution Recor Medical: Research Funds to the Institution Astra Zeneca: Advisory Board 2
3 Risk Stratification Massive (High) Submassive (Int-high) (Int-low) Lower Risk OHCA 10%? 50% Insights Imaging 2011;2:705; EHJ 2014;35:3033. Thromb Haemost. 2008;100:747. Circulation 2000;101:2817 & 2011;123:
4 Rationale for Advanced Therapy Wood KE. Critical Care Clinics 2011;27(4):
5 Can We Prevent This? 5
6 PE Therapeutic Options: All Over the Map Anticoagulation IV Thrombolysis IVC Filter Catheter Directed Thrombolysis Surgical Embolectomy Pharmaco-Mechanical Catheter Treatment ECMO 6
7 Chatterjee, et al. JAMA
8 Chatterjee, et al. JAMA
9 Weighing Benefits & Risks of PE Intervention Major Bleeding Prevent early mortality Improve symptoms Prevent CTEPH ICH Precipitate Decompensation 9
10 Theoretical Advantages for Local Lytic Higher local concentration Lower overall dose Ability to fragment clot if desired PA pressure monitoring Scmitz-Rode CVIR 1998;21:
11 Options for CDT Cragg-McNamara 4-5 F 100 cm catheter length 5-10 cm infusion length $ Unifuse 4-5 F 100 cm catheter length 5-10 cm infusion length $ EKOS 5F 100 cm catheter length 5-10 cm infusion length $
12 Catheter-Directed Thrombolysis 4-24 hour treatment lytic dose (8-24 mg TPA)? Bleeding impact? thrombus resolution impact Faster than passive catheter-directed alone (?) 12
13 Who Knows? Longer Infusion Reduced Dose 13
14 All Studies Major Bleeding Comparison Catheter-Directed Lysis Non-ICH Major Bleed Systemic Lysis No Bleeding P = 0.08 Chatterjee, et al. JAMA Kucher, et al. Circulation Piazza, et al. JACC Intvn Piazza et al. JACC Intvn 2018 Giri, et al. Manuscript in Press 14
15 All Studies ICH Comparison ICH No ICH Catheter-Directed Lysis Systemic Lysis P = 0.64 Chatterjee, et al. JAMA Kucher, et al. Circulation Piazza, et al. JACC Intvn Piazza et al. JACC Intvn 2018 Giri, et al. Manuscript in Press 15
16 CDT Trade-Offs Pros We do not know the ICH risk with CDT (though Lower Dose we hope it is less than systemic lysis) The Can non-ich halt infusion major bleeding rate Technical may be Expertise similar with CDT compared to systemic lysis Less off-target exposure No (theoretical) randomized comparative studies of CDT vs ST exist and few observational studies exist Better Clot Penetration (theoretical) 1 Cons Longer Infusion Resource Intensive Deep Vein Access (not absolutely required) Can Destabilize Patient Acutely 1 Blinc, et al. Thromb Haemost May 6;65(5):
17 Major Lessons 1) You are more likely to feel better sooner 1) Do not algorithmically lyse patients with RV dysfunction/enlargement and + cardiac biomarkers 2) Additional criteria needed to support aggressive care 2) The cost of this is a higher risk of bleeding and HR > 110, Soft BP a Cool small exambut real risk of ICH Inability to speak a full sentence Difficulty with minimal activity (eg: bed to chair) Echo or Clinical Signs of Low Cardiac Output/Stroke Volume 3) We cannot promise you that this will make you 3) Monitor for 48 hours with therapeutic UFH if any doubt about live the longer above or prevent the development of longterm 4) Be conservative dyspneawith or pulmonary intermediate-risk hypertension patients who from have bleeding your PE risks 17
18 Sample Devices for PE Intervention Jaber et al. JACC. 2016; 67(8):
19 Get Ready for PE Devices with Limited Data Be careful with embolectomy devices in intermediate risk patients Angiovac No comparative data of any kind Largest Published Study 14 patients $14K per device Minimal comparative evidence of safety/efficacy versus conservative strategies Flowtriever Huge Potential Market 510k with 108 patient single arm study (FLARE study) $5K per device We do not know that these therapies influence long-term CTEPH/CTED Indigo System (Penumbra) 510k for removal of thrombus within the periphery No published series for PE Looking for 510k with patient single arm study Reserve for patients who are on-the-edge and have bleeding contraindications 19
20 High Risk PE patients Very High Mortality (30-60% at days) Very Different Approach 20
21 High Risk PE patients - Paradigm Shift First Question: Should I institute emergent mechanical circulatory support? 1) No life-threatening comorbids 2) Reasonable Age (<80) 3) Escalating Pressors or In- Hospital Arrest 21
22 Bridge to Definitive Therapy 22
23 66 year old male smoker w/ HTN p/w 2 weeks dyspnea, CP, dizziness, LE edema acutely worse Vitals BP 88/73 HR Sat 89%, RR>30 s/p IVF and 100% o2 BP 107/89 HR 101 Sat 100% Lactate 5.5 Trop wnl, Cr wnl HgB 9.2 NTproBNP 236 EKG: Sinus Tach. RBBB. LAFB 23
24 Right heart Strain Bilateral PE involving R/L main PA and into lobar and segmental branches LLL infarct 24
25 Notable ROS -No bleeding hx -No recent travel -No Surgery -No immobilization -NO personal or Fam Hx of VTE or SCD HAS-BLED=1 PESI Class V, Very High Risk: % 30-day mortality 25
26 PERT TEAM Consulted. How would you proceed? Therapeutic Anticoagulation/Heparin Systemic Thrombolysis Surgical Embolectomy Catheter Directed Thrombolysis Catheter Based Embolectomy 26
27 Hospital Day #0 Hybrid OR MAC Anesthesia 26F Gore Dryseal: R Fem Vein 16F ECMO Cannula : Left Fem Vein 27
28 Chest bumps and high fives 28
29 Initial Course: Hospital Day #1 Admitted to CT SICU Off Pressors MvO2 22% 2 Pressor Shock and Respiratory Failure Placed on emergent VA ECMO via existing femoral arterial and venous sheaths 29
30 What would you offer? (Patient supported with VA ECMO) Continue Therapeutic Anticoagulation/Heparin Systemic Thrombolysis Surgical Embolectomy Catheter Directed Thrombolysis Catheter Based Embolectomy 30
31 Hospital Day #1 on bifemoral VA ECMO Antegrade Perfusion 7F cannula (micropuncture) 5F Cragg-McNamara valved infusion catheters in Right and Left interlobar pulmonary arteries -6F Right Basilic Vein -6F Left common femoral vein 31
32 Penn Catheter Directed Thrombolysis 1-3mg Alteplase/catheter bolus 1mg/catheter/hr x 6 hours 0.5mg/hr thereafter, based upon response Labs q 4hr, CBC, PTT ~ (continue low dose heparin), Fibrinogen > Stop Alteplace, pull venous sheaths minutes later, 5 min hemostasis, Lovenox STAT and BID 32
33 Hospital Day #1 (continued) Patient Returned to CT-SICU from cath lab Within 6 hours patient had return of pulsatility, pressors weaned off After 24 mg Alteplase, infusion catheters and sheaths removed Patient restarted on therapeutic dose unfractionated heparin LE Duplex: Acute DVT L femoral vein Acute and Chronic DVT R and L popliteal 33
34 Hospital Day #4 Decannulated from VA ECMO and Extubated 34
35 Hospital Day #7 Bard Denali IVC Filter (Retrievable) 35
36 Discharged to home Hospital Day #13 Ambulatory Off Oxygen Xarelto 36
37 6 week follow up with Pulmonary Clinic (PERT Follow up) 37
38 IVC Filter Retrieved at 8 weeks 38
39 Thank You Mentors in PE Care Robert Schainfeld, MD Michael Jaff, DO PERT Consortium Ken Rosenfield - MGH Victor Tapson Cedar Sinai Jana Montgomery Lahey Clinic Many Others Penn Pulmonary Embolism Response Team Steven Pugliese Jeremy Mazurek Barry Fuchs Prashanth Vallabhajosyula Tai Kobayashi Sameer Khandhar Harold Palevsky PE Research Collaborators Saurav Chatterjee U Conn Ido Weinberg - MGH Geoffrey Barnes - UMich Chris Kabhrel - MGH Ken Rosenfield MGH Akhi Sista - NYU Bram Geller & Srinath Adusumalli - Penn Lee Greenspon, MD William Gray, MD Emile Mohler, MD
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