Cardioprotection by endogenous fibroblast growth factor 2 in cardiac ischemia-reperfusion injury in vivo
|
|
|
- Anastasia Richard
- 5 years ago
- Views:
Transcription
1 Washington University School of Medicine Digital Conference Abstracts and Posters Division of Emergency Medicine/Emergency Care Research Section 2011 Cardioprotection by endogenous fibroblast growth factor 2 in cardiac ischemia-reperfusion injury in vivo Stacey House Washington University School of Medicine in St. Louis Carla Weinheimer Washington University School of Medicine in St. Louis Attila Kovacs Washington University School of Medicine in St. Louis David Ornitz Washington University School of Medicine in St. Louis Follow this and additional works at: Recommended Citation House, Stacey; Weinheimer, Carla; Kovacs, Attila; Ornitz, David, Cardioprotection by endogenous fibroblast growth factor 2 in cardiac ischemia-reperfusion injury in vivo (2011). Conference Abstracts and Posters. Paper 7. em_conf/7 This Presentation Paper is brought to you for free and open access by the Division of Emergency Medicine/Emergency Care Research Section at Digital Commons@Becker. It has been accepted for inclusion in Conference Abstracts and Posters by an authorized administrator of Digital Commons@Becker. For more information, please contact engeszer@wustl.edu.
2 Cardioprotection by Endogenous Fibroblast Growth Factor 2 in Cardiac Ischemia- Reperfusion Injury In Vivo Stacey House MD PhD, Carla Weinheimer MS, Attila Kovacs MD, and David Ornitz MD PhD Washington University in St. Louis School of Medicine Society for Academic Emergency Medicine Great Plains Regional Research Forum St. Louis, MO. September 2011 Stacey House, 2011
3 Fibroblast Growth Factor 2 22 different FGF family members (10 in heart) FGF2 or basic FGF first member of the FGF family identified, expressed fairly ubiquitously FGF2 expressed in all developmental stages of heart; found in cardiomyocytes, fibroblasts, endothelium FGF2 known functions: Hematopoiesis Angiogenesis Wound Healing Mesoderm Induction Cell Survival/Death Cardiac Hypertrophy
4 FGF2 Isoforms FGF2 mrna (1) (484) (951) 5 AUG (486) CUG (86) CUG (319) CUG (346) CUG (361) Stop(951) 3 HMW LMW 34 kda 24 kda 22.5 kda 22 kda 18 kda nuclear cytoplasmic Nuclear localization signal
5
6 FGF2 and Cardioprotection Isolated work-performing global low-flow IR injury- Fgf2 KO have worsened post-ischemic function Cardiac-specific human FGF2 Tg have -improved post-ischemic cardiac function -reduced infarct size FGF2-induced cardioprotection mediated through PKC, MAPK, and NOS signaling
7 What is the in vivo cardioprotective efficacy of FGF2?
8 FGF2 Knockout Targeted ablation of all isoforms of FGF2 Viable and fertile No difference from wildtype with respect to cardiac morphometry, function, or vessel density
9 Closed Chest Ischemia-Reperfusion Instrumentation 90 min Ischemia 7 Days 7 Days Reperfusion Echo Day 1 Echo Day 7 From Dewald et al. 2004
10 Echo Determination of Ejection Fraction
11 Endogenous FGF2 in Cardiac Function Post IR Injury 80 Wildtype 70 FGF2 KO Ejection Fraction % * * day 7 day n=6 *p<0.05 vs. wildtype
12 Echo Analysis of LV Wall Motion Abnormalities
13 Echo Analysis of LV Wall Motion Abnormalities 50 Wildtype * * FGF2 KO % Infarct Size day 7 day n=6 *p<0.05 vs. wildtype
14 Trichrome Staining of Fibrosis Wildtype Fgf2 KO
15 Picosirius Red Stain of Collagen Fibrils
16 Endogenous FGF2 Effect on Cardiac Hypertrophy Heart Wt vs. Body Wt Ratio Wildtype FGF2 KO Heart Wt vs. Body Weight Ratio n=7
17 Myocyte Area Staining Wildtype Fgf2 KO
18 Myocyte Cross Sectional Area Post IR Injury Myocyte Cross Sectional Area (um 2 ) Wildtype Fgf2 KO n=6
19 Smooth Muscle Actin Staining Wildtype Fgf2 KO
20 Vessel Density After IR injury SMA (# vessels/10x field) * Wildtype Fgf2 KO Diameter (µm) * Wildtype Fgf2 KO 0 0 Vessel Area / 10X field (µm2) Wildtype Fgf2 KO 0 n=6 *p<0.05 vs. wildtype
21 Future Directions Analysis of capillary density and vascular remodeling at early time points post IR injury Analysis of inflammatory response post IR injury
22 Acknowledgements Dave Ornitz Carla Weinheimer Attila Kovacs Sarah Davis Funding Sources American Heart Association Emergency Medicine Foundation Missouri ACEP
Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemiareperfusion
ORIGINAL RESEARCH Physiological Reports ISSN 25-87X Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemiareperfusion injury Stacey L. House,2, Joy
Genetic ablation of Acp1 (Lmptp) in mice prevents heart failure
Genetic ablation of Acp1 (Lmptp) in mice prevents heart failure Coralie Poizat, Ph.D. Director, Cardiovascular Research Program KFSHRC-Riyadh Saudi Heart Failure Working Group Jeddah, 5 December 2015 Cardiovascular
Supplementary Figure 1. Confocal immunofluorescence showing mitochondrial translocation of Drp1. Cardiomyocytes treated with H 2 O 2 were prestained
Supplementary Figure 1. Confocal immunofluorescence showing mitochondrial translocation of Drp1. Cardiomyocytes treated with H 2 O 2 were prestained with MitoTracker (red), then were immunostained with
Gender differences in the prevalence and patterns of alcohol use among 9th-12th graders in a St. Louis suburban high school
Washington University School of Medicine Digital Commons@Becker Posters 2003: Drinking and the High School Student 2003 Gender differences in the prevalence and patterns of alcohol use among 9th-12th graders
c Ischemia (30 min) Reperfusion (8 w) Supplementary Figure bp 300 bp Ischemia (30 min) Reperfusion (4 h) Dox 20 mg/kg i.p.
a Marker Ripk3 +/ 5 bp 3 bp b Ischemia (3 min) Reperfusion (4 h) d 2 mg/kg i.p. 1 w 5 w Sacrifice for IF size A subset for echocardiography and morphological analysis c Ischemia (3 min) Reperfusion (8
DECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST A potential anti-hypertrophic agent Riham Abouleisa Cardiac hypertrophy is a compensatory response to maintain function during increased stress. A sustained hypertrophic
The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
Washington University in St. Louis Washington University Open Scholarship All Theses and Dissertations (ETDs) Spring 3-8-2014 The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility
Viral infections in airway remodeling
Viral infections in airway remodeling Nikos Papadopoulos As. Proffesor,Head, Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Overview Acute events may have long term consequences Remodeling appears
Supplementary Figure 1. Spatial distribution of LRP5 and β-catenin in intact cardiomyocytes. (a) and (b) Immunofluorescence staining of endogenous
Supplementary Figure 1. Spatial distribution of LRP5 and β-catenin in intact cardiomyocytes. (a) and (b) Immunofluorescence staining of endogenous LRP5 in intact adult mouse ventricular myocytes (AMVMs)
Ischaemic Preconditioning prevents the differentiation induced by ischaemia/reperfusion injury of rat cardiac fibroblast to myofibroblast
Ischaemic Preconditioning prevents the differentiation induced by ischaemia/reperfusion injury of rat cardiac fibroblast to myofibroblast Kartika Pertiwi1 and Lisa Chilton2 1: Biology Education Department,
Gene expression was analyzed by real time PCR (SYBR GREEN PCR Master. Mix, Roche Applied Science) using specific oligonucleotides.
1 SUPPLEMENTAL MATERIAL SUPPLEMENT METHODS Real Time PCR. Gene expression was analyzed by real time PCR (SYBR GREEN PCR Master Mix, Roche Applied Science) using specific oligonucleotides. Rat ST2L forward
SUPPLEMENTARY INFORMATION
doi:10.1038/nature10188 Supplementary Figure 1. Embryonic epicardial genes are down-regulated from midgestation stages and barely detectable post-natally. Real time qrt-pcr revealed a significant down-regulation
Common and unique genetic contributions to conduct disorder and two stages of alcohol dependence development in women
Washington University School of Medicine Digital Commons@Becker Posters 2007: Alcohol Use Across the Lifespan 2007 Common and unique genetic contributions to conduct disorder and two stages of alcohol
Mesenchymal Stem Cells to Repair Vascular Damage after Chemotherapy: Past, Present and Future
Mesenchymal Stem Cells to Repair Vascular Damage after Chemotherapy: Past, Present and Future Cell Therapy 2014 Las Vegas, NV, USA Sulaiman Al-Hashmi, PhD Sultan Qaboos University Oman What are MSCs? Stem
Tissue repair. (3&4 of 4)
Tissue repair (3&4 of 4) What will we discuss today: Regeneration in tissue repair Scar formation Cutaneous wound healing Pathologic aspects of repair Regeneration in tissue repair Labile tissues rapid
Endothelial PGC 1 - α 1 mediates vascular dysfunction in diabetes
Endothelial PGC-1α mediates vascular dysfunction in diabetes Reporter: Yaqi Zhou Date: 04/14/2014 Outline I. Introduction II. Research route & Results III. Summary Diabetes the Epidemic of the 21st Century
E. Cervio, P. Danieli, C. Ciuffreda, F. Pisano, M. Roccio, M. Gnecchi. The authors have no financial disclosures to declare
16 th ISCT Annual Meeting SOLUBLE FACTORS RELEASED BY HUMAN MESENCHYMAL STEM CELLS OF FETAL ORIGIN LEAD TO CARDIOMYOCYTE PROTECTION THROUGH THE INHIBITION OF PRO-APOPTOTIC SIGNALING E. Cervio, P. Danieli,
Cardiovascular disease (CVD) is the primary cause of
Cardiac-Specific Overexpression of Fibroblast Growth Factor-2 Protects Against Myocardial Dysfunction and Infarction in a Murine Model of Low-Flow Ischemia Stacey L. House, BS; Craig Bolte, BA; Ming Zhou,
When is strain assessment mandatory?
When is strain assessment mandatory? Geneviève Derumeaux University of Lyon France Presenter Disclosure Information Geneviève Derumeaux When is strain assessment mandatory? DISCLOSURE INFORMATION: None
Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2013 Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart Kory J. Lavine Washington
The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
Iorga et al. Biology of Sex Differences (2017) 8:33 DOI 10.1186/s13293-017-0152-8 REVIEW The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen
Do genetic influences on abuse and dependence overlap? Explorations using cannabis and alcohol diagnoses
Washington University School of Medicine Digital Commons@Becker Posters 2004: Alcoholism and the Latest Genetics and Neuroscience Findings 2004 Do genetic influences on abuse and dependence overlap? Explorations
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury
Autophagy 11:9, 1537--1560; September 2015; 2015 Taylor & Francis BASIC RESEARCH PAPER Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion
Race, tobacco, and alcohol in a high risk family study
Washington University School of Medicine Digital Commons@Becker Posters 6: Alcohol and Tobacco Dependence: from Bench to Bedside 6 Race, tobacco, and alcohol in a high risk family study Alexis Duncan Wilma
Detection and Assessment of MI: Use of Imaging Methods. Robert O. Bonow, M.D.
Detection and Assessment of MI: Use of Imaging Methods Robert O. Bonow, M.D. Detection and Assessment of MI: Use of Imaging Methods Robert O. Bonow, M.D. No Relationships to Disclose Expert Consensus Document
1. Cardiomyocytes and nonmyocyte. 2. Extracellular Matrix 3. Vessels שאלה 1. Pathobiology of Heart Failure Molecular and Cellular Mechanism
Pathobiology of Heart Failure Molecular and Cellular Mechanism Jonathan Leor Neufeld Cardiac Research Institute Tel-Aviv University Sheba Medical Center, Tel-Hashomer שאלה 1 התא הנפוץ ביותר (75%~) בלב
Reactive oxygen species: Importance for ischemia/reperfusion (injury)
Physiologisches Institut Reactive oxygen species: Importance for ischemia/reperfusion (injury) Prof. Dr. Rainer Schulz Reactive oxygen species (ROS) in ischemia/reperfusion injury (IRI) ROS GOOD: Endogenous
Stimulant users are sensitive to the stimulant properties of alcohol as indexed by alcohol-induced heart rate increase
Washington University School of Medicine Digital Commons@Becker Posters 2004: Alcoholism and the Latest Genetics and Neuroscience Findings 2004 Stimulant users are sensitive to the stimulant properties
Supplemental Figure I
Supplemental Figure I Kl ( mmol/l)-induced Force orta M (mn) 1 (mn) 1 Supplemental Figure I. Kl-induced contractions. and, Kl ( mmol/l)-induced contractions of the aorta () and those of mesenteric arteries
Early cigarette use behaviors and alcohol
Washington University School of Medicine Digital Commons@Becker Posters 2003: Drinking and the High School Student 2003 Early cigarette use behaviors and alcohol Pamela A. Madden Washington University
Uncovering the mechanisms of wound healing and fibrosis
Any Questions??? Ask now or contact support support@sabiosciences.com 1-888-503-3187 International customers: SABio@Qiagen.com Uncovering the mechanisms of wound healing and fibrosis Webinar related questions:
In Vivo Animal Models of Heart Disease. Why Animal Models of Disease? Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison
In Vivo Animal Models of Heart Disease Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison Why Animal Models of Disease? Heart Failure (HF) Leading cause of morbidity and mortality
Fuel the Failing Heart: glucose or fatty acids? Rong Tian, MD, PhD Mitochondria and Metabolism Center University of Washington, Seattle
Fuel the Failing Heart: glucose or fatty acids? Rong Tian, MD, PhD Mitochondria and Metabolism Center University of Washington, Seattle Metabolic Remodeling: Fatty Acids Carbohydrates PCr/ATP Glucose vs.
Cardiovascular Diseases (BMM9) and Getting to Know CNIC course Course
Cardiovascular Diseases (BMM9) and Getting to Know CNIC course Course 2013-2014 A. Lectures: 13-30 January (09:30-12:15 h) I. Form and function of the cardiovascular system (13-15 January) 13 January (09.30
The association of early risky behaviors and substance dependence and depression in an ethnically diverse sample
Washington University School of Medicine Digital Commons@Becker Posters 2010: Disentangling the Genetics of Alcoholism: Understanding Pathophysiology and Improving Treatment 2010 The association of early
Extracellular matrix Basic and translational science: Highlights of the congress
Extracellular matrix Basic and translational science: Highlights of the congress Stephane Heymans, Maastricht University Medical Centre, CARIM, Netherlands Speaker The extracellular matrix modulates cardiac
Myocardial Infarction
Myocardial Infarction MI = heart attack Defined as necrosis of heart muscle resulting from ischemia. A very significant cause of death worldwide. of these deaths, 33% -50% die before they can reach the
Qualitative and Quantitative Assessment of Perfusion
APCDE 2011 Qualitative and Quantitative Assessment of Perfusion Hyun Ju Yoon Chonnam National University Hospital Gwangju, Korea ISCHEMIC CASCADE Blood flow mismatch Perfusion defects on nuclear imaging,
Heart Failure with Preserved Ejection Fraction: Mechanisms and Management
Heart Failure with Preserved Ejection Fraction: Mechanisms and Management Jay N. Cohn, M.D. Professor of Medicine Director, Rasmussen Center for Cardiovascular Disease Prevention University of Minnesota
E10.5 E18.5 P2 10w 83w NF1 HF1. Sham ISO. Bmi1. H3K9me3. Lung weight (g)
Myociyte cross-sectional Relative mrna levels Relative levels Relative mrna levels Supplementary Figures and Legends a 8 6 4 2 Ezh2 E1.5 E18.5 P2 1w 83w b Ezh2 p16 amhc b-actin P2 43w kd 37 86 16 wt mouse
Postn MCM Smad2 fl/fl Postn MCM Smad3 fl/fl Postn MCM Smad2/3 fl/fl. Postn MCM. Tgfbr1/2 fl/fl TAC
A Smad2 fl/fl Smad3 fl/fl Smad2/3 fl/fl Tgfbr1/2 fl/fl 1. mm B Tcf21 MCM Tcf21 MCM Smad3 fl/fl Tcf21 MCM Smad2/3 fl/fl Tcf21 MCM Tgfbr1/2 fl/fl αmhc MCM C 1. mm 1. mm D Smad2 fl/fl Smad3 fl/fl Smad2/3
Challenging Issues in Cardiac Biomarker interpretation. F. Nikaeen. MD interventional Cardiologist
Challenging Issues in Cardiac Biomarker interpretation F. Nikaeen. MD interventional Cardiologist Biomarkers Types of Troponin Troponin C Binds calcium Troponin I Binds actin Troponin T Binds tropomyosin
Basic Mechanisms of Remote Ischemic Conditioning
Basic Mechanisms of Remote Ischemic Conditioning Rajesh K Kharbanda Oxford, GB ESC 2012. From Bench to Practice: Bridging the gap Mechanisms and Clinical use of Ischaemic Conditioning Disclosure Shareholder
Topically Applicable Stromal Cell Growth Factors - Encapsulated Cosmeceuticals
Topically Applicable Stromal Cell Growth Factors - Encapsulated Cosmeceuticals Stem cells move to injured area, differentiate into neighboring cells, and replace the damaged cells Cell Eons Stem cells
Devices are So Old School: The New World of Myocardial Regeneration
Devices are So Old School: The New World of Myocardial Regeneration Todd K. Rosengart, M.D. Professor and Chairman DeBakey-Bard Chair of Surgery Michael E. DeBakey Department of Surgery Professor, Texas
Nature Genetics: doi: /ng Supplementary Figure 1. Parameters and consequences of mononuclear cardiomyocyte frequency.
Supplementary Figure 1 Parameters and consequences of mononuclear cardiomyocyte frequency. (a) Correlation of the frequency of mononuclear cardiomyocytes to the frequency of cardiomyocytes with three or
MR Assessment of Myocardial Viability
MR Assessment of Myocardial Viability Definition of Viability Clinical Metabolism: Presence of glucose uptake Perfusion / Perfusion reserve Morphology: Wall thickness, wall thickening Contractility: Recovery
Alterations in cardiomyocyte function during diastolic heart failure
Alterations in cardiomyocyte function during diastolic heart failure Attila Borbély VUmc UDMHSC, Division of Clinical Physiology, Institute of Cardiology, Debrecen, Hungary Laboratory for Physiology, ICaR-VU
Coronary heart disease (CHD)
1 Coronary heart disease (CHD) 2 Institute of Pathological Physiology Martin Vokurka mvoku@lf1.cuni.cz Winter Semester 3 CORONARY CIRCULATION AND MYOCARDIAL METABOLISM 4 Blood flow: resting: 250 ml/min
I have no financial disclosures
Manpreet Singh MD I have no financial disclosures Exercise Treadmill Bicycle Functional capacity assessment Well validated prognostic value Ischemic assessment ECG changes ST segments Arrhythmias Hemodynamic
1) Severe, crushing substernal chest pain 2) radiate to the neck, jaw, epigastrium, or left arm. 3- rapid and weak pulse 4- nausea (posterior MI).
1) Severe, crushing substernal chest pain 2) radiate to the neck, jaw, epigastrium, or left arm. 3- rapid and weak pulse 4- nausea (posterior MI). 5- cardiogenic shock (massive MIs >40% of the left ventricle)
Inflammation in heart failure: biomarker, bystander or mediator
Inflammation in heart failure: biomarker, bystander or mediator Novel matricellular proteins to target Javier Díez, MD, PhD. Centre of Applied Medical Research and University Clinic School of Medicine,
Antifibrotic Therapy Delays Progression from Paroxysmal to Persistent Atrial Fibrillation
Antifibrotic Therapy Delays Progression from Paroxysmal to Persistent Atrial Fibrillation José Jalife, M.D. Center for Arrhythmia Research University of Michigan No Disclosures The mechanisms that maintain
J Jpn Coll Angiol, 2009, 49:
Online publication October 6, 2009 48 2 20 J Jpn Coll Angiol, 2009, 49: 293 297 atrial natriuretic peptide, brain natriuretic peptide, guanylyl cyclase-a receptor, cardiac remodeling, cardiac hypertrophy
Progression of atrial fibrillation: can we prevent it? Early catheter ablation will stop progression of atrial fibrillation pro
Progression of atrial fibrillation: can we prevent it? Early catheter ablation will stop progression of atrial fibrillation pro Jerónimo Farré MD, Madrid, ES AF: the kingdom of wishful thinking In AF we
Mast Cell Tryptase Modifies The Contraction Of Human Joint Capsule Cells In Vitro
Mast Cell Tryptase Modifies The Contraction Of Human Joint Capsule Cells In Vitro Kevin A. Hildebrand, MD 1, Lindsey M. Logan 1, Mei Zhang 1, David A. Hart, PhD 1, Paul T. Salo, MD 1, A. Dean Befus, PhD
Biomarkers in cardiovascular disease. Felix J. Rogers, DO, FACOI April 29, 2018
Biomarkers in cardiovascular disease Felix J. Rogers, DO, FACOI April 29, 2018 Biomarkers NIH: A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological
Am J Physiol Heart Circ Physiol 304: H1382 H1396, First published March 11, 2013; doi: /ajpheart
m J Physiol Heart Circ Physiol 34: H38 H396, 3. First published March, 3; doi:.5/ajpheart.63.. Low molecular weight fibroblast growth factor- signals via protein kinase C and myofibrillar proteins to protect
HYPERTENSION AND HEART FAILURE
HYPERTENSION AND HEART FAILURE Kenya Cardiac Society Symposium Feb 2017 Dr Jeilan Mohamed No conflict of interests . Geoffrey, 45 yr old hypertensive office worker male from Nairobi, has just watched his
Previous MI with no intervention
Previous MI with no intervention F. Mut, M. Beretta Nuclear Medicine Service, Asociacion Española Montevideo, Uruguay Clinical history Woman 68 y.o. Recent acute MI (3 weeks) with no intervention. Discharged
Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury
Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury Luigi Adamo,, Deepta Bhattacharya, Douglas L. Mann JCI Insight. 2018;3(11):e120137.. Research Article Cardiology
DOWNLOAD PDF CARDIAC REMODELING AND CELL DEATH IN HEART FAILURE
Chapter 1 : The fibrosis-cell death axis in heart failure Remodeling may be defined as changes in the morphology, structure, and function of the heart related to alterations in loading conditions and/or
Exercise in Adverse Cardiac Remodeling: of Mice and Men
Exercise in Adverse Cardiac Remodeling: of Mice and Men 17-01-2013 Dirk J Duncker Experimental Cardiology, Cardiology, Thoraxcenter Cardiovascular Research Institute COEUR Erasmus MC, University Medical
3/27/2014. Introduction.
Introduction. Myocardial perfusion & contractility becomes abnormal immediately after the onset of ischaemia, even before the development of the symptoms & ST segment changes. 1 Myocardial Wall Motion
Remodeling the failing heart: : the biology and future treatment options
Remodeling the failing heart: : the biology and future treatment options J-L Balligand (UCL-Brussels, BE) jl.balligand@uclouvain.be Myocardial remodeling: definitions phenotypic plasticity : remodeling
Medical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece
Medical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece Disclosures Grants: ALARM investigator received research grants
Ventricular tachycardia and ischemia. Martin Jan Schalij Department of Cardiology Leiden University Medical Center
Ventricular tachycardia and ischemia Martin Jan Schalij Department of Cardiology Leiden University Medical Center Disclosure: Research grants from: Boston Scientific Medtronic Biotronik Sudden Cardiac
Supporting Information. Calculation of the relative contributions of myocyte proliferation, stem cell. Supporting Information Fig 1 (page 9)
Supporting Information Table of contents Calculation of the relative contributions of myocyte proliferation, stem cell differentiation and cardioprotection (page 2) Supporting Information Fig 1 (page 9)
Pathophysiology of Coronary Microvascular Dysfunction
Pathophysiology of Coronary Microvascular Dysfunction Cheol Woong Yu, MD, PhD Cardiology Department Division of Internal Medicine Korea University Anam Hospital. Etiologies of Chest Pain without obstructive
9/23/2017. Prof. Steven S. Saliterman. Department of Biomedical Engineering, University of Minnesota
Department of Biomedical Engineering, University of Minnesota http://saliterman.umn.edu/ Murphy, S. V., and A. Atala. "3d Bioprinting of Tissues and Organs." Nature Biotechnology 32, no. 8 (Aug 2014):
Smoking in offspring of alcoholic twins
Washington University School of Medicine Digital Commons@Becker Posters 2006: Alcohol and Tobacco Dependence: from Bench to Bedside 2006 Smoking in offspring of alcoholic twins Jeffrey F. Scherrer Washington
Fibroblast Growth Factor-2 Regulates Myocardial Infarct Repair
The American Journal of Pathology, Vol. 171, No. 5, November 2007 Copyright American Society for Investigative Pathology DOI: 10.2353/ajpath.2007.070003 Cardiovascular, Pulmonary and Renal Pathology Fibroblast
Structural abnormalities of the heart and vascular system in CKD & Dialysis - Thick but weak
Structural abnormalities of the heart and vascular system in CKD & Dialysis - Thick but weak Kerstin Amann Nephropathology, Dept. of Pathology, University of Erlangen-Nürnberg Krankenhausstr. 8-10 91054
Preserved EF with heart failure (HF pef) 50% 5 year survival. Both have type 2 diabetes Both have hypertension Both have normal ejection fractions
Research companies Government / University research Preserved EF with heart failure (HF pef) 50% 5 year survival Both have type 2 diabetes Both have hypertension Both have normal ejection fractions Introduction
2228 FEBS Journal 280 (2013) ª 2013 The Authors Journal compilation ª 2013 FEBS
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart Mari
Qualifying Examination (Part I)
Department of Pharmacology Qualifying Examination (Part I) December 12 & 13, 2006 Please remember that this is a closed-book examination. You must be prepared to answer 4 of the 7 questions. Although not
European Society of Cardiology Congress DONOR AGE NEGATIVELY INFLUENCES THE CYTOPROTECTIVE PARACRINE EFFECTS EXERTED BY HUMAN MESENCHYMAL STEM CELLS
European Society of Cardiology Congress 28 Aug - 01 Sep 2009, Stockholm - Sweden DONOR AGE NEGATIVELY INFLUENCES THE CYTOPROTECTIVE PARACRINE EFFECTS EXERTED BY HUMAN MESENCHYMAL STEM CELLS Massimiliano
Tissue renewal and Repair. Nisamanee Charoenchon, PhD Department of Pathobiology, Faculty of Science
Tissue renewal and Repair Nisamanee Charoenchon, PhD Email: nisamanee.cha@mahidol.ac.th Department of Pathobiology, Faculty of Science Topic Objectives 1. Describe processes of tissue repair, regeneration
Cardiac MRI: Cardiomyopathy
Cardiac MRI: Cardiomyopathy Laura E. Heyneman, MD I do not have any relevant financial relationships with any commercial interests Cardiac MRI: Cardiomyopathy Laura E. Heyneman, MD Duke University Medical
IRB consortia as an approach to facilitating effective and efficient reviews
Washington University School of Medicine Digital Commons@Becker Human Research Protection Program (HRPP) Education Human Research Protection Office 2008 IRB consortia as an approach to facilitating effective
Molecular Basis of Cardioprotection by Erythropoietin
56 Current Molecular Pharmacology, 2009, 2, 56-69 Molecular Basis of Cardioprotection by Erythropoietin D. Burger 1, A. Xenocostas 2,3 and Q.P. Feng*,1,2,3 1 Department of Physiology and Pharmacology,
Martin G. Keane, MD, FASE Temple University School of Medicine
Martin G. Keane, MD, FASE Temple University School of Medicine Measurement of end-diastolic LV internal diameter (LVIDd) made by properly-oriented M-Mode techniques in the Parasternal Long Axis View (PLAX):
Prolactin and its cleaved 16-kDa subform. enhance myocardial injury after ischemia/reperfusion
Prolactin and its cleaved 16-kDa subform enhance myocardial injury after ischemia/reperfusion Hatice Yamac, Denise Hilfiker-Kleiner Department of Cardiology & Angiology Hannover, Medical School There is
Atrial fibrillation and stroke. Isabelle C Van Gelder University Medical Center Groningen The Netherlands
Atrial fibrillation and stroke Isabelle C Van Gelder University Medical Center Groningen The Netherlands ESC stroke council Prague January 2018 Content Stroke what is the problem for patients with AF?
Tcf21 MCM ; R26 mtmg Sham GFP Col 1/3 TAC 8W TAC 2W. Postn MCM ; R26 mtmg Sham GFP Col 1/3 TAC 8W TAC 2W
A Tcf21 MCM ; R26 mtmg Sham GFP Col 1/3 Tcf21 MCM ; R26 mtmg TAC 2W Tcf21 MCM ; R26 mtmg TAC 8W B Postn MCM ; R26 mtmg Sham GFP Col 1/3 Postn MCM ; R26 mtmg TAC 2W Postn MCM ; R26 mtmg TAC 8W Supplementary
Nox-Dependent Mechanisms of Cardiomyocyte Dysfunction in a Model of Pressure Overload
Nox-Dependent Mechanisms of Cardiomyocyte Dysfunction in a Model of Pressure Overload Giovanna Frazziano, PhD Vascular Medicine Institute Department of Pharmacology and Chemical Biology University of Pittsburgh
Australian children of alcoholic female twins
Washington University School of Medicine Digital Commons@Becker Posters 2005: Alcoholism and Comorbidity 2005 Australian children of alcoholic female twins Wendy S. Slutske Follow this and additional works
The Cardiovascular System and Aging- Is it Built to Fail?
The Cardiovascular System and Aging- Is it Built to Fail? Francis G. Spinale, MD, PhD Professor of Surgery and Cell Biology and Anatomy University of South Carolina School of Medicine Veterans Affairs
Ethical issues in human subjects research
Washington University School of Medicine Digital Commons@Becker Human Research Protection Program (HRPP) Education Human Research Protection Office 2004 Ethical issues in human subjects research Martha
Diastolic Heart Failure
Diastolic Heart Failure Presented by: Robert Roberts, M.D., FRCPC, MACC, FAHA, FRSC Professor of Medicine and Chair ISCTR University of Arizona, College of Medicine Phoenix Scientist Emeritus and Advisor,
Imaging of Coronary Artery Disease: II
Acta Radiológica Portuguesa, Vol.XIX, nº 74, pág. 45-51, Abr.-Jun., 2007 Imaging of Coronary Artery Disease: II Jean Jeudy University of Maryland School of Medicine Department of Diagnostic Radiology Armed
The relationship between adolescent/young adult BMI and subsequent non-problem and problem alcohol use
Washington University School of Medicine Digital Commons@Becker Posters 2007: Alcohol Use Across the Lifespan 2007 The relationship between adolescent/young adult BMI and subsequent non-problem and problem
Review of Cardiac Imaging Modalities in the Renal Patient. George Youssef
Review of Cardiac Imaging Modalities in the Renal Patient George Youssef ECHO Left ventricular hypertrophy (LVH) assessment Diastolic dysfunction Stress ECHO Cardiac CT angiography Echocardiography - positives
Top 10 Facts in Contrast Echocardiography. Pamela R. Burgess, BS, RDCS, RDMS, RVT, FASE
Top 10 Facts in Contrast Echocardiography Pamela R. Burgess, BS, RDCS, RDMS, RVT, FASE Presenter Disclosure The following relationship exist related to this presentation: Pamela R. Burgess, BS, RDCS, RDMS,
INNOVATION THAT REALLY MATTERS. Prof. Lina Badimon. Institut Català de Ciències Cardiovasculars (ICCC), Barcelona
INNOVATION THAT REALLY MATTERS Prof. Lina Badimon, Barcelona THE INSTITUTION THE INSTITUTION THE ICCC CATALAN INSTITUTE FOR CARDIOVASCULAR SCIENCE (ICCC) Objectives LEADING AN STRATEGIC PLANNING IN CVR
Getting the Most Out of Stress Echo
Getting the Most Out of Stress Echo Vera H. Rigolin, MD, FASE, FACC, FAHA Professor of Medicine Northwestern University Feinberg School of Medicine Medical Director, Echocardiography Laboratory Northwestern
Microvascular Disease: How to Diagnose and What s its Treatment
Microvascular Disease: How to Diagnose and What s its Treatment Laxmi S. Mehta, MD, FACC The Ohio State University Medical Center Assistant Professor of Clinical Internal Medicine Clinical Director of
Cells and reagents. Synaptopodin knockdown (1) and dynamin knockdown (2)
Supplemental Methods Cells and reagents. Synaptopodin knockdown (1) and dynamin knockdown (2) podocytes were cultured as described previously. Staurosporine, angiotensin II and actinomycin D were all obtained