SediVue Dx Urine Sediment Analyser. Fresh samples / Revolutionary technology / A new standard of care. The Complete Diagnostic Solution

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1 SediVue Dx Urine Sediment Analyser Fresh samples / Revolutionary technology / A new standard of care

2 SediVue Dx Urine Sediment Analyser Improving the standard of care Automation ensures consistent, accurate results from only 165 μl (4 5 drops) of urine. Examines the equivalent of 45 high-power fields in approximately 3 minutes to thoroughly analyse each sample. Leveraging cutting-edge convolutional neural network technology to identify and classify elements within the sediment. Produces high-resolution, high-contrast digital images from a fresh sample, for dependable results that can be shared in real time. Results for the most clinically relevant elements in canine and feline urine to support preventive, acute, and chronic care. Dimensions and weight Width: 32 cm (320 mm) Depth: 32 cm (320 mm) Height: 34 cm (340 mm) Weight: 15 kg

3 Powered by three cutting-edge technologies Conventional centrifugation 2,000 RCF* SediVue Dx Urine Sediment Analyser 260 RCF* Precision centrifugation for preservation of fragile structures The onboard gravitational centrifuge spins at a significantly lower force than most in-house centrifuges to preserve delicate casts. Spins for precisely 30 seconds to gently deposit formed elements into a monolayer at the bottom of the cartridge. Inverted microscopy for optimal evaluation of the monolayer Utilises the gold standard microscopy technique for urine sediment evaluation. Examines the equivalent of 45 high-power fields from beneath the sample to maximize visibility of clinically relevant elements. Captures 70 high-resolution images using the latest in high speed digital camera technology. Autofocuses on each shot for crisp images. Adjusts exposure with each image to ensure optimal contrast. Convolutional neural network for the identification of elements This artificial intelligence is specially calibrated to identify, classify and count the elements present in each sample. Uses a proprietary image processing algorithm similar to facial recognition software. Trained for consistent and sensitive recognition of clinically relevant particles, and to discern them from debris. The algorithm prioritises the images based on the medical importance of the formed elements observed. *Relative centrifugal force.

4 Results for most clinically relevant elements Cells Bacteria Casts Crystals Blood cells Red blood cells (RBCs) White blood cells (WBCs) Epithelial cells Squamous (originating from the distral urethra or beyond) Nonsquamous (originating from locations above and including the bladder e.g. Transitional cells) Rods Cocci Hyaline Nonhyaline (e.g., cellular casts, granular casts) Struvite (coffin lids) Calcium oxalate dihydrate (Scottish flags) Unclassified (all other crystals) High-resolution, high-contrast images with tools for enhanced viewing Zoom in and out for a more detailed view of elements. Tagging can be turned on as required to help identify cells, casts and crystals.

5 Perform all 3 parts of a Complete Urinalysis faster and with greater accuracy than ever before With IDEXX all this happens in 3 minutes Sediment analysis with SediVue Dx Chemical analysis with VetLab UA Analyser Pipette 165 μl urine 2 mins Dispense urine onto IDEXX UA strip. Insert strip in IDEXX VetLab UA Analyser. Press start button and walk away 3 mins Dispense sample Physical analysis conducted as normal Enter physical findings in the IDEXX VetLab station Press start button and walk away 1 min Identify when deeper insights are needed. Confidently send away for specialised testing. IDEXX SDMA IDEXX Advantage programs Rapid & Accurate Microbiology *Times indicated above are a guide only and are representative for the analysis of a typical sample.

6 A smart solution for challenging samples SediVue Dx automatically generates alerts and messages to prompt further review or action when samples are overcrowded or include suspect elements. Examples of sample dilution messages Overlapping cells, crystals, or debris. Examples of bacteria messages Review images to classify elements. Re-run using equal parts sample:diluent Review images to confirm bacteria visually Review images to confirm bacteria visually IDEXX Support Our customer support team are available to answer any questions related to your results, simply call (option 2, option 2). Our professional services team are available to provide written or verbal interpretation of results, simply call to find out more.

7 Offering diagnostic insights in real-time Providing evidence for pet owners and opportunities for consensus Here are some real world examples of how the SediVue Dx has enhanced clinical investigations. Observed elements in the sediment using the SediVue Dx What was the outcome facilitated by the SediVue Dx analysis? Red blood cells, white blood cells, and bacteria rods Confirmed urinary tract infection even before the patient exhibited clinical signs. Calcium oxalate dihydrate crystals Alerted to the possibility of kidney stones, triggering an ultrasound. The presence of uroliths on ultrasound determined that surgical removal was necessary. Numerous casts Identified kidney injury and a follow up with an IDEXX SDMA test and UPC. Nonsquamous epithelial cells Follow up with stained, cytological slide preparation and further classified cells as transitional cell carcinoma.

8 - AUS Integrated solutions for better medicine and an enhanced client experience Timely analysis of a fresh sample is the GOLD Standard, and only IDEXX delivers lab based technology for an accurate and comprehensive patient report in 15 minutes. Client: Hunt, Tina (23189) Patient Name: Kaiser Species: Canine Breed: German Shepherd Gender: Male / Castrated Weight: 35kg Age: 8 years Doctor: Smith, Susan Avenue Veterinary Hospital 12 The Avenue, Sydney NSW 2000 Test Results Reference Interval LOW NORMAL HIGH LaserCyte 14/05/2010 3:57 PM 1/12/2009 1:11 PM RBC HCT HGB MCV MCH MCHC RDW %RETIC RETIC WBC %NEU %LYM %MONO %EOS %BASO NEU LYM MONO EOS BASO PLT MPV PDW PCT 4.09 x10^12/l LOW 29.2 % LOW 8.9 g/dl LOW 71.4 fl pg 30.5 g/dl 19.2 % HIGH 3.6 % K/μL x10^9/l HIGH 80.8 % 3.3 % 15.3 % 0.3 % 0.3 % x10^9/l HIGH 0.84 x10^9/l 3.89 x10^9/l HIGH 0.08 x10^9/l LOW 0.08 x10^9/l 120 K/μL LOW fl 19.3 % 0.3 % ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) Catalyst Dx 14/05/2010 3:57 PM 1/12/2009 1:11 PM GLU BUN CREA PHOS BUN/CREA Ca TP ALB GLOB ALB/GLOB ALT ALKP GGT TBIL CHOL AMYL LIPA 6.10 mmol/l 8.9 mmol/l 150 μmol/l 2.10 mmol/l mmol/l 55 g/l 23 g/l 32 g/l U/L 480 U/L 10 U/L 8.6 μmol/l 6.63 mmol/l 707 U/L 365 U/L HIGH HIGH HIGH ( ) ( ) (44 159) ( ) ( ) (52 82) (23 40) (25 45) (10 100) (23 212) (0 7) ( ) ( ) ( ) ( ) Integrated patient report Comprehensive Chemistry Analysis with TT4 A CBC with absolute reticulocyte count Urine sediment analysis Urine chemistry analysis Physical analysis of the urine minutes minutes minutes minutes minute

9 Connected solutions to support your clinical decision making IDEXX VetConnect PLUS provides quick and convenient access to all your diagnostic information for a timely, informed, and confident assessment of patient health. Stay up to date on every case for better patient care and more responsive client service The personalized IDEXX VetConnect PLUS mobile app for iphone or Android devices instantly alerts you when a patient s results are available. Quickly and easily access complete diagnostic information anytime, anywhere. View combined historical diagnostic results anywhere, anytime Easily access digital images and results from IDEXX inhouse analysers and IDEXX SNAP point-of-care tests as well as diagnostic test results and pathology imaging results from IDEXX Reference Laboratories. Quickly spot abnormalities with easy-tointerpret images, graphs, and side-by-side past and current diagnostic result comparisons Simply share a patient s diagnostic results with other practices, specialists or your clients Easily link patients results with other practices and/or referring specialists.

10 The SediVue Dx enables the minimum database to be obtained within the consult period A full chemistry profile including electrolytes, a complete blood count (CBC), and a complete urinalysis (physical examination, chemical examination, and sediment examination) should be part of the minimum database for a wide range of signalments and preventive care cases. A complete urinalysis (physical examination, chemical examination, and sediment examination) provides insight that a blood chemistry or CBC alone may miss. That s why a complete urinalysis is a valuable diagnostic for patients.

11 For general information about anaemia, dehydration, inflammation and infection. For specific information about the underlying health of the kidney, liver and pancreas. Complete Blood Count Modern Chemistry Panel Complete Urinalysis Disease Specific Tests For assessment of kidneys and urinary tract. For accurate interpretation of Complete Blood Count, Chemistry and Electrolytes. For critical information about the metabolic status of the patient.

12 IDEXX Laboratories Pty Ltd. Unit 6 / South St Rydalmere NSW IDEXX Laboratories, Inc. All rights reserved iphone is a trademark of Apple Inc., registered in the United States and other countries. Android is a trademark of Google Inc. All other /TM marks are owned by IDEXX Laboratories, Inc. or its affiliates in the United States and/or other countries. The IDEXX Privacy Policy is available at idexx.com.

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