ACB Bio-Chelate 5 PF. Skin & Hair Conditioning, Nourishing. Tomorrow s Vision Today!

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1 ACB Bio-Chelate 5 PF Skin & Hair Conditioning, Nourishing Tomorrow s Vision Today!

2 ACB Bio-Chelate 5 PF Technical Information Product Code: 20339PF INCI Name: Water & Saccharomyces/Zinc Ferment & Saccharomyces/Copper Ferment & Saccharomyces/Magnesium Ferment & Saccharomyces/Iron Ferment & Saccharomyces/Silicone Ferment INCI Status: Conforms Suggested Use Level: % Suggested Applications: Skin & Hair Conditioning, Nourishing

3 Minerals: Skin & Hair Care A growing trend! o Improve the appearance of the skin: o Damage o Inflammation o Wrinkles o Vitamins & minerals are perceived as health promoters by consumers Stress depletes nutrients

4 Minerals: Skin & Hair Care Minerals Just like vitamins, they play a key role in overall health Are constituents of the hair, bones, teeth, muscle, blood, soft tissues & nerve cells Minerals have many functions: Zinc Enzymatic activity, antioxidant, wound healing, protein synthesis, cellular function Copper Cofactor, utilization of iron, elastin, keratin, enzymatic activities

5 Minerals: Skin & Hair Care Magnesium Fatty acid & Vitamin C metabolism, neuromuscular activity Iron Helps red blood cells deliver oxygen, support the immune system, required for energy production, protein formation & cell maturation Silicon Protein matrix construction, structure of connective tissue, bone development

6 ACB Bio-Chelate 5 PF: What is it? A mineral glycopeptide complex containing 5 essential minerals, which are fermented with yeast Consisting of: Zinc Copper Magnesium Iron Silicon

7 ACB Bio-Chelate 5 PF: Why Fermented Minerals? Compared to inorganic salts & synthetically chelated minerals, fermented minerals have increased bio-availability Cells can recognize & use the minerals Enhances efficacy Coincides with trend for natural ingredients

8 ACB Bio-Chelate 5 PF: Benefits to the skin? Enhances Barrier Function Provides Anti-Inflammatory Effect Increases Growth Factor Expression Decreases Stress Related Factors Increases Cellular Energy Production

9 ACB Bio-Chelate 5 PF: Benefits to the hair & scalp? Smoothes the cuticle of physically & chemically damaged hair Research demonstrates minerals penetrate deep into the hair Does not create buildup that weights hair down Increases hydration to minimize dryness, which can cause flaking Enhances health of the scalp

10 In-vivo Efficacy Data: ACB Bio-Chelate 5 PF Hair Smoothing Properties 1. European blonde hair tresses were damaged by a 2X-bleach/wave process 2. Individual hair fibers were cut into equal halves to produce six hair strands. Three hair strands function as the test materials & the remaining three functioned as controls 3. The three damaged test fibers were treated with 100% ACB Bio- Chelate 5 PF & allowed to dry 4. Scanning Electron Microscopy (SEM) was utilized to observe the surface architecture of the hair strands

11 In-vivo Efficacy Data: ACB Bio-Chelate 5 PF Hair Smoothing Properties Results Scan Electron Microscopy images illustrate the smoothing benefits of ACB Bio-Chelate 5 PF on the hair shaft The images on the right appear significantly smoother & healthier SEM results indicate that ACB Bio- Chelate 5 PF can smooth the cuticle of physically & chemically damaged hair

12 Percent (%) Difference Between Sites/ Materials Tested In-vitro Efficacy Data: ACB Bio-Chelate 5 PF Skin Density Comparison 16.00% 14.00% 12.00% 10.00% 8.00% 6.00% 4.00% 2.00% 0.00% t = 24 1 week 2 week 3 week 4 week Experimental vs. Untreated Base Lotion vs. Untreated Experimental vs. Base Lotion Figure 1: Improvements in skin density following application of the test materials after a period of 3 weeks. Protocol Equipment: DermaLab Combo Principle of measurement: Ultrasound Probe Subjects: 10 (m/f) Test area: Volar forearms Concentration of active used: 2.0% Frequency of application: Twice Daily

13 Antioxidant Capacity µmte) In-vitro Efficacy Data: ACB Bio-Chelate 5 PF ORAC Assay 101 Protocol Trolox was used as the positive control Solutions were prepared at two concentrations, as a reference 60 Florescent measurements were taken every 2 minutes for 2 hours ACB Bio-Chelate 5 PF showed antioxidant activity 0 100µM Trolox 12.5µM Trolox 0.5% ACB Bio- Chelate 5 PF 0.1% ACB Bio- Chelate 5 PF 0.05% ACB Bio- Chelate 5 PF Figure 2. Antioxidant capacity of ACB Bio-Chelate 5 PF.

14 In-vitro Efficacy Data: ACB Bio-Chelate 5 PF DNA Microarray Monitors expression levels of thousands of genes simultaneously Each spot contains a unique DNA fragment with a known sequence Labeled mrna from the test sample binds to the spot containing its homologous DNA fragment Results DNA Microarray had 21,629 different DNA fractions Results illustrated that 1,155 genes were altered by more than 30% 591 genes were down-regulated 564 genes were up-regulated Conditions: 24 hour exposure to 5.0% ACB Bio-Chelate 5 PF in water

15 IL-6 Concentration (pg/ml) In-vitro Efficacy Data: ACB Bio-Chelate 5 PF IL-6 ELISA Analysis ACB Bio-Chelate 5 IL-6 ELISA % ACB Bio-Chelate 5 0.1% ACB Bio-Chelate % ACB Bio-Chelate Positive Control Negative Control Figure 1: ACB Bio-Chelate 5-treated fibroblasts IL-6 concentrations Protocol Analysis was conducted to assess the changes in IL-6 levels in ACB Bio-Chelate 5-treated in vitro cultured human dermal fibroblasts Human dermal fibroblasts were seeded into 12-well tissue culture plates Concentrations: 0.01%, 0.1%, and 1.0% ACB Bio-Chelate 5-exhibited antiinflammatory effects on LPS-treated fibroblasts Changes in IL-6 production using ACB Bio-Chelate 5 appears to be dose dependent

16 In-vitro Efficacy Data: ACB Bio-Chelate 5 PF DNA Microarray Benefits Enhances barrier function Provides anti-inflammatory effects Increases growth factor expression Decreases stress related factors Improves cellular energy production

17 ACB Bio-Chelate 5 PF Additional Data Dermal and Ocular Irritation Tests: Non-Irritating RIPT: Non-Primary Irritant and Non-Primary Sensitizer

18 ACB Bio-Chelate 5 PF Technical Information Product Code: 20339PF INCI Name: Water & Saccharomyces/Zinc Ferment & Saccharomyces/Copper Ferment & Saccharomyces/Magnesium Ferment & Saccharomyces/Iron Ferment & Saccharomyces/Silicone Ferment INCI Status: Conforms Suggested Use Level: % Suggested Applications: Skin & Hair Conditioning, Nourishing

19 ACB Bio-Chelate 5 PF THANK YOU For more information Visit our website!