AC Cinnamon Liposome Skin Brightening + Natural Skin Lightener + Antioxidant. Tomorrow s Vision Today!

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1 AC Cinnamon Liposome Skin Brightening + Natural Skin Lightener + Antioxidant Tomorrow s Vision Today!

2 AC Cinnamon Liposome Technical Information: Code: INCI Name: Water & Cinnamomum Cassia Bark Extract & Phospholipids Status: Conforms Suggested Use Levels: % Suggested Applications: Evens Skin Tone, Skin Lightening, Antioxidant, Enhanced Delivery

3 Cinnamomum Cassia Bark Facts: Chinese cinnamon from the bark of the evergreen tree, Cinnamomum cassia, is used widely in Chinese medicine Anti-inflammatory agent Reduces blood sugar levels Contains phytocompounds capable of evening skin tone Potent antioxidant activity Rich in vitamins & minerals Ascorbic Acid Beta Carotene Calcium Iron Magnesium

4 Enhanced Delivery Liposome: Small unilamellar vessicle Exceptional stability High shear processing Smaller, more uniform particle size o < 300nm Enhanced delivery to the skin

5 AC Cinnamon Liposome AC Cinnamon Liposome is Cinnamomum cassia bark extract encapsulated into a liposome to potientate its benefits Cinnamomum cassia bark extract was found to contains two powerful natural components: o Linderanolide B o Subamolide A These components are capable of chelating copper atoms Copper is chelated, therefore, preventing tyrosinase activity Without tyrosinase, melanogenesis can not be initiated

6 Natural Skin Brightener Tyrosinase: Melanin is responsible for skin pigmentation Tyrosinase is needed for melanin production o Enzyme involved in melanogenesis Copper is a cofactor of tyrosinase & is required for its catalytic activity Copper atoms interact with oxygen to form a highly reactive intermediate to oxidize the reaction of melanogenesis

7 Natural Skin Brightener Tyrosinase + Copper: The structure reveals hydrophobic pockets adjoining the copper active sites Linderanolide B and Subamolide A, components of Cinnamomum cassia bark, interact with catalytic copper The interaction between these components and copper limits tyrosinase activity

8 Melanogenesis Tyrosine is converted to (DOPA) Tyrosinase acts as the catalyst needed for the reaction to occur Melanin is produced in one of two ways: o Oxidation o Polymerization

9 Oxygen + Melanogenesis Melanin synthesis is an oxygen dependent pathway Tyrosinase carries out the oxidation of phenols, such as tyrosine, to activate melanogenesis Melanogenesis is accompanied by an increased production of reactive oxidative species (ROS)

10 Antioxidant Concentration (μmte) AC Cinnamon Liposome Efficacy Assay Results ORAC Assay: Protocol Trolox was used as the positive control Solutions were prepared at three concentrations μM Trolox μM Trolox 0.50% AC Cinnamon Liposome Results: AC Cinnamon Liposome exhibits antioxidant properties in a dose dependent fashion % AC Cinnamon Liposome % AC Cinnamon Liposome Fluorescent measurements were taken every two minutes for two hours AC Cinnamon Liposome showed antioxidant activity in concentrations as low as 0.05%

11 Percent (%) Inhibition AC Cinnamon Liposome Efficacy Assay Results Tyrosinase Inhibition: Protocol Studies were conducted on isolated mushroom tyrosinase UV-visible Spectrophotometry was used to measure absorbance after treatment of AC Cinnamon Liposome & Kojic Acid % Kojic Acid 2.00% AC Cinnamon Liposome 5.00% AC Cinnamon Liposome Results: 2.00% AC Cinnamon Liposome inhibits tyrosinase activity by 40.60% and 5.00% AC Cinnamon Liposome inhibits tyrosinase activity by 65.40% Kojic Acid acted as the positive control

12 AC Cinnamon Liposome Efficacy Assay Results in-vivo Skin Lightening Study: Protocol 5 (M/F) volunteers between the ages of 24 and 33 years old Volunteers applied 2.00mg of a base lotion containing 2.00% AC Cinnamon Liposome to their volar forearms twice daily for 14 days Equipment: DermaLab Combo Skin Lab (color detecting chip) equipped with a pigmentation probe Two high intensity white LED lights provide illumination, and the probes color sensor records readings Calculates the melanin index to provide pigmentation level & reaction to irritants Melanin value is measured as an index. The higher the index, the higher the pigmentation level

13 Percent (%) Decrease AC Cinnamon Liposome Efficacy Assay Results Changes in Melanin: Day 3 Day 7 Day 14 AC Cinnamon Liposome compared to untreated control AC Cinnamon Liposome compared to base cream Results: 2.00% AC Cinnamon Liposome has significant impact on melanin levels AC Cinnamon Liposome reduced melanin levels by 10.00% compared to the untreated control AC Cinnamon Liposome reduced melanin levels by 12.00% compared to the base cream

14 Benefits Lightens Evens skin tone Illuminates complexion Potent Antioxidant Novel Approach Capitalizes on the combination of copper sequestration and competitive inhibition within the oxidative steps of melanogenesis Enhances delivery

15 AC Cinnamon Liposome Technical Information: Code: INCI Name: Water & Cinnamomum Cassia Bark Extract & Phospholipids Status: Conforms Suggested Use Levels: % Suggested Applications: Evens Skin Tone, Skin Lightening, Antioxidant, Enhanced Delivery