Dear Colleague, Ravindra L Mehta, MBBS MD DM FACP FRCP(UK) Chairman, Organizing Committee

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2 Dear Colleague, I would like to invite you to join us for the upcoming 18th International Conference on Continuous Renal Replacement Therapies. The CRRT Conference continues to provide a comprehensive coverage of the rapidly developing field of Critical Care Nephrology and CRRT. It highlights the recent advances in our understanding of pathophysiology of critical illness, acute kidney injury, emerging strategies in the management of sepsis, multiorgan failure, development and use of biomarkers, technical advances in CRRT and the appropriate utilization of these techniques. This year's program presents exciting new developments and evidence for hemodynamic monitoring, fluid management, dialysis timing, and extracorporeal support for critically ill patients. A mix of invited lectures, pro-con debates, interactive workshops, tutorials, poster sessions and panel discussions are planned to continue the tradition of multidisciplinary interactions. Again this year we are offering a Pre-Conference AKI Symposium titled: Changing Paradigms in Acute Kidney Injury: From Mechanism to Management. The workshop will provide a comprehensive review of the most recent developments in the field. Topics include, mechanisms, pathways of AKI and its effects on other organs, biomarkers and their applications and the findings from the recent clinical trials. We hope that this course will provide participants an opportunity to interact with experts in the field and emerge with a better understanding of this rapidly evolving area Conference Topic Highlights: Meet The Expert Sessions Interact and Learn from Experts on How to Evaluate and Manage ICU Patients with Difficult Clinical Problems. Organ Dysfunction in the Critically Ill Patient Emerging Concepts in Organ Cross-talk, Sepsis, Microcirculation & Oxidative Stress, Infections Raising Awareness of Acute Kidney Injury (AKI) Pathophysiology, Microcirculation, Mechanisms of Injury and Repair, Biomarkers Targets for Early Intervention, Risk Assessment, Early Recognition and Response, Long Term Outcomes Controversies in Management of the Critically Ill Patient Fluid Management, Risk Stratification, Non-Invasive Monitoring, Blood gas and Electrolyte Disorders, End-Of Life Care Challenges and Controversies in Renal Support & CRRT When to Start and Stop, What Dose of Dialysis, Fluid Management, Type of Anticoagulant, Pharmacokinetics of Antimicrobials, Nutritional Support, Quality Measures, New Techniques, Acid Base Problems, Intradialytic Hypotension Biomarkers for Management of Critically Ill Patients Risk Stratification, Surveillance, Diagnosis, Targeted Intervention and Prognosis Special Sessions for Nurses and Allied Personnel Competency Assessment, Ethical Dilemmas and End of Life Care Special Pre Conference Sympoisum and Workshops Fundamentals of CRRT, Emerging Research in AKI, Hands On training for CRRT Devices, Pediatric Hands-On Workshop, Hemodynamic Monitoring A special focus this year is on rasing awareness of AKI worldwide to correspond with the theme for World Kidney Day. A dedicated plenary session and a workshop will explore the dimension of the problem and offer tools to educate caregivers, patients about this devastating illness. As always, we hope to provide the right environment to foster learning and mutually beneficial communications and collaborations. We hope that you will join us to share your knowledge and experience as it is through multidisciplinary interactions that we will gain a better understanding of critical illness and it is only through our collective efforts that we will improve the lives of our patients. We look forward to welcoming you to San Diego for the eighteenth time. Ravindra L Mehta, MBBS MD DM FACP FRCP(UK) Chairman, Organizing Committee

3 EIGHTEENTH INTERNATIONAL CONFERENCE ON CONTINUOUS RENAL REPLACEMENT THERAPIES CRRT 2013 Endorsed by The International Society of Nephrology Acute Kidney Injury Network ORGANIZING COMMITTEE (partial list) CHAIRMAN Ravindra L. Mehta, MBBS, MD, DM, FACP, FRCP(UK) USA Steven R. Alexander, MD Linda Awdishu, PharmD Jorge Cerda, MD, FACP, FASN Stuart Goldstein, MD Thomas A. Golper, MD John Kellum, MD Eileen Lischer, MA, BSN, RN, CNN Bruce Mueller, PharmD, FCCP Emil P. Paganini, MD, FACP, FRCP David M. Ward, MD, FRCP CANADA Noel Gibney, MD SOUTH AMERICA Emmanuel Burdmann, MD, PhD EUROPE Andrew Davenport, MD, FRCP Patrick Honore, MD Claudio Ronco, MD Miet Schetz, MD, PhD JAPAN Hiroyuki Hirasawa, MD, PhD Kazo Kaizu, MD INDIA Rajasekara Chakravarthi, MD, DNB IMPORTANT CONFERENCE DATES Abstract Submission (see page 7) Open Online Registration Begins November 1, 2012 Deadline for Receipt of Abstracts (see page 7) December 7, 2012 Notification of Abstract Acceptance January 8, 2013 Postmark/Online Deadline for Early Bird Registration January 4, 2013 Hotel Reservation Deadline January 23, 2013 On-site Registration Fees Begin February 8, 2013 Poster Mounting and Viewing February 12, 2013 Conference and Standard Workshop Sessions February 12-15, 2013 Pre-Conference AKI Workshop (Tuesday) - PW1 (see page 4) February 12, 2013 Elective Workshops (Tuesday) - HW1& HW2, HW3 & HW4 (see page 4) February 12,

4 Anupam Agarwal, MD DM Univ of Alabama Birmingham AL USA Steven R. Alexander, MD Stanford University Medical Center Stanford, CA USA Amelia Allsteadt, BSN RN CNN Texas Childrens Hospital Richmond, TX USA David Askenazi, MD Children's Hospital Birmingham, AL USA Saima Aslam, MD University of California, San Diego San Diego, CA USA Linda Awdishu, MD University of California, San Diego San Diego, CA USA Sean M Bagshaw, MD MSc FRCPC University of Alberta Edmonton, CANADA Rajit Basu, MD Cincinnati Children's Hospital Medical Center Cincinnati, OH USA Josee Bouchard, MD University of Montreal Montreal, Quebec CANADA Emmanuel Burdmann, MD PhD University of São Paulo São Paulo BRAZIL Jorge Cerda, MD FACP FASN Albany Medical College & Capital District Renal Physicians Albany, NY USA Lakhmir S. Chawla, MD George Washington University Medical Center Washington DC USA William R. Clark, MD Indiana University School of Medicine Indianapolis, IN USA Rolando Claure, MD UCSD Medical Center San Diego, CA USA Dinna Cruz, MD, MPH UCSD Medical Center San Diego, CA USA Helen Currier, BSN RN CNN Texas Children's Hospital Houston, TX USA Andrew Davenport, MD FRCP Royal Free Hospital London, ENGLAND (UK) Geoffrey Fleming, MD Monroe Carell Jr Children's Hospital Nashville, TN USA FACULTY (partial List) Noel Gibney, MD University of Alberta Edmonton, AB CANADA Robert Gish, MD University of California, San Diego San Diego, CA USA Stuart L. Goldstein, MD University of Cincinnati College of Medicine Cincinnati, OH USA Thomas A. Golper, MD Vanderbilt University Medical Center Nashville, TN USA Patricia Graham, MS RN CCRN CS UCSD Medical Center San Diego, CA USA Hiroyuki Hirasawa, MD Chiba University Graduate School of Medicine Chiba JAPAN Patrick M. Honoré, MD ICU Consultant Leuven, BELGIUM Can Ince, PhD University of Amsterdam Amsterdam, The NETHERLANDs Rajiv Jalan, MD, PhD University College London London, UK Luis Juncos, MD University of Mississippi Jackson, MS USA Kazou Kaizu, MD Yokohama Chuo Hospital Yokohama JAPAN Kianoush Kashani, MD Mayo Clinic Rochester, MN USA John A. Kellum, MD University of Pittsburgh Pittsburgh, PA USA Andrew Lewington, MD Leeds Teaching Hospitals, NHS Trust Leeds UK Eileen Lischer, MA BSN RN CNN UCSD Medical Center San Diego, CA USA Etienne Macedo, MD University of São Paulo São Paulo BRAZIL William Macias, MD, PhD Eli Lilly and Company Indianapolis, IN USA Ravindra L. Mehta, MD FACP University of California, San Diego San Diego, CA USA Bruce Molitoris, MD University of Indiana Indianapolis, IN USA Jolyn Morgan, RN CDN Cincinnati Children's Hospital Cincinnati, OH USA Theresa Mottes, RN CDN Cincinnati Children's Hospital Cincinnati, OH USA Bruce A. Mueller, PharmD FCCP University of Michigan, University Hospital Ann Arbor, MI USA Mark Okusa, MD University of Virginia Charlottesville, VA USA Emil P. Paganini, MD FACP FRCP Cleveland Clinic Foundation Chesterland, OH USA Alisa Palazzolo, BSN, RN Cincinnati Children's Hospital Cincinnati, OH USA Claudio Ronco, MD St. Bortolo Hospital Vicenza ITALY Mitchell H. Rosner, MD FACP University of Virginia Health System Charlottesville, VA USA Miet Schetz, MD, PhD University Hospital Gasthuisberg Leuven BELGIUM Andrew D. Shaw, MD FRCA FCCM Duke University Durham, NC USA Scott Sutherland, MD Stanford University Medical Center Stanford, CA United States Jordan Symons, MD Seattle Children's Hospital Seattle, WA USA Ashita Tolwani, MD University of Alabama at Birmingham Birmingham, AL USA David Ward, MD University of California, San Diego San Diego, CA USA Martin Westphal, MD, PhD University Hospital of Muenster Muenster, GERMANY FACULTY DISCLOSURE STATEMENT It is the policy of the University of California, San Diego School of Medicine to ensure balance, independence, objectivity and scientific rigor. All persons involved in the selection, development and presentation of content are required to disclose any real or apparent conflicts of interest. All conflicts of interest will be resolved prior to an educational activity being delivered to learners through one of the following mechanisms 1) altering the financial relationship with the commercial interest, 2) altering the individual s control over CME content about the products or services of the commercial interest, and/or 3) validating the activity content through independent peer review. All persons are also required to disclose any discussions of off label/unapproved uses of drugs or devices. Persons who refuse or fail to disclose are disqualified from participating in the CME activity. Participants will be asked to evaluate whether the speaker s outside interests reflect a possible bias in the planning or presentation of the activity. This information is used to plan future activities. 2

5 Visit the conference website for the most current program information, abstract submission, online registration and online hotel reservations. CONFERENCE DATES AND LOCATION The inclusive dates for all scientific sessions of the EIGHTEENTH INTERNATIONAL CONFERENCE ON RENAL REPLACEMENT THERAPIES (CRRT 2013) are February 12-15, There will be elective workshops held on Tuesday, February 12. The Conference will be held at the Hilton San Diego Bayfront, 1 Park Boulevard, San Diego, California, USA 92101, Tel: , Fax: Online Reservations are available directly with the hotel. Please use the Hotel Reservations link on the conference website for reservations and more information about the hotel. Group reservations of 5 or more hotel rooms need to contact the conference administration directly at REGISTRATION INFORMATION Please visit our website to register (online registration required), worksheet provided on page 16. All participants must register and pay the appropriate fee. Fee includes access to all Plenary Sessions, Standard Workshops, Exhibit Area, Welcome Reception & Poster Sessions (Tue.), Exhibit Reception (Wed.), CME Accreditation, Conference Syllabus on digital media, Two Lunches (Wed. & Thur.), Continental Breakfasts (Thur. & Fri.) and all conference coffee breaks. Conference Registration Fee DOES NOT include Elective Workshops on Tuesday. (see page 4 for list). Poster Viewing will begin on Tuesday evening February 12, Registration will begin on the evening of Monday, February 11, For additional registration times see the program. REGISTRATION FEES Early Bird Pre-Registration On-Site Registration On or before Jan. 7, 2013 thru Feb. 10 thru Jan. 6, 2013 Feb. 9, 2013 Feb. 15, 2013 Physicians/Other (MD, PhD, etc.) $ 675 $ 740 $ 795 With Multimedia Package $ 875 $ 940 $ 995 Nurses/Dieticians/ Pharmacists/Residents*/Fellows* $ 480 $ 550 $ 595 With Multimedia Package $ 680 $ 750 $ 795 Industry $ 675 $ 740 $ 795 With Multimedia Package $ 875 $ 940 $ 995 *with letter of verification from department head GENERAL INFORMATION ONLINE MULTIMEDIA PRESENTATIONS $200 (with registration) Again in 2013 we will capture PLENARY SESSIONS and selected STANDARD WORK- SHOPS for post-conference viewing online. Add this package to your registration to review presentations in a state-of-the-art format that includes streaming audio and video, and synchronized slides. Make this purchase when registering for the conference online and SAVE significantly over post-conference purchase of individual plenary sessions and workshops. Please visit the conference website for details regarding the presentation list, free demo lecture and purchase details. AKI Pre Conference Symposium & Fundamentals Workshops also available! GUEST FEE $185 Includes: Access to Exhibit Area, Welcome Reception (Tuesday), Exhibit Reception (Wednesday) and two Lunches (Wednesday & Thursday). Guests are not admitted to the General Sessions or Workshops. 3 General Information continues on following page

6 ELECTIVES (CME Available) PRE-CONFERENCE AKI SYMPOSIUM Sponsored by UAB/UCSD O Brien Center for AKI Research TUESDAY - Full Day (limited enrollment, see page 8 for schedule) $260* A full online mulitmedia review of this symposium is available to attendees for an additional $125 See website for details! CRRT Conference Attendance is NOT Required for this Symposium* PW1: Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management Tuesday, February 12 8:00am-5:30pm (includes lunch, AM & PM breaks) Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding the mechanisms and pathways of AKI and its effects on other organs. Recent identification of biomarkers has provided new tools and techniques to characterize this disorder, This pre-course will provide a comprehensive review of the most recent developments in the field and describe emerging knowledge from basic and translational research applicable to clinical care. * A $30 discount will be given to attendees that register for the CRRT Conference. To receive the discount you must sign up for this symposium at the same time you register for the conference (valid for full price registrations only.) CONFERENCE ELECTIVE WORKSHOPS TUESDAY - Full Day Elective Workshop (limited enrollment, see page 9 for schedule) $185 A full online mulitmedia review of this workshop is available to attendees for an additional $125 See website for details! HW1: Fundamentals of CRRT 8:00am-5:30pm (includes 12:30 lunch, AM & PM breaks) This workshop offers an introduction to CRRT techniques and is developed to provide a core set of information on the principles and practice of CRRT. This workshop will cover the components and basic principles of continuous renal replacement therapy. The operating characteristics of CRRT techniques for solute and fluid management, drug management will be discussed along with the potential applications of these techniques. Requirements for developing a successful CRRT program and selecting machines will also be described. TUESDAY - Half Day Elective Workshops (limited enrollment) $120 10:30am-3:30pm (both include 12:30 lunch) HW2: Pediatric Hands-On Workshop This workshop will focus upon the practical aspects of care including clinical program development, discussion of various models of ICU and Nephrology medical nursing care and hands on machine setup and operation. HW3: Hemodynamic Monitoring and Use of Drugs Critically ill Patients require frequent assessments and monitoring of hemodynamic and respiratory parameters to optimize stability and guide ventilator support. Several techniques are now available and utilized to manage patients including devices to assess the microcirculation, volume responsiveness and cardiac performance. This workshop will cover the principles and strategies for hemodynamic and microcirculatory monitoring in critically ill patients. CONFERENCE CANCELLATION POLICY If your registration must be cancelled, your fee, less $100 U.S. for administrative costs, will be refunded upon your written request. No refunds will be made after January 12, Allow 6-8 weeks for refund. CONFERENCE OFFICE / INFORMATION RES Seminars. Phone: Conference Website: 4425 Cass Street, Suite A Fax: San Diego, CA USA res@crrtonline.com 4

7 INDUSTRY EVENTS (Non-CME) CME CREDITS DO NOT APPLY INDUSTRY WORKSHOP Runs concurrently with PW1, HW1, HW2 & HW3 TUESDAY - Half Day Elective Workshop (limited enrollment) $120 10:30am-3:30pm (includes 12:30 lunch) IND1: GAMBRO Hands-On Physician s Workshop: Practical CRRT - The Nuts and Bolts Through case studies, lecture and Prismaflex System hands-on practice, this workshop will provide practical approaches to prescribing and delivering CRRT with Gambro s leading CRRT system. INDUSTRY LUNCHEONS Hosted by Conference - RSVP required, selection made during registration process. WEDNESDAY, February 13 11:45am-1:00pm (see page 12 for descriptions) GAMBRO Symposium Luncheon - Does CRRT Improve Renal Recovery? ALEXION Symposium Luncheon - Advances in the Diagnosis and Management of Systemic and Progressive TMAs ALERE Focus Group Luncheon - Rethinking AKI: The Importance of Subclinical Injury THURSDAY, February 14 12:40pm-2:00pm (see page 14 for description) ASTUTE - New AKI Biomarkers, a Revolution in Risk Assessment ACTIVITIES SOCIAL ACTIVITIES Welcome Reception and Poster Review Tuesday, February 12, :00pm-7:30pm All attendees are invited to review the CRRT poster presentations including fellows in training and meet the presenters and faculty. This is a great opportunity to pick-up credentials, register on-site, organize your workshops and prepare for the upcoming CRRT meeting. Light appetizers & refreshments will be served. Exhibit Reception and Poster Session Wednesday, February 15, :15pm-7:30pm Meet and interact with the CRRT poster presenters while you review the latest in equipment and products in the exhibit area. This is a great opportunity to network and meet your colleagues. Light appetizers & refreshments will be served. TOURS The San Diego Gaslamp, Balboa Park & Coronado Tour Adult/Child: $85.00 Includes Round-trip transportation, semi-private tour and guide. Wednesday, February 13, :00 AM- 12:00 PM Join us on this fantastic driving tour of 'America s Finest City'! You will be transported throughout the loveliest and most renowned parts of our city. This comprehensive sightseeing tour includes the charming Coronado Island, historic Gaslamp Quarter, and the artistic and cultural Balboa park. Let us show you why this spectacular city beckons Californians and travelers from far abroad alike to sink their toes into sand and their souls into the fabric of this vibrant place. We look forward to having you as our guests and showing off our beautiful city to you with the utmost style and class. USS Midway Tour Adults: $40.00 Children ages 6-17: $32.00 Thursday, February 14, :45 AM- 12:15 PM Enjoy one of San Diego's most visited attractions. With over 40 different stops around the Midway- see, hear, and experience what it would have been like to be a part of the crew. Take pleasure in a simulated flight on a World War II strike fighter. The USS Midway is also home to some of the most meticulously restored aircraft and helicopters. We invite you to literally climb inside the history of the Midway! Tours are based on availability and subject to change. 5

8 ABSTRACT INFORMATION DEADLINE FOR RECEIPT OF ABSTRACTS: December 7, 2012 Abstract Submission Via Our Website is Required: GENERAL INFORMATION 1. The abstract must be written in English. 2. Deadline: abstracts MUST BE RECEIVED no later than December 7, Online abstract submissions are required. See website for details: 4. Presenting authors must pay the registration fee and attend the meeting. Authors of accepted abstracts are not provided with travel funds. 5. All accepted abstracts will be published and distributed electronically in the CRRT Conference Syllabus. Hardcopy syllabus booklets will be available for purchase during the conference. Abstracts and digital posters (if submitted) will also be published online at: 6. Notification of acceptance will be mailed by January 8, Selected abstracts will be eligible for digital poster discussions with experts on Tuesday Feb. 13 evening from 630-8:00pm. Details will be provided on website. CONTENT OF THE ABSTRACT 1. Abstracts are limited to 2500 characters. Please see sample on website: 2. Abstract Body: purpose of the study, methods used, summary of the results and conclusion reached. 3. Author list is limited to References and credits MUST NOT be included in the abstract. 5. Simple tables, figures and graphs may be included, but avoid the use of special characters. 6. Formulas should be avoided. 7. Use standard abbreviations in parentheses after the full word appears the first time. 8. Please indicate the subject category your abstract most closely represents: a) Epidemiology and Outcomes from AKI, b) Research in AKI (Basic, translational, clinical including clinical trials), c) RRT Technique Characteristics, d) RRT Applications and Targeted Interventions, e) New Technology, f) RRT Research, g) Nursing Issues (education, training, care delivery) 9. Abstracts will be published as submitted. Proof and edit your submission accordingly. TRAVEL AND REGISTRATION AWARDS FOR FELLOWS IN TRAINING. Fellows in an accredited training program who submit a poster abstract to be presented at the CRRT Conference are eligible to apply for Registration and Travel Awards for the conference. Awards will be based on the quality and relevance of the research as judged by the abstract review committee. Awards will be provided based on availability of funds. The top three abstracts will be recognized. Award recipients are required to be present at their poster session on Tues. Feb. 12 and Wed. Feb Registration Awards - Conference Registration Fee for both the regular CRRT Conference and an Elective Workshop held on Tuesday, February 12, Travel Awards - Checks for up to a maximum of $500 will be presented at the time of the conference. 3. Recognition Awards - The top three Fellow abstracts will be awarded recognition awards. CRITERIA FOR GRANTS AND/OR AWARDS 1. Submit a poster abstract (via CRRT web site) and present a poster in the topics covered in the CRRT conference at the Poster Session: Tuesday, Feb. 12 and Wednesday, Feb. 13, Fellows must be currently enrolled in an accredited fellowship program in their host country. 3. Submit a signed letter (same time as abstract) from their program director verifying their current status in the program. NOTE: Signed letter must be faxed or ed to CRRT administration office (fax: or res@crrtonline.com) on the same date as submission of abstract. Abstracts submitted without dated faxed letter will not be accepted for Grants. 4. Designate request for financial support on the CRRT website abstract application form. 5. Fellows must attend an offered workshop. SUBMISSION 1. Notification of acceptance will be mailed by January 8, 2013 with additional information regarding poster dimensions, digital file submission and presentation of your poster. 2. For additional information or if you are unable to complete an online submission contact: RES Seminars Phone: Website: crrtonline.com 4425 Cass Street, Suite A Fax: San Diego, CA USA res@crrtonline.com 6

9 CME INFORMATION LEARNER OBJECTIVES The CRRT conference provides a comprehensive review of advances in clinical care, research and technology in critical care medicine with a focus on the kidney and renal support techniques. The conference is designed to facilitate interdisciplinary interactions among caregivers involved in the management of patients in intensive care units. Physicians, nurses, pharmacists, nutritionists and other allied personnel from industry have opportunities to learn from each other. The conference utilizes a combination of invited lectures; case based small group workshops, debates, hands on interactive workshops and focused panel discussions coupled with oral and poster presentations to provide a wide variety of opportunities for CME credits. At the end of this conference attendees should be able to: 1. Describe the recent advances in the management of critically ill patients with sepsis, acute kidney injury and multiorgan failure 2. Discuss the optimal ways to diagnose, treat and follow up patients with acute kidney injury 3. Recognize the best practices for utilizing CRRT techniques for renal support in critically ill patients ACCREDITATION STATEMENT This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the University of California, San Diego School of Medicine and CRRT, Inc. The University of California, San Diego School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of California, San Diego School of Medicine designates this live activity for a maximum of AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. BRN: For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credits issued by organizations accredited by the ACCME. For the purpose of relicensure, the California Board of Registered Nursing accepts AMA PRA Category 1 Credits (report up to hours of credit and list "CME Category 1" as the provider number). NEEDS ASSESSMENT The needs assessment for the CRRT conference is to increase knowledge and enhance competencies in the management of ICU patients particularly those who require renal support. The content of this conference was based on an assessment of areas with the greatest practice variations where new information is available. Sources include feedback from participants in prior programs, expert faculty opinion, literature review, clinical practice and new medical knowledge. TARGET AUDIENCE The CRRT target audience includes: MD/DOs, NP/PA/Nurses, Dieticians, Industry, Pharmacists, Residents and Fellows. Specialties include: Anesthesiology, Cellular & Molecular Medicine, Critical Care, Emergency Medicine, Family & Preventive Medicine, Geriatrics, and Internal Medicine. The following Workshops, Plenary Sessions and Luncheons qualify for CME Credit: Tuesday ELECTIVES - PW1 Changing Paradigms in AKI, HW1 Fundamentals of CRRT, HW2: Pediatric Hands-On Workshop, HW3: Hemodynamic Monitoring and Use of Drugs, GROUP 1 - SIMULTANEOUS STANDARD WORKSHOPS Wednesday GROUP 2 - SIMULTANEOUS STANDARD WORKSHOPS GROUP 3 - SIMULTANEOUS STANDARD WORKSHOPS OPENING SESSION I: PATIENT CHARACTERISTICS Thursday GROUP 4 - SIMULTANEOUS STANDARD WORKSHOPS SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE Nursing Forum Luncheon Friday SESSION III: TECHNIQUE CHARACTERISTICS SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE CULTURAL AND LINGUISTIC COMPETENCY This activity is in compliance with California Assembly Bill 1195 which requires continuing medical education activities with patient care components to include curriculum in the subjects of cultural and linguistic competency. Cultural competency is defined as a set of integrated attitudes, knowledge, and skills that enables health care professionals or organizations to care effectively for patients from diverse cultures, groups, and communities. Linguistic competency is defined as the ability of a physician or surgeon to provide patients who do not speak English or who have limited ability to speak English, direct communication in the patient s primary language. Cultural and linguistic competency was incorporated into the planning of this activity. Additional resources on cultural and linguistic competency and information about AB1195 can be found on the UCSD CME website at 7

10 5:00-8:00pm 7:30am PROGRAM MONDAY, FEBRUARY 11 Conference Registration Open TUESDAY, FEBRUARY 12 Conference Registration Open PW1 - PRE-CONFERENCE AKI SYMPOSIUM (CME Available) Sponsored by UAB/UCSD O Brien Center for AKI Research Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management CRRT Conference registration is NOT required for this elective symposium. See page 4 for details. 7:55 am Opening Remarks Ravindra Mehta, MD PLENARY 1 Molecules, Mechanisms and Targets Co-Chairs: Anupam Agarwal, MD and Roland Blantz, MD 8:00-8:20 Ischemic Preconditioning and the Cytoresistant State - Richard Zager, MD 8:20-8:40 Mitochondrial Dysfunction in AKI - Samir Parikh, MD 8:40-9:00 Glomerular Participation in Ischemic and Septic AKI - Bruce Molitoris, MD 9:00-9:20 Vasopressin Analogues in Septic Shock: Implications for the Kidney - Martin Westphal, MD 9:20-9:40 Novel Mechanisms of Progression of AKI to CKD - Joe Bonventre, MD 9:40-10:00 Regulatory T Cells: Quelling the Storm - Mark Okusa, MD 10:00-10:15 Coffee Break PLENARY 2 Translational Research: Bedside to Bench & Back Co-Chairs: Bruce Molitoris, MD & John Kellum, MD 10:15-10:35 MRI Imaging: Real time Assessment of Renal Physiology- Dileep Lobo, MD 10:35-10:55 Alkaline Phosphatase for Kidney Injury in Sepsis - Jean Louis Vincent, MD 10:55-11:15 Is Choride a Problem? - Rinaldo Bellomo, MD 11:15-11:35 Is AKI Pro-inflammatory or Anti-inflammatory? - Sarah Faubel, MD 11:35-11:55 Complement Mediated Renal Injury - Joshua Thurman, MD 11:55-12:15 Emerging Strategies for Management of AKI in Cirrhosis: Targeting the Gut-Liver-Kidney Axis - Rajiv Jalan, MD 12:15-1:15 pm Lunch Hosted by Conference PLENARY 3 Of Mice and Men: Developing Relevant Models for Translational Research Co-Chairs: Paul Sanders MD and Rinaldo Bellomo MD 1:15-1:35 Pre-Clinical Models for Translational Research in AKI - Volker Vallon, MD 1:35-1:55 Studying Renal Physiology In-vivo - Can Ince, PhD 1:55-2:15 Acute Renal Failure Around the World: Lessons from the ICON Study - Jean Louis Vincent MD 2:15-2:35 Cell-cycle Arrest Biomarkers of AKI - John Kellum, MD 2:35-2:55 Efficient Trial Designs for Novel Drug and Biologics in AKI - William Macias, MD 2:55-3:15 Prevention Trials in AKI: Lessons from PRESERVE - Paul Palevsky, MD 3:15-3:30 Coffee Break PLENARY 4 Emerging Trends in AKI Co-Chairs: Mark Okusa MD and Paul Palevsky MD 3:30-3:50 Novel Compounds for the Treatment of Acute Kidney Injury - Mitchell Rosner, MD 3:50-4:10 Disentanglement of the AKI Syndrome - Lakhmir Chawla, MD 4:10-4:30 How Should We Use Biomarkers in AKI: An Update from the ADQI Conference - Patrick Murray, MD 4:30-4:50 AKI Biomarkers: Does Their Performance in Different Population Lend Insight Into Mechanisms? -David Askenazi, MD 4:50-5:10 Intraabdominal Hypertension: A Mechanism for AKI - TBN 5:10-5:30 Innovations in Extracorporeal Support: What s Emerging? - Claudio Ronco, MD 5:30 Adjourn 8

11 7:30am TUESDAY, FEBRUARY 12 Conference Registration Open HW1 - ELECTIVE WORKSHOP (CME Available) Fundamentals of CRRT This full day workshop offers an introduction to CRRT techniques and is developed to provide a core set of information on the principles and practice of CRRT. This workshop will cover the components and basic principles of continuous renal replacement therapy. The operating characteristics of CRRT techniques for solute and fluid management, drug management will be discussed along with the potential applications of these techniques. Requirements for developing a successful CRRT program and selecting machines will also be described. SESSION 1 7:55 Opening Remarks - Co-Chairs Jorge Cerda, MD, FACP, FASN & Ashita Tolwani, MD 8:00-8:30 Operating Principles of CRRT - William R. Clark, MD 8:30-9:00 Access/Membrane and Circuit - Luis Juncos, MD 9:00-9:30 Anticoagulation - Ashita Tolwani, MD 9:30-10:00 Solute Control and Dose - Rolando Claure, MD 10:00-10:15 Discussion 10:15-10:30 Coffee Break SESSION 2 10:30-11:00 Solutions - Ashita Tolwani, MD 11:00-11:30 Fluid Management - Ravindra L. Mehta, MBBS, MD, DM, FACP, FRCP 11:30-12:00 Drug Management - Patrick Honoré, MD 12:00-12:30 Patient Selections and Outcomes - Jorge Cerda, MD, FACP, FASN 12:30-1:15 Lunch Hosted by Conference for Workshop Participants SESSION 3 1:15-1:45 Organizational and Financial Aspects - Jorge Cerda, MD, FACP, FASN 1:45-2:15 Pharmacy Support - Linda Awdishu, PharmD 2:15-2:45 Nursing Issues - Eileen Lischer, MA, BSN, RN, CNN 2:45-3:15 Nutritional Support - Michael Connor, MD 3:15-3:30 Coffee Break SESSION 4 3:30-4:00 Monitoring and Preventing Complications - Marlies Ostermann, MD 4:00-4:30 CRRT Outcome Studies - Sean Bagshaw, MD 4:30-5:00 Available Technology - Noel Gibney, MD 5:00-5:30 Questions and Discussion - Jorge Cerda, MD, FACP, FASN & Ashita Tolwani, MD 5:30pm Adjourn HW2, HW3 - HALF DAY ELECTIVE WORKSHOPS (CME Available) (see page 4 & 5 for half day and additional industry workshop descriptions) SESSION 1 10:30-12:15 HW2: Pediatric Hands-On Workshop - Part 1 10:30-12:15 HW3: Hemodynamic Monitoring and Use of Drugs - Part 1 12:15-1:15 Lunch Hosted by Conference for Workshop Participants SESSION 2 1:15-3:30 HW2: Pediatric Hands-On Workshop - Part 2 1:15-3:30 HW3: Hemodynamic Monitoring and Use of Drugs - Part 2 9

12 TUESDAY AFTERNOON, FEBRUARY 12 4:00-5:30pm STANDARD WORKSHOPS - Groups 1-4 (CME Available for All) Open to all participants - applicable to physicians, nurses and allied personnel Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel Workshops presented in a series are marked with a 1 for a primary discussion and 2 for a more complex or advanced discussion in the topic. Series workshops 1 and 2 can be taken subsequently (following each other) or independently (e.g. workshop 1 can be taken without taking workshop 2 and vice versa). 4:00-5:30pm GROUP 1 - SIMULTANEOUS STANDARD WORKSHOPS (choose one) A01 Physiologic Biomarkers of Renal Function (C,N,AP) Renal functional biomarkers including urine electrolytes, GFR and RBF measurements contrast and Doppler ultrasound, MRI imaging. Assessment of the microcirculation to assess tissue perfusion will be shown. B02 Strategies for Optimizing the CRRT Circuit (C,N,AP) Case based discussions on best practices to maintain circuits for CRRT focusing on the Access, Anticoagulation and Monitoring C03 Critical Care Pharmacology: Vasopressors, and Inotropes (A,N,AP) Pathophysiology of shock and the principles and practical use of vasopressors, ionotropes, vasodilators in critically ill patients. D04 Vexing Problems in ICU Patients 1: Acid Base and Electrolyte Problems (C,N,AP) Test and update your knowledge with these interactive case studies focused on recognizing and managing acid base and electrolyte problems in critically ill patients. E05 Managing Patients with AKI and Liver Failure 1: Pathophysiology, Differential Diagnosis, Therapy, Monitoring (C,N,AP) Pathophysiology of AKI in setting of acute and chronic hepatic failure and management strategies for differential diagnosis and therapy F06 Competency Assessment in Renal Support Techniques in the ICU (C,N) Description on training requirements, core curriculum and skills assessment for CRRT care delivery. G07 Renal Support in the ICU with IHD, PIRRT, PD, Hybrid Devices (A) Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research H08 Preventing and Managing Complications of Dialysis 1: Intradialytic Hypotension (C,N) Definitions and pathophysiology of intradialytic hypotension. Strategies for prevention and management. ME1 MEET THE EXPERT 1: How Do I Assess Risk for AKI and Manage High Risk Surgical and ICU Patients Kathleen Liu, MD and Andrew Shaw, MD 6:00-7:30pm Tuesday Evening Reception & Poster Review - For All Conference Attendees Make your hotel reservations early! Information/web link at crrtonline.com OR call the hotel directly... Hilton San Diego Bayfront

13 WEDNESDAY MORNING, FEBRUARY 13 7:00am-4:30pm Conference Registration Open 8:30-10:00am GROUP 2 - SIMULTANEOUS STANDARD WORKSHOPS (choose one) A09 Using Kidney Biomarkers for AKI 1: Risk Assessment, Diagnosis and Staging (C,N,AP) Practical issues for use of kidney biomarkers for assessing risk and for early recognition and interventions in AKI. B10 CRRT for the Experienced User 1 (I,N,AP) Interactive case based discussions on dose adjustments, monitoring for adequacy, modality selection and transitions in CRRT. C11 Critical Care Management: Nutrition Assessment and Delivery (I,N,AP) Pathophysiology of malnutrition in critically ill patients. Principles of nutritional assessment and support and adjustments for RRT. D12 Vexing Problems in ICU Patients on RRT 2: Drug Management for Problematic Infections, Sedation, Organ Support (I,N,AP) Case based discussions for adjustments in drug dosing, renal support and monitoring of complex ICU patients with comorbidities and drug resistant infections. E13 Managing Patients with AKI and Liver Failure 2: Use of RRT, Liver Support, Strategies for Bridge to Transplant (A,N) Interactive case studies describing the rationale for use of different extracorporeal support techniques (Cell based systems, MARS, CRRT) for hepatic support as a bridge to transplant or functional recovery. F14 Patient Centered Care in the ICU: The Team Approach (C,N,AP) Taking good care of patients requires communication and understanding of patient and loved ones needs. This workshop will discuss the principles and practice of patient centered care utilizing case studies. G15 Plasma Exchange Therapy and Hybrid Techniques (C,N,AP) Principles of plasma exchange, sorbent based and hybrid therapies for extracorporeal support and case based discussion of practical application. H16 Preventing and Managing Complications of Dialysis 2: Operation, Fluids, Electrolytes and Acid Base (C,N) Case based discussions of related complications in ICU patients. ME2 MEET THE EXPERT 2: How I Assess Patients in the ICU and My Approach to Oliguria Jean Louis Vincent and Rajiv Jalan 10:00-10:15am Coffee Break 10:15-11:45am GROUP 3 - SIMULTANEOUS STANDARD WORKSHOPS (choose one) A17 Using Kidney Biomarkers for AKI 2: Differential Diagnosis, Interventions and Prognosis (C,N,AP) Strategies for the effective use of kidney biomarkers for managing patients with AKI to guide interventions and predict outcomes. B18 CRRT for the Experienced User 2: Solutions, Fluid Removal Fluid Balance, Monitoring (A) Interactive case based discussion on strategies for fluid management in CRRT to achieve patient driven outcomes for fluid, electrolyte and acid base balance. C19 Fluids and Solutions in the Critically Ill 1 (A) How to select and use colloids, crystalloids and blood products. D20 Managing Patients with Sepsis 1 : Pathophysiology, Diagnosis, Assessment, Resuscitation and Drug Management (C,N,AP) Case based discussions on pathophysiology of sepsis, rationale and strategies for fluid and vasopressor use for resuscitation and supportive therapy with the sepsis bundle. E21 Managing Heart Failure and Cardiorenal Syndrome 1: Pathophysiology, Diagnosis, Drug Management (I) (C,N,AP) Pathophysiology, recognition and management strategies for cardiac and renal failure in the critically ill patient. F22 Ensuring Patient Safety and Quality Measures for RRT in AKI 1: Water Standards, Infection Control (C,N,AP) Discussion of the recent developments in ensuring quality and patient safety for acute dialysis delivery. G23 H24 Pediatric CRRT: The Basics (I,N,AP) Technique requirement and application for use in children excluding neonates. Covering epidemiology of pediatric acute kidney injury, and a focus on the pediatric CRRT prescription (anticoagulation, fluid composition, modality, and nutrition provision), as well as outcome in pediatric CRRT. Withdrawing & Withholding Support for AKI: Ethical Issues in the ICU (I,N,AP) Factors influencing decisions for withholding and withdrawing dialysis in the management of critically ill patients. General principles for ethical decisions and how an approach can be developed to manage patients requiring dialysis. ME 3 MEET THE EXPERT 3: How I Use the KDIGO AKI Guidelines to Manage Patients John Kellum and Claudio Ronco 11:45am-1:00pm Lunches Hosted by Conference - see following page for details 11

14 WEDNESDAY AFTERNOON, FEBRUARY 13 11:45am-1:00pm Lunches Hosted by Conference - RSVP required, selection made during registration process. CONFERENCE Luncheon (No CME Available) GAMBRO Symposium Luncheon Does CRRT Improve Renal Recovery? Findings from the RENAL study will be presented highlighting the impact of renal replacement therapy modality on renal recovery in survivor s of severe acute kidney injury. ALEXION Symposium Luncheon - Advances in the Diagnosis and Management of Systemic and Progressive Thrombotic Microangiopathies (TMA s) Systemic TMA is a process of widespread thrombi and inflammation in the small blood vessels of vital organs throughout the body. The multiple thrombi and inflammation occurs throughout the body, affecting the brain, kidneys, heart, organs of the gastrointestinal system, and lungs. The clinical presentation of ahus can have significant clinical overlap (signs and symptoms) with other diseases, some of which are caused by systemic TMA such as TTP and STEC-HUS. ALERE Focus Group Luncheon Rethinking AKI: The Importance of Subclinical Injury The concept of subclinical acute kidney injury suggests the need to revisit consensus criteria for AKI. Changes in novel biomarkers, such as NGAL, may have clinical relevance even in the absence of traditional parameters used to diagnosis AKI. A faculty of experts will discuss the value in identifying subclinical injury, related patient impact and potential role for NGAL. SESSION I: PATIENT CHARACTERISTICS (CME Available - All Sessions) 1:10-3:45 Plenary 1 - MINI-SYMPOSIA Organ Dysfunction in the Critically Ill Patient: Emerging Concepts 1:10-1:15 Opening Remarks Ravindra L Mehta, MD FACP 1:15-1:30 ICU Nephrology: The Implications of Cardiovascular Alterations in the Acutely Ill Jean Louis Vincent, MD 1:30-1:45 Pathophysiology and Management of Post-cardiac Arrest Syndrome Hiroyuki Hirasawa, MD 1:45-2:00 Acute Kidney Injury and Sepsis: A Toll Like Receptor (TLR) Hyper-Responsive State Richard Zager, MD 2:00-2:15 The Angiopoietins in Sepsis: Markers and Potential Mediators of Vascular Leak and Injury Samir Parikh, MD 2:15-2:30 The Global Increased Permeability Syndrome: Recognition & Management TBN 2:30-2:45 Metabolic conditioning and Nutritional Modulation for Improving Perioperative Outcomes Dileep Lobo, MD 2:45-3:00 Acute Lung injury and ARDS: What s New? Kathleen Liu, MD 3:00-3:25 SPECIAL LECTURE The Global Renal Circulation in Sepsis Rinaldo Bellomo, MD 3:25-3:45 Panel Discussion Moderator: John Kellum MD 3:45-4:15 Coffee Break 12 4:15-6:30 Plenary 2 - MINI-SYMPOSIA Acute Kidney Injury (AKI): Pathophysiology 4:15-4:30 Is Restoration of a Near Normal Milieu Advantageous in AKI? Bruce Molitoris, MD 4:30-4:45 Normal and Maladaptive Repair After Injury Joe Bonventre, MD 4:45-5:00 Pathophysiology of Plasma Cell Dyscrasias: A Model for Targeted Intervention Paul Sanders, MD 5:00-5:15 Systemic Effects of AKI Sarah Faubel, MD 5:15-5:30 Differential Diagnosis and Therapeutic Strategies of Thrombotic Micro Angiopathies (TMA) Joshua Thurman, MD 5:30-5:50 Cardio-Renal Interactions in Heart Failure: An update from the ADQI 11 Conference Claudio Ronco, MD 5:50-6:00 Panel Discussion Moderator: Anupam Agarwal, MD 6:00-6:30 SPECIAL SESSION Critical Care Nephrology Jeopardy Nephrologists vs Intensivists Moderator: Noel Gibney, MD 6:30 Adjourn 6:30-8:00 EXHIBIT RECEPTION AND POSTER SESSION

15 THURSDAY MORNING, FEBRUARY 14 7:00am-4:30pm Conference Registration Open 7:00-8:00 Continental Breakfast 8:00-9:30am GROUP 4 - SIMULTANEOUS STANDARD WORKSHOPS (choose one) A25 Raising Awareness of AKI: Risk, Recognition, and Response (C,N,AP) This workshop will describe the urgent need for educating care givers, patients and the lay public on the devastating effects of AKI. Strategies and tools for risk assessment, recognition and early response for AKI will be discussed. B26 CRRT for the Experienced User 3: Technique Adjustments Case Studies (A) Interactive cases demonstrating the flexibility and adaptiveness of CRRT techniques for dynamic comprehensive renal support. C27 Drug Induced Kidney Injury in the ICU: Mechanisms, Susceptibility, Diagnosis, Management Strategies (A,N) Causes and consequences of drug induced nephrotoxicity, factors contributing to toxicity, strategies for preventing and managing toxicity. Utilization of dialysis techniques for drug removal. D28 Managing Patients With Sepsis 2: Techniques for Disease Modification, Organ Support and Renal Protection (A) Technical considerations and practical application of extracorporeal support techniques for sepsis. Results of human studies for use of high permeability membranes, HVHF, VHVHF and hybrid techniques for sepsis E29 Managing Heart Failure and Cardio-Renal Syndrome 2: Ultrafiltration, Renal Support and RRT for Patients with Ventricular Assist Devices and Artificial Hearts (A,N) Technical considerations, practical application and results of different methods to treat heart failure and cardio-renal syndrome including ultrafiltration techniques. F30 Ensuring Patient Safety and Quality Measures for RRT in AKI 2: Dialysis Adequacy, Monitoring, Nursing Issues (C,N,AP) Discussion of the principles of a systems based approach to implementing and monitoring quality to reduce errors in therapy prescription and delivery. G31 CRRT in the Newborn: Principles and Practical Issues (C,N,AP) Pathophysiology and management of metabolic disorders, neonatal AKI and intoxications with CRRT. H32 Starting and Stopping RRT for AKI: Principles and Practice (A) Principles of determining when to start and stop RRT. Case based discussion of various approaches. ME4 Meet the Expert 4: How I Design and Conduct Clinical Trials in AKI Rinaldo Bellomo, MD, William Macias, MD and Paul Palevsky, MD 9:30-9:45 Coffee Break SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE 9:45-12:40 Plenary 3 - MINI-SYMPOSIA Controversies in Management of the Critically Ill Patient: Fluid Management and Renal Protection 9:45-10:00 Does Sedation Affect Kidney Function? Andrew Shaw, MB FRCA FCCM 10:00-10:15 How Much fluid is Enough for AKI? Kathleen Liu, MD 10:15-10:30 Does Fluid Composition Influence Renal Function? Dileep Lobo, MD 10:30-10:45 Achieving Fluid balance and Preserving Kidney Function: The Role of CRRT Ravindra L. Mehta, MD 10:45-11:00 Heart Failure Management: Implications for the Kidney Alan Maisel, MD 11:00-11:15 How Should You Manage Oliguria Sean Bagshaw, MD 13 11:15-11:30 Fluid Resuscitation Strategies Lessons from the 6S and CHEST Trials Rinaldo Bellomo, MD 11:30-12:15 Controversies: What Fluids Should be Used for Resuscitation to Protect the Kidney? Bicarbonate - Paul Palevsky, MD Colloids - Dileep Lobo, MD Blood - Can Ince, PhD Anything but Saline - John Kellum, MD They are all OK if Used Cautiously - Martin Westphal, MD 12:15-12:30 Panel Discussion Moderator: Noel Gibney, MD 12:30-12:40 Top Abstract Awards 12:40-2:00 Lunches Hosted by Conference (see following page for details)

16 THURSDAY AFTERNOON, FEBRUARY 14 12:40-2:00pm Lunches Hosted by Conference - RSVP required, selection made during registration process. Conference Luncheon Nursing Forum Luncheon (CME Available) Mapping the Exposome: How Wireless Technology and Social Media are Changing Our Perceptions of Medical Care Kevin Patrick MD The rapid explosion of wireless technology and social media applications is leading to the development of sensor based technologies that will revolutionize our approach to research and medicine. This special lecture will describe some of the innovations that are being deployed and what they will mean for care delivery in the near future. Astute Industry Symposium Luncheon (No CME) New AKI Biomarkers, a Revolution in Risk Assessment Current tools to identify Acute Kidney Injury (AKI) have remained mostly unchanged for decades and have focused primarily on functional renal change. Join this educational symposium to learn about novel AKI biomarkers. SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE 2:00-3:30 Plenary 4 MINI-SYMPOSIA Drug Induced Kidney Injury: From Mechanisms to Management 2:00-2:15 Mechanisms of Drug Nephrotoxicity Bruce Mueller, PharmD 2:15-2:30 Genetic Determinants of Drug Induced Kidney Injury Linda Awdishu, PharmD 2:30-2:45 Nephrotoxic Medication Associated AKI in Children: The Epidemic Exists Stuart Goldstein, MD 2:45-3:00 Drug Dosing During Extracorporeal Support: Can We Protect the Kidney? Miet Schetz, MD 3:00-3:15 Renal Toxicity of Recreational Drugs Richard Clark, MD 3:15-3:30 EXTRIP: What and Who is it? Mark Ghannoum, MD 3:30-4:00 Coffee Break 4:00-6:00 Plenary 5 MINI-SYMPOSIA Challenges and Controversies in Renal Support and CRRT 4:00-4:15 Circulatory Stress During Dialysis: Contributor to Endotoxemia? Chris McIntyre, MD 4:15-4:30 Permissive Hypofiltration Lakhmir Chawla, MD 4:30-4:45 Automated Citrate Anticoagulation for Dialysis Balazs Szamosfalvi, MD 4:45-5:00 RRT for the Morbidly Obese Patient: Challenges and Solutions Charuhas Thakar, MD 5:00-5:15 Prolonged Intermittent Dialysis: Experience with Different Modalities Etienne Macedo, MD 5:15-5:30 Extracorporeal Support for the Patient with an Artificial Heart and Heart Assist Devices Luis Juncos, MD 5:30-5:45 Preventing and Managing Catheter Based Infections Saima Aslam, MD 5:45-6:00 Treatment of Refractory Ascites: Taps, TIPSS and Now Pumps Rajiv Jalan, MD 6:00 Adjourn Free Evening 14

17 7:00am-1:00pm 7:00-8:00am FRIDAY, FEBRUARY 15 Conference Registration Open Continental Breakfast SESSION III: TECHNIQUE CHARACTERISTICS 7:30-10:00 Plenary 6 MINI SYMPOSIA Raising Awareness of AKI 7:30-7:45 Raising Awareness: What Are the Issues? Jorge Cerda, MD 7:45-8:00 Lessons from the O'Brien Center International AKI Registry Josee Bouchard, MD 8:00-8:15 Kidney Attack in the ICU: The Epidemic is Here John Kellum, MD 8:15-8:30 Derivation, Validation and Application of the Renal Angina Index in Critical Illness Rajit Basu, MD 8:30-8:45 Surveillance with an EMR: Does it Make a Difference? Kianoush Kashani, MD 10:45-1:00 Plenary 7 MINI SYMPOSIA Emerging Strategies in AKI and Extracorporeal Support 10:30-12:30 Update from Ongoing and Recent Trials (12 minutes each) 1. Ultrafiltration for Heart Failure: CARESS Trial Emil Paganini MD 2. Curcurumin for AKI Amit Garg, MD 3. Stem cells for AKI: Allocure Trial (TBN) 4. SCD Immunomodulation for AKI David Humes, MD 5.Polymixin Binding Filter for Sepsis: EUPHRATES Trial Sean Bagshaw, MD 8:45-9:00 Improving Outcomes from AKI: Lessons from the UK Andrew Lewington, MD 9:00-9:15 Determining Long Term Outcomes From AKI: The ARID Study Chris McIntyre, MD 9:15-10:15 The Changing Face of AKI: Snapshots from Around the World Brazil Emmanuel Burdmann, MD India Raj Chakravarthi, MD Japan TBN China Li Yang, MD UK Andrew Davenport, MD Canada Amit Garg, MD Australia Rinaldo Bellomo, MD USA Stuart Goldstein, MD USA Ashita Tolwani, MD Europe Patrick Honore, MD 10:15-10:45 Coffee Break SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE 6. Cytokine-Adsorbing Hemofilter CHDF for Sepsis Hiroyuki Hirasawa, MD 7. Pre-mixed Citrate Solutions for CRRT Patrick Honore, MD 8. Thrasos Trial James Tumlin, MD 12:30-12:55 Critical Care Nephrology: Literature Review Noel Gibney, MD 12:55-1:00 Closing Remarks Ravindra L. Mehta, MD FACP Chairman 1:00 Conference Adjourns Mark Your Calendar Now for 2013 AND 2014! CRRT 2014 Manchester Grand Hyatt San Diego, California March 4-7,

18 CONFERENCE REGISTRATION WORKSHEET Online Registration is Required: Use this worksheet to review optional selections made during registration. A mail-in registration form may be completed online for those that wish to submit payment via check, but please note that your registration is not valid until your check is received. A downloadable/printable registration form is also available online. Online registration is available for those attending only the AKI Workshop (downloadable form also available). REGISTRATION FEES Early Bird Pre-Registration On-Site Reg. On or before Jan. 5 thru Feb. 8 thru Jan. 4, 2013 Feb. 7, 2013 Feb. 15, 2013 Registrants (MD, PhD, etc.) $ 675 $ 740 $ 795 With Multimedia Package $ 875 $ 940 $ 995 Nurses/Dieticians/Pharmacists Residents*/Fellows*/ With Multimedia Package $ 480 $ 680 $ 550 $ 750 $ 595 $ 795 Industry $ 675 $ 740 $ 795 With Multimedia Package $ 875 $ 940 $ 995 *requires letter of verification from dept. head Total Registration Fees: Fee Includes: Access to Plenary Sessions, Conference Standard Workshops (Tue, Wed & Thur), Exhibit Area, Welcome Reception & Poster Session (Tues) Exhibit Reception (Wed), two lunches (Wed & Thur) and all conference breaks. Registration fee does not include Elective Workshops, Meet the Expert breakfasts, Online Presentations or Tours LUNCHEON SELECTION (included with registration, rsvp required - made during reg. process) Wednesday: Conference Lunch Gambro Alexion Alere None Thursday: Conference Lunch Nurses Astute None ELECTIVES PRE-CONFERENCE AKI SYMPOSIUM see details on page 4 Tuesday, Feb. 12th - 8:00am-5:30pm Full day Symposium only $260 x = Symposium - after discount (must also pay Conference registration fee) $230 x = Add Post-conference Online Presentation (see website for details) $125 x = ELECTIVE WORKSHOPS see details on page 4 Tuesday, Feb. 12th - 8:00am-5:30pm Full day HW1 $185 x = Add Post-conference Online Presentation (see website for details) $ 125 x = Tuesday Feb. 12th - 10:30am -3:30pm Half day HW2, HW3, HW4 $120 x = PRINTED SYLLABUS complete digital version on usb drive included with registration Spiral-bound, approx. 120 page 8.5x11booklet $45 x = GUEST FEE (Guests are not admitted to Sessions or Workshops) $185 x = Includes access to Exh. Area, Reception (Tues.), Exh. Reception (Wed.) & 2 Lunches (Wed. & Thur.). TOUR FEES see page 5 for details SD Gaslamp, Coronado, Balboa Park Wed, Feb. 13, 2013 $85 x = USS Midway Tour Thursday, Feb. 14, 2013 Adult $40 x = Child Ages 6-17 $32 x = 16 TOTAL FEES:

19 CRRT 2013 PROGRAM AT A GLANCE CME Available for All Session Unless Noted With * Time Tuesday Feb 12 Time Wednesday Feb 13 Time Thursday Feb 14 Time Friday Feb 15 7:55-10:00 PW1: AKI HW1: Fundamentals 8:30-10:00 Workshops GROUP 2 8:00-9:30 Workshops GROUP 4 7:30-10:15 Plenary 6 Raising Awareness of AKI 10:00-10:15 10:15-12:15 12:15-1:15 1:15-3:15 1:15-3:30 Break PW1: AKI HW1: Fundamentals HW2: Pediatrics HW3: Hemodynamic IND1: Gambro Lunch* PW1: AKI HW1: Fundamentals HW2: Pediatrics HW3: Hemodynamic IND1: Gambro 10:00-10:15 10:15-11:45 11:45-1:00 1:10-3:45 Break Workshops GROUP 3 Luncheons* Plenary 1 Organ Dysfunction in the Critically Ill Patient: Emerging Concepts 9:30-9:45 9:45-12:40 12:40-2:00 2:00-3:30 Break Plenary 3 Controversies in Management of the Critically Ill Patient: Fluid Management and Renal Protection Luncheons (Astute *) Plenary 4 Drug Induced Kidney Injury: From Mechanisms to Management 10:15-10:45 10:45-1:00 1:00pm Break Plenary 7 Emerging Strategies in AKI and Extracorporeal Support Adjourn 3:15:3:30 3:30-5:30 4:00-5:30 Break PW1: AKI HW1: Fundamentals Standard Workshops GROUP 1 3:45-4:15 4:15-6:30 Break Plenary 2 Acute Kidney Injury (AKI): Pathophysiology 3:30-4:00 4:00-6:00 Break Plenary 5 Challenges and Controversies in Renal Support and CRRT 6:00-7:30 Reception and Poster Review* 6:30-8:00 Exhibits Reception And Poster Session* 6:00 Adjourn Free Evening PW1 = Pre-Conference Symposium HW = Elective Workshops

20 CRRT 2013 c/o RES Seminars 4425 Cass Street, Suite A San Diego, CA USA THE EIGHTEENTH INTERNATIONAL CONFERENCE ON CONTINUOUS RENAL REPLACEMENT THERAPIES CRRT 2013 February 12-15, 2013 San Diego, California Hilton San Diego Bayfront crrtonline.com