SURVEYS 2016 INDEX. Performance Improvement Program in Surgical Pathology CASE SUMMARY REPORT AND ANATOMIC PATHOLOGY EDUCATION PROGRAMS

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1 INDEX Performance Improvement Program in Surgical Pathology SURVEYS 2016 AND ANATOMIC PATHOLOGY EDUCATION PROGRAMS CASE SUMMARY REPORT 2016 College of American Pathologists. The College does not permit reproduction of any substantial portion of the material in this Report without its written authorization. The College hereby authorizes participants in the program to use the material in this Report solely for educational purposes within their own institutions. The College prohibits use of the material in the Report and any unauthorized use of the College s name or logo in connection with promotional efforts by marketers of laboratory equipment, reagents, materials, or services. Data from this program do not necessarily indicate the superiority or inferiority of instruments, reagents, or other materials used by participating laboratories. Use of these data to suggest such superiority or inferiority may be deceptive and misleading. The College will take all steps open to it under the law to prevent unauthorized reproduction of substantial portions of the material in this Report, deceptive use of any such material, and any unauthorized use of the College s name or logo in connection with promotional efforts by marketers of laboratory equipment, reagents, materials, or services.

2 PIP CASE SUMMARY INDEX Breast Angiosarcoma 86% Tubular adenoma 97% Medullary carcinoma 97% Phyllodes tumor 95% Infiltrating lobular carcinoma 87% Adenoid cystic carcinoma 95% Lobular carcinoma in situ 86% Tubular adenoma 88% Infiltrating ductal carcinoma 88% Low grade cystosarcoma phyllodes 96% Silicone granuloma 94% Papillary carcinoma 83% Ductal hyperplasia without atypia 67% Well differentiated adenocarcinoma 60% Phyllodes tumor 66% Sarcoma 89% Metaplastic carcinoma 92% Lipid rich carcinoma 65% Infiltrating mammary carcinoma, NOS 24% Hyperplasia, lobular, atypical (Kodachrome) 56% Lactating adenoma 93% Ductal carcinoma in situ, comedo-type 91% Silicone reaction (silicone granuloma) 89% Infiltrating ductal carcinoma breast 59% Invasive lobular carcinoma of the breast, pleomorphic type 98% Cystosarcoma phyllodes with sclerosing liposarcoma 88% Lactating adenoma, breast 87% Ductal carcinoma in situ, low grade 80% Colloid carcinoma (mucinous carcinoma) 99% Adenomyoepithelioma 76% Infiltrating lobular carcinoma 88% Ductal carcinoma in situ 72% Infiltrating ductal carcinoma of no special type 84% Undifferentiated carcinoma 28% Invasive ductal carcinoma of no special type, grade III/III 94% Benign phyllodes tumor 79% Invasive micropapillary carcinoma 93% Myofibroblastoma 87% Phyllodes tumor 87% Metaplastic carcinoma 85% Metaplastic carcinoma 95% Sarcomatoid carcinoma (metaplastic carcinoma) 94% Malignant phyllodes tumor 99% Infiltrating duct carcinoma, poorly differentiated 96% Invasive lobular carcinoma 98%

3 Breast Pseudoangiomatous stromal hyperplasia 97% Phyllodes tumor, low grade 90% Epithelioid angiosarcoma 97% Nodular fasciitis 95% Invasive ductal carcinoma with micropapillary features 94% Extranodal Rosai-Dorfman disease 97% Tubular adenoma 96% Cardiovascular Endocrine Giant cell myocarditis 94% Temporal arteritis (giant cell arteritis) 99% Granulomatous myocarditis 71% Acute cellular rejection, moderate 16% Eosinophilic myocarditis 97% Vasculitis, histologically compatible with polyarteritis nodosa 72% Cardiac myxoma 97% Severe acute cellular rejection and chronic vasculopathy 69% Cardiac hemosiderosis 48% Cardiac myxoma 98% Chagas disease, acute reactivation following transplantation 95% Myxoma 99% Arrhythmogenic Right Ventricular Dysplasia 97% Cardiac amyloidosis 98% Cardiac allograft vasculopathy 92% Angiosarcoma 99% Parathyroid adenoma 94% Hashimoto thyroiditis 89% Follicular lesion (follicular neoplasm) of thyroid 73% Papillary thyroid carcinoma 71% Malignant pancreatic endocrine tumor (islet cell) 86% Adrenal cortical adenoma 62% Medullary carcinoma 94% Pheochromocytoma 90% Primary parathyroid hyperplasia 88% Paraganglioma 81% Nodular goiter 91% Adrenal cortical carcinoma 90% Papillary carcinoma 85% Follicular carcinoma, insular type 65% Parathyroid adenoma 96% Hashimoto thyroiditis 65% Brown tumor of hyperparathyroidism 85% Papillary carcinoma 99% Angioinvasive follicular carcinoma 37% Adrenal cortical carcinoma 83% Anaplastic carcinoma 78% Pheochromocytoma (composite variant) 96%

4 Endocrine Follicular thymic hyperplasia 90% Medullary carcinoma 84% Hürthle cell papillary adenoma 65% Adrenal pseudocyst 87% Myelolipoma 88% Parathyroid adenoma 92% Chronic lymphocytic thyroiditis - slide unavailable (data can not be calculated) Diffuse toxic goiter 70% Medullary thyroid carcinoma 94% Pheochromocytoma 95% Precursor T-cell acute lymphoblastic lymphoma 95% Myelolipoma 95% Hashimoto thyroiditis, fibrous variant 86% Paraganglioma 92% Graves Disease (diffuse toxic goiter) 88% Papillary carcinoma (NOS, usual type) 49% Pheochromocytoma 96% Solid-pseudopapillary tumor 78% Extranodal marginal zone B-cell (MALT) lymphoma 78% Hürthle cell carcinoma 65% Ganglioneuroma 96% Neuroblastoma, poorly differentiated 69% Undifferentiated (anaplastic) carcinoma 97% Adrenal cortical carcinoma 89% Myelolipoma 95% Papillary carcinoma, classical type 80% Undifferentiated (anaplastic) carcinoma 97% Follicular variant of papillary carcinoma 97% Autoimmune (Hashimoto) thyroiditis 99% Adrenal cortical carcinoma 87% Carcinoma with thymus-like elements 86% Pheochromocytoma 98% Medullary carcinoma 99% Acinar cell carcinoma 96% Neuroblastoma, poorly differentiated 89% Pancreatic neuroendocrine tumor 96% Solid-pseudopapillary neoplasm 97% Adrenal cortical carcinoma 96% Multinodular adenomatous goiter 97% Fibrosing variant of Hashimoto's disease, end stage 96% Thymic follicular hyperplasia 93% Serous microcytic adenoma 97% Acinar cell carcinoma 97% Medullary thyroid carcinoma 97% Thymoma 98% Myelolipoma 98%

5 Gastrointestinal Hyperplastic polyp 90% Cloacogenic carcinoma, basaloid type, of anal canal 99% Stromal tumor (cellular leiomyoma) of stomach 90% Crohn disease of ileum 98% Familial adenomatous polyposis coli 99% Villous adenoma 90% Carcinoid tumor of the appendix 92% Crohn disease of colon 86% Helicobacter pylori gastritis 66% Ulcerative colitis 64% Adenocarcinoma of stomach, diffuse type (linitis plastica) 98% Adenocarcinoma of colon, moderately to poorly differentiated grade II/III 77% Leiomyosarcoma of the stomach 75% Pseudomembranous colitis 99% Barrett's esophagus with dysplasia 89% Acute infectious colitis 86% Ulcerative colitis 95% Epithelioid leiomyoma of stomach 90% Ischemic colitis 94% Leiomyosarcoma of colon 94% Pneumatosis cystoides intestinales 95% Acute appendicitis 85% Barrett's esophagus 95% Mucinous adenocarcinoma of rectum 95% Microcystic adenoma 90% Diversion colitis 79% Crohn disease 83% Small cell carcinoma of the colon 82% Carcinoid tumor of small bowel 94% Malignant gastric stromal tumor 89% Collagenous colitis (kodachrome) 78% Adenocarcinoma, pancreas 53% Crohn disease 95% Solid-cystic papillary epithelial neoplasm, pancreas 61% Pancreatic endocrine tumor 76% Adenocarcinoma, cecum 62% Fibromatosis, small bowel 94% Acute self-limited colitis (infectious colitis) 54% Malignant gastrointestinal stromal tumor N/A Cytomegalovirus colitis 66% Chronic active gastritis 80% Adenocarcinoma 93% Neutropenic enterocolitis (typhilitis) 73% Pneumatosis cystoides intestinalis 93% Inflammatory fibroid polyp 87% Microcystic adenoma 95%

6 Gastrointestinal Pancreatoblastoma 91% Ischemic colitis 94% Hirschsprung's disease 90% Strongyloidiasis (autoinfection) 96% Peutz-Jeghers (hamartomatous) polyp 87% Familial polyposis 98% Crohn colitis 82% Adenocarcinoma 77% Ulcerative colitis 96% Acinar cell carcinoma 94% Cytomegalovirus esophagitis 82% Pancreatic endocrine tumor (gastrinoma) 90% Diffuse B-cell lymphoma (Gastric large cell lymphoma) 84% Eosinophilic gastroenteritis 99% Lymphocytic colitis 80% Basaloid squamous carcinoma 60% Clostridium difficile pseudomembranous colitis 98% Solid-pseudopapillary tumor 75% Gastrointestinal stromal tumor 91% Ductal adenocarcinoma 91% Inflammatory fibroid polyp 67% Malakoplakia 93% Invasive poorly differentiated adenocarcinoma with mucinous and signet ring cell features N/A Active chronic gastritis, Helicobacter pylori-associated (type B gastritis, chronic antral gastritis) 99% Pancreatic endocrine neoplasm (islet tumor) 84% Gastrointestinal stromal tumor, malignant 99% Active chronic colitis, severe, consistent with fulminant phase of chronic ulcerative colitis 57% Cytomegalovirus colitis 90% Serous microcystic adenoma 97% Adenocarcinoma, intestinal type 74% Adenocarcinoma, primary 82% Ischemic colitis 81% Teratoma 94% Adenocarcinoma of gallbladder 87% Signet-ring carcinoma 82% Burkitt lymphoma 83% Pseudomembranous colitis 98% Mixed carcinoid-adenocarcinoma 98% Bacillary angiomatosis 71% Adenocarcinoma 92% Melanoma 60% Metastatic renal cell carcinoma 99% Mucinous cystic neoplasm (mucinous cystadenoma) 95% Pancreatic endocrine carcinoma - 97% Adenocarcinoma of the small bowel, arising in celiac disease 74%

7 Gastrointestinal Microcystic serous cystadenoma 97% Crohn disease 99% Mucinous carcinoma arising in an intraductal papillary mucinous neoplasm 92% Gastrointestinal stromal tumor 99% Lymphoepithelial cyst 88% Plasmacytoma 99% Adenocarcinoma, diffuse (signet ring cell) type 96% Sclerosing mesenteritis 96% Acinar cell carcinoma 92% Solid pseudopapillary neoplasm 98% Ulcerative colitis 94% Pseudomembranous colitis secondary to Clostridium difficile infection 98% Pneumatosis (cystoides) intestinalis related to progressive systemic sclerosis 91% Crohn disease 96% Well-differentiated pancreatic endocrine tumor 90% Medullary carcinoma 80% Multicystic peritoneal mesothelioma 95% Clostridium difficile pseudomembranous colitis 98% Mucinous adenocarcinoma 86% Epithelioid trophoblastic tumor 88% Microcystic serous cystadenoma 98% Collagenous colitis 96% Gastrointestinal stromal tumor 97% Mesenteric fibromatosis 94% Sclerosing mesenteritis 94% Neuroendocrine tumor, WHO grade 2 92% Burkitt lymphoma 97% Metastatic appendiceal goblet cell carcinoid (mixed adenoneuroendocrine carcinoma) 97% Pseudomembranous colitis 99% Peutz-Jeghers polyp 98% Well-differentiated squamous cell carcinoma 94% Ulcerative colitis 98% Familial adenomatous polyposis 99% Medullary carcinoma 91% Crohn disease 99% Diffuse large B-cell lymphoma 97% Follicular dendritic sarcoma 97% High-grade neuroendocrine carcinoma 97% Mucinous adenocarcinoma of stomach 96% Gastrointestinal stromal tumor (GIST) 99% Non-Hodgkin B-cell lymphoma, low-grade 97% Genetic Familial adenomatous polyposis 99% Tumoral calcinosis 96% Wilson Disease 97%

8 Gynecologic Ovary, clear cell adenocarcinoma 95% Uterus, hydatidiform mole (partial or complete) 88% Endodermal sinus tumor (yolk sac tumor) 97% Serous cystadenoma of low malignant potential 82% Sclerosing stromal tumor 63% Endometrium, late secretory 92% Endometrioid adenocarcinoma of ovary 92% Serous papillary carcinoma of endometrium 50% Simple hyperplasia of the endometrium 45% Chorioamnionitis 98% Placental infarct 82% Sertoli-Leydig cell tumor, poorly differentiated 58% Mucinous carcinoma of low malignant potential 69% Term diamniotic, monochorionic twin placenta 86% Villitis of unknown etiology 69% Leiomyosarcoma 46% CIN III 95% Adenocarcinoma of endometrium 78% Müllerian adenosarcoma of 41% Malignant mesothelium of peritoneum 93% Juvenile granulosa cell tumor of ovary 84% Mature (solid) teratoma 52% Cystadenofibroma of ovary 74% Endometrioid adenocarcinoma 70% Brenner tumor of ovary 90% Carcinosarcoma of endometrium 81% Adnexal tumor of probable Wolffian origin 74% Clear cell carcinoma 83% 93-K2 Simple endometrial hyperplasia 16% Endometrioid carcinoma of the ovary 70% Serous borderline tumor 88% Granulosa cell tumor 96% Immature teratoma, high grade 77% Metastatic colonic adenocarcinoma 53% Chorangioma 98% Granular cell tumor 97% Adenocarcinoma endometrioid, grade III 60% Listeria monocytogenes 88% Lichen sclerosis w/ squamous cell hyperplasia 71% Dysgerminoma 97% Small cell carcinoma 75% Massive diffuse perivillous fibrinoid deposition 64% Mucinous adenoma 91% Myxoid leiomyosarcoma 76% Adenosarcoma 73% Luteoma of pregnancy 86%

9 Gynecologic Uterine papillary serous carcinoma 82% Acute chorioamnionitis 95% Cellular fibroma 35% Metastatic gastric adenocarcinoma 66% Endometrioid tumor of low malignant potential 49% Necrotizing funisitis due to congenital syphilis 89% Sertoli-Leydig cell tumor intermediate-to-poorly differentiated 78% Yolk sac tumor 95% Endometrial stromal sarcoma high grade 73% Adenomatoid tumor 87% Complex endometrial hyperplasia with atypia 74% Hyperreactor luteinalis 86% Borderline (proliferating) Brenner tumor 81% Parvovirus B19 fetopathy with hydrops fetalis 69% Acute lymphoblastic leukemia 28% Serous borderline tumor (serous tumor of low malignant potential) 92% Partial hydatidiform mole 72% Primary transitional cell carcinoma 37% Sex cord tumor with annular tubules 49% Partial hydatidiform mole 72% Primary peritoneal papillary serous carcinoma, low grade 76% Thecoma 37% Clear cell carcinoma 92% Sertoli-Leydig cell tumor w/ granulosa cell tumor and heterologous elements 56% Malignant mixed Müllerian tumor, heterologous type 97% Mucinous tumor of borderline malignancy 96% Low grade endometrial stromal sarcoma with sex cord elements 57% Dysgerminoma 90% Small cell carcinoma 93% Adult granulosa cell tumor 94% Lymphoplasmacytic villitis due to cytomegalovirus infection 74% Pregnancy luteoma 39% Acute bacterial villitis 92% Sclerosing stromal tumor 67% Carcinoid tumor 79% Brenner tumor 87% Endometrioid carcinoma 62% Adenocarcinoma 70% Epithelioid leiomyoma 83% Immature teratoma 90% Mature cystic teratoma 95% Liposarcoma wit myxoid features 72% Hydatidiform mole, complete 82% Endocervical adenomyoma 74% Epithelioid trophoblastic tumor 32% Yolk sac tumor (endodermal sinus tumor) 76%

10 Gynecologic Listeria monocytogenes infection 91% Fallopian tube adenocarcinoma 71% Chorangiomatosis 50% Sertoli-Leydig cell tumor 55% Serous borderline cystadenofibroma 71% Adult granulosa cell tumor 89% Endometrial polyp 85% Metastatic pancreatic adenocarcinoma 65% Leiomyosarcoma 90% Aggressive angiomyxoma 97% Fibroma 87% Juvenile granulosa cell tumor 85% Clear cell carcinoma 62% Mucinous borderline tumor 67% Metastatic gastric carcinoma 77% Mature teratoma 89% Yolk sac tumor (endodermal sinus tumor) 94% Stromal carcinoid 95% Endometrial stromal tumor with sex-cord like elements 89% Serous carcinoma, high grade 91% Acute villitis 73% Ovarian small cell carcinoma, hypercalcemic type 50% Hydrops placentalis 78% Sex cord tumor with annular tubules 72% Carcinosarcoma (malignant mixed Müllerian tumor) 52% Endometrioid adenocarcinoma 56% Brenner tumor 99% Adult granulosa cell tumor 95% Sclerosing stromal tumor 75% Lipoleiomyoma 97% Endometrial stromal sarcoma, low grade 93% Epithelioid leiomyosarcoma 30% Malignant mixed Müllerian tumor 61% Clear cell carcinoma 94% Hepatoid carcinoma 74% Embryonal rhabdomyosarcoma with anaplasia 89% Juvenile granulosa cell tumor 96% Metastatic colorectal adenocarcinoma 98% Chronic villitis secondary to cytomegalovirus infection 98% Serous neoplasm of low malignant potential 95% High grade endometrioid carcinoma, grade 3 94% Endometrial stromal sarcoma, low grade 98% Endometrioid adenocarcinoma 96% Myeloid sarcoma 94% Yolk sac tumor 99% Complete hydatidiform mole 92% Myxoid/round cell liposarcoma 97%

11 Gynecologic Steroid cell tumor, not otherwise specified 89% Adult granulosa cell tumor 93% Dysgerminoma 97% Endometrioid adenocarcinoma 98% Chronic villitis secondary to cytomegalovirus infection 89% Complete hydatidiform mole 93% Complete hydatidiform mole 97% Juvenile granulosa cell tumor 95% Benign Brenner tumor 96% Müllerian adenosarcoma 81% Angiomyofibroblastoma 93% Sclerosing stromal tumor 96% Dysgerminoma 98% Cellular fibrothecoma 87% Endometrial stromal sarcoma 99% Mesenchymal dysplasia 87% Dysgerminoma 99% Mucinous cystadenocarcinoma of ovary, Grade I 95% Varicella zoster virus infection 92% Immature teratoma 97% Extramammary Paget disease 99% Uterine Leiomyosarcoma 97% Chorangioma 98% Sertoli-Leydig cell tumor 89% Thecoma 91% Severe acute chorioamnionitis w/ fusobacteria 87% Endometrial adenocarcioma, endometrioid type FIGO grade 2 98% Aggressive angiomyxoma 98% Clear cell carcinoma 96% Granulosa cell tumor 98% Edematous chorionic villi (placental hydrops) with erythroblastosis secondary to infection - B19 with parvovirus 94% Adenocarcinoma 99% Diffuse Melanosis Coli 99% Endometriosis 95% Malignant PEComa (perivascular epithelioid cell tumor) 94% Cellular angiofibroma 93% Serous carcinoma 98% Scherosing stromal tumor 98% Villitis of unknown etiology (VUE) 95% Adenocarcinoma 89% Metastatic pleomorphic lobular carcinoma of breast 97% Brenner tumor with mucious cystadenoma 97% Low-grade endometrial stromal sarcoma 97% Yolk sac tumor 95% Endometrial stromal sarcoma 95% Adenocarcinoma ex goblet cell carcinoid 98%

12 Gynecologic Placenta previa increta 86% Gestational trophoblastic disease, complete molar type 97% Diffuse malignant peritoneal mesothelioma, epithelioid type 98% Endometrioid borderline tumor 95% Leiomyoma with bizarre nuclei 96% Head & Neck Mucoepidermoid carcinoma 97% Warthin's tumor 99% Pleomorphic adenoma (benign mixed tumor) 89% Squamous cell carcinoma of larynx 86% Adenoid cystic carcinoma 96% Benign lymphoepithelial lesion of parotid gland 78% Acinic cell adenocarcinoma 87% Allergic fungal sinusitis 64% Low grade adenocarcinoma (nasopharyngeal papillary adenocarcinoma) 84% Cystic nonkeratinizing squamous cell carcinoma, metastatic to neck lymph node 64% Carcinoma ex-mixed tumor 75% Pleomorphic adenoma 91% Squamous papilloma 89% Acinic cell adenocarcinoma 73% Synovial sarcoma, monophasic 86% Warthin tumor 99% Spindle cell lipoma 69% Extraosseous plasmacytoma 99% Acinic cell carcinoma 99% Basaloid squamous cell carcinoma 97% Chagas disease, acute reactivation following transplantation 95% Acinic cell carcinoma with high-grade transformation 93% Anaplastic thyroid carcinoma with heterologous differentiation (leiomyosarcoma) 97% Solitary fibrous tumor, malignant 92% Heme/Lymphatic Reactive follicular hyperplasia, non-specific 97% Diffuse small lymphocytic lymphoma (well-differentiated) 89% Follicular small cleaved cell (nodular poorly differentiated lymphocytic) lymphoma 96% Reactive lymph node hyperplasia 93% Hodgkin disease, nodular sclerosing type 99% Metastatic lobular breast carcinoma in lymph node 91% Diffuse large cell lymphoma 95% Diffuse large cell lymphoma, non-cleaved 50% Metastatic malignant melanoma 66% Cat scratch disease 98% Encapsulated thymoma 75%

13 Heme/Lymphatic Carcinoid of the thymus 92% Melanoma in lymph node 87% Nodular lymphoma 68% Castleman's disease 95% Hodgkin disease, nodular sclerosing 95% Hodgkin disease, nodular sclerosing 88% Burkett lymphoma 91% Malignant lymphoma, non-hodgkin, small non-cleaved cell 78% Large cell malignant lymphoma 74% Malignant lymphoma, mantle cell type 48% Hodgkin disease 88% Hodgkin disease, nodular sclerosis type 99% Malignant lymphoma, diffuse large cell type 73% Hairy cell leukemia of the spleen 91% Idiopathic thrombocytopenia purpura 88% Malignant lymphoma, follicular 60% Malignant lymphoma, MALT type, low grade 63% Castleman's disease 91% Lymphocyte-predominant thymoma 87% Malignant lymphoma, small non-cleaved cell type 57% Thymoma, epithelial predominant (cortical) 95% Malignant lymphoma, mantle cell type, cecum 30% Malignant lymphoma large cell type 57% Marginal zone/malt lymphoma 77% Thymic carcinoma 71% Hodgkin disease, mixed cellularity type 78% Hepatosplenic γδ T-cell lymphoma 82% Extramedullary hematopoiesis of spleen in agnogenic myeloid metaplasia 90% Malignant lymphoma, diffuse, mixed small cleaved and large cell type 72% Infectious mononucleosis 74% Littoral cell angioma 59% Primary amyloidosis, lymph node 66% Prolymphocytic leukemia 40% Anaplastic large cell lymphoma 83% Angiosarcoma, spleen 46% Lymphocyte predominant Hodgkin lymphoma 63% Multiple myeloma 87% Splenic involvement by small lymphocytic lymphoma/chronic lymphocytic N/A Cat scratch disease 96% Extramedullary myeloid tumor 50% Carcinoid tumor consistent with thymic origin 93% Hairy cell leukemia 96% Nodular sclerosis Hodgkin disease 94% Langerhans cell histiocytosis 92% Mantle cell lymphoma 89% Follicular lymphoma 84% Hodgkin lymphoma, nodular sclerosis type 88%

14 Heme/Lymphatic Hepatosplenic T-cell lymphoma 86% Mantle cell lymphoma 83% Small lymphocytic lymphoma 88% Typical carcinoid 72% Littoral cell angioma 78% Diffuse large B-cell lymphoma (anaplastic variant) 95% Follicular lymphoma 95% Myeloid sarcoma ( chloroma ) 90% Systemic mastocytosis 93% Classical Hodgkin lymphoma 92% Inflammatory myofibroblastic tumor 94% Acute myeloid leukemia 39% Gaucher disease 92% Thymic carcinoid 97% Angiosarcoma 88% Hepatosplenic T-cell lymphoma 96% Splenic marginal zone lymphoma Angiofollicular hyperplasia (Castleman disease) 96% Lymphoepithelial thymoma 96% Lymphangioma 85% Paraganglioma 96% Hairy cell leukemia 97% Littoral cell angioma 97% Spindle cell thymoma (WHO type A) 92% Lymphangioma (Lymphatic malformation) 96% Mantle cell lymphoma 83% Low grade fibromyxoid sarcoma with giant collagen rosettes 95% Hairy cell leukemia 97% Niemann-Pick disease 85% Nodular sclerosis classical Hodgkin lymphoma 97% Diffuse large B-cell lymphoma, NOS 98% Viral associated hemophagocytic syndrome 98% Splenic marginal zone lymphoma 91% Follicular dendritic cell sarcoma 97% Gaucher disease 99% Amyloidosis 99% Intra-abdominal desmoplastic small round cell tumor 98% Hepatosplenic T-cell lymphoma 85% Mantle cell lymphoma 99% Splenic extramedullary hematopoiesis secondary to primary myelofibrosis - 99% Sclerosing extramedullary hematopoietic tumor 89% Merkel cell carcinoma 99% Small lymphocytic lymphoma/chronic lymphocytic leukemia 97% Nodular lymphocyte-predominant Hodgkin lymphoma 95% Classical Hodgkin lymphoma 99% Littoral cell angioma 96% Splenic marginal zone lymphoma 96%

15 Heme/Lymphatic Non-necrotizing granulomatous inflammation/sarcoidosis 99% Follicular lymphoma 99% Reactive follicular hyperplasia 94% Sclerosing angiomatoid nodular transformation 95% Littoral cell angioma 97% Metastatic prostatic adenocarcinoma 96% Hepatobiliary Hepatocellular cellular carcinoma 94% Micronodular cirrhosis, etiology uncertain 97% Focal nodular hyperplasia 93% Chronic passive congestion 99% Primary biliary cirrhosis 71% Focal nodular hyperplasia 91% Hepatocellular carcinoma 95% Cirrhosis 75% Primary sclerosing cholangitis 11% Hepatoblastoma 94% Chronic active hepatitis 89% Hepatocellular carcinoma 27% Acute acetaminophen hepatotoxicity 90% Biliary cystadenoma with mesenchymal stroma 95% Cholangiocarcinoma 78% Fibrolamellar carcinoma 86% Chronic hepatitis C, with mild activity (grade 2) & mild periportal (stage 2) 91% Budd-Chiari syndrome 74% Liver cell adenoma 80% Angiosarcoma 69% Mesenchymal hamartoma 89% Epithelial hepatoblastoma, mixed fetal and embryonal types 39% Fibrolamellar hepatocellular carcinoma 90% Recurrent pyogenic cholangitis 65% Adenocarcinoma 93% Acute myeloid leukemia 93% Amyloidosis 98% Chronic rejection 81% Liver cell carcinoma 80% Primary biliary cirrhosis 92% Embryonal (undifferentiated) sarcoma 89% Hepatocellular adenoma 61% Hepatobiliary cystadenoma 60% Focal nodular hyperplasia 91% Mesenchymal hamartoma 98% Congenital hepatic fibrosis 78%

16 Hepatobiliary Focal nodular hyperplasia 83% Metastatic hemangiopericytoma 58% Hepatoblastoma 93% Mastocytosis 89% Polycystic liver disease 72% Cirrhosis due to alpha-1-antitrypsin deficiency 75% Amyloidosis with biliary-type fibrosis 96% Herpes simplex virus hepatitis 73% Submassive hepatic necrosis 64% Hepatoblastoma 89% Fibrolamellar hepatocellular carcinoma 94% Aggressive systemic mastocytosis 93% Focal nodular hyperplasia 98% Angiosarcoma 95% Cavernous hemangioma 99% Herpes simplex virus hepatitis 95% Hepatocellular carcinoma 98% Alpha-1-antitrypsin deficiency 96% Hepatocellular carcinoma 99% Cholesterolosis 99% Cavernous hemangioma 95% Fibrolamellar carcinoma 97% Congenital hepatic fibrosis 95% Biliary cirrhosis secondary to cystic fibrosis 96% Glycogen storage disease, type IV 97% Hepatoblastoma 99% Alcoholic liver disease with cirrhosis 99% Hepatitis C with alpha-1-antitrypsin intracytoplasmic globules 99% Focal nodular hyperplasia 97% Mesenchymal hamartoma 96% Fibrolamellar hepatocellular carcinoma 99% Angiosarcoma 98% Undifferentiated embryonal sarcoma of liver 94% Alagille syndrome 90% Chronic pyelonephritis w/ granulomas and scarring 96% Epitheloid hemangioendothelioma 96% Budd-Chiari syndrome (primary) 87% Metastatic neuroendocrine tumor (NET) 99% Hepatic nuclear factor 1 alpha (HNF!A) inactivated hepatocellular adenoma 94% Focal nodular hyperplasia 99% Billary cystadenoma 95% Clear-cell hepatocellular carcinoma 98% Hepatoblastoma 98% Solid-pseudopapillary neoplasm 97%

17 Male Genital Granulomatous prostatitis, non-specific 95% Basal cell hyperplasia of the prostate 96% Granulomatous orchitis (autoimmune orchitis) 90% Cryptorchid testis 95% Seminoma 90% Malignant lymphoma, diffuse, large cell 85% Teratocarcinoma 97% Adenocarcinoma 95% 92-K1 Prostatic adenocarcinoma 69% Idiopathic granulomatous orchitis 87% Seminoma 93% Mixed germ cell neoplasm 68% Sertoli cell adenoma, arising in a patient with complete androgen insensitivity syndrome 73% High grade prostatic intraepithelial neoplasia 91% Adenomatoid tumor 97% Spermatocytic seminoma, testis 77% Immature teratoma, testis 80% Seminoma 96% Spermatocytic seminoma 95% Seminoma 97% Aggressive angiomyxoma 81% Leydig cell tumor 97% Primary testicular lymphoma, diffuse large B-cell type 95% Seminoma 98% Stromal tumor of uncertain malignant potential 88% Yolk sac tumor 99% Testicular seminoma 99% Seminoma spermatocytic 96% Diffuse large B-cell lymphoma 96% Mixed germ cell tumor 98% Squamous cell carcinoma, poorly differentiated 92%

18 Nervous System Aggressive angiomyxoma 92% Glioblastoma multiforme (astrocytoma grade III-IV) 98% Meningioma 99% Alzheimer's disease 93% Cerebral infarct, recent, mixed anemic and hemorrhagic 97% Neuroblastoma 95% Oligodendroglioma 55% Ganglioneuroblastoma 84% Transitional meningioma 98% Papillary meningioma 62% Cytomegalovirus ventriculitis 84% HIV encephalitis 65%? Progressive multifocal leukoencephalopathy 67% Cryptococcal meningitis 92% Primary CNS lymphoma 93% Ganglioneuroblastoma, recurrent, lumbar epidural space and retroperitoneum (neuroblastoma also accepted) 83% Acute demyelinating process 58% Dementia with Lewy bodies 32% Subependymal giant cell astrocytoma 85% Cerebral amyloid angiopathy 85% Human prion disease: Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease) 2% Histoplasmosis 74% Gliomatosis cerebri 88% Pilocytic astrocytoma 90% Progressive multifocal leukoencephalopathy 91% Central neurocytoma 72% Aggressive angiomyxoma 92% Oligodendroglioma, WHO grade III 87% Desmoplastic infantile astrocytoma/ganglioma 79% Schwannoma 78% Differentiating neuroblastoma 75% Fibrous meningioma 93% West Nile encephalitis 80% Choroid plexus carcinoma 63% Intravascular lymphoma 92%

19 Nervous System Ependymoma 88% Microcystic meningioma 62% Recurrent high grade astrocytoma with gemistocytic features (WHO grade III-IV) 85% Gliomatosis cerebri (WHO grade III) 85% Paraganglioma of the cauda equine 82% Atypical meningioma (WHO grade II) 33% Pituitary adenoma 98% Chordoid meningioma 95% Anaplastic hemangiopericytoma of the nervous system 90% Gliomatosis cerebri 91% Cortical tuber associated with tuberous sclerosis 88% Malignant peripheral nerve sheath tumor 96% Chordoid meningioma, WHO grade II 95% Cellullar schwannoma, encapsulated w/ focal cystic degeneration 92% Meningioma with predominantly meningothelial pattern 96% Ganglioneuroblastoma 93% Meningioma 99% Oral Path Ameloblastoma 94% Odontogenic keratocyst 53% Central giant cell granuloma 94% Peripheral ossifying fibroma 42% Dentigerous follicular cyst 80% Mucocele 98% Oral lichen planus 85% Ameloblastoma 92% Premalignant epithelial dysplasia 54% Adenoid cystic carcinoma 88% Lipoblastomatosis 98% Salivary duct carcinoma 97% Respiratory Normal lung (kodachrome, FNA) 78% Small cell carcinoma 94% Adenocarcinoma with numerous tumor giant cells 99% Spindle cell variant of squamous cell carcinoma 95% Adenocarcinoma, moderately differentiated 97% Bronchiolo-alveolar carcinoma 79% Pneumocystic carinii pneumonia 98% Squamous cell carcinoma 83% Kaposi sarcoma 96% Measles pneumonia (giant cell pneumonia) with severe diffuse alveolar damage 59% Diffuse alveolar damage 93% Oat cell carcinoma 95% Carcinoid tumor 69% Acute interstitial pneumonia 30%

20 Respiratory Adenocarcinoma, poorly differentiated 47% Broncho-alveolar adenocarcinoma 77% Actinomycosis 87% Microcystic adenoma 91% Diffuse septal amyloidosis 67% Pulmonary cryptococcosis 93% Acute interstitial pneumonia 46% Localized fibrous tumor of pleura 91% Granulomatous lung disease, NOS 65% Adenosquamous carcinoma 75% Giant cell interstitial pneumonia 60% Low grade pleuropulmonary blastoma 25% Herpes simplex pneumonia 73% Solitary fibrous tumor, pleura 82% Malignant mesothelioma, tubulopapillary type 96% Intralobar pulmonary sequestration 86% Silicosis 70% Pulmonary lymphangioleiomyomatosis 85% Pulmonary coccidioidomycosis 84% Kaposi sarcoma 86% Inflammatory myofibroblastic tumor 94% Wegener s granulomatosis 91% Epithelioid hemangioendothelioma 44% Cystic fibrosis 90% Legionella pneumonia 74% Respiratory syncytial virus pneumonia 69% Bronchioloalveolar adenocarcinoma 96% Peripheral primitive neuroectodermal tumor 89% Pulmonary hyperplasia 32% Solitary fibrous tumor 94% Lymphangioleiomyomatosis 89% Thymoma 94% Small cell carcinoma 55% Extranodal marginal zone (MALT) lymphoma 89% Bronchiectasis 82% Pulmonary amyloidosis, diffuse parenchymal type 92% Biphasic pulmonary blastoma 90% Cytomegalovirus pneumonia 85% Bronchioloalveolar carcinoma, mucinous type 92% Solitary fibrous tumor 95% Thymoma 90% Bronchioloalveolar carcinoma, mucinous type 93% Acute lobar pneumonia 86% Malignant solitary fibrous tumor 94% Pulmonary cryptococcosis 91% Follicular dendritic cell tumor/sarcoma 92%

21 Respiratory Cytomegalovirus pneumonia and Pneumocystis pneumonia 92% Small cell carcinoma 82% Pulmonary adenocarcinoma, mixed subtype 83% Extranodal marginal zone lymphoma, MALT type 98% Squamous cell carcinoma 95% Lymphangioleiomyomatosis 98% Cryptococcosis 98% Recurrent respiratory papillomatosis 93% Alveolar capillary dysplasia 85% Invasive mucinous adenocarcinoma 93% Extranodal marginal zone B-cell lymphoma 99% Adenocarcinoma, predominantly acinar type 96% Pleomorphic carcinoma 87% Biphasic epithelioid mesothelioma 97% Invasive mucinous adenocarcinomal/colloid carcinoma 98% Recurrent synovial sarcoma 98% Skin Pilomatrixoma (calcifying epithelioma of malherbe) 97% Malignant melanoma 81% Congenital nevus 79% Dermatofibrosarcoma protuberans 87% Merkel cell tumor 79% Peripheral neuroectodermal tumor 63% Proliferating trichilemmal cyst 85% Giant congenital melanocytic nevus 80% Extramammary Paget s disease 87% Atypical nevus with mild dysplasia 81% Malignant melanoma 79% Warty dyskeratoma 82% Desmoplastic trichoepithelioma 62% Extramammary Paget s disease 97% Discoid lupus erythematous 90% Cutaneous blastomycosis 84% Merkel cell carcinoma 95% Epithelioid and spindle cell nevus 88% Endometriosis 95% Angiosarcoma 97% Angiosarcoma 93% Condyloma acuminatum 96% Angiosarcoma 87% Nodular melanoma 97%

22 Soft Tissue/Bone/Joint Epithelioid sarcoma 98% Parosteal osteosarcoma 86% Paget's disease 96% Ewing sarcoma 93% Extra abdominal desmoid tumor (fibromatosis) 95% Rheumatoid synovitis 99% Aneurysmal bone cyst 85% Chondrosarcoma 84% Fibrous dysplasia 86% Synovial sarcoma, monophasic 79% Malignant fibrous histiocytoma 86% Lipoma, intramuscular 10% Schwannoma 95% Liposarcoma, high grade 71% Nodular fascitis 90% Myxoid liposarcoma 84% Pleomorphic lipoma/well-differentiated liposarcoma 61% Elastofibroma 89% Rheumatoid nodule 92% Malignant fibrous histiocytoma, storiform-pleomorphic type 87% Well-differentiated liposarcoma 72% Angiolipoma 71% Fibrous dysplasia 59% Schwannoma (neurilemmoma) 65% Lymphangiomyoma 90% Biphasic synovial sarcoma 57% Aggressive angiomyxoma 81% Embryonal rhabdomyosarcoma 85% Osteoarthritis 82% Angiosarcoma 90% Chondrosarcoma 52% Avascular necrosis, osteonecrosis 97% Inflammatory myofibroblastic tumor 89% Intramuscular myxoma 93% Leiomyomatosis peritonealis disseminata 96% Alveolar soft part sarcoma 43% Amyloid tumor 95% Neurofibroma 95% Myxoid/round cell liposarcoma 90% Rhabdomyoma, adult type 90% Chronic synovitis consistent with rheumatoid arthritis 44% Pleomorphic leiomyosarcoma 65% Giant cell fibroblastoma with dermatofibrosarcoma protuberans 68% Chordoma 43% Schwannoma (neurilemmoma), soft tissue 85% Elastofibroma, subscapular area 90%

23 Soft Tissue/Bone/Joint Diffuse malignant mesothelioma 88% Pigmented villonodular synovitis 97% Synovial sarcoma, right parietal pleura 41% Osteosarcoma with grade IIB treatment effect 82% Malignant fibrous histiocytoma 94% Neuroblastoma, poorly differentiated 15% Malignant mesothelioma 21% Desmoid tumor (abdominal fibromatosis) 93% Diffuse neurofibroma 75% Fibrous hamartoma of infancy 89% Extranodal Rosai-Dorfman disease 56% Alveolar soft part sarcoma 93% Myxoid liposarcoma 90% Rhabdomyosarcoma with treatment effect 67% Spindle cell lipoma 84% Multicystic mesothelioma, peritoneum 94% Granular cell tumor of soft tissue 97% Cerebral abscess 89% Myositis ossificans 82% Meningothelial meningioma 85% Extra-abdominal fibromatosis (desmoid tumor) 54% Myxopapillary ependymoma of the filum terminale 71% Hibernoma 96% Juxta-articular myxoma 78% Giant cell tumor 91% Granulomatous inflammation due to Coccidioidomycosis (C. immitis) 65% Clear cell myomelanocytic tumor of hepatic falciform ligament/ligamentum 68% Castleman disease 96% Malignant peripheral nerve sheath tumor 87% Monophasic synovial sarcoma 94% Chondrosarcoma 97% Sclerosing well-differentiated liposarcoma 72% Myxoid/round cell liposarcoma 66% Epithelioid hemangioendothelioma 34% Ewing sarcoma-pnet 94% Incontinentia pigmenti 71% Kimura Disease 93% Pleomorphic hyalinizing angiectatic tumor 95% Synovial chondromatosis 77% Perivascular epithelioid cell tumor (PEComa) 79% Infantile fibrosarcoma 83% Malignant solitary fibrous tumor 62% Elastofibroma 84% Lipoblastoma 82% Malignant peripheral nerve sheath tumor 92%

24 Soft Tissue/Bone/Joint Alveolar soft part sarcoma 95% Intramuscular myxoma 93% Plexiform neurofibroma 88% Myxoid liposarcoma 91% Spindle cell lipoma 94% Ewing sarcoma/primitive neuroectodermal tumor 92% Osteosarcoma 76% Alveolar soft part sarcoma 67% Post radiation osteosarcoma, fibroblastic type 96% Plasmacytoma, extramedullary 93% Metastatic melanoma 99% Angiomyofibroblastoma-like tumor of the male genital tract 84% Malignant mesothelioma 95% Desmoid-type fibromatosis 93% Chondrosarcoma 95% Mammary-type myofibroblastoma 65% Ganglioneuroma 97% Leiomyosarcoma 99% Myxoid liposarcoma 91% Metastatic mucinous adenocarcinoma (mucinous carcinoma peritonei) 97% Schwannoma with degenerative changes 86% Elastofibroma 95% Myxoma 98% Osteosarcoma, chondroblastic type 93% Angiosarcoma 97% Well-differentiated liposarcoma 90% Primary renal Ewing sarcoma/primitive neuroectodermal tumor 90% Intraosseous osteosarcoma, low-grade 87% Glomus tumor 98% Kaposiform hemangioendothelioma 92% Malignant mesothelioma 99% Synovial sarcoma 99% Chondrosarcoma, well-differentiated 96% Kimura lymphadenopathy 91% Infantile fibrosarcoma 92% Ewing sarcoma/primitive neuroectodermal tumor 98% PEComa 94% Intramuscular myxoma 96% Primary synovial chondromatosis 92% Solitary fibrous tumor 98% Castleman disease 99% Alveolar soft part sarcoma 98% Pigmented villonodular synovitis, diffuse-type 92% Paraganglioma 98% Plexiform neurofibroma 97%

25 Soft Tissue/Bone/Joint Hibernoma 99% Myelolipoma 98% Malignant melanoma, nodular type 98% Chordoma 99% Chondrosarcoma, grade 2 95% Alveolar rhabdomyosarcoma 94% Solitary fibrous tumor 94% Low-grade fibromyxoid sarcoma 95% Thymoma, WHO type AB 93% Leiomyoma 99% Intramuscular hemangioma 95% Malignant rhabdoid tumor 93% Invasive well diff SCC with verrucous features 99% Small cell carcinoma, metastatic 99% Chondroblastoma 94% Liposarcoma, dedifferentiated 93% Malignant fibrous histiocytoma (pleomorphic-storiform type) 97% Ganglioneuroma 97% Spindle cell/pleomorphic lipoma 96% Lymphangioma 96% Myosis ossificans 96% Fungal infection due to hyalohyphomycotic organism (Scedosporium Apiospermum) 98% Paraganglioma 99% Pilomatricoma w/metaplastic ossification 94% Mesenteric fibromatosis 93% High-grade (conventional) osteosarcoma 97% Extraosseous Ewing sarcoma 92% Clear cell sarcoma 97% Pleomorphic liposarcoma 94% Myxoid liposarcoma 98% High-grade chondrosarcoma 95% Granular cell tumor 98% Chordoma 98%

26 Urinary Oncocytoma (grade 1 granular cell neoplasm) 98% Renal cell carcinoma 62% Nephrogenic adenoma (urothelial metaplasia) 72% Mesoblastic nephroma 98% Wilms tumor 94% Xanthogranulomatous pyelonephritis 79% Papillary transitional cell carcinoma 95% Renal cell carcinoma 99% Renal cell carcinoma, sarcomatoid 86% Transplant rejection of kidney, acute 98% Papillary transitional cell carcinoma, non-invasive 87% Congenital mesoblastic nephroma 86% Renal cell carcinoma, chromophobe cell subtype 26% Renal allograft rejection, acute and chronic 57% 95-K2 Focal and segmental glomerulonephritis 78% Myeloma cast nephropathy 94% 96-K1 IGA nephropathy 92% Renal medullary carcinoma 64% Nephroblastoma (Wilms tumor), favorable histology 36% Ethylene glycol nephrotoxicity 80% Invasive transitional cell carcinoma 83% Xanthogranulomatous pyelonephritis 95% Metanephric adenoma 73% Clear cell carcinoma 99% Chromophobe renal cell carcinoma 82% Wilms tumor with diffuse anaplasia 68% Angiomyolipoma 85% Sarcomatoid renal cell carcinoma 78% Urothelial neoplasm of low malignant potential 70% Oncocytoma 91% Clear cell sarcoma 54% Renal cell carcinoma, unclassified 64% Leiomyosarcoma 89% Sarcomatoid urothelial carcinoma 78% Wilms tumor, blastema predominant 84% Pseudosarcomatous reactive myofibroblastic proliferation N/A Mixed epithelial and stromal tumor 40% Oncocytoma 93% Chromophobe renal cell carcinoma 87% Acute cellular rejection with mild chronic transplant nephropathy 78% Leiomyosarcoma 89% Collecting duct carcinoma 92% Embryonal rhabdomyosarcoma, NOS 89% Angiomyolipoma 95% Papillary urothelial carcinoma, low grade 84% Wilms tumor 89% Xanthogranulomatous pyelonephritis 96%

27 Urinary Mucinous tubular and spindle cell carcinoma of kidney 51% Congenital mesoblastic nephroma, cellular type 70% Carcinoid tumor 91% Angiomyolipoma 99% Acute cellular allograft rejection 73% Metanephric adenoma 71% Low grade papillary urothelial carcinoma 62% Oncocytoma 96% Chromophobe renal cell carcinoma 97% Papillary renal cell carcinoma 87% Mixed epithelial and stromal tumor 86% Clear cell renal cell carcinoma 94% Angiomyolipoma 85% Non-invasive papillary urothelial carcinoma 98% Chromophobe renal cell carcinoma 97% Renal cell carcinoma with sarcomatoid component 96% Wilms tumor, favorable histology 94% Renal medullary carcinoma 87% Congenital mesoblastic nephroma 96% Angiomyolipoma 99% Urothelial carcinoma 98% Oncocytoma 98% Chromophobe renal cell carcinoma 99% Urothelial carcinoma, micropapillary variant 93% Congenital mesoblastic nephroma 96% Autosomal dominant polycystic kidney disease 96% Papillary renal cell carcinoma, type 1 90% Wilms tumor, blastemal prominent 98% Sarcomatoid renal cell carcinoma 99% Papillary urothelial carcinoma 96% Translocation renal cell carcinoma 95% Angiomyolipoma 99% Renal cell carcinoma with rhabdoid differentiation 95% Cystic nephroma/mixed epithelial and stromal tumor 97% Chromophobe renal cell carcinoma 95% Papillary renal cell carcinoma, type 1 93% Urothelial carcinoma, plasmacytoid type 94%

28 NOTES

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