Table S4A- GOBP functional annotation of celecoxib-modulated genes common between CO
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1 Table S4A- GOBP functional annotation of celecoxib-modulated genes common between CO Terms ListHits ListTotal PopulationHits cell proliferation cell cycle DNA replication and chromosome cycle DNA replication response to DNA damage stimulus response to endogenous stimulus DNA repair DNA metabolism response to stress cellular physiological process cell growth and/or maintenance nucleobase/, nucleoside/, nucleotide and nucleic acid metabolism DNA-dependent DNA replication metabolism regulation of cell cycle regulation of transcription from Pol II promoter transcription from Pol II promoter ER to Golgi transport cytokinesis ubiquitin cycle G1 phase of mitotic cell cycle mitotic cell cycle nuclear division traversing start control point of mitotic cell cycle DNA replication initiation M phase regulation of biological process RNA catabolism physiological process sister chromatid segregation mitotic sister chromatid segregation positive regulation of transcription from Pol II promoter regulation of I-kappaB kinase/nf-kappab cascade protein modification G1/S transition of mitotic cell cycle pyridine nucleotide biosynthesis keratinocyte differentiation glycerophospholipid metabolism regulation of DNA replication water-soluble vitamin metabolism mitotic anaphase deoxyribonucleotide metabolism water-soluble vitamin biosynthesis Golgi vesicle transport nucleotide metabolism dtmp biosynthesis regulation of sister chromatid cohesion DNA synthesis during DNA repair deoxyribonucleoside monophosphate biosynthesis
2 deoxyribonucleoside monophosphate metabolism pyrimidine deoxyribonucleoside monophosphate metabolism pyrimidine deoxyribonucleoside monophosphate biosynthesis trna catabolism viral intracellular protein transport trna 5'-leader removal host cell protein transport mitotic spindle positioning or orientation positive regulation of mitotic metaphase/anaphase transition negative regulation of sister chromatid cohesion dtmp metabolism regulation of viral protein levels dermatan sulfate proteoglycan biosynthesis/, polysaccharide chain bios cell cycle arrest vitamin biosynthesis phosphoinositide biosynthesis protein localization lipid metabolism cell death translational initiation death telomerase-dependent telomere maintenance regulation of cellular process I-kappaB kinase/nf-kappab cascade meiosis carboxylic acid metabolism organic acid metabolism G2/M transition of mitotic cell cycle telomere maintenance phosphoinositide metabolism apoptosis programmed cell death base-excision repair positive regulation of I-kappaB kinase/nf-kappab cascade nucleotide biosynthesis mrna capping seryl-trna aminoacylation biotin metabolism G1-specific transcription in mitotic cell cycle pyrimidine nucleoside monophosphate metabolism pyrimidine nucleoside monophosphate biosynthesis pyrimidine deoxyribonucleotide biosynthesis RNA capping negative regulation of transcriptional preinitiation complex formation glucocorticoid receptor signaling pathway positive regulation of cell cycle positive regulation of mitosis negative regulation of proteolysis and peptidolysis glycerophospholipid catabolism dermatan sulfate proteoglycan biosynthesis chondroitin sulfate proteoglycan biosynthesis/, polysaccharide chain bio cellular process
3 vitamin metabolism DNA recombination protein transport meiotic recombination translation response to unfolded protein mitosis glycerophospholipid biosynthesis protein secretion secretory pathway positive regulation of signal transduction M phase of mitotic cell cycle meiosis I meiotic prophase I pyridine nucleotide metabolism cysteinyl-trna aminoacylation male meiosis deoxyribonucleotide biosynthesis UV protection malate metabolism regulation of mitotic metaphase/anaphase transition bile acid catabolism retrograde protein transport/, ER to cytosol establishment of protein localization dermatan sulfate proteoglycan metabolism base-excision repair/, DNA ligation DNA ligation during DNA repair macromolecule metabolism chromosome segregation intracellular protein transport receptor mediated endocytosis pyrimidine nucleotide biosynthesis regulation of DNA metabolism regulation of metabolism oxidoreduction coenzyme metabolism nitrogen metabolism bile acid biosynthesis mitotic metaphase/anaphase transition arachidonic acid metabolism myoblast differentiation endothelial cell differentiation chondroitin sulfate proteoglycan biosynthesis cofactor metabolism negative regulation of transcription from Pol II promoter vesicle-mediated transport positive regulation of transcription/, DNA-dependent lipid biosynthesis cell organization and biogenesis amino acid transport regulation of transcription from Pol III promoter imprinting glycosaminoglycan catabolism
4 deoxyribonucleoside diphosphate metabolism response to UV NAD biosynthesis negative regulation of catabolism acidic amino acid transport L-glutamate transport organic acid catabolism NAD metabolism ER-associated protein catabolism misfolded or incompletely synthesized protein catabolism unfolded protein response phosphatidylinositol biosynthesis carboxylic acid catabolism aminoglycan catabolism chondroitin sulfate proteoglycan metabolism regulation of protein secretion negative regulation of metabolism regulation of cell proliferation regulation of nucleobase/, nucleoside/, nucleotide and nucleic acid meta RNA metabolism amine transport cell cycle checkpoint cellular morphogenesis sister chromatid cohesion parturition DNA ligation nucleoside diphosphate metabolism regulation of transcriptional preinitiation complex formation phosphatidylinositol metabolism transcriptional preinitiation complex formation positive regulation of cell proliferation regulation of physiological process regulation of translational initiation intracellular transport membrane lipid metabolism coenzyme biosynthesis cofactor biosynthesis transcription regulation of cyclin dependent protein kinase activity pyrimidine nucleotide metabolism RNA processing transcription/, DNA-dependent regulation of signal transduction regulation of cell size cell growth ER-nuclear signaling pathway plasma membrane organization and biogenesis lipopolysaccharide metabolism lipopolysaccharide biosynthesis urea cycle cortical cytoskeleton organization and biogenesis cortical actin cytoskeleton organization and biogenesis
5 arginine catabolism phospholipid metabolism protein amino acid dephosphorylation chromosome organization and biogenesis (sensu Eukaryota) negative regulation of transcription dephosphorylation pyrimidine deoxyribonucleotide metabolism organic acid transport carboxylic acid transport nuclear organization and biogenesis protein folding positive regulation of apoptosis positive regulation of programmed cell death GPI anchor metabolism GPI anchor biosynthesis dicarboxylic acid transport galactose metabolism initiation of viral infection estrogen receptor signaling pathway viral entry steroid catabolism negative regulation of nucleobase/, nucleoside/, nucleotide and nucleic carbohydrate biosynthesis regulation of transcription/, DNA-dependent trna processing regulation of transcription fatty acid metabolism phospholipid biosynthesis angiogenesis bile acid metabolism membrane protein ectodomain proteolysis response to hormone stimulus beta-amyloid metabolism steroid metabolism ubiquitin-dependent protein catabolism modification-dependent protein catabolism nucleotide-excision repair response to radiation negative regulation of transcription/, DNA-dependent blood vessel development regulation of gene expression/, epigenetic phosphorus metabolism phosphate metabolism protein kinase cascade regulation of cell growth DNA packaging insulin receptor signaling pathway phospholipid catabolism L-amino acid transport regulation of proteolysis and peptidolysis NLS-bearing substrate-nucleus import DNA unwinding
6 sulfur metabolism tricarboxylic acid cycle intermediate metabolism integrin-mediated signaling pathway nuclear transport positive regulation of transcription chloride transport protein metabolism vesicle docking during exocytosis histone deacetylation fatty acid beta-oxidation proteoglycan biosynthesis cell fate determination regulation of cell migration spindle assembly mitotic spindle assembly vesicle docking regulation of secretion coenzyme metabolism regulation of apoptosis regulation of growth glutamine family amino acid metabolism regulation of programmed cell death growth prostaglandin metabolism Notch signaling pathway response to nutrients cell fate commitment prostanoid metabolism trna metabolism nucleocytoplasmic transport positive regulation of nucleobase/, nucleoside/, nucleotide and nucleic a cholesterol metabolism microtubule stabilization protein amino acid deacetylation response to stimulus viral life cycle membrane lipid biosynthesis organic acid biosynthesis carboxylic acid biosynthesis calcium-mediated signaling circadian rhythm chromosome condensation membrane lipid catabolism biological_process unknown trna aminoacylation for protein translation amino acid activation trna aminoacylation lipid transport energy coupled proton transport/, down electrochemical gradient ATP synthesis coupled proton transport sterol metabolism double-strand break repair
7 ceramide metabolism secretion cell migration protein-nucleus import/, docking response to extracellular stimulus covalent chromatin modification histone modification microtubule cytoskeleton organization and biogenesis protein-nucleus import nuclear import protein ubiquitination actin cytoskeleton organization and biogenesis nicotinamide metabolism M phase specific microtubule process sphingoid metabolism nucleoside phosphate metabolism ATP biosynthesis trna modification RNA splicing regulation of catabolism membrane organization and biogenesis regulation of actin filament length transcription from Pol III promoter glutamine family amino acid catabolism glutamine metabolism induction of programmed cell death induction of apoptosis protein lipidation fatty acid oxidation lipoprotein biosynthesis polysaccharide biosynthesis arginine metabolism establishment and/or maintenance of chromatin architecture ATP metabolism actin filament-based process glycerol metabolism endosome transport porphyrin biosynthesis response to drug urea cycle intermediate metabolism nitric oxide metabolism proteoglycan metabolism nitric oxide biosynthesis heterocycle metabolism regulation of translation cell-matrix adhesion polyol metabolism steroid hormone receptor signaling pathway maintenance of fidelity during DNA-dependent DNA replication axon guidance mismatch repair RNA modification
8 rhythmic behavior intracellular receptor-mediated signaling pathway B-cell activation endosome organization and biogenesis amino acid metabolism lipid catabolism positive regulation of metabolism phosphorylation intracellular signaling cascade glycosaminoglycan metabolism membrane fusion complement activation\, classical pathway nucleoside monophosphate biosynthesis porphyrin metabolism aminoglycan metabolism nucleoside monophosphate metabolism regulation of development Ras protein signal transduction triacylglycerol metabolism negative regulation of cell cycle purine nucleoside triphosphate biosynthesis purine ribonucleoside triphosphate biosynthesis ribonucleoside triphosphate biosynthesis tricarboxylic acid cycle group transfer coenzyme metabolism nucleoside triphosphate biosynthesis organic anion transport neutral lipid metabolism glycerolipid metabolism induction of apoptosis by extracellular signals acylglycerol metabolism glycerol ether metabolism mrna-nucleus export mrna transport amine metabolism RNA splicing/, via transesterification reactions with bulged adenosine as RNA splicing/, via transesterification reactions nuclear mrna splicing/, via spliceosome ribonucleoside triphosphate metabolism purine ribonucleoside triphosphate metabolism purine nucleoside triphosphate metabolism nucleoside metabolism icosanoid metabolism chromatin modification chromatin assembly or disassembly regulation of protein kinase activity cyclic nucleotide metabolism nucleoside triphosphate metabolism proton transport hydrogen transport regulation of mitosis iron ion transport
9 oxidative phosphorylation anti-apoptosis RNA localization RNA-nucleus export nucleic acid transport RNA transport complement activation biosynthesis amino acid and derivative metabolism viral infectious cycle axonogenesis lipoprotein metabolism JNK cascade nuclear export negative regulation of apoptosis purine ribonucleotide biosynthesis negative regulation of programmed cell death mrna processing fertilization (sensu Metazoa) protein amino acid phosphorylation non-covalent chromatin modification chromatin remodeling nucleobase/, nucleoside/, nucleotide and nucleic acid transport translational elongation purine nucleotide biosynthesis purine ribonucleotide metabolism fertilization organelle organization and biogenesis ribonucleotide biosynthesis humoral defense mechanism (sensu Vertebrata) protein complex assembly regulation of protein biosynthesis carbohydrate metabolism purine nucleotide metabolism regulation of enzyme activity neurogenesis sphingolipid metabolism ribonucleotide metabolism regulation of biosynthesis polysaccharide metabolism exocytosis mrna metabolism amino acid catabolism fatty acid biosynthesis transition metal ion transport amine catabolism negative regulation of cell proliferation development alcohol metabolism regulation of GTPase activity transcription initiation macromolecule biosynthesis
10 reproductive physiological process small GTPase mediated signal transduction digestion protein targeting cell differentiation response to oxidative stress macromolecule catabolism endocytosis epidermis development cytoplasm organization and biogenesis glycoprotein metabolism lymphocyte activation hemopoiesis steroid biosynthesis cytoskeleton organization and biogenesis ectoderm development humoral immune response immune cell activation cell activation catabolism antimicrobial humoral response (sensu Vertebrata) oxygen and reactive oxygen species metabolism antimicrobial humoral response microtubule-based process blood coagulation cellular defense response behavior sexual reproduction reproduction inflammatory response hemostasis sodium ion transport response to wounding response to abiotic stimulus cell-cell signaling histogenesis circulation regulation of body fluids central nervous system development response to pest/, pathogen or parasite transmembrane receptor protein tyrosine kinase signaling pathway morphogenesis innate immune response coagulation response to chemical substance nucleosome assembly protein amino acid glycosylation response to external biotic stimulus male gamete generation spermatogenesis transport localization
11 glycoprotein biosynthesis carbohydrate catabolism cell motility di-/, tri-valent inorganic cation transport cell adhesion synaptic transmission main pathways of carbohydrate metabolism monovalent inorganic cation transport neuromuscular physiological process transmission of nerve impulse gametogenesis anion transport enzyme linked receptor protein signaling pathway protein biosynthesis hexose metabolism energy pathways proteolysis and peptidolysis monosaccharide metabolism cation transport protein catabolism second-messenger-mediated signaling signal transduction inorganic anion transport potassium ion transport energy derivation by oxidation of organic compounds response to biotic stimulus organogenesis immune response metal ion transport electron transport perception of smell organismal movement response to external stimulus cell communication ion transport defense response sensory perception of chemical stimulus neurophysiological process sensory perception organismal physiological process detection of external stimulus cell surface receptor linked signal transduction G-protein coupled receptor protein signaling pathway
12 OX-2 expressers and non-expressers PopulationTotal Fisher Exact P-Values TermID E-10 GO: E-09 GO: E-09 GO: E-08 GO: E-08 GO: E-08 GO: E-07 GO: E-06 GO: E-06 GO: E-06 GO: E-05 GO: E-05 GO: E-04 GO: E-04 GO: E-04 GO: E-04 GO: E-04 GO: E-04 GO: E-04 GO: E-04 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-03 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO:
13 E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO:
14 E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO:
15 E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: GO: GO: GO: GO: GO: GO: GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: GO: GO: E-02 GO: E-02 GO: E-02 GO: GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: GO: GO: GO: GO: GO: GO:
16 GO: E-02 GO: E-02 GO: E-02 GO: E-02 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
17 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
18 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
19 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
20 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
21 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
22 GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO: GO:
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