Cerebellum 1/20/2016. Outcomes you need to be able to demonstrate. MHD Neuroanatomy Module

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1 This power point is made available as an educational resource or study aid for your use only. This presentation may not be duplicated for others and should not be redistributed or posted anywhere on the internet or on any personal websites. Your use of this resource is with the acknowledgment and acceptance of those restrictions. Cerebellum MHD Neuroanatomy Module February 8, 2016 Gregory Gruener, MD, MBA Vice Dean for Education, SSOM Professor & Associate Chair, Department of Neurology LUHS/Trinity Health and Catholic Health East Outcomes you need to be able to demonstrate Outline Major organizational divisions Identify cerebellar peduncles and deep nuclei List afferent and efferent components Define the origins of the mossy and climbing fibers Describe the wiring diagram of the cerebellum Define the functional components of the cerebellum Describe the somatotopic maps of the cerebellum 1

Lancet Neurol 2014; 13: 100 12 Cerebellum overview

Systems Vestibular nuclei Thalamus Red nucleus

spinal cord Afferent information Vestibular

Sensorimotor cortex Auditory system Visual system

Enter the Cerebellar cortex Purkinje cells Deep

to match those intended Cerebellum overview gross

, 2009 http://www.bartleby.com/107/illus702.

2 Lancet Neurol 2014; 13: Cerebellum overview Inputs Cerebellar Cortex Nuclei Outputs Motor Systems Vestibular nuclei Thalamus Red nucleus (reticular formation) No direct connection to the spinal cord Afferent information Vestibular Proprioceptive & skin receptor information Sensorimotor cortex Auditory system Visual system Information Processing Mossy & Climbing fibers Enter the Cerebellar cortex Purkinje cells Deep nuclei Coordination Correction of current movements to match those intended Cerebellum overview gross anatomy Nolte J. The Human Brain, 6 th ed., Fitzgerald MJT, Gruener G, Mtui E. Clinical Neuroanatomy and Neuroscience, 6th Ed., W. B. Saunders

3 Cerebellum overview MRI anatomy Cerebellum overview MRI anatomy Cerebellum overview MRI anatomy 3

4 Cerebellum overview MRI anatomy Cerebellum overview gross anatomy Horizontal fissure Cerebellum overview cerebellar peduncles midline Molson Medical Informatics Project M. Afferents to the Cerebellum. MedEdPORTAL; Available from: 4

Cerebellum overview somatotopic anatomy One to

Neuroscience: An Outline Approach, 2002 Grimaldi

Topography of Cerebellar Deficits in Humans.

cerebellar peduncles Superior cerebellar peduncle

, Wolters Kluwer, 2015 Inferior Cerebellar

5 Cerebellum overview somatotopic anatomy One to remember Castro, Merchut, Neafsey, Wurster; Neuroscience: An Outline Approach, 2002 Grimaldi G, Manto M. Topography of Cerebellar Deficits in Humans. Cerebellum 11: , 2012 Cerebellum overview cerebellar peduncles Superior cerebellar peduncle Middle cerebellar peduncle Inferior cerebellar peduncle Siegel A, Sparu HN. Essential Neuroscience, 3 rd Ed., Wolters Kluwer, 2015 Inferior Cerebellar Peduncle Afferents Inferior olivary nucleus Vestibular nuclei Spinal cord Trigeminal nuclei Reticular formation Cerebellar efferents Vestibular nuclei 5

6 Middle Cerebellar Peduncle Afferents: Cerebral cortex For the detailed minded among you Superior Cerebellar Peduncle Afferents: Anterior Spinocerebellar tract Cerebellar efferents Originate from the deep cerebellar nuclei 6

7 Cerebellum flocculonodular lobe (input & output) Inferior cerebellar peduncle Castro, Merchut, Neafsey, Wurster; Neuroscience: An Outline Approach, 2002 Cerebellum vermis (input & output) Medial hemisphere (Uncinate fasciculus) Castro, Merchut, Neafsey, Wurster; Neuroscience: An Outline Approach, 2002 Cerebellum hemisphere (input & output) Castro, Merchut, Neafsey, Wurster; Neuroscience: An Outline Approach,

Molecular layer Mainly axons and dendrites Basket cells axons synapse

dendrites Purkinje cell layer Purkinje cells only axons that leave the

the molecular layer as parallel fibers White matter Nolte J and

6 th edition, 2010; Mosby Elsevier Climbing fibre Gray s anatomy: The

8 Molecular layer Mainly axons and dendrites Basket cells axons synapse on the Purkinje cell body Stellate cells axons synapse on Purkinje cell dendrites Purkinje cell layer Purkinje cells only axons that leave the cerebellar cortex Granular layer Granular cells send their axons into the molecular layer as parallel fibers White matter Nolte J and Sundsten. The Human Brain: An introduction to its functional anatomy. 6 th edition, 2010; Mosby Elsevier Climbing fibre Gray s anatomy: The anatomical basis of clinical practice, 40 th edition; Churchill Livingstone, London 8

9 Granule cell Neuroscience. 2nd edition.purves D, Augustine GJ, Fitzpatrick D, et al., editors. Sunderland (MA): Sinauer Associates;

1/2/2019. Basal Ganglia & Cerebellum a quick overview. Outcomes you want to accomplish. MHD-Neuroanatomy Neuroscience Block. Basal ganglia review

1/2/2019. Basal Ganglia & Cerebellum a quick overview. Outcomes you want to accomplish. MHD-Neuroanatomy Neuroscience Block. Basal ganglia review This power point is made available as an educational resource or study aid for your use only. This presentation may not be duplicated for others and should not be redistributed or posted anywhere on the