Pediatric Bone and Soft Tissue Sarcomas

Transcription

1 Pediatric Oncology Pediatric Bone Bearbeitet von Alberto S Pappo 1. Auflage Buch. xiv, 240 S. Hardcover ISBN Format (B x L): 19,1 x 23,5 cm Gewicht: 677 g Weitere Fachgebiete > Medizin > Sonstige Medizinische Fachgebiete > Radiologie, Bildgebende Verfahren schnell und portofrei erhältlich bei Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, ebooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8 Millionen Produkte.

2 IX 1 Epidemiology of Bone Logan G. Spector, Julie A. Ross, Rajaram Nagarajan 1.1 Descriptive Epidemiology of Bone Tumors Worldwide Statistics North American Statistics Mortality and Survivorship Etiology of Bone Sarcomas Bone Sarcomas: Future Directions Epidemiology of Soft Tissue Sarcomas References Pathologic and Molecular Techniques Used in the Diagnosis and Treatment Planning of Sarcomas Timothy Triche, Deborah Schofield 2.1 Introduction Standard Histopathology Light Microscopy Immunohistochemistry Electron Microscopy Cytogenetics Classical Cytogenetic Analysis In-Situ Hybridization Spectral Karyotyping Comparative Genomic Hybridization Molecular Genetic Techniques Introduction PCR and Q-PCR Microarrays Proteomics Conclusion References Diagnostic Imaging of Pediatric Bone Thomas D. Henry, Mary E. McCarville, Fredric A. Hoffer 3.1 Introduction Initial Evaluation of Bone Imaging Techniques for Evaluating the Primary Tumor Staging Local Extent of the Tumor Detection of Metastatic Disease Criteria for Evaluating Treatment Response Outcome Criteria Biopsy of the Primary Lesion Imaging Characteristics of Specific Tumors Bone Sarcomas Osteosarcoma Chondrosarcoma Ewing Sarcoma of Bone Soft Tissue Sarcomas Differentiating Benign from Malignant Soft Tissue Lesions Soft Tissue Ewing Sarcoma Family of Tumors Rhabdomyosarcoma Non-rhabdomyosarcoma Soft Tissue Sarcomas Synovial Sarcoma Congenital Fibrosarcoma Hemangiopericytoma Malignant Peripheral Nerve Sheath Tumors (MPNST) Post-treatment Imaging Concerns Radiofrequency Ablation References

3 X 4 Local Control Issues in Pediatric Bone John C. Breneman, David Rodeberg, Ruth F. Lavigne, Ken Brown, Eugene S. Wiener 4.1 Significance of Local Control in Pediatric Sarcomas Background to Local Control Modalities Patterns of Tumor Growth Surgery Biopsy Guidelines Surgical Margins Radiation Therapy Types of Radiation Techniques of Radiotherapy Treatment Morbidity Combined Surgery and Radiotherapy for Local Control Chemotherapy for Local Control Ewing s Sarcoma Surgery for Ewing s Sarcoma Radiation Therapy for Ewing s Sarcoma Radiotherapy Treatment Factors Rhabdomyosarcoma Surgery for Rhabdomyosarcoma Radiotherapy for Rhabdomyosarcoma Site Specific Approaches to Local Control Orbit and Head & Neck Genitourinary: Bladder/Prostate Vagina and Uterine Sites Paratestes Extremity Trunk Non-Rhabdomyosarcomatous Soft Tissue Sarcomas Surgery for Non-Rhabdo Soft Tissue Sarcomas Radiotherapy for Non-Rhabdo Soft Tissue Sarcomas Osteosarcoma Surgery for Osteosarcoma Radiotherapy for Osteosarcoma References Drug Discovery in Pediatric Bone Using In Vivo Models Jennifer K. Peterson, Peter J. Houghton 5.1 Introduction Pediatric Tumor Models General Criteria for Selecting Appropriate Models Expression Profiles Criteria for Selecting RMS Xenografts for Drug Evaluation In Vivo Models in Drug Discovery Models for Optimizing Therapy Combination Therapy Molecular Targeted Agents Combining Signal Transduction Inhibitors Future Directions References Pediatric Rhabdomyosarcoma: Biology and Results of the North American Intergroup Rhabdomyosarcoma Trials Alberto Pappo, Fred G. Barr, Suzanne L. Wolden 6.1 Epidemiology Pathology and Biology of Rhabdomyosarcoma Pathologic Classification of Rhabdomyosarcoma Chromosomal Translocations in Alveolar Rhabdomyosarcoma Allelic Loss of 11p15.5 in Embryonal Rhabdomyosarcoma Other Genetic Changes in Rhabdomyosarcoma Clinical Presentation and Evaluation of Extent of Disease Head and Neck Region Genitourinary Tumors Extremity Tumors Trunk Other Sites Staging Prognostic Factors Treatment Role of Local Therapies Multi-institutional Trials Clinical Group I Clinical Group II Clinical Group III Clinical Group IV Management of Specific Tumor Sites Parameningeal Tumors Orbital Tumors Head and Neck Non-Orbital, Non-Parameningeal Tumors Parotid Tumors Extremity Tumors Paratesticular Rhabdomyosarcoma

4 XI Female Genital Tract Tumors Bladder and Prostate Rhabdomyosarcoma Other Sites Biliary Tract Tumors Perineal and Perianal Rhabdomyosarcoma Pelvic and Retroperitoneal Rhabdomyosarcoma Acute and Long Term Effects of Therapy Future Directions Outcome and Therapy of Relapse References Non-Rhabdomyosarcoma Soft Tissue Sarcomas Sheri L. Spunt, Suzanne L. Wolden, Deborah E. Schofield, Stephen X. Skapek 7.1 Epidemiology/Pathogenesis Incidence Risk Factors Pathology/Molecular Pathology Molecular Pathogenesis Synovial Sarcoma and the SYT/SSX Translocation Infantile Fibrosarcoma and ETV6-NTRK Rhabdoid Tumor and INI Inflammatory Myofibroblastic Tumor and ALK Gastrointestinal Stromal Tumors and the KIT Transferase Dermatofibrosarcoma Protuberans and PDGF Histologic Classification Synovial Sarcoma Malignant Peripheral Nerve Sheath Tumor Infantile Fibrosarcoma Adult Type Fibrosarcoma Rhabdoid Tumor Inflammatory Myofibroblastic Tumor Gastrointestinal Stromal Tumor Infantile Hemangiopericytoma Desmoplastic Small Round Cell Tumor Grading Systems Clinical Presentation and Diagnosis Presenting Features Differential Diagnosis The Diagnostic Biopsy Evaluation of Disease Extent Prognostic Factors and Clinical Staging Prognostic Factors Clinical Staging Treatment Surgery Surgical Management of the Primary Tumor Surgical Management of Metastases Radiation Therapy Radiation Planning Timing of Radiotherapy Brachytherapy New Technologies Acute Side Effects of Radiotherapy Long-Term Side Effects of Radiotherapy Chemotherapy Adjuvant Chemotherapy Neoadjuvant Chemotherapy Other Approaches to the Use of Standard Chemotherapy High-Dose Chemotherapy Novel Agents Late Effects of Chemotherapy Current Problems and Future Challenges References Fibrous and Fibrohistiocytic Tumors Diane Nam, Benjamin A. Alman 8.1 Fibrous and Fibrohistiocytic Tumors Soft Tissue Fibrous Tumors Epidemiology/Pathogenesis Pathology/Molecular Biology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging Treatment of Fibrous Tumors Current Problems and Future Challenges Fibrohistiocytic Tumors So-Called Fibrohistiocytic Tumors Histologic Classification Benign Benign Fibrous Histiocytoma Epidemiology/Pathogenesis Pathology/Molecular Pathology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging Giant Cell Tumor of Tendon Sheath and Diffuse-Type Giant Cell Tumor Epidemiology/Pathogenesis Pathology/Molecular Pathology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging

5 XII Intermediate Giant Cell Fibroblastoma and Dermatofibrosarcoma Protuberans Epidemiology/Pathogenesis Pathology/Molecular Pathology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging Plexiform Fibrohistiocytic Tumor Epidemiology/Pathogenesis Pathology/Molecular Pathology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging Giant Cell Tumor of Soft Tissue Epidemiology/Pathogenesis Pathology/Molecular Pathology Clinical Presentation and Diagnosis Prognostic Factors and Clinical Staging Treatment of Fibrohistiocytic Tumors Current Problems and Future Challenges References Ewing Sarcoma Family of Tumors Carlos Rodriguez-Galindo, Fariba Navid, Joseph Khoury, Matthew Krasin 9.1 Introduction Epidemiology Pathogenesis Pathology Microscopic Features Molecular Pathology Clinical Features Extraosseous ESFT Laboratory and Radiologic Evaluation Prognostic Factors Treatment Treatment of Patients with Localized Disease Four-Drug Regimens Role of Ifosfamide and Etoposide Increasing Dose Intensity Current Studies Local Control in ESFT Surgical Therapy Surgery and Adjuvant Radiation Therapy Definitive Radiation Therapy Role of Systemic Chemotherapy in Local Control Treatment of Metastatic ESFT Myeloablative Therapy with Hematopoietic Stem Cell Rescue for Metastatic ESFT Second Malignancies Recurrent ESFT Future Developments References Osteosarcoma Paul A. Meyers 10.1 Incidence Etiology/Pathogenesis Molecular Biology Pathology Clinical Presentation and Natural History Diagnostic Evaluation Biopsy Staging Prognostic Factors Treatment Surgery Radiation Therapy Recurrent Disease Future Directions References Subject Index