The Advent of Immunotherapy in Cancer Therapy

Transcription

1 The Memorial Hospital Alumni Society Presents The Advent of Immunotherapy in Cancer Therapy October 17-18, 2013 Rockefeller Research Laboratories 430 East 67th Street, New York, NY WT1

2 The Advent of Immunotherapy in Cancer Therapy October 17 18, 2013 COURSE INFORMATION COURSE OVERVIEW The aim of the two-day program, presented by staff and invited speakers, is to highlight developments in the clinical care of patients and provide useful insights into ongoing cancer research at the Center. TARGET AUDIENCE The intended audience is comprised of members of the Memorial Hospital Alumni Society (physicians who have trained at Memorial Sloan-Kettering for six months or more and staff members who have been at MSKCC for six months or more), any current medical staff, and physicians trained elsewhere who wish to attend. These physicians include medical oncologists, pathologists, radiation oncologists, surgeons, and allied scientists. EDUCATIONAL OBJECTIVES The course objective is to advance and disseminate knowledge of cancer, with the sharing of objectives between community physicians and the Center. The goal is also to inform primary care clinicians about current approaches to the diagnosis and treatment of cancers. COURSE DESIGN This course is comprised of lectures and discussions, encouraging the exchange of ideas between faculty and participants. ACCREDITATION is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians. CME CREDIT DESIGNATION STATEMENT designates this conference for a maximum of 14 ½ hours in Category 1 credit toward the AMA Physician s Recognition Award. Each physician should claim only those hours of credit he/she actually spent in the conference.

3 DISCLOSURE POLICY STATEMENT relies on faculty participants in its CME Program to provide educational information that is objective and as free from bias as possible. In accordance with the nationally accepted guidelines, faculty members are asked to indicate any commercial relationship that might be perceived as a real or apparent conflict of interest. REGISTRATION Pre-registration is preferred. The fee for Alumni Society Members is $ for the two-day program, $50.00 for one day (pathologists only), and $ for outside physicians. Registration for MSKCC staff is free of charge with MSKCC ID. Registration will begin promptly at 7:20 a.m. in the lobby of the Rockefeller Research Laboratories,following breakfast. The fee includes breakfast and buffet luncheon Thursday, two coffee breaks, and CME certification. ALUMNI RECEPTION AND DINNER DANCE The Annual Reception and Dinner Dance takes place at the New York Marriott East Side, located at 525 Lexington Avenue at 49th Street, the evening of Thursday, October 17, Tickets are $125 per person and are reserved for alumni, staff, and their guests only. Current fellows are invited to attend at a reduced rate and will need to reserve a ticket with the alumni office. PATHOLOGY ALUMNI ANNUAL MEETING This meeting commences Friday, October, 18, 2013, at 9:15 a.m. It is open to all Memorial Hospital alumni. The Annual Pathology Alumni Dinner will be held at The Water Club, The East River at 30th Street. Contact Donna Bauer in the Pathology Department at or bauerd@mskcc.org to purchase tickets. COURSE LOCATION The Scientific Sessions will be held in the Arlene and Arnold Goldstein Auditorium of the Rockefeller Research Laboratories. The Pathology Slide Seminar will also be held in the Auditorium. HOTEL ACCOMMODATIONS We are pleased to provide the following information on hotels in the vicinity of : Courtyard New York Manhattan/Midtown East 866 Third Avenue (Between 52nd and 53rd Streets) New York, NY Reservations: Additional hotel options can be found on the MSKCC Web site at accommodations FOR FURTHER INFORMATION PLEASE CONTACT Keith Yearwood, Manager, Alumni Affairs 633 Third Avenue, New York, NY , yearwook@mskcc.org

4 The Advent of Immunotherapy in Cancer Therapy October 17 18, 2013 SCIENTIFIC AGENDA THURSDAY, OCTOBER 17 7:00 am Breakfast 7:20 am Registration 8:00 am Welcome: Renier Brentjens, MD, PhD Associate Attending Chief, Cellular Therapeutics Center,, Leukemia Service Memorial Sloan-Kettering Cancer Center SESSION 1: ANTIBODY THERAPY OF CANCER Moderator: David A. Scheinberg, MD, PhD 8:10 am Jeff J. Molldrem, MD The University of Texas MD Anderson Cancer Center, Houston, TX MAbs for Cancer 8:30 am Nai-Kong V. Cheung, MD, PhD Department of Pediatrics Diagnostic and Therapeutic Potentials of Bispecific Humanized Antibodies 8:50 am Jedd D. Wolchok, MD, PhD Antibody Mediated Immune Checkpoint Blockade 9:10 am Cheng Liu, PhD Eureka Therapeutics, Emeryville, CA Discovery of Fully-human MAbs against novel cancer targets through phage display technology 9:30 am Panel Discussion 9:50 am Coffee Break SESSION 2: CONJUGATED ANTIBODY THERAPY OF CANCER Moderator: Joseph Jurcic, MD New York-Presbyterian/Columbia University, New York, NY 10:20 am Oliver Press, MD, PhD Fred Hutchinson Cancer Research Center, Seattle, WA Radio Immunotherapy of Lymphoma 11:00 am Joseph Jurcic, MD New York-Presbyterian/Columbia University, New York, NY Radio Immunotherapy of AML 11:20 am Steven M. Larson, MD Department of Radiology Radio Immunotherapy of Solid Tumors 11:40 am William Olsen, PhD Progenics Pharmaceuticals, Tarrytown, NY Antibody-drug Conjugates: Finding Success with Trojan Horse Ploy 12:00 pm Panel Discussion 12:20 pm Buffett Lunch SESSION 3: VACCINE BASED CANCER THERAPY Moderator: Peter Maslak, MD 1:20 pm Peter Maslak, MD Department of Laboratory Medicine and Medicine WT1 Vaccination in AML 1:40 pm Paul J. Sabbatini, MD Vaccines for remission in Ovarian Cancer

5 2:00 pm David Avigan, MD Beth Israel Deaconess Medical Center, Boston, MA Challenges in Designing Vaccine Therapy for Hematological Malignancies 2:20 pm Panel Discussion 2:40 pm Coffee Break SESSION 4: ADOPTIVE CELL THERAPIES OF CANCER Moderator: Michael Sadelain, MD, PhD and Pediatrics 3:00 pm Marcel R. M. van den Brink, MD, PhD Hematopoietic Stem Cell Transplantation as a Platform for Immune and Cell Therapy of Cancer 3:20 pm Renier Brentjens, MD, PhD Adoptive T Cell Therapy of Cancer 3:40 pm Ronald DeMatteo, MD Department of Surgery Tumor Immunology logistics 4: 00 pm Katharine C. Hsu, MD, PhD Unleashing Anti-Tumor Effects of the Natural Killer Cell 4:20 pm Richard J. O Reilly, MD Department of Pediatrics Adoptive T-cell therapies for leukemia relapse and EBVassociated lymphomas following allogenic HSCT 4:40 PM PANEL DISCUSSION 5:00 pm Day 1 Closing Remarks Renier Brentjens, MD, PhD Memorial Sloan-Kettering Cancer Center 7:00 pm Annual Alumni Reception and Dinner Dance The Marriott East Side, New York FRIDAY, OCTOBER 18 Medical Grand Rounds 8:00 am Speaker: David A. Scheinberg, MD, PhD Vincent Astor Chair Chairman, Molecular Pharmacology and Chemistry Program Experimental Therapeutics Center Targeting Un-druggable Cancer Targets with Antibodies 9:15 am Welcome David S. Klimstra, MD Chair, 9:20 am Dick Kempson s Favorites: A Series of Case Presentations on Topics Near and Dear Introduction by Robert A. Soslow, MD 9:30 am Case 1: Uterine mesenchymal neoplasia Robert A. Soslow, MD 10:10 am Case 2: Noninvasive breast neoplasia Edi Brogi, MD, PhD 10:50 am Coffee break 11:10 am Case 3: Myxoid neoplasms of soft tissue Cristina R. Antonescu, MD 11:50 am Presentation of the Fred W. Stewart Award David S. Klimstra, MD THE THIRTY-SIXTH FRED W. STEWART AWARD Richard A. Kempson, MD Emeritus Professor of Pathology Stanford University School of Medicine 2:00 pm ANATOMIC PATHOLOGY SLIDE SEMINAR (RRL Auditorium) Moderator: Meera R. Hameed, MD, Acting Chief, Surgical Pathology Service Case 1. Carlie Sigel, MD Case 2. Melissa Murray, DO Case 3. Laura Tang, MD, PhD Case 4. Christopher Y. Park, MD, PhD 3:20 pm Coffee break 3:40 pm Case 5. Dara Ross, MD Case 6. Snjezana Dogan, MD Case 7. Natasha Rekhtman, MD, PhD Case 8. Marc K. Rosenblum, MD 5:00 pm Adjournment 6:00 pm Pathology Alumni Dinner

6 COURSE FACULTY PROGRAM CHAIRMAN Renier Brentjens, MD, PhD Associate Attending; Chief, Cellular Therapeutics Center,, Leukemia Service, Memorial Sloan-Kettering Cancer Center GUEST FACULTY David Avigan, MD Director, Hematological Malignancy and Bone Marrow Transplantation Program Beth Israel Deaconess Medical Center; Associate Professor of Medicine, Harvard Medical School, Boston, MA Joseph Jurcic, MD Professor of Clinical Medicine; Director, Hematologic Malignancies Section, Division of Hematology/Oncology, Columbia University, New York, NY Richard A. Kempson, MD Professor Emeritus of Pathology Stanford University School of Medicine, Stanford, CA Cheng Liu, PhD President & CEO Eureka Therapeutics, Emeryville, CA Jeff J. Molldrem, MD Professor of Medicine; Virginia H. Cockrell Distinguished Professorship in Immunology Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX William Olsen, PhD Senior Vice President, Research & Development, Progenics Pharmaceuticals, Tarrytown, NY Oliver Press, MD, PhD Member and Endowed Chair of Lymphoma Research, Professor of Medicine, University of Washington; Adjunct Professor of Bioengineering, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA FACULTY Cristina R. Antonescu, MD Attending Pathologist Edi Brogi, MD, PhD Attending Pathologist Nai-Kong V. Cheung, MD, PhD Enid A. Haupt Chair in Pediatric Oncology; Member and Attending Department of Pediatrics Ronald DeMatteo, MD Vice Chair, Department of Surgery Chief, Division of General Surgical Oncology; Leslie H. Blumgart Chair in Surgery Snjezana Dogan, MD Meera R. Hameed, MD Attending Pathologist and Acting Chief, Surgical Pathology Service Katharine C. Hsu, MD, PhD Associate Attending Physician, Adult Bone Marrow Transplantation Service David S. Klimstra, MD Attending Pathologist Chair, Steven M. Larson, MD, FACNM, FACR Donna & Benjamin M. Rosen Chair Attending, Molecular Imaging and Therapy Service, Department of Radiology; Member and Lab Head Molecular Pharmacology and Chemistry Program; Professor, The Gerstner Sloan-Kettering Graduate School of Biomedical Sciences Peter Maslak, MD Chief, Hematology Laboratory Service Department of Laboratory Medicine Melissa Murray, DO Richard J. O Reilly, MD Chair, Department of Pediatrics Chief, Pediatric Bone Marrow Transplant Service; Claire L. Tow Chair in Pediatric Oncology Research Christopher Y. Park, MD, PhD Assistant Attending Physician Natasha Rekhtman, MD, PhD Marc K. Rosenblum, MD Attending Pathologist and Chief, Neuropathology and Autopsy Service Dara Ross, MD Paul J. Sabbatini, MD Deputy Physician-in-Chief for Clinical Research; Attending Physician, Gynecologic Medical Oncology Service Michael Sadelain, MD, PhD Attending Geneticist and Pediatrics David A. Scheinberg, MD, PhD Vincent Astor Chair Chairman, Molecular Pharmacology and Chemistry Program Experimental Therapeutics Center Carlie Sigel, MD Robert A. Soslow, MD Attending Pathologist Laura Tang, MD, PhD Associate Attending Pathologist Marcel R. M. van den Brink, MD, PhD Alan N. Houghton Chair, Immunology Program; Head, Division of Hematologic Oncology Jedd D. Wolchok, MD, PhD Associate Chair, Immunotherapeutics Associate Attending Physician, Melanoma-Sarcoma Service

7 REGISTRATION FORM The Memorial Hospital Alumni Society 633 Third Avenue, 12th Floor, New York, NY I will attend the following activities: Two-day $ (Outside Physicians) $ Two-day $ (Alumni Only) $ One-day $ (Pathologists Only) $ Current MSKCC staff and fellows may attend free of charge. Annual Alumni Dinner Dance......(Alumni, Staff and Their Guests Only) For people at $125 each $ 2013 Annual Membership Dues: $ $ A gift to the Alumni Society $ TOTAL $ Name Phone number Organization (if appropriate) Address City State Zip Please check if this is a new address. Please make your check payable to : The Memorial Hospital Alumni Society Pay by Credit Card Full Name as it Appears on Credit Card Credit Card Type Credit Card Number Expiration Date (MM/YY) Cardholder s Signature (I authorize MSKCC to debit my credit card account.) Date Please enclose with payment and mail to: Keith Yearwood, Manager, Alumni Affairs 633 Third Avenue, 12th Floor New York, NY 10017

8 Office of Alumni Affairs 633 Third Avenue, 12th floor New York, New York The Advent of Immunotherapy in Cancer Therapy October 17-18, 2013