BSG/TSL GI workshops EQA011 preliminary response analysis

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1 BSG/TSL GI workshops 06 EQA0 preliminary response analysis

2 GI Neoplasia case Female 68 years Oesophagus Tumour TN0 pre-op staging : No chemotherapy Adenoid cystic carcinoma (pt) Adenocarcinoma (ptb, ptbn) Basaloid squamous cell carcinoma Basaloid carcinoma (pt) 4 Basaloid squamous cell carcinoma Adenoid cystic carcinoma (pt, pt) Adenocarcinoma (with Barrett's) Squamous cell carcinoma Basaloid carcinoma Adenosquamous carcinoma 0 6

3 GI Neoplasia case Male 6 years Oesophagus tumour. Oesophagectomy- extensively dilated up to 6. cm with a poylpoid tumour Squamous cell carcinoma (well, moderately differentiated,pt, pt) 9 Sarcomatoid carcinoma Squamous cell carcinoma ( well diff, mod diff)(pt) Verrucous SCC

4 GI Neoplasia case Female 76 years Large semi-pedunculated tumour removed endoscopically from the lower oesophagus? sarcoma Sarcomatoid carcinoma Kaposi sarcoma Glomus tumour Squamous cell carcinoma (poorly differentiated) Rhabdomyosarcoma Solitary fibrous tumour Haemangiopericytoma Adenocarcinoma (poorly differentiated) Liposarcoma (poorly differentiated) Malignant fibrous histiocytoma Malignant spindle cell tumour (GIST, Leiomyosarcoma, Pleomorphic sarcoma) Sarcomatoid carcinoma Adenocarcinoma (poorly differentiated) HGIEN Angiosarcoma Fibrosarcoma GIST (epithelioid, malignant) Signet ring carcinoma Squamous cel carcinoma (poorly differentiated) 4 4

5 GI Neoplasia case 4 Female 70 years Large cystic fundic polyp Hyperplastic polyp Juvenile polyp Fundic gland polyp (with low, high grade dysplasia -? Syndrome) Adenomatous polyp (with moderate dysplasia) Adenocarcinoma (papillary, well differentiated) Adenomatous polyp (Tubulovillous, Tubular, villoglandular, intestinal type) Inflammatory polyp Hyperplastic polyp Fundic gland polyp Polyp with early maligancy Gastritis cystica polyposis Juvenile polyp 7 4

6 GI Neoplasia case Male 6 years Liver metastasis. Ischaemic bowel with perforation. Small bowel resetion Large cell neuroendocrine carcinoma (pt) Neuroendocrine tumour (carcinoid) Invasive adenocarcinoma, carcinoid variant Adenocarcinoma (metastatic) 4 4 Lymphoma Metastatic cancer/adenocarcinoma Neuroendocrine neoplasia/tumour Carcinoid tumour Adenocarcinoma (poorly differentiated) Small cell carcinoma Neuroendocrine carcinoma 4 6

7 GI Neoplasia case 6 Male 0 years Sigmoid polyp 6 mm Hyperplastic polyp (microvesicular type) Serrated adenoma/polyp, sessile serrated polyp Tubular, Tubulovillous adenoma (low grade, high grade dysplasia) Invasive adenocarcinoma, carcinoid variant Adenocarcinoma (mucinous) Hyperplastic polyp (with mild dysplasia) Inflammatory polyp Serrated adenomatous polyp/sessile serrated polyp/serrated villous adenoma Adenomatous polyp Adenocarcinoma Tubulovillous adenoma

8 GI Neoplasia case 7 Female 60 years Previous Hartman's and right hemi-colectomy for colonic carcinoma, 9 years prior. Presently two separate lesions in the descending colon Signet ring cell carcinoma (poorly diff. Adenocarcinoma, pt) Mixed signet ring carciinoma pt and mod diff. adenocarcinoma pt Signet ring cell carcinoma and medullary carcinoma (pt) Mucinous carcinoma with mod. Diff. Adenocarcinoma Moderately differentiated adenocarcinoma Mucinous carcinoma Clear cell carcinoma Harmatomatous polyp Adenocarcinoma (+mucinous carcinoma, mod diff, with poorly diff) (pt, pt) Signet ring cell (adeno) carcinoma (pt) Malignant melanoma Carcinoid tumour 6 8

9 GI Neoplasia case 8 Male 70 years U. C. not settling on medical management. Previous bad appendicitis Tubular adenoma (with HGD) Inflammatory pseudopolyp Pedunculated villous adenomatous polyp with high grade dysplasia Tubular adenomatous polyp with LGD on background UC Villous adenoma with LGD UC with severe dysplasia and carcinoid carcinoma Hyperplastic polyp with moderate dysplasia Adenomatous polyp (Tubulovillous, villous, Tubular, LGD, HGD) Inflammatory polyp (with UC) Adenocarcinoma (villo-glandular) Lymphoma Juvenile polyp Crohn's disease 4 9

10 GI Neoplasia case 9 Female 49 years Bony metastasis - Unknown primary. Perforated colonic mass in pelvis involving upper rectum, sigmoid/transverse colon. Extended left hemicolectomy. Clinical Diagnosis :? stercoral / diverticular perforation Malignant lymphoid tumour (probably MALTOMA) Plasmacytoma Stercoral colitis Signet ring cell carcinoma (pt) Non-Hodgkin's lymphoma (IHC required) Diverticulitis with perforation Neuroendocrine tumour Mucinous carcinoma Adenocarcinoma (poorly differentiated) Adenocarcinoma (signet ring cell) Metastatic carcinoma/signet ring cell carcinoma Leiomyosarcoma Pseudomyxoma peritonei Granular cell tumour Small cell carcinoma chronic non-specific ulcerative necrotising inflammatory lesion Intestinal neuronal dysplasia Plasmacytoma Metastatic Osteosarcoma 8 0

11 GI Neoplasia case 0 Male 78 years Lower / polyp. Lower anterior resection. Inflamed/scarred anteriorly.? margins involved Adenocarcinoma (well differentiated, arising in TVA/TA, pt, pt4 Dukes B) 7 Papillary carcinoma Adenomatous polyp with HGD and invasive component (pt, pt) Peutz Jeghers polyp Adenocarcinoma (Papillary, villous, serrated, background adenoma)(pt4, pt, pt)

12 GI Neoplasia case Female years Sigmoid colon tumour Adenocarcinoma (mod diff, pt, pt, Dukes' B) 9 Basosquamous carcinoma Adenocarcinoma (cribriform comedo variant, mod diff)(pt, pt) 0 Moderately Granular cell tumour

13 GI Neoplasia case Male 6 years Oesophageal Nodule at cm Adenocarcinoma (mod diff pt, pt) Leiomyoma Granular cell myoblastoma Ganglioneuroma Granular cell tumour Leiomyoma GANT Ganglioneuroma Inflammatory 6

14 GI Neoplasia case Male 4 years Giant florid Perianal warts. Urgent histology please. These warts are growing fast enough to be malignant. Condyloma accuminatum (with AIN ) Squamous cell papilloma Inverted papilloma AIN Verrucae with areas of severe dysplasia 6 Condyloma acuminatum (with ulceration) Squamous papilloma Squamous cell carcinoma (mod diff) Verrucae (vulgaris, negative for dysplasia) Carcinoma in-situ (Bowen's disease) Microinvasive carcinoma AIN Squamous papilloma (with dysplasia) 7 4

15 GI Neoplasia case 4 Male 8 years Right hemicolectomy for caecal cancer Adenocarcinoma (moderately, poorly diff, pt) Medullary (adeno) carcinoma Lymphoepithelioma like carcinoma Non-Hodgkin's Lymphoma MALToma 4 Adenocarcinoma (poorly diff,)(pt) Non-Hodgkin's lymphoma/malignant lymphoma (with lymphoplasmactyic differentiation) MALToma Medullary (adeno) carcinoma Leiomyosarcoma High grade neuroendocrine tumour Carcinoid tumour Squamous cell carcinoma (poorly diff)

16 GI Soft tissue case Male years Oesophageal polyp from cricopharyngeum to GOJ. Smooth surface. Fibrolipoma Lipoma Liposarcoma (well diff) ATLT Lipoma Fibrolipoma Liposarcoma (pleomorphic) Atypical lipoma Fibrovascular polyp 6

17 GI Soft tissue case Male years Nodule at cm distal oesophagus Granular cell tumour Granular cell tumour coexisting with SCC Leiomyoma (benign mesenchymal tumour SCC Organising oesophagitis Dermatofibroma Granular cel tumour Giant muscular hypertrophy Leiomyoma Squamous cell carcinoma Lipoma Leiomyosarcoma Pleomorphic sarcoma Oesophagitis Squamous papilloma 6 7

18 GI Soft tissue case Male years Resection of oesophageal stricture Haemangioma Myxoma Leiomyosarcoma (myxoid) Carcinosarcoma/sarcomatoid carcinoma GIST (IHC required) Benign fibrocascular polyp Angiomyofibroma GIST (malignant) Leiomyoma Pleomorphic sarcoma/malignant spindle cell tumour Cavernous haemagioma Alveolar soft part sarcoma GIST Leiomyosarcoma Desmoid tumour Oesophageal Granulomatous tissue with muscular hypertrophy Fibromatosis 6 8

19 GI Soft tissue case 4 Female 74 years Gastric polyp?hyperplastic Inflammatory fibroid polyp Angiolymphoid hyperplasia with eosinophilia Fundic polyp Hyperplastic polyp with LGD Kaposi sarcoma Eosinophilic oesophagitis (probably parasitic) Leiomyoma Inflammatory pseudotumour/inflammatory fibroid polyp/proliferative fasciitis Hyperplastic polyp HP associated severe chronic gastritis with IM and dysplasia Liposarcoma Kaposi sarcoma Inflammatory polyp (submucous) Juvenile polyp Brunner gland hyperplasia/harmatoma 4 9

20 GI Soft tissue case Female 9 years Excision of GIST from the stomach - cm GIST (epithelioid - signet ring cell type)(intermediate risk) 6 Schwannoma (cuff of lymphoid aggregates present IHC) Leiomyoma GIST (Miettinen group, intermediate risk) 0 Leiomyoma 0

21 GI Soft tissue case 6 Female 7 years Total gastrectomy, 0cm lobulated lesion in the wall of the stomach GIST (epithelioid)(high risk)(malignant) Solitary fibrous tumour Adenocarcinoma (difuse Infiltrating) Epithelioid haemangioendothelioma Schwannoma Liposarcoma (well diff) GIST (epithelioid) Liposarcoma (de-differentiated, well differentiated) GIST (malignant, high risk) Leiomyoma Sarcoma 9

22 GI Soft tissue case 7 Male 44 years History of neurofibromatosis. 6cm mass in small bowel - resected. Malignant peripheral nerve sheath tumour GIST (neural type) Leiomyoma Neurofibroma Schwannoma (S00 to confirm) Neurofibroma (plexiform type) Schwannoma (cellular) Malignant peripheral nerve sheet tumour/malignant spindle cell tumour GIST (benign) Liposarcoma Leiomyoma Kaposis sarcoma Lymphoma coexisting with MPNST 6 4

23 GI Soft tissue case 8 Male 48 years Sessile polyp in colon. GIST (malignant) Leiomyoma (location in muscle layer - check for other masses) Benign mesenchymal neoplasm Myoepithelioma Leiomyosarcoma (poorly diff) Leiomyoma (cellular, atypical, mitotically active) GIST GIST (malignant)(epithelioid) Malignant spindle cell tumour/histiocytic sarcoma Leiomyosarcoma Carcinosarcoma Benign mesenchymal neoplasm Inflammatory pseudotumour 0

24 GI Soft tissue case 9 Male 78 years Colon cancer - large nodule from mesentery GIST (Ex-epithelioid, IHC)(high risk) PECOMA Kaposi sarcoma Neuroendocrine tumour Metastatic mesenchymal neoplasm Liposarcoma (poorly diff) Carcinoid/neuroendocrine tumour Malignant vascular tumour/angiosarcoma Inflammatory fibroid polyp GIST (malignant)(metastatic) Neuroendocrine carcinoma Metastatic carcinoma Metaplastic carcinoma Haemangiopericytoma GIST Lymph node metastatic adenocarcinoma PEComa (perivascular epithelioid cell tumour) 6 4

25 GI Soft tissue case 0 Male 9 years Anorectal polyp -?benign/malignant Squamous cell carcinoma Stercoral proctitis Intraepithelial Benign ancient change Perineurioma Malignant melanoma Angiosarcoma Adenocarcinoma (poorly diff) Squamous cell carcinoma (mod diff, poorly diff) Adenocarcinoma (mod diff, poorly diff, malignant polyp) Melanosis coli MPNST (low grade) Malignant GIST than do my I sarcoma Proctors Gangliocytic paraganglioma 8 4

26 GI Soft tissue case Female 4 years Retrorectal tumour Ganglioneuroblastoma Ganglioneuroma GANT Neurofibroma Angiomyolipoma Myoma Benign neural tumour/neurofibroma/neurofibromatosis Fibromatosis/Fibroma Ganglioneuroma Leiomyoma Rhabdomyosarcoma Inflammatory myofibroblastic tumour Schistosomiasis Myxoma Solitary fibrous tumour

27 GI Soft tissue case Female 66 years Retrorectal tumour Rhabdomyosarcoma (poorly differentiated, pleomorphic) AT/RT Pleomorphic sarcoma Squamous cell carcinoma (poorly diff.) Carcinoma (poorly differentiated) Liposarcoma (dedifferentiated with heterologous rhabdomyosarcoma) Lipoma Inflammatory myofibroblastic tumour Leiomyosarcoma Alveolar soft part sarcoma Malignant Peripheral Nerve Sheath Tumour Epithelioid sarcoma Metaplastic carcinoma Oncocytic carcinoma Rhabdomyosarcoma (pleomorphic) Malignant lymphoma 7

28 PARTICIPANTS divine 78 ELEGANZA 88 SJ SAYOLOVE ABC06 NaijaBoy Full TSL OLAT Aturu 44 The Other Room Michael Nweke Uchenna Ezenkwa Duncan Iyawe Bedazzle UBE DUO BeeGee ANA09 AAUEKP 0 olumo RMW M.O.O 0I0 MD JIN Xinus Ade EHIDI odu ogba sand sola STATES Lagos Kwara Ogun Oyo Akwa Ibom Bayelsa Gombe Edo Abuja Abia 8

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