Yes You Can! New! Amazing EVO C18. Core-Shell Technology

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1 Core-Shell Technology Yes You Can! New! Amazing EVO C8 Develop robust methods from ph - Get improved peak shape for bases Easily reduce run times and increase sensitivity

2 THE PAST Fully Porous You used to have to deal with chromatographic band broadening, low sensitivity, and long run times caused by classical fully porous silica. More Band Broadening And don t forget about system dependency and extremely high backpressure caused by me! Sub- µm Phenomenex l WEB:

Core-Shell Technology THE PRESENT Core-Shell Technology That was until

came to liberate you with core-shell particles for each of your specific

Less Band Broadening Improved Results Increased Productivity Easy

3 Core-Shell Technology THE PRESENT Core-Shell Technology That was until Phenomenex, the leading Core-Shell Technology developer and manufacturer, came to liberate you with core-shell particles for each of your specific techniques and applications. Less Band Broadening Improved Results Increased Productivity Easy Transferability Significant Cost Savings 9 Small Molecules Synthetic Oligonucleotides Peptides / Proteins And Now Core-Shell Technology

O O O O O O O Si Si O Si S Si O Si O Si Si O O O O O O O O C Si O Si Si O Si Si O Si Si O Si C O O O O O O O O C O Si Si O Si Si O Si Si O Si Si O O O O O O Kinetex EVO uses a patented organo-silica

4 AMAZING NEW KINETEX EVO, NOW! Introducing Kinetex EVO This is truly the next step in the evolution of the chromatographic particle. With Kinetex EVO you now have the freedom to achieve improved results, cost savings, and overall higher productivity at low, neutral, and high ph! O O O O O O O Si Si O Si S Si O Si O Si Si O O O O O O O O C Si O Si Si O Si Si O Si Si O Si C O O O O O O O O C O Si Si O Si Si O Si Si O Si Si O O O O O O Kinetex EVO uses a patented organo-silica grafting process which incorporates uniform stabilizing ethane cross-linking to provide resistance to high ph attack while maintaining mechanical strength of the core-shell particle. Develop robust methods from ph - Get improved peak shape for bases Easily reduce run times and increase sensitivity Phenomenex l WEB:

5 Core-Shell Technology What emotion will Kinetex EVO bring out in you... STRENGTH... pp. 6-7 TRUST... pp. 8-9 PRIDE...p. CONFIDENCE...p. HAPPINESS... pp. - WONDER... pp. - DESIRE... pp. 6-7 ZEST... pp. 8-9 LOVE... pp. - EVO

6 STRENGTH ph at Your Control While low ph mobile phases are quite useful, once the door to both low and high ph is opened, your method development options rapidly increase. The illustrations below exemplify how easy it can be to influence the retention behavior and peak shape of ionizable compounds by adjusting your mobile phase ph. Effects of mobile phase ph on Acids Effects of mobile phase ph on Bases Below pk a Low ph Below pk a At pk a At pk a Above pk a High ph Above pk a 6 Phenomenex l WEB:

7 Core-Shell Technology STRENGTH Show Those Peaks Who s Boss With excellent performance across a large ph range, Kinetex EVO columns allow you to transform chromatograms and manipulate retention order, no matter the combination of compound functionalities. Now is your chance to break the mold and let your creative LC side flourish ph. ph 7 6 APP ID 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Dimensions: x.6 mm Part No.: F-6-E Mobile Phase: A: mm Potassium Phosphate B: Acetonitrile Gradient: -7 % B in utes Flow Rate:. ml/ Temperature: C Detection: nm Sample:. Ibuprofen. Diphenhydrae. Ethyl Benzene 7 6 ph APP ID

8 TRUST Rugged and Wonderful With its unique chemistry, the Kinetex EVO particle ensures improved ph stability at alkaline mobile phase conditions along with amazing core-shell performance. It s time for you to expand your method development options and go where other core-shell products can t! % High ph Stability % % Initial Efficiency for Amitriptyline 9% 8% 7% 6% % % Injection Cycle Conditions for all columns: Column: Kinetex μm EVO C8 Poroshell.7 μm HPH-C8 UltraCore μm Super C8 Dimensions: x. mm Mobile Phase: A: mm Ammonium bicarbonate (ph.) B: Acetonitrile Gradient: % to 9% B in.. Hold at 9 % B for.7. Re-equilibrate at % B for.. Flow Rate:.8 ml/ Temperature: 6 C Detection: nm Sample:. Amitriptyline Kinetex µm EVO C8 Agilent Poroshell.7 µm HPH-C8 ACE UltraCore µm Super C8 Agilent and Poroshell are registered trademarks of Agilent Technologies, Inc. ACE is a registered trademark and UltraCore is a trademark of Advanced Chromatography Technologies Limited. Phenomenex is not affiliated with any of the above listed companies. Comparative separations may not be representative of all applications. 8 Phenomenex l WEB:

9 Core-Shell Technology TRUST Dependability Batch-to-Batch, Column-to-Column Exceptionally rigorous quality control and manufacturing steps ensure that Kinetex EVO columns deliver the pinnacle of performance values and mechanical strength time after time. Simply put, that s reproducibility that you can trust and feel at ease with! 7 One of Many Internal Batch/Column QC Tests Customer Example Run-to-Run Consistency Batch Batch 7 APP ID 7 APP ID 7 7, st Injection 6 th Injection APP ID 7 6 Batch APP ID 7, 6 APP ID 7 Column: Kinetex µm EVO C8 Dimensions: x.6 mm Part No.: F-6-E Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Acetonitrile Gradient: -9 % B in 7.76 utes Flow Rate:. ml/ Temperature: C Detection: nm Sample:. Uracil. Pindolol. Chlorphenirae. Nortriptyline. -Methyl--Nitrobenzoic acid 6. -hydroxy,-methylbenzaldehyde 7. Hexanophenone Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: B-6-AN Mobile Phase: A:. % Ethanolae in Water (ph~.) B:. % Ethanolae in Acetonitrile Gradient: Time () Flow Rate:. ml/ Temperature: C Detection: nm % B 9 Sample:. Pyridine. Aniline. Unknown peak. Benzyl alcohol. Toluene 6. Unknown peak Data Courtesy of: Róbert Kormány, Egis Pharmaceuticals Plc., Hungary 9

10 PRIDE Wow! Look at those Marvelous Peak Shapes! You re going to be the talk of the lab and department when you switch to Kinetex EVO for your basic compound analyses. The unique organo-silica layer of ethane cross-linking found within each Kinetex EVO particle creates a highly inert surface which provides the additional benefit of better peak shape for bases. Kinetex µm EVO C8 x.6 mm Pressure: 76 bar Peak Capacity: 69 Supelco Ascentis Express µm C8 x.6 mm Pressure: bar Peak Capacity: 87 APP ID 76 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Ascentis Express µm C8 Dimensions: x.6 mm Mobile Phase: A: mm Sodium phosphate dehydrate ph 7. B: Methanol Gradient: % to 9 % B over utes Flow Rate: ml/ Temperature: Ambient Detection: Sample:. Scopolae. Pseudoephedrine. Doxylae. Chlorphenirae. Diphenhydrae Ascentis and Supelco are registered trademarks of Sigma-Aldrich Co. Phenomenex is not affiliated with any of the above listed companies. Comparative separations may not be representative of all applications. Phenomenex l WEB:

11 Core-Shell Technology CONFIDENCE Do More Load-to-Load Use Kinetex EVO columns to avoid the effects of peak shape distortion for bases that traditional fully porous and core-shell columns display. Even across multiple loading conditions, sharp compound peak shape is kept consistently good and strong using a Kinetex EVO LC column. Core-Shell µm C8 Kinetex µm EVO C APP ID 76 APP ID 77 Conditions for all columns: Column: Kinetex µm EVO C8 Core-Shell µm C8 Dimensions: x.6 mm Mobile Phase:. % TFA in Water /. % TFA in Acetonitrile (:6) Flow Rate:. ml/ Temperature: Ambient Detection: Sample: µg to µg Loads of Nortriptyline

HAPPINESS Instant Improvement of µm and µm Methods Now you can cheerfully improve the resolution, productivity, and sensitivity of your current

This revolutionary coreshell particle was specifically developed to give you great performance and true ph durability at very low HPLC

12 HAPPINESS Instant Improvement of µm and µm Methods Now you can cheerfully improve the resolution, productivity, and sensitivity of your current µm and µm methods using Kinetex EVO µm Core-Shell Technology. This revolutionary coreshell particle was specifically developed to give you great performance and true ph durability at very low HPLC backpressures. Up to 9 % higher average efficiency Up to % higher average efficiency at half the pressure µm VS. µm VS. Fully Porous µm Fully Porous µm Kinetex EVO Core-Shell Kinetex EVO Core-Shell Phenomenex l WEB:

13 Core-Shell Technology HAPPINESS Drop in a Kinetex EVO µm Column to Start Smiling With the combination of rugged ph stability from - and the core-shell performance advantage, you can easily replace old hybrid silica columns and gain immediate method improvements without increasing backpressure. It s time to let chromatography cheer appear! Kinetex µm EVO C8 x.6 mm 6 Pressure: bar Waters XBridge. µm C8 x.6 mm Pressure: 6 bar APP ID APP ID Conditions for all columns: Column: Kinetex µm EVO C8 XBridge µm C8 XBridge. µm C8 Dimensions: x.6 mm Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Acetonitrile Gradient: % to 9 % B over utes Flow Rate:. ml/ Temperature: Ambient Detection: Sample:. Uracil. Pindolol. Chlorophenirae. Nortriptyline. -Methyl--Nitrobenzoic acid 6. -hydroxy,-methylbenzaldehyde 7. Hexaphenone 7 Waters XBridge µm C8 x.6 mm 8 6 Pressure: bar 7 6 APP ID Waters and XBridge are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications.

14 WONDER Imagine No Suppression Ever have that moment of panic when polar analytes elute way too early in low or neutral ph mobile phases? It s time to put that worry to rest and marvel at the way you can use the enhanced ph stability of Kinetex EVO columns to dramatically improve the retention of polar, basic compounds. Low ph High ph 8.e 8.e 7.e 7.e 6.e 6.e Intensity, cps.e.e Intensity, cps.e.e.e.e.e.e APP ID 7.e.e APP ID 7 Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: D-6-Y Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Gradient: Time (). Flow Rate:.7 ml/ Temperature: Ambient Detection: MS % B 7 7 Sample:. -Hydroxycotinine. Nornicotine. Cotinine. Anabasine. Nicotine Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: D-6-Y Mobile Phase: A: mm Ammonium bicarbonate (unadjusted ph ~8.) B: Methanol Gradient: Time (). Flow Rate:.7 ml/ Temperature: Ambient Detection: MS % B 7 7 Sample:. -Hydroxycotinine. Nornicotine. Cotinine. Anabasine. Nicotine Phenomenex l WEB:

15 Core-Shell Technology WONDER Increased Sensitivity for LC/MS Applications Alongside LC/UV analyses, the high performance and low pressure of the Kinetex EVO μm make it a tremendous tool for LC/MS and LC/MS/MS. Increased polar basic retention provided by the Kinetex EVO allows for greater use of organic within the mobile phase, subsequently leading to improved ionization and increased sensitivity..e.8e.6e.e Intensity, cps.e.e 8.e 6.e.e.e APP ID 7 6 Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Gradient: Time () % B Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: B-6-AN Mobile Phase: A: mm Ammonium Bicarbonate (ph 8.) B: Methanol Gradient: Time () Flow Rate:. ml/ Temperature: Ambient Detection: MS/MS (AB SCIEX API ) Sample:. Sufentanil % B 8 8 8

16 DESIRE The Best C8 Columns For You With more C8 s on the market than any other phase, it s important to understand how the best ones can benefit you! Switch between the combination of the all-purpose Kinetex C8 and butyl side chain bonded XB-C8 to get small defined changes in retention and selectivity. Use the Kinetex EVO for enhanced peak shape of bases and extra alkaline ph stability. Kinetex µm EVO C8 Kinetex µm XB-C8 APP ID 79 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Kinetex µm XB-C8 Kinetex µm C8 Dimensions: x.6 mm Mobile Phase: A: mm Potassium phosphate (ph.) B: Acetonitrile Gradient: - % B in utes Flow Rate:. ml/ Temperature: C Detection: nm Sample: Nutraceutical Mix Kinetex µm C8 APP ID Phenomenex l WEB:

17 Core-Shell Technology DESIRE Built For Your Needs Two exceptional selectivities give you retention enhancement without performance loss. Use the multi-functional Kinetex Biphenyl or ph stable Kinetex EVO C8 to reach the desired solution for your method..8e.6e.e.e.e.8e.6e.e.e.e 8.e 6.e.e.e Kinetex µm C8 6 APP ID 7.8e.6e.e.e.e.8e.6e.e.e.e 8.e 6.e.e.e Keep same mobile phase Kinetex µm Biphenyl 6 APP ID 7.8e.6e.e.e.e.8e.6e.e.e.e 8.e 6.e.e.e Switch to high ph mobile phase Kinetex µm EVO C8 6 APP ID 7 Conditions for all columns: Column: Kinetex µm C8 Kinetex µm Biphenyl Kinetex µm EVO C8 Dimensions: x. mm Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Mobile Phase: A: mm Ammonium Bicarbonate (ph 8.) B: Methanol Gradient: Time () Flow Rate:. ml/ Temperature: Ambient % B Detection: MS/MS (AB SCIEX API ) Sample: Opiates Mix 7

18 ZEST Get Enthusiastic About Prep LC Reach new levels of purification with the ground-breaking combination of Kinetex EVO coreshell particles and AXIA preparative column technology. This technological combination provides genuine benefits including excellent loadability, high efficiency levels, and incredible ph stability. On top of all this, scaling and method optimization from analytical to prep is a breeze. Waters XBridge µm C8 x.6 mm Kinetex µm EVO C8 x.6 mm Impurity Not Resolved APP ID 7 6 Excellent Resolution APP ID Analytical to PREP Scalability Conditions for all columns: Column: Kinetex µm EVO C8 XBridge µm C8 Dimensions: x.6 mm x. mm (Kinetex AXIA Packed) Mobile Phase: A:. % TFA in Water B:. % TFA in Acetonitrile Gradient: % to 7 % B over utes Flow Rate:. ml/ ml/ (Kinetex AXIA) Temperature: Ambient Detection: Sample: Proprietary Pharmaceutical Sample Kinetex µm EVO C8 x. mm AXIA 6 8 APP ID 7 8 Waters and XBridge are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. Phenomenex l WEB:

19 Core-Shell Technology ZEST Got an Appetite For Better Results? Kinetex EVO will easily pave the way to enhanced purification and isolation levels with its incredible ph durability and core-shell performance gains. Get ready for a future of high yields and chromatographic improvements over traditional fully porous and hybrid materials. Kinetex µm EVO C8 Waters Xbridge µm C8 x. mm AXIA x 9 mm Prep OBD 7 Amazing Peak Shape Over All Sample Loads 7 mv 7 APP ID 768 mv 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Axia packed XBridge µm C8 Prep OBD Dimensions: x. mm (Kinetex) x 9 mm (XBridge) Mobile Phase: A:. % TFA in Water B:. % TFA in Acetonitrile Gradient: -9 % B in. Hold for. Re-equilibrate for. Flow Rate: ml/ Temperature: Ambient Detection: Sample:. Amitriptyline Sample Load: mg mg mg mg mg 8 mg Waters and XBridge are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. 9

20 Get Method Development Flexibility For Your Small Molecule Analysis Recommended Selectivities If You re Working With: Acids Bases Neutrals Aromatics Kinetex C8 Kinetex EVO C8 Kinetex C8 Kinetex Biphenyl Kinetex XB-C8 Kinetex XB-C8 Kinetex C8 Kinetex Phenyl-Hexyl Kinetex Phenyl-Hexyl Kinetex Biphenyl Kinetex Biphenyl Kinetex C8 Acids, Bases, and Neutrals Highly Polar Compounds High ph Kinetex C8 Kinetex EVO C8 Kinetex HILIC Kinetex EVO C8 Kinetex Biphenyl Kinetex C8 Kinetex EVO C8 Kinetex Biphenyl Upgrading Your Fully Porous Methods: Fully Porous µm or µm Fully Porous sub- µm Fully Porous Preparative LC µm Kinetex or Kinetex EVO Drop-in for easy performance improvements with no backpressure increase.6 µm Kinetex Dramatically improve results with efficiency/ peak capacity gains.6 µm Kinetex Get similar efficiencies at lower backpressure allowing for greater productivity gains.7 µm Kinetex Up to % greater efficiencies resulting in drop-in improvements. µm Kinetex Incredible efficiency gains on high end UHPLC systems µm Kinetex or Kinetex EVO Drop-in for easy performance improvement with no backpressure increase Phenomenex l WEB:

21 Choosing The Best Core-Shell Platform For You is Easy! Core-Shell Technology For Small Molecules µm.6 µm.6 µm.7 µm. µm UHPLC HPLC PREP LC Material Phase Best Use ph Stability Available Particle Size(s) Kinetex EVO C8 Robust reversed phase methods even in alkaline conditions with improved peak shape for polar basic compounds - µm Kinetex C8 XB-C8 C8 Biphenyl Phenyl-Hexyl HILIC All purpose phase that offers the hydrophobic retention and methylene selectivity chromatographers expect from a C8 column C8 phase with protective butyl side chains for improved peak shape for basic compounds under neutral and acidic conditions USP L7 phase that provides less hydrophobic and methylene selectivity than a C8 % aqueous stable and allows for excellent reversed phase retention and enhanced polar and aromatic selectivity Reversed phase chemistry that allows for greater retention and separation of aromatic hydrocarbons Unbonded silica phase for HILIC conditions to provide selectivity for polar compounds * µm.6 µm.7 µm. µm * µm.6 µm.7 µm * µm.6 µm.7 µm * µm.6 µm.7 µm * µm.6 µm.7 µm µm.6 µm.7 µm Phenomenex Application Specific Core-Shell Products Material Phase Best Use ph Stability Available Particle Size(s) For Peptides (, Da) Aeris PEPTIDE XB-C8 Excellent hydrophobicity and methylene selectivity for peptide and peptide mapping separations µm.6 µm.6 µm.7 µm For Proteins (, Da) Aeris WIDEPORE XB-C8 XB-C8 C Maximum hydrophobicity and high temp stability for hydrophilic and PEGylated proteins Medium hydrophobicity and high temp stability for moderately hydrophobic proteins and glycosylated proteins Lowest hydrophobicity for very large or very hydrophobic proteins µm µm µm For Synthetic Oligonucleotides (DNA/RNA) Clarity Rapid, high efficiency reversed phase LC/MS analysis for QC C8 Oligo-MS and characterization *ph stability under gradient conditions. ph stability is.- under isocratic conditions *.6 µm.7 µm

22 Ordering Information SecurityGuard μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. x. x. /pk EVO C8 B-6-AN D-6-AN F-6-AN AJ-998 Biphenyl A-67-AN B-67-AN D-67-AN AJ-99 XB-C8 A-6-AN B-6-AN D-6-AN AJ-878 C8 A-6-AN B-6-AN D-6-AN F-6-AN AJ-878 C8 B-68-AN D-68-AN AJ-878 Phenyl-Hexyl B-6-AN D-6-AN AJ-8788 for. mm ID SecurityGuard μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. x. /pk If you are not completely satisfied with Kinetex core-shell columns, send in your comparative data to a similar product within days and keep the column for FREE. EVO C8 B-6-Y D-6-Y F-6-Y AJ-997 Biphenyl B-67-Y D-67-Y F-67-Y AJ-98 XB-C8 B-6-Y D-6-Y F-6-Y AJ-877 C8 B-6-Y D-6-Y F-6-Y AJ-877 C8 B-68-Y D-68-Y AJ-8777 Phenyl-Hexyl B-6-Y D-6-Y AJ-878 for. mm ID SecurityGuard μm Analytical Columns (mm) ULTRA Cartridges Phases x.6 x.6 x.6 x.6 /pk EVO C8 B-6-E D-6-E F-6-E G-6-E AJ-996 Biphenyl B-67-E D-67-E F-67-E G-67-E AJ-97 XB-C8 B-6-E D-6-E F-6-E G-6-E AJ-8768 C8 B-6-E D-6-E F-6-E G-6-E AJ-8768 C8 B-68-E D-68-E F-68-E G-68-E AJ-877 Phenyl-Hexyl B-6-E D-6-E F-6-E G-6-E AJ-877 for.6 mm ID SecurityGuard μm Semi-Preparative Columns (mm) SemiPrep Cartridges*** Phases x x x /pk C8 F-6-N G-6-N AJ-978 Biphenyl F-67-N G-67-N AJ-98 for mm ID SecurityGuard μm Axia Packed Preparative Columns (mm) PREP Cartridges* Phases x. x. x. x. x. /ea EVO C8 B-6-P-AX D-6-P-AX F-6-P-AX G-6-P-AX AJ-9 /ea Biphenyl B-67-P-AX D-67-P-AX F-67-P-AX G-67-P-AX AJ-97 XB-C8 B-6-P-AX D-6-P-AX F-6-P-AX G-6-P-AX AJ-9 C8 B-6-P-AX D-6-P-AX F-6-P-AX G-6-P-AX AJ-9 C8 B-68-P-AX D-68-P-AX F-68-P-AX G-68-P-AX AJ-9 Phenyl-Hexyl B-6-P-AX D-6-P-AX F-6-P-AX G-6-P-AX AJ-97 HILIC D-66-P-AX F-66-P-AX G-66-P-AX AJ-977 for. mm ID SecurityGuard μm Axia Packed Preparative Columns (mm) PREP Cartridges** Phases x x x x x /ea Biphenyl F-67-U-AX AJ-97 XB-C8 B-6-U-AX D-6-U-AX F-6-U-AX G-6-U-AX AJ-9 C8 B-6-U-AX D-6-U-AX F-6-U-AX G-6-U-AX AJ-9 C8 B-68-U-AX D-68-U-AX F-68-U-AX G-68-U-AX AJ-97 Phenyl-Hexyl B-6-U-AX D-6-U-AX F-6-U-AX G-6-U-AX AJ-96 for mm ID Phenomenex l WEB: SecurityGuard ULTRA Cartridges require holder, Part No.: AJ-9 * PREP SecurityGuard Cartridges require holder, Part No.: AJ-8 ** PREP SecurityGuard Cartridges require holder, Part No.: AJ-877 *** SemiPrep SecurityGuard Cartridges require holder, Part No.: AJ-98

23 Ordering Information Core-Shell Technology SecurityGuard.6 μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. 7 x. x. x. /pk Biphenyl A-6-AN B-6-AN D-6-AN F-6-AN AJ-99 XB-C8 A-96-AN B-96-AN C-96-AN D-96-AN F-96-AN AJ-878 C8 A-6-AN B-6-AN C-6-AN D-6-AN F-6-AN AJ-878 C8 A-97-AN B-97-AN C-97-AN D-97-AN F-97-AN AJ-878 HILIC A-6-AN B-6-AN C-6-AN D-6-AN F-6-AN AJ-8786 Phenyl-Hexyl A-9-AN B-9-AN C-9-AN D-9-AN F-9-AN AJ-8788 for. mm ID SecurityGuard.6 μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. 7 x. x. x. /pk Biphenyl B-6-Y D-6-Y F-6-Y AJ-98 XB-C8 A-96-Y B-96-Y C-96-Y D-96-Y F-96-Y AJ-877 C8 A-6-Y B-6-Y C-6-Y D-6-Y F-6-Y AJ-877 C8 A-97-Y B-97-Y C-97-Y D-97-Y F-97-Y AJ-8777 HILIC A-6-Y F-6-Y AJ-8779 Phenyl-Hexyl B-9-Y D-9-Y F-9-Y AJ-878 for. mm ID SecurityGuard.6 μm Analytical Columns (mm) ULTRA Cartridges Phases x.6 x.6 7 x.6 x.6 x.6 /pk Biphenyl B-6-E D-6-E F-6-E AJ-97 XB-C8 B-96-E C-96-E D-96-E F-96-E AJ-8768 C8 A-6-E B-6-E C-6-E D-6-E F-6-E AJ-8768 C8 B-97-E C-97-E D-97-E F-97-E AJ-877 HILIC B-6-E C-6-E D-6-E F-6-E AJ-877 Phenyl-Hexyl B-9-E C-9-E D-9-E F-9-E AJ-877 for.6 mm ID SecurityGuard.7 μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. x. x. /pk Biphenyl B-68-AN D-68-AN F-68-AN AJ-99 XB-C8 A-98-AN B-98-AN D-98-AN F-98-AN AJ-878 C8 A-7-AN B-7-AN D-7-AN F-7-AN AJ-878 C8 A-99-AN B-99-AN D-99-AN F-99-AN AJ-878 HILIC A-7-AN B-7-AN D-7-AN AJ-8786 Phenyl-Hexyl B--AN D--AN F--AN AJ-8788 for. mm ID SecurityGuard.7 μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. x. /pk XB-C8 A-98-Y B-98-Y D-98-Y AJ-877 C8 B-7-Y D-7-Y AJ-877 C8 A-99-Y B-99-Y D-99-Y AJ-8777 HILIC B-7-Y AJ-8779 for. mm ID. μm Minibore Columns (mm) Phases x. x. C8 A--AN B--AN SecurityGuard ULTRA Cartridges require holder, Part No.: AJ-9 Terms and Conditions Subject to Phenomenex Standard Terms & Conditions, which may be viewed at Trademarks Phenomenex, Clarity, and Kinetex are registered trademarks of Phenomenex. Axia, Aeris, Oligo-MS, MidBore and SecurityGuard are trademarks of Phenomenex. Waters and XBridge are registered trademarks of Waters Corporation. Agilent and Poroshell are registered trademarks of Agilent Technologies, Inc. Ascentis and Supelco are registered trademarks of Sigma-Aldrich Co. ACE is a registered trademark and UltraCore is a trademark of Advanced Chromatography Technologies Limited. Disclaimer Phenomenex is not affiliated with Advanced Chromatography Technologies Limited, Agilent Technologies, Sigma-Aldrich Co., or Waters Corporation. Comparative separations may not be representative of all applications. SecurityGuard is patented by Phenomenex. U.S. Patent No. 6,6,6. CAUTION: this patent only applies to the analytical-sized guard cartridge holder, and does not apply to SemiPrep, PREP or ULTRA holders, or to any cartridges. Axia is patented by Phenomenex. U.S. Patent No. 7, 67, 8 Kinetex EVO is patented by Phenomenex. U.S. Patent Nos. 7,6,67 and 8,68,8 and foreign counterparts. The opinions stated herein are solely those of the speaker and not necessarily those of any company or organization. Phenomenex, Inc. All rights reserved.

24 Introducing Kinetex EVO! Develop robust methods from ph - Get improved peak shape for bases Easily reduce run times and increase sensitivity Core-Shell Technology Australia t: f: auinfo@phenomenex.com Austria t: -9- f: -9- anfrage@phenomenex.com Belgium t: (French) t: 8666 (Dutch) f: + ()-879 beinfo@phenomenex.com Canada t: (8) -68 f: () info@phenomenex.com Denmark t: 8 88 f: nordicinfo@phenomenex.com Finland t: f: nordicinfo@phenomenex.com France t: 9 f: 9 franceinfo@phenomenex.com Germany t: f: anfrage@phenomenex.com India t: - f: - indiainfo@phenomenex.com Ireland t: 7 f: eireinfo@phenomenex.com Italy t: 67 f: 67 italiainfo@phenomenex.com Luxembourg t: + ()-87 f: + ()-879 nlinfo@phenomenex.com Mexico t: f: tecnicomx@phenomenex.com The Netherlands t: -87 f: -879 nlinfo@phenomenex.com New Zealand t: f: nzinfo@phenomenex.com Norway t: 8 f: nordicinfo@phenomenex.com Puerto Rico t: (8) -HPLC f: () info@phenomenex.com Sweden t: f: nordicinfo@phenomenex.com United Kingdom t: 6-67 f: ukinfo@phenomenex.com United States t: () - f: () info@phenomenex.com All other countries: Corporate Office USA t: () - f: () info@phenomenex.com Phenomenex products are available worldwide. For the distributor in your country, contact Phenomenex USA, International Department at international@phenomenex.com BR87_I

Awesome! Unconventionally. Kinetex EVO C18 HPLC/UHPLC Core-Shell Columns 2.6. Core-Shell Technology

Awesome! Unconventionally. Kinetex EVO C18 HPLC/UHPLC Core-Shell Columns 2.6. Core-Shell Technology Core-Shell Technology Kinetex EVO C8 HPLC/UHPLC Core-Shell Columns Greater Polar Retention with % Aqueous Stability Robust Methods from ph - Improved Peak Shape for Bases NEW.7 µm NEW. µm µm Unconventionally