Core-Shell Technology. Kinetex. Columns. The chosen core-shell brand to drive UHPLC performance to the next level. Core-Shell Technology

Transcription

1 Kinetex. µm UHPLC Coumns The chosen core-she brand to drive UHPLC performance to the next eve

2 Simpy Advantageous The band broadening (wide peaks) and engthy retention times of traditiona fuy porous products can imit your resuts. Now you can use the incredibe efficiency eves of Kinetex to achieve shorter run times, higher eves of sensitivity, and overa better UHPLC resuts. Kinetex Core-She Traditiona Fuy Porous Get faster, better resuts with me! APP ID Kinetex Core-She Traditiona Fuy Porous

3 The First. µm Core-She Coumn Upgrade the efficiency and performance of your current traditiona sub- μm coumn with a Kinetex. μm core-she coumn. Extra resoution, higher peak capacities, and greater sensitivity are a within your reach with Kinetex. Kinetex. µm XB-C8 AU % 8 % % Higher Resoution (between peaks and ) Higher Resoution (between peaks and 6) 6 Higher Resoution (between peaks and 8) APP ID 98 Waters ACQUITY BEH. µm C8 AU APP ID 98 Conditions for both coumns: Coumn: Kinetex. µm XB-C8 Detection: nm (ambient) ACQUITY BEH. µm C8 Dimensions: x. mm Backpressure: 89 bar (Kinetex) 9 bar (ACQUITY) Mobie Phase: A: Mii-Q Water Instrument: Waters ACQUITY UPLC B: Acetonitrie Sampe:. Hydrocortisone Gradient: Time () % B. Cortisone. Corticosterone. Cortisone--Acetate Fow Rate:. ml/. DHEA (Dehydroepiandrosterone) Temperature: Ambient 6. -Hydroxyprogesterone. Deoxycorticosterone 8. Progesterone Comparative separations may not be representative of a appications.

4 Superior and Faster Resoving Power The increased efficiency of Kinetex. μm aows you to use shorter coumns for faster run times whie keeping optima performance. Now it s time for you to chaenge your difficut separations with the superior efficiency and resoving power of a Kinetex. μm core-she coumn..e Kinetex. µm C8 Faster anaysis, better sensitivity, and overa better resoution! Intensity, cps APP ID Fuy Porous. µm C8 Intensity, cps APP ID 686.e Fused-Core. µm C8 Intensity, cps 6 APP ID Conditions for a coumns: Coumns: Fuy porous. µm C8 ( x. mm) Fused-Core. µm C8 ( x. mm) Kinetex. µm C8 ( x. mm) Mobie Phase: A: mm Ammonium Formate B: Acetonitrie Gradient: Time (). % B Comparative separations may not be representative of a appications. Fow Rate:. ml/ Temperature: C Detection: MS/MS (SCIEX API ) Sampe: Lorazepam gucuronide

5 Trust / Consistency Highy sensitive UHPLC separations are dependent upon consistent quantitation and consistent resuts. With the reiabiity of the Kinetex coumns and media batches, you no onger have to sette for the inconsistent resuts of inferior products that exist on the market. Our highest standards of quaity wi ensure that you are fuy satisfied with each and every Kinetex coumn! 6 6 Batch APP ID 8 6 Batch 6 APP ID Batch APP ID 8 Conditions same for a batches: Coumn: Kinetex. µm F Dimensions: x.6 mm Mobie Phase: A:. % Formic Acid in Water B:. % Formic Acid in Acetonitrie Gradient: -9 % B over Fow Rate:.8 ml/ Temperature: C Detection: nm (ambient) Sampe:. Uraci. Pindoo. Chorphenirae. Nortriptyine. -Methy--Nitrobenzoic acid 6. -Methy Saicy Adehyde. Hexaphenone Comparative separations may not be representative of a appications.

6 Upgrade from Hybrid Materias By upgrading from fuy porous hybrid UHPLC coumns to the Kinetex. μm EVO C8, you can keep the ph stabiity but gain much greater performance. With the core-she advantage at your disposa your new methods wi be faster and more sensitive, eaving room for greater productivity. 8 Berberine Standard Kinetex. µm EVO C8 % Increase in Peak Height Response Waters ACQUITY BEH. µm C8 6 Greater Resoution of Impurities APP ID and 9 Conditions for both coumns: Coumn: Kinetex. µm EVO C8 ACQUITY BEH. µm C8 Dimensions: x. mm Mobie Phase: A:. % Formic Acid in Water B:. % Formic Acid in Methano Gradient: Time () Fow Rate:. ml/ Temperature: º C Detection: Sampe:. Berberine % B 9 nm (ambient) Comparative separations may not be representative of a appications.

7 UHPLC Compatibe Kinetex coumns are compatibe with ALL UHPLC Instruments. Kinetex on Agient 9 Kinetex on JASCO X-LC Kinetex on Shimadzu Nexera Kinetex on Waters ACQUITY UPLC Need hep instaing your Kinetex coumn?

8 Utiizing Powerfu Seectivities With the combination of the nove Kinetex EVO C8, F, and Bipheny seectivities at your disposa, reversed phase UHPLC method deveopment can be taken to the next eve. With its exceptiona peak shape for basic compounds, the EVO C8 is a dynamic too that gives core-she high performance whie aowing retention to be enhanced by adjusting the ph of the mobie phase. Kinetex. µm EVO C8 8 6 EVO C8 ph. APP ID 9 Mo Orth So 6 6 Kinetex. µm EVO C8 EVO C8 ph Utiize High ph Stabiity of EVO C8 to Enhance Retention APP ID 8 6 Conditions for a coumns same except where noted: Coumn: Kinetex. µm EVO C8 Dimensions: x. mm Part No.: B-6-AN Mobie Phase: A: mm Potassium phosphate (ph.) B: Methano Mobie Phase: A: mm Potassium phosphate (ph ) B: Methano Gradient: Time () 8. ml/ º C % B 9 Fow Rate: Temperature: Detection: nm (ambient) Sampe:. Fuvoxae

9 Utiizing Powerfu Seectivities Next to the EVO C8, the orthogona Kinetex F and Bipheny wi drive enhancement of reversed phase methods with their versatie array of interaction mechanisms. Varying degrees of eectrostatic, aromatic, reversed phase, steric, and hydrogen bonding between the F and Bipheny mean that these two stationary phases are both exceent aternatives to a C8. Additionay the F is known for its abiity to separate isomeric species, whie the pi eectron coud created by the dua ring of the Bipheny phase acts ike a weak negative charge and aids basic compound retention. Kinetex. µm F ve to ogona utions! 6 6 F F 6 Kinetex. µm Bipheny F F F F Bipheny ph. ph. APP ID 8 APP ID 8 6 Conditions for a coumns: Coumn: Kinetex. µm F Kinetex. µm Bipheny Dimensions: x. mm Part No.: Kinetex F: B--AN Kinetex Bipheny: B-68-AN Mobie Phase: A: mm Potassium phosphate (ph.) B: Methano Gradient: Time () 8 % B 9 Fow Rate:. ml/ Temperature: º C Detection: nm (ambient) Sampe:. Fuvoxae

10 Protect any UHPLC Coumn Protect your coumn, incuding Kinetex coreshe coumns, from damaging contaants and microparticuates with the SecurityGuard ULTRA guard cartridge system! Simpe to use Extend coumn ifetime Pressure rated to, psi (,8 bar) Fits virtuay a manufacturers coumns. to.6 mm ID UHPLC Coumn Protection From Injection SecurityGuard ULTRA Guard Cartridge System (Cartridge connected to Hoder) SecurityGuard ULTRA UHPLC Coumn to Detector Hoder Cartridge Frit Materia Chamber Compounds of Interest Contaants } and Particuates See it in action:

11 Kinetex Phase Seection Phase Best Use ph Stabiity EVO C8 C8 XB-C8 C8 F Bipheny Pheny-Hexy HILIC Robust reversed phase methods even in akaine conditions with improved peak shape for poar basic compounds A purpose phase that offers the hydrophobic retention and methyene seectivity chromatographers expect from a C8 coumn C8 phase with protective buty side chains for improved peak shape for basic compounds under neutra and acidic conditions USP L phase that provides ess hydrophobic and methyene seectivity than a C8 Highy reproducibe pentafuoropheny propy phase that offers a unique combination of poar, hydrophobic, aromatic, and shape seectivity % aqueous stabe and aows for exceent reversed phase retention and enhanced poar and aromatic seectivity Reversed phase chemistry that aows for greater retention and separation of aromatic hydrocarbons Unbonded siica phase for HILIC conditions to provide seectivity for poar compounds *ph stabiity under gradient conditions. ph stabiity is.- under isocratic conditions *. - 8.*. - 8.* *. - 8.*. -. Ordering Information SecurityGuard. μm Minibore Coumns (mm) ULTRA Cartridges Phases x. x. x. x. /pk EVO C8 B-6-AN D-6-AN F-6-AN AJ-998 F B--AN D--AN F--AN AJ-9 Bipheny B-68-AN D-68-AN F-68-AN AJ-99 XB-C8 A-98-AN B-98-AN D-98-AN F-98-AN AJ-88 C8 A--AN B--AN D--AN F--AN AJ-88 C8 A-99-AN B-99-AN D-99-AN F-99-AN AJ-88 HILIC A--AN B--AN D--AN AJ-886 Pheny-Hexy B--AN D--AN F--AN AJ-888 for. mm ID SecurityGuard ULTRA Cartridges require hoder, Part No.: AJ-9 If you are not competey satisfied with Kinetex core-she coumns, send in your comparative data to a simiar product within days and keep the coumn for FREE.

12 Austraia t: +6 ()-98-6 f: +6 ()-98-6 Austria t: + ()-9- f: + ()-9- anfrage@phenomenex.com Begium t: + () (French) t: + () 8666 (Dutch) f: + ()-89 beinfo@phenomenex.com Canada t: + (8) -68 f: + () 8-68 info@phenomenex.com China t: +86 () f: +86 () 89-8 chinainfo@phenomenex.com Denmark t: f: nordicinfo@phenomenex.com Finand t: +8 () f: nordicinfo@phenomenex.com France t: + () 9 f: + () 9 franceinfo@phenomenex.com Germany t: +9 ()6-88- f: +9 ()6-88- anfrage@phenomenex.com India t: +9 ()- f: +9 ()- indiainfo@phenomenex.com Ireand t: + () f: eireinfo@phenomenex.com Itay t: +9 6 f: +9 6 itaiainfo@phenomenex.com Luxembourg t: + ()-8 f: + ()-89 ninfo@phenomenex.com Mexico t: f: tecnicomx@phenomenex.com The Netherands t: + ()-8 f: + ()-89 ninfo@phenomenex.com New Zeaand t: +6 ()9-89 f: +6 ()9-89 nzinfo@phenomenex.com Norway t: + 8 f: nordicinfo@phenomenex.com Puerto Rico t: + (8) -HPLC f: + () 8-68 info@phenomenex.com Spain t: f: espinfo@phenomenex.com Sweden t: +6 () f: nordicinfo@phenomenex.com United Kingdom t: + ()6-6 f: + ()6-96 ukinfo@phenomenex.com USA t: + () - f: + () 8-68 info@phenomenex.com A other countries Corporate Office USA t: + () - f: + () 8-68 info@phenomenex.com products are avaiabe wordwide. For the distributor in your country, contact USA, Internationa Department at internationa@phenomenex.com BR986_I_ Terms and Conditions Subject to Standard Terms & Conditions, which may be viewed at Trademarks Kinetex is a registered trademark and SecurityGuard is a trademark of. Waters, ACQUITY, and UPLC are registered trademarks, and BEH Technoogy is a trademark of Waters Corporation. Agient is a registered trademark of Agient Technoogies, Inc. Shimadzu and Nexera are registered trademarks of Shimadzu Corporation. JASCO is a registered trademark of JASCO, Corporation. Fused-Core is a registered trademark of Advanced Materias Technoogy, Inc. API is a trademark of AB SCIEX Pte. Ltd. AB SCIEX is being used under icense. Mii-Q is a registered trademark of Merck KGaA, Darmstadt, Germany. Discaimer is not affiiated with Advanced Materias Technoogy, Agient Technoogies, JASCO, or Waters Corporation. Comparative separations may not be representative of a appications. Kinetex EVO is patented by. U.S. Patent Nos.,6,6 and 8,68,8 and foreign counterparts. 6, Inc. A rights reserved.