Awesome! Unconventionally. Kinetex EVO C18 HPLC/UHPLC Core-Shell Columns 2.6. Core-Shell Technology
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- Lenard Barber
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1 Core-Shell Technology Kinetex EVO C8 HPLC/UHPLC Core-Shell Columns Greater Polar Retention with % Aqueous Stability Robust Methods from ph - Improved Peak Shape for Bases NEW.7 µm NEW. µm µm Unconventionally Awesome!
2 THE PAST Fully Porous You used to have to deal with chromatographic band broadening, low sensitivity, and long run times caused by classical fully porous silica. More Band Broadening And don t forget about system dependency and extremely high backpressure caused by me! Sub- µm Phenomenex, Inc. All rights reserved. Phenomenex l WEB:
3 Core-Shell Technology THE PRESENT Core-Shell Technology That was until Phenomenex, the leading Core-Shell Technology developer and manufacturer, came to liberate you with core-shell particles for each of your specific techniques and applications. Less Band Broadening Improved Results Increased Productivity Easy Transferability Significant Cost Savings 9 Small Molecules Synthetic Oligonucleotides Peptides / Proteins And Now Core-Shell Technology
4 AMAZING NEW KINETEX EVO, NOW! Introducing Kinetex EVO C8 This is truly the next step in the evolution of the chromatographic particle. With Kinetex EVO C8 you now have the freedom to achieve improved results, cost savings, and overall higher productivity at low, neutral, and high ph! O O O O O O O Si CH CH Si O Si S CH CH Si CH CH O Si O Si Si CH CH O O O O O O O O CH C CH Si O Si CH Si O Si CH CH CH CHSi O Si Si O Si CH CH C O O O O O O O O C CH CH O Si Si O Si Si CH CH CH CH CH O Si Si O Si Si CH CH O O O O O O Kinetex EVO C8 uses a patented organo-silica grafting process which incorporates uniform stabilizing ethane cross-linking to provide resistance to high ph attack while maintaining mechanical strength of the coreshell particle. Develop robust methods from ph - Get improved peak shape for bases Easily reduce run times and increase sensitivity Phenomenex l WEB:
5 Core-Shell Technology What emotion will Kinetex EVO C8 bring out in you... STRENGTH...pp. -7 ph Stability TRUST...pp. 8-9 Rugged & Reproducible PRIDE...pp. - CONFIDENCE...pp. - HAPPINESS...pp. -7 Better Peak Shape Excellent Loadability & Separation Power Incredibly High Efficiency WONDER...pp. 8-9 Increased Sensitivity DESIRE...pp. - Novel Selectivity ZEST...pp. - Preparative LC LOVE...pp. -7 Ordering Information UHPLC HPLC PREP NEW.7 µm % higher efficiency than fully porous.7 µm columns NEW. µm Achieve sub- µm performance on HPLC and UHPLC systems µm µm or better efficiencies at µm pressures for HPLC and PREP LC methods
6 STRENGTH ph at Your Control While low ph mobile phases are quite useful, once the door to both low and high ph is opened, your method development options rapidly increase. The illustrations below exemplify how easy it can be to influence the retention behavior and peak shape of ionizable compounds by adjusting your mobile phase ph. Effects of mobile phase ph on Acids Effects of mobile phase ph on Bases Below pk a Low ph Below pk a At pk a At pk a Above pk a High ph Above pk a Use my ph - stability to influence retention of acids and bases! EVO C8 Phenomenex l WEB:
7 Core-Shell Technology STRENGTH Show Those Peaks Who s Boss With excellent performance across a large ph range, Kinetex EVO C8 columns allow you to transform chromatograms and manipulate retention order, no matter the combination of compound functionalities. Now is your chance to break the mold and let your creative LC side flourish. 7 7 ph. ph 7 APP ID 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: F--E Mobile Phase: A: mm Potassium phosphate B: Acetonitrile Gradient: -7 % B in utes Flow Rate:. ml/ Temperature: C Detection: nm Sample:. Ibuprofen. Diphenhydrae. Ethyl Benzene 7 ph APP ID
8 TRUST Rugged and Wonderful With its unique chemistry, the Kinetex EVO C8 particle ensures improved ph stability at alkaline mobile phase conditions along with amazing core-shell performance. It s time for you to expand your method development options and go where other core-shell products can t! % High ph Stability Comparison % % Initial Efficiency for Amitriptyline 9% 8% 7% % % % Injection Cycle Conditions for all columns: Column: Kinetex μm EVO C8 Poroshell.7 μm HPH-C8 UltraCore μm Super C8 Dimensions: x. mm Mobile Phase: A: mm Ammonium bicarbonate (ph.) B: Acetonitrile Gradient: % to 9% B in.. Hold at 9 % B for.7. Re-equilibrate at % B for.. Flow Rate:.8 ml/ Temperature: C Detection: nm Sample: Amitriptyline Kinetex µm EVO C8 Agilent Poroshell.7 µm HPH-C8 ACE UltraCore µm Super C8 Agilent and Poroshell are registered trademarks of Agilent Technologies, Inc. ACE is a registered trademark and UltraCore is a trademark of Advanced Chromatography Technologies Limited. Phenomenex is not affiliated with any of the above listed companies. Comparative separations may not be representative of all applications. 8 Phenomenex l WEB:
9 Core-Shell Technology TRUST Dependability Batch-to-Batch, Column-to-Column Exceptionally rigorous quality control and manufacturing steps ensure that Kinetex EVO C8 columns deliver the pinnacle of performance values and mechanical strength time after time. Simply put, that s reproducibility that you can trust and feel at ease with! 7 8 One of Many Internal Batch/Column QC Tests 8 Batch 8 7 Batch 7 APP ID 7 APP ID 7 Customer Example Run-to-Run Consistency 7,, st Injection th Injection APP ID 7 Batch 7 APP ID 7 APP ID 7 8 Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: F--E Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Acetonitrile Gradient: -9 % B in 7.7 utes Flow Rate:. ml/ Temperature: C Detection: nm Sample:. Uracil. Pindolol. Chlorphenirae. Nortriptyline. -Methyl--Nitrobenzoic acid. -Hydroxy, -methylbenzaldehyde 7. Hexanophenone Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: B--AN Mobile Phase: A:. % Ethanolae in Water (ph~.) B:. % Ethanolae in Acetonitrile Gradient: Time () Flow Rate:. ml/ Temperature: C Detection: nm Sample:. Pyridine. Aniline. Unknown peak. Benzyl alcohol. Toluene. Unknown peak % B 9 Data Courtesy of: Róbert Kormány, Egis Pharmaceuticals Plc., Hungary 9
10 PRIDE Wow! Look at Those Marvelous Peak Shapes! You re going to be the talk of the lab and department when you switch to Kinetex EVO C8 for your basic compound analyses. The unique organo-silica layer of ethane cross-linking found within each Kinetex EVO C8 particle creates a highly inert surface which provides the additional benefit of better peak shape for bases. Kinetex µm EVO C8 x. mm Pressure: 7 bar Peak Capacity: 9 Supelco Ascentis Express µm C8 x. mm Pressure: bar Peak Capacity: 87 APP ID 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Ascentis Express µm C8 Dimensions: x. mm Mobile Phase: A: mm Sodium phosphate dehydrate ph 7. B: Methanol Gradient: % to 9 % B over utes Flow Rate: ml/ Temperature: Ambient Detection: nm Sample:. Maleate. Pseudoephedrine. Scopolae. Doxylae. Chlorphenirae. Diphenhydrae Ascentis and Supelco are registered trademarks of Sigma-Aldrich Co. Phenomenex is not affiliated with any of the above listed companies. Comparative separations may not be representative of all applications. Phenomenex l WEB:
11 Core-Shell Technology PRIDE Amazing Ruggedness and Versatility Even with the similar structured halogenated derivatives of a basic drug, resolution comes easy with the Kinetex EVO C8. The ability to use a high ph mobile phase in combination with the high efficiency and excellent peak shape given by the Kinetex EVO C8 column means that you now have the ultimate HPLC/UHPLC tool for basic compound analysis. Kinetex. µm EVO C8 x. mm Cl N N APP ID 97 Are your columns stable from ph -? I AM!!! Column: Kinetex. µm EVO C8 Dimensions: x. mm Part No.: F-7-E Mobile Phase: A: mm Ammonium bicarbonate (ph.) B: Acetonitrile Gradient: Time () Flow Rate:. ml/ Temperature: Ambient Detection: nm % B Sample:. Phenirae. Chlorphenirae. Bromphenirae EVO C8
12 CONFIDENCE Do More Load-to-Load Use Kinetex EVO C8 columns to avoid the effects of peak shape distortion for bases that traditional fully porous and core-shell columns display. Even across multiple loading conditions, sharp compound peak shape is kept consistently good and strong using a Kinetex EVO C8 LC column. Core-Shell µm C8 Kinetex µm EVO C APP ID 7 APP ID 77 Conditions for all columns: Column: Kinetex µm EVO C8 Core-Shell µm C8 Dimensions: x. mm Mobile Phase:. % TFA in Water /. % TFA in Acetonitrile (:) Flow Rate:. ml/ Temperature: C Detection: nm Sample: µg to µg Loads of Nortriptyline Phenomenex l WEB:
13 Core-Shell Technology CONFIDENCE More Resolution and More Peaks Utilize the amazing performance gains of Kinetex EVO C8 columns to achieve more resolution between the peaks you really care about. Now you can better identify and quantitate low-level metabolites, degredants, or even post-translationally modified peptides. Cefaclor Forced Degradation Phosphorylase B Peptide Map APP ID 988 APP ID 987 Column: Kinetex. µm EVO C8 Dimensions: x. mm Part No.: D-7-E Mobile Phase: A:.% H PO in Water B:.% H PO in Acetonitrile Gradient: Time () Flow Rate:.7 ml/ Temperature: Ambient Detection: nm Sample:. Cefaclor % B Column: Kinetex. µm EVO C8 Dimensions: x. mm Part No.: F-7-E Mobile Phase: A:.% TFA/% Acetonitrile in Water B:.% TFA/Acetonitrile (:9) Gradient: Time () 8 Flow Rate:. ml/ Temperature: C % B 7 Detection: nm (Ambient) Sample: Phosphorylase B Peptide Map.7 µm Need even more resolving power? Try out the stunning Kinetex.7 µm EVO C8 UHPLC particle!
14 HAPPINESS Easy Transfer Between All Your LC Instrumentation The cross-particle scalability of Kinetex EVO C8 (from µm to. µm to.7 µm) particles sets it apart from other core-shell products outside the Kinetex product family. Now you can smoothly scale core-shell ph - methods from UHPLC to HPLC to Preparative HPLC. Imagine how much development time this will help save within your lab and even between other lab locations. Kinetex.7 µm EVO C8 x. mm Fast UHPLC Method (R&D) Kinetex µm EVO C8 x. mm Low Pressure HPLC Method (QC) 7 APP ID APP ID Column: Kinetex.7 µm EVO C8 Dimensions: x. mm Part No.: B-7-AN Mobile Phase: A: mm Potassium phosphate (ph.) B: Acetonitrile Gradient: Time (). Flow Rate:. ml/ Temperature: C % B 9 9 System: Waters ACQUITY UPLC Detection: nm Sample:. -Hydroxybenzoic Acid. Labetolol. Propanolol. Citalopram. Protriptyline. Paroxetine 7. Ibuprofen Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: F--E Mobile Phase: A: mm Potassium phosphate (ph.) B: Acetonitrile Gradient: Time () 7 7. Flow Rate: ml/ Temperature: C System: Agilent Detection: nm % B 9 9 Sample:. -Hydroxybenzoic Acid. Labetolol. Propanolol. Citalopram. Protriptyline. Paroxetine 7. Ibuprofen Phenomenex l WEB:
15 Core-Shell Technology HAPPINESS A Simple Upgrade for Potential Greater Performance! For scientists who are interested in high performance and fast run times,. µm Kinetex EVO C8 columns are an amazing UHPLC solution. Start by matching a Kinetex. µm column to the sub- µm column you re currently using. With lower backpressure and similar or better performance, you ll then have three options: keep the lower pressure for less system strain, increase the flow for higher productivity, or utilize a longer column length to increase potential resolving power. Waters ACQUITY BEH.7 µm C8 Kinetex. µm EVO C8 AU.7 x. mm Bar AU.7 x. mm 9 Bar.... Lower the Pressure,. Retain High Performance Conditions for all columns unless otherwise noted: Column: Kinetex. µm EVO C8 ACQUITY BEH.7 µm C8 Dimensions: x. mm Mobile Phase: A: mm Potassium phosphate (ph.) B: Acetonitrile Gradient: Time (). Flow Rate:. ml/ Temperature: C Detection: nm % B 7 7 Sample:. Green Coffee Extract (Chlorogenic Acid and Antioxidants) Waters and ACQUITY are registered trademarks, and BEH Technology is a trademark of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. AU.... APP ID.. Higher Flow Rate, Increased Productivity ml/ 7 Bar APP ID AU..... Longer Column, Increased Resolution x. mm Bar APP ID APP ID
16 HAPPINESS Instant Improvement of µm and µm Methods Now you can cheerfully improve the resolution, productivity, and sensitivity of your current µm and µm methods using Kinetex µm EVO C8 Core-Shell Technology. This revolutionary coreshell particle was specifically developed to give you great performance and true ph durability at very low HPLC backpressures. µm Up to 9 % higher average efficiency VS. µm Up to % higher average efficiency at half the pressure VS. Fully Porous µm Fully Porous µm Kinetex EVO Core-Shell Kinetex EVO Core-Shell Phenomenex l WEB:
17 Core-Shell Technology HAPPINESS Drop in a Kinetex µm EVO C8 Column to Start Smiling With the combination of rugged ph stability from - and the core-shell performance advantage, you can easily replace old hybrid silica columns and gain immediate method improvements without increasing backpressure. It s time to let chromatography cheer appear! Kinetex µm EVO C8 x. mm Pressure: bar Waters XBridge. µm C8 x. mm Pressure: bar APP ID 78 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 XBridge µm C8 XBridge. µm C8 Dimensions: x. mm Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Acetonitrile Gradient: % to 9 % B over utes Flow Rate:. ml/ Temperature: Ambient Detection: nm Sample:. Uracil. Pindolol. Chlorphenirae. Nortriptyline. -Methyl--Nitrobenzoic acid. -Methyl Salicyl Aldehyde 7. Hexaphenone 7 Waters XBridge µm C8 x. mm 8 Pressure: 7 bar 7 APP ID 7 8 Waters and XBridge are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. 7
18 WONDER Imagine No Suppression Ever have that moment of panic when polar analytes elute way too early in low or neutral ph mobile phases? It s time to put that worry to rest and marvel at the way you can use the enhanced ph stability of Kinetex EVO C8 columns to dramatically improve the retention of polar, basic compounds. Low ph High ph 8.e 8.e 7.e 7.e.e.e Intensity, cps.e.e Intensity, cps.e.e.e.e.e.e APP ID 7.e.e APP ID 7 Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: D--Y Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Gradient: Time (). Flow Rate:.7 ml/ Temperature: Ambient % B 9 Detection: amu (ambient) Detector: AB SCIEX API Sample:. -Hydroxycotinine. Nornicotine. Cotinine. Anabasine. Nicotine Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: D--Y Mobile Phase: A: mm Ammonium bicarbonate (unadjusted ph ~8.) B: Methanol Gradient: Time (). Flow Rate:.7 ml/ Temperature: Ambient % B 9 Detection: amu (ambient) Detector: AB SCIEX API Sample:. -Hydroxycotinine. Nornicotine. Cotinine. Anabasine. Nicotine 8 Phenomenex l WEB:
19 Core-Shell Technology WONDER Increased Sensitivity for LC/MS Applications Alongside LC/UV analyses, the high performance and low pressure of the Kinetex μm EVO C8 make it a tremendous tool for LC/MS and LC/MS/MS. Increased polar basic retention provided by the Kinetex EVO C8 allows for greater use of organic within the mobile phase, subsequently leading to improved ionization and increased sensitivity..e.8e.e.e Intensity, cps.e.e 8.e.e.e.e APP ID 7 and 7 Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Gradient: Time () % B Column: Kinetex µm EVO C8 Dimensions: x. mm Part No.: B--AN Mobile Phase: A: mm Ammonium bicarbonate (ph 8.) B: Methanol Flow Rate:. ml/ Temperature: C Gradient: Time () % B Detection: MS/MS (AB SCIEX API ) ambient Sample:. Sufentanil 9
20 DESIRE The Best C8 Columns For You With more C8 s on the market than any other phase, it s important to understand how the best ones can benefit you! Switch between the combination of the all-purpose Kinetex C8 and butyl side chain bonded XB-C8 to get small defined changes in retention and selectivity. Use the Kinetex EVO C8 for enhanced peak shape of bases and extra alkaline ph stability. Kinetex µm EVO C8 Kinetex µm XB-C8 APP ID 79 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Kinetex µm XB-C8 Kinetex µm C8 Dimensions: x. mm Mobile Phase: A: mm Potassium phosphate (ph.) B: Acetonitrile Gradient: - % B in utes Flow Rate:. ml/ Temperature: C Detection: nm Sample: Nutraceutical Mix Kinetex µm C8 APP ID 78 8 Phenomenex l WEB:
21 Core-Shell Technology DESIRE Built For Your Needs Two exceptional selectivities give you retention enhancement without performance loss. Use the multi-functional Kinetex Biphenyl or ph stable Kinetex EVO C8 to reach the desired solution for your method..8e.e.e.e.e.8e.e.e.e.e 8.e.e.e.e Kinetex µm C8 APP ID 7.8e.e.e.e.e.8e.e.e.e.e 8.e.e.e.e Keep same mobile phase Kinetex µm Biphenyl APP ID 7.8e.e.e.e.e.8e.e.e.e.e 8.e.e.e.e Switch to high ph mobile phase Kinetex µm EVO C8 APP ID 7 Conditions for all columns: Column: Kinetex µm C8 Kinetex µm Biphenyl Kinetex µm EVO C8 Dimensions: x. mm Mobile Phase: A:. % Formic acid in Water B:. % Formic acid in Methanol Mobile Phase: A: mm Ammonium bicarbonate (ph 8.) B: Methanol Gradient: Time () Flow Rate:. ml/ Temperature: Ambient % B Detection: MS/MS (AB SCIEX API ) Sample: Opiates Mix
22 ZEST Get Enthusiastic About Prep LC Reach new levels of purification with the ground-breaking combination of Kinetex EVO C8 core-shell particles and AXIA preparative column technology. This technological combination provides genuine benefits including excellent loadability, high efficiency levels, and incredible ph stability. On top of all this, scaling and method optimization from analytical to prep is a breeze. Waters XBridge µm C8 x. mm Kinetex µm EVO C8 x. mm 8 8 Impurity Not Resolved APP ID 7 Excellent Resolution APP ID Analytical to PREP Scalability Conditions for all columns: Column: Kinetex µm EVO C8 XBridge µm C8 Dimensions: x. mm x. mm (Kinetex AXIA Packed) Mobile Phase: A:. % TFA in Water B:. % TFA in Acetonitrile Gradient: % to 7 % B over utes Flow Rate:. ml/ ml/ (Kinetex AXIA) Temperature: Ambient Detection: nm Sample: Proprietary Pharmaceutical Sample Kinetex µm EVO C8 x. mm AXIA 8 APP ID 7 Waters and XBridge are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. Phenomenex l WEB:
23 Core-Shell Technology ZEST Got an Appetite For Better Results? Kinetex EVO C8 will easily pave the way to enhanced purification and isolation levels with its incredible ph durability and core-shell performance gains. Get ready for a future of high yields and chromatographic improvements over traditional fully porous and hybrid materials. Kinetex µm EVO C8 Waters XBridge µm C8 x. mm AXIA x 9 mm Prep OBD 7 Amazing Peak Shape Over All Sample Loads 7 mv 7 APP ID 78 mv 7 APP ID Conditions for all columns: Column: Kinetex µm EVO C8 Axia packed XBridge µm C8 Prep OBD Dimensions: x. mm (Kinetex) x 9 mm (XBridge) Mobile Phase: A:. % TFA in Water B:. % TFA in Acetonitrile Gradient: -9 % B in. Hold for. Re-equilibrate for. Flow Rate: ml/ Temperature: Ambient Detection: nm Sample: Amitriptyline Sample Load: mg mg mg mg mg 8 mg Waters and XBridge are registered trademarks, OBD is a trademark of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications.
24 Get Method Development Flexibility For Your Small Molecule Analysis Recommended Selectivities If You re Working With: Acids Bases Neutrals Aromatics Kinetex C8 Kinetex F Kinetex Phenyl-Hexyl Kinetex EVO C8 Kinetex XB-C8 Kinetex Biphenyl Kinetex C8 Kinetex C8 Kinetex Biphenyl Kinetex Biphenyl Kinetex Phenyl-Hexyl Kinetex F Acids, Bases, and Neutrals Highly Polar Compounds High ph Isomers Kinetex C8 Kinetex Biphenyl Kinetex EVO C8 Kinetex F Kinetex EVO C8 Kinetex F Kinetex Biphenyl Kinetex HILIC Kinetex EVO C8 Kinetex F Upgrading Your Fully Porous Methods: Fully Porous µm or µm Fully Porous sub- µm Fully Porous Preparative LC Kinetex µm Drop-in for easy performance improvements with no backpressure increase Kinetex. µm Dramatically improve results with efficiency/peak capacity gains Kinetex. µm Get similar efficiencies at lower backpressure allowing for greater productivity gains Kinetex.7 µm Up to % greater efficiencies resulting in drop-in improvements Kinetex. µm Incredible efficiency gains on high end UHPLC systems Kinetex µm Drop-in for easy performance improvement with no backpressure increase Phenomenex l WEB:
25 Core-Shell Technology Choosing The Best Core-Shell Platform For You is Easy! For Small Molecules UHPLC HPLC PREP LC µm. µm. µm.7 µm. µm Phase Best Use ph Stability Available Particle Size(s) EVO C8 C8 XB-C8 C8 F Biphenyl Phenyl-Hexyl HILIC Robust reversed phase methods even in alkaline conditions with improved peak shape for polar basic compounds All purpose phase that offers the hydrophobic retention and methylene selectivity chromatographers expect from a C8 column C8 phase with protective butyl side chains for improved peak shape for basic compounds under neutral and acidic conditions USP L7 phase that provides less hydrophobic and methylene selectivity than a C8 Highly reproducible pentafluorophenyl propyl phase that offers a unique combination of polar, hydrophobic, aromatic, and shape selectivity % aqueous stable and allows for excellent reversed phase retention and enhanced polar and aromatic selectivity Reversed phase chemistry that allows for greater retention and separation of aromatic hydrocarbons Unbonded silica phase for HILIC conditions to provide selectivity for polar compounds - µm. µm.7 µm * µm. µm.7 µm. µm * µm. µm.7 µm * µm. µm.7 µm µm.7 µm * µm. µm.7 µm * µm. µm.7 µm µm. µm.7 µm Phenomenex Application Specific Core-Shell Products Material Phase Best Use ph Stability Available Particle Size(s) For Peptides (, Da) Aeris PEPTIDE XB-C8 Excellent hydrophobicity and methylene selectivity for peptide and peptide mapping separations µm. µm. µm.7 µm For Proteins (>, Da) Aeris WIDEPORE XB-C8 XB-C8 C Maximum hydrophobicity and high temp stability for hydrophilic and PEGylated proteins Medium hydrophobicity and high temp stability for moderately hydrophobic proteins and glycosylated proteins Lowest hydrophobicity for very large or very hydrophobic proteins µm µm µm For Synthetic Oligonucleotides (DNA/RNA) Clarity Oligo-MS C8 Rapid, high efficiency reversed phase LC/MS analysis for QC and characterization *ph stability under gradient conditions. ph stability is.- under isocratic conditions *. µm.7 µm
26 Ordering Information SecurityGuard μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. x. x. /pk EVO C8 A--AN B--AN D--AN F--AN AJ-998 Protect Your LC Investment! Biphenyl A-7-AN B-7-AN D-7-AN AJ-99 XB-C8 A--AN B--AN D--AN AJ-878 C8 A--AN B--AN D--AN F--AN AJ-878 C8 B-8-AN D-8-AN AJ-878 Phenyl-Hexyl B--AN D--AN AJ-8788 for. mm ID SecurityGuard μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. x. /pk EVO C8 B--Y D--Y F--Y AJ-997 novum simplified liquid extraction Remove interferences such as proteins, phospholipids, salts, and more in a quick and simple procedure Novum Biphenyl B-7-Y D-7-Y F-7-Y AJ-98 XB-C8 B--Y D--Y F--Y AJ-877 C8 B--Y D--Y F--Y AJ-877 C8 B-8-Y D-8-Y AJ-8777 Phenyl-Hexyl B--Y D--Y AJ-878 for. mm ID SecurityGuard μm Analytical Columns (mm) ULTRA Cartridges Phases x. x. x. x. /pk Convenient and inexpensive way to remove particulates from HPLC samples Phenex EVO C8 B--E D--E F--E G--E AJ-99 Biphenyl B-7-E D-7-E F-7-E G-7-E AJ-97 XB-C8 B--E D--E F--E G--E AJ-878 C8 B--E D--E F--E G--E AJ-878 C8 B-8-E D-8-E F-8-E G-8-E AJ-877 Phenyl-Hexyl B--E D--E F--E G--E AJ-877 for. mm ID SecurityGuard μm Semi-Preparative Columns (mm) SemiPrep Cartridges*** Phases x x x /pk C8 F--N G--N AJ-978 Biphenyl F-7-N G-7-N AJ-98 for mm ID SecurityGuard μm Axia Packed Preparative Columns (mm) PREP Cartridges* Phases x. x. x. x. x. /ea EVO C8 B--P-AX D--P-AX F--P-AX G--P-AX AJ-9 /ea Biphenyl B-7-P-AX D-7-P-AX F-7-P-AX G-7-P-AX AJ-97 XB-C8 B--P-AX D--P-AX F--P-AX G--P-AX AJ-9 C8 B--P-AX D--P-AX F--P-AX G--P-AX AJ-9 C8 B-8-P-AX D-8-P-AX F-8-P-AX G-8-P-AX AJ-9 Phenyl-Hexyl B--P-AX D--P-AX F--P-AX G--P-AX AJ-97 HILIC D--P-AX F--P-AX G--P-AX AJ-977 for. mm ID SecurityGuard μm Axia Packed Preparative Columns (mm) PREP Cartridges** Phases x x x x x /ea EVO C8 B--U-AX D--U-AX F--U-AX G--U-AX AJ-9 /ea Biphenyl F-7-U-AX AJ-97 XB-C8 B--U-AX D--U-AX F--U-AX G--U-AX AJ-9 C8 B--U-AX D--U-AX F--U-AX G--U-AX AJ-9 C8 B-8-U-AX D-8-U-AX F-8-U-AX G-8-U-AX AJ-97 Phenyl-Hexyl B--U-AX D--U-AX F--U-AX G--U-AX AJ-9 for mm ID Protect your Kinetex LC columns from contaants and extend their lifetime. guardit If you are not completely satisfied with Kinetex core-shell columns, send in your comparative data to a similar product with the Kinetex column within days for a FULL REFUND. SecurityGuard ULTRA Cartridges require holder, Part No.: AJ-9 * PREP SecurityGuard Cartridges require holder, Part No.: AJ-8 ** PREP SecurityGuard Cartridges require holder, Part No.: AJ-877 *** SemiPrep SecurityGuard Cartridges require holder, Part No.: AJ-98 Phenomenex l WEB:
27 Ordering Information SecurityGuard. μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. 7 x. x. x. /pk Core-Shell Technology EVO C8 A-7-AN B-7-AN D-7-AN F-7-AN AJ-998 F A-7-AN B-7-AN D-7-AN F-7-AN AJ-9 Biphenyl A--AN B--AN D--AN F--AN AJ-99 XB-C8 A-9-AN B-9-AN C-9-AN D-9-AN F-9-AN AJ-878 C8 A--AN B--AN C--AN D--AN F--AN AJ-878 C8 A-97-AN B-97-AN C-97-AN D-97-AN F-97-AN AJ-878 HILIC A--AN B--AN C--AN D--AN F--AN AJ-878 Phenyl-Hexyl A-9-AN B-9-AN C-9-AN D-9-AN F-9-AN AJ-8788 for. mm ID SecurityGuard. μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. 7 x. x. x. /pk EVO C8 B-7-Y D-7-Y F-7-Y AJ-997 F B-7-Y D-7-Y F-7-Y AJ-9 Biphenyl B--Y D--Y F--Y AJ-98 XB-C8 A-9-Y B-9-Y C-9-Y D-9-Y F-9-Y AJ-877 C8 A--Y B--Y C--Y D--Y F--Y AJ-877 C8 A-97-Y B-97-Y C-97-Y D-97-Y F-97-Y AJ-8777 HILIC A--Y F--Y AJ-8779 Phenyl-Hexyl B-9-Y D-9-Y F-9-Y AJ-878 for. mm ID SecurityGuard. μm Analytical Columns (mm) ULTRA Cartridges Phases x. x. 7 x. x. x. /pk EVO C8 B-7-E D-7-E F-7-E AJ-99 F B-7-E D-7-E F-7-E AJ-9 Biphenyl B--E D--E F--E AJ-97 XB-C8 B-9-E C-9-E D-9-E F-9-E AJ-878 C8 A--E B--E C--E D--E F--E AJ-878 C8 B-97-E C-97-E D-97-E F-97-E AJ-877 HILIC B--E C--E D--E F--E AJ-877 Phenyl-Hexyl B-9-E C-9-E D-9-E F-9-E AJ-877 for. mm ID SecurityGuard.7 μm Minibore Columns (mm) ULTRA Cartridges Phases x. x. x. x. /pk EVO C8 B-7-AN D-7-AN F-7-AN AJ-998 F B-7-AN D-7-AN F-7-AN AJ-9 Biphenyl B-8-AN D-8-AN F-8-AN AJ-99 XB-C8 A-98-AN B-98-AN D-98-AN F-98-AN AJ-878 C8 A-7-AN B-7-AN D-7-AN F-7-AN AJ-878 C8 A-99-AN B-99-AN D-99-AN F-99-AN AJ-878 HILIC A-7-AN B-7-AN D-7-AN AJ-878 Phenyl-Hexyl B--AN D--AN F--AN AJ-8788 for. mm ID SecurityGuard.7 μm MidBore Columns (mm) ULTRA Cartridges Phases x. x. x. /pk XB-C8 A-98-Y B-98-Y D-98-Y AJ-877 C8 B-7-Y D-7-Y AJ-877 C8 A-99-Y B-99-Y D-99-Y AJ-8777 HILIC B-7-Y AJ-8779 for. mm ID. μm Minibore Columns (mm) Phases x. x. C8 A--AN B--AN SecurityGuard ULTRA Cartridges require holder, Part No.: AJ-9 Terms and Conditions Subject to Phenomenex Standard Terms & Conditions, which may be viewed at Trademarks Phenomenex, Clarity, and Kinetex are registered trademarks of Phenomenex. Aeris, Axia, Oligo-MS, Novum, Phenex, MidBore, and SecurityGuard are trademarks of Phenomenex. Waters, ACQUITY, UPLC, and XBridge are registered trademarks, OBD and BEH Technology are trademarks of Waters Corporation. Agilent and Poroshell are registered trademarks of Agilent Technologies, Inc. Ascentis and Supelco are registered trademarks of Sigma-Aldrich Co. ACE is a registered trademark and UltraCore is a trademark of Advanced Chromatography Technologies Limited. API is a trademark of AB SCIEX Pte. Ltd. AB SCIEX is being used under license. Disclaimer Phenomenex is not affiliated with Advanced Chromatography Technologies Limited, Agilent Technologies, Sigma-Aldrich Co., or Waters Corporation. Comparative separations may not be representative of all applications. Axia column and packing technology is patented by Phenomenex. U.S. Patent No. 7, 7, 8 Kinetex EVO is patented by Phenomenex. U.S. Patent Nos. 7,,7 and 8,8,8 and foreign counterparts. The opinions stated herein are solely those of the speaker and not necessarily those of any company or organization. Phenomenex, Inc. All rights reserved. 7
28 Introducing Kinetex EVO C8! Develop robust methods from ph - Get improved peak shape for bases Easily reduce run times and increase sensitivity Australia t: + ()-98- f: + ()-98- auinfo@phenomenex.com Core-Shell Technology Luxembourg t: + ()-87 f: + ()-879 nlinfo@phenomenex.com Austria t: + ()-9- f: + ()-9- anfrage@phenomenex.com Belgium t: + () (French) t: + () 8 (Dutch) f: + ()-879 beinfo@phenomenex.com Canada t: + (8) -8 f: + () info@phenomenex.com China t: +8 () 8-8 f: +8 () 89-8 chinainfo@phenomenex.com Denmark t: f: + 8 nordicinfo@phenomenex.com Finland t: +8 ()9 789 f: + 8 nordicinfo@phenomenex.com France t: + () 9 f: + () 9 franceinfo@phenomenex.com Germany t: +9 ()-88- f: +9 ()-88- anfrage@phenomenex.com India t: +9 ()- f: +9 ()- indiainfo@phenomenex.com Ireland t: + () 7 f: eireinfo@phenomenex.com Mexico t: f: tecnicomx@phenomenex.com The Netherlands t: + ()-87 f: + ()-879 nlinfo@phenomenex.com New Zealand t: + ()9-789 f: + ()9-789 nzinfo@phenomenex.com Norway t: +7 8 f: + 8 nordicinfo@phenomenex.com Puerto Rico t: + (8) -HPLC f: + () info@phenomenex.com Spain t: f: espinfo@phenomenex.com Sweden t: + ()8 9 f: + 8 nordicinfo@phenomenex.com United Kingdom t: + ()-7 f: + ()-79 ukinfo@phenomenex.com USA t: + () - f: + () info@phenomenex.com All other countries Corporate Office USA t: + () - f: + () info@phenomenex.com Italy t: +9 7 f: +9 7 italiainfo@phenomenex.com Phenomenex products are available worldwide. For the distributor in your country, contact Phenomenex USA, International Department at international@phenomenex.com BR8_W
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