October 25-26, Fifth Avenue 3rd Floor New York, NY (USA)

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1 October 25-26, Fifth Avenue 3rd Floor New York, NY (USA) Join CurePSP and the PSP Association for the First International Research Symposium on PSP & CBD at the Royal College of Physicians in London, UK. There will be a welcome reception and talks the evening of Thursday, October 25, 2018 followed by a full day of scientific and clinical presentations and poster sessions on Friday, October 26, Watling Street West Towcester, Northamptonshire NN12 6BX (UK) psp@pspassociation.org.uk Scientists from academia and pharma will present their latest research results in the field of PSP, CBD, and related diseases. Sessions include updates from the PSP Genetics Consortium, the brain banks in North America and Europe, and the latest clinical trials; patient registries and natural history studies, biomarkers as well as keynote lectures on the newest results in tauopathy research. For further information please go to:

2 The First International Research Symposium on PSP & CBD AGENDA October 25 26, 2018 Royal College of Physicians 11 St Andrews Place Regent s Park, London NW1 4LE, UK THURSDAY, OCTOBER 25, :00 6:20pm Welcome and Introductions Kate Arkell, PSP Association, Towcester (UK) Alex Klein, CurePSP, New York, NY (USA) Her Royal Highness The Duchess of Gloucester 6:20 6:35pm PSPA Clinical Research Fellow Chair: Kate Arkell, PSP Association, Towcester (UK) Developing Biomarkers for PSP Edwin Jabbari, UCL, London (UK) 6:35 6:50pm CurePSP Grantee Chair: Alex Klein, CurePSP, New York, NY (USA) In-Home Care for PSP Patients Jori Fleisher, Rush University, Chicago, IL (USA) 6:50 7:20pm Chair: Huw Morris, UCL, London (UK) Twenty-Five Years Progress in Progressive Supranuclear Palsy Lawrence I. Golbe, Rutgers University, New Brunswick, NJ (USA) 7:20 9:00pm Posters and Cocktail Reception FRIDAY, OCTOBER 26, :30 8:20am Registration 8:20 8:30am Welcome John C. Steele, M.D., FRCP(C) 8:30 8:55am Chair: Karen Duff, Columbia University, New York, NY (USA) Tau-Induced Laminopathy is a Mechanistic Driver of Neurodegeneration Bess Frost, University of Texas San Antonio (USA) 8:55 9:40am Neuropathology Chair: James Rowe, University of Cambridge, Cambridge (UK) Update on the Mayo Clinic Brain Bank Dennis Dickson, Mayo Clinic, Jacksonville, FL (USA) Update on the Queen Square Brain Bank Janice Holton, Queen Square Brain Bank, London (UK) Mapping the Progression of Tauopathies Helen Ling, UCL, London (UK) 9:40 10:00am Coffee Break and Poster Session

3 FRIDAY, OCTOBER 26, 2018 CONTINUED 10:00am 12:00pm Genetics Session and Panel Discussion Chair: Jeff Friedman, CurePSP, San Diego, CA (USA) Insights into the Genetics of PSP John Hardy, UCL, London (UK) Update on the PSP Genetics Consortium Gerald Schellenberg, University of Pennsylvania, Philadelphia, PA (USA) Epigenetics of PSP Guenter Hoeglinger, German Center of Neurodegenerative Diseases, Munich (Germany) Clinical and Genetic Variation in PSP Huw Morris, UCL, London (UK) NINDS/NIH Funding Policies and Strategies in Genetics Marg Sutherland, NINDS, Bethesda, MD (USA) 12:00 1:00pm Lunch and Poster Session 1:00 1:30pm Chair: Jean-Christoph Corvol, Hôpital Pitié-Salpêtrière, Paris, (France) Non-Genetic, Non-Antibody Novel Therapeutic Strategies in Tauopthies Karen Duff, Columbia University, New York, NY (USA) 1:30 3:00pm Clinical Research Chair: Lawrence I. Golbe, Rutgers University, New Brunswick, NJ (USA) Breaking News in PSP/CBD Clinical Trials Adam Boxer, University of California San Francisco, CA (USA) How Representative is the Population Included in PSP Clinical Trials? Jean-Christoph Corvol, Hôpital Pitié-Salpêtrière, Paris, (France) Lesson Learnt from HD Trials Anne Rosser, Cardiff University,Wales (UK) Pharma Updates Panel Discussion 3:00 3:20pm Coffee Break and Poster Session 3:20 4:05pm Registries / Natural History Studies Chair: Huw Morris, UCL, London (UK) Update on the FTD Disorder Registry Dianna Wheaton, FTD Disorder Registry, Dallas, Texas (USA) Update on the Prospect Study and CBD Registry John Woodside, UCL, London (UK) Update on DescribePSP and ProPSP Studies Gesine Respondek, DZNE, Munich (Germany) 4:05 5:05pm Tau Biomarkers and Imaging Chair: Guenter Hoeglinger, DZNE, Munich (Germany) Latest Results in Tau-PET Imaging James Rowe, University of Cambridge, Cambridge (UK) Latest Results in Fluid Biomarkers Henrik Zetterberg, University of Gothenburg, (Sweden) Latest Results in MRI Imaging Jennifer Whitwell, Mayo Clinic, Rochester, MN (USA) 5:05 5:15pm PSPA/CurePSP Early-Career Researcher Award + Poster Prize 5:15 5:25pm Closing Remarks Andrew Symons, PSP Association, Towcester (UK) David Kemp, CurePSP, New York, NY (USA) 5:25 8:00pm Poster Session and Cocktail Reception Agenda is subject to change. For further information please go to:

4 The First International Research Symposium on PSP & CBD October 25 26, 2018 Royal College of Physicians 11 St Andrews Place Regent s Park, London NW1 4LE, UK SPONSORSHIP OPPORTUNITIES Exclusive Signature Sponsor: 50,000 Sponsorship of the lunch for attendees Full page ad in the Symposium Program with a hyperlink and throughout the event as the Signature Sponsor One promotional giveaway designed and printed by the sponsor First choice of exhibit table or booth location complete with drape, two chairs, electrical outlet and admission for 2 representatives Admission for 6 additional symposium attendees Gold Sponsors: 25,000 Half-page program ad and throughout the event as a Gold Sponsor One promotional giveaway designed and printed by the sponsor display your company material complete with drape, Admission for 4 additional symposium attendees Silver Sponsors: 10,000 Quarter-page program ad and throughout the event as a Silver Sponsor display your company material complete with drape, Admission for 2 additional symposium attendees Post Conference Reception Sponsors: 6,000 Inclusion of sponsor logo in the program and on poster in the break area Sponsors may provide napkins imprinted with their company logo to accompany the breaks with a link to your website Admission for 2 symposium attendees

5 The First International Research Symposium on PSP & CBD Sponsorship Opportunities Exclusive Event Mobile App Sponsor: 6,000 Put your company s brand and message right in attendees hands with a mobile app sponsorship package! Attendees will have the ability to access session content, a schedule of events, exhibitor listings, all general event information and a floor plan using their mobile devices. Logo and company links on all app marketing material Logo included on the app promotions section Placement on recogniti with corporate logo Admission for 2 symposium attendees Exclusive Poster Session Sponsor: 3,500 Poster session naming privileges display your company material complete with drape, Exhibitor: 2,000 Exhibit table with 2 representatives to display your company material complete with drape, Exclusive Branded Lanyard Sponsor: 1,200 Logo of your choice and company name in color on the badge lanyards with a link to your website Full Page Program Ad: 2,000 Half Page Program Ad: 1,000 Printed in the program distributed onsite to an estimated 150 international attendees Tailored Sponsorship Packages Any budget is welcome and the above are examples of the potential level of branding and exposure that we offer. From speaking, to branding, to supporting a networking reception, there s something for your company, and every package can be tailored to your specific organizational development needs! Special NGO tariffs available; please inquire with events@curepsp.org. For further information and to become an event sponsor, contact: Jaclyn Zendrian Director of Events, CurePSP Zendrian@curepsp.org Phone: Break Sponsors: 2,000 Two breaks are held during the day. Inclusion of sponsor logo in the program and on poster in the break area with a link to your website Sponsors may provide napkins imprinted with their company logo to accompany the breaks